Activation of proMMP-2 by U46619 occurs via involvement of p 38MAPK-NFκB-MT1MMP signaling pathway in pulmonary artery smooth muscle cells

Molecular and Cellular Biochemistry

Volumn 385, Issue 1-2, 2014, Pages 53-68

  Chowdhury, Animesh ^a   Roy, Soumitra ^a   Chakraborti, Tapati ^a   Dey, Kuntal ^a   Chakraborti, Sajal ^a  

^a UNIVERSITY OF KALYANI   (India)

Author keywords

MT1 MMP; NF B; p38MAPK; proMMP 2; TIMP 2

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GELATINASE A; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE 14; MITOGEN ACTIVATED PROTEIN KINASE 14; PROMATRIX METALLOPROTEINASE 2; SMALL INTERFERING RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; COW; CYTOSOL; DNA BINDING; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; MOLECULAR BIOLOGY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; PULMONARY ARTERY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; CATTLE; DOWN-REGULATION; ENZYME ACTIVATION; ENZYME PRECURSORS; GELATINASES; I-KAPPA B PROTEINS; MATRIX METALLOPROTEINASE 14; MYOCYTES, SMOOTH MUSCLE; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PULMONARY ARTERY; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TISSUE INHIBITOR OF METALLOPROTEINASE-2; UP-REGULATION;

EID: 84890504266     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1814-4     Document Type: Article

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