Poor pregnancy outcome in women with type 1 diabetes is predicted by elevated HbA1c and spikes of high glucose values in the third trimester

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 27, Issue 2, 2014, Pages 149-154

  Damm, Peter ^a   Mersebach, Henriette ^b   Råstam, Jacob ^b   Kaaja, Risto ^c   Hod, Moshe ^d   McCance, David R ^e   Mathiesen, Elisabeth R ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c UNIVERSITY OF TURKU   (Finland)

^d TEL AVIV UNIVERSITY   (Israel)

^e ROYAL VICTORIA HOSPITAL   (United Kingdom)

Author keywords

Glucose spikes; HbA1c; Predictors; Pregnancy outcome

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; HUMAN INSULIN; INSULIN;

ALBUMINURIA; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FETUS; FETUS GROWTH; FETUS MALFORMATION; FETUS WASTAGE; GESTATIONAL AGE; GLUCOSE BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PERINATAL DEATH; PREECLAMPSIA; PREGNANCY OUTCOME; PREMATURE LABOR; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); THIRD TRIMESTER PREGNANCY;

ADULT; ALBUMINURIA; BLOOD GLUCOSE; CONGENITAL ABNORMALITIES; DIABETES MELLITUS, TYPE 1; FEMALE; FETAL DEATH; FOOD; GESTATIONAL AGE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN; INSULIN ASPART; INSULIN, ISOPHANE; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY IN DIABETICS; PREGNANCY OUTCOME; PREGNANCY TRIMESTER, THIRD;

EID: 84890517938     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2013.806896     Document Type: Article

References (25)

1. Hawthorne G, Robson S, Ryall EA, et al. Prospective population based survey of outcome of pregnancy in diabetic women: results of the Northern Diabetic Pregnancy Audit, 1994. Br Med J 1997;315: 279-81. (Pubitemid 27326231)
2. Casson IF, Clarke CA, Howard CV, et al. Outcomes of pregnancy in insulin dependent diabetic women: results of a five year population cohort study. Br Med J 1997;315:275-78. (Pubitemid 27326208)
3. Nielsen GL, SØrensen HT, Nielsen PH, et al. Glycosylated hemoglobin as predictor of adverse foetal outcome in type 1 diabetic pregnancies. Acta Diabetol 1997;34:217-22. (Pubitemid 27485062)
4. Suhonen L, Hiilesmaa V, Teramo K. Glycemic control during early pregnancy and foetal malformations in women with type 1 diabetes mellitus. Diabetologia 2000;43:79-82. (Pubitemid 30129305)
5. Kerssen A, de Valk HW, Visser GH. Increased second trimester maternal glucose levels are related to extremely large-forgestational- age infants in women with type 1 diabetes. Diabetes Care 2007;30:1069-74. (Pubitemid 46684626)
6. Holmes VA, Young IS, Patterson CC, et al; for the Diabetes And Pre-eclampsia Intervention Trial study group. Optimal glycemic control, pre-eclampsia, and gestational hypertension in women with type 1 diabetes in the Diabetes and Pre-eclampsia Intervention Trial. Diabetes Care 2011;34:1683-8.
7. Metzger BE, Lowe LP, Dyer AR, et al; HAPO Study Cooperative Research Group. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008;358:2061-3.
8. American Diabetes Association. Preconception care of women with diabetes (Position Statement). Diabetes Care 2004;27:S76-8.
9. Landon MB, Gabbe SG, Piana R, et al. Neonatal morbidity in pregnancy complicated by diabetes mellitus: predictive value of maternal glycemic profiles. Am J Obstet Gynecol 1987;156: 1089-95. (Pubitemid 17075453)
10. Page RC, Kirk BA, Fay T, et al. Is macrosomia associated with poor glycemic control in diabetic pregnancy? Diabet Med 1996;13: 170-4. (Pubitemid 26075527)
11. Mello G, Parretti E, Mecacci F, et al. Excursion of daily glucose profiles in pregnant women with IDDM: relationship with perinatal outcome. J Perinat Med 1997;25:488-97. (Pubitemid 28014579)
12. Mello G, Parretti E, Mecacci F, et al. What degree of maternal metabolic control in women with type 1 diabetes is associated with normal body size and proportions in full-term infants? Diabetes Care 2000;23:1494-8.
13. Buchanan TA, Schemmer JK, Freinkel N. Embryotoxic effects of brief maternal insulin-hypoglycemia during organogenesis in the rat. J Clin Invest 1986;78:643-9. (Pubitemid 16024797)
14. Mathiesen ER, Kinsley B, Amiel SA, et al. Maternal glycemic control and hypoglycemia in type 1 diabetic pregnancy: a randomized trial of insulin aspart versus human insulin in 322 pregnant women. Diabetes Care 2007;30:771-6. (Pubitemid 46556565)
15. Hod M, Damm P, Kaaja R, et al. Fetal and perinatal outcomes in type 1 diabetes pregnancy: a randomized study comparing insulin aspart with human insulin in 322 subjects. Am J Obstet Gynecol 2008;198:186.e1-7.
16. Murphy HR, Steel SA, Roland JM, et al. Obstetric and perinatal outcomes in pregnancies complicated by Type 1 and Type 2 diabetes: influences of glycaemic control, obesity and social disadvantage. Diabet Med 2011;28:1060-7.
17. Owens LA, O,Sullivan EP, Kirwan B, et al. ATLANTIC DIP: the impact of obesity on pregnancy outcome in glucose-tolerant women. Diabetes Care 2010;33:577-9.
18. Ekbom P, Damm P, Feldt-Rasmussen B, et al. Pregnancy outcome in type 1 diabetic women with microalbuminuria. Diabetes Care 2001;24:1739-44. (Pubitemid 33716475)
19. Dalfr̀ MG, Sartore G, Di Cianni G, et al. Glucose variability in diabetic pregnancy. Diabetes Technol Ther 2011;13:853-9.
20. de Veciana M, Major CA, Morgan MA, et al. Postprandial versus preprandial blood glucose monitoring in women with gestational diabetes mellitus requiring insulin therapy. N Engl J Med 1995;333: 1237-41.
21. Manderson JG, Patterson CC, Hadden DR, et al. Preprandial versus postprandial blood glucose monitoring in type 1 diabetic pregnancy: a randomized controlled clinical trial. Am J Obstet Gynecol 2003;189:507-12.
22. Glinianaia SV, Tennant PW, Bilous RW, et al. HbA(1c) and birthweight in women with pre conception type 1 and type 2 diabetes: a population-based cohort study. Diabetologia 2012;55: 3193-203.
23. Weissmann-Brenner A, Simchen MJ, Zilberberg E, et al. Maternal and neonatal outcomes of macrosomic pregnancies. Med Sci Monit 2012;18:PH77-81.
24. Clausen, TD, Mathiesen ER, Hansen T, et al. High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes - the role of intrauterine hyperglycemia. Diabetes Care 2008;31: 340-6. (Pubitemid 351213348)
25. Clausen TD, Mathiesen ER, Hansen T, et al. Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellituus or type 1 diabetes. J Clin Endocrinol Metab 2009;94:2464-70.