In Vivo Imaging of Lymphatic Drainage of Cerebrospinal Fluid in Mouse

Fluids and Barriers of the CNS

Volumn 10, Issue 1, 2013, Pages

  Mathieu, Emily ^a,b   Gupta, Neeru ^a,b   Macdonald, R L ^a,b   Ai, Jinglu ^a,b   Yücel, Yeni H ^a,b  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Cerebrospinal fluid; Hyperspectral imaging; In vivo imaging; Lymphatic; Mouse; Nanotechnology; Non invasive imaging; Quantum dot

Indexed keywords

QUANTUM DOT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID DRAINAGE; CISTERNA MAGNA; CONTROLLED STUDY; DURA MATER; FLUORESCENCE IMAGING; HISTOLOGY; IN VIVO STUDY; LYMPH NODE; LYMPHATIC DRAINAGE; MALE; MOUSE; NONHUMAN; OBSERVATIONAL STUDY; PRIORITY JOURNAL;

EID: 84890489469     PISSN: None     EISSN: 20458118     Source Type: Journal    
DOI: 10.1186/2045-8118-10-35     Document Type: Article

References (20)

1. Kapoor KG, Katz SE, Grzybowski DM, Lubow M. Cerebrospinal fluid outflow: an evolving perspective. Brain Res Bull 2008, 77:327-334. 10.1016/j.brainresbull.2008.08.009, 18793703.
2. van Gijn J, Hijdra A, Wijdicks EF, Vermulen M, van Crevel H. Acute hydrocephalus after aneurysmal subarachnoid hemorrhage. J Neurosurg 1985, 63:355-362. 10.3171/jns.1985.63.3.0355, 4020461.
3. Kida S, Pantazis A, Weller RO. Cerebrospinal fluid drains directly from the subarachnoid space into nasal lymphatics in the rat. Anatomy, histology, and immunological significance. Neuropathol Appl Neurobiol 1993, 19:480-488. 10.1111/j.1365-2990.1993.tb00476.x, 7510047.
4. Boulton M, Flessner M, Armstrong D, Mohamed R, Hay J, Johnston M. Contribution of extracranial lymphatics and arachnoid villi to the clearance of a CSF tracer in the rat. Am J Physiol 1999, 276:R818-R823.
5. Bradbury MW, Cole DF. The role of the lymphatic system in drainage of cerebrospinal fluid and aqueous humour. J Physiol 1980, 299:353-365. 1279229, 6155466.
6. Boulton M, Young A, Hay J, Armstrong D, Flessner M, Schwartz M, Johnston M. Drainage of CSF through lymphatic pathways and arachnoid villi in sheep: measurement of 125I-albumin clearance. Neuropathol Appl Neurobiol 1996, 22:325-333. 10.1111/j.1365-2990.1996.tb01111.x, 8875467.
7. Pile-Spellman JM, McKusick KA, Strauss HW, Cooney J, Traveras JM. Experimental in vivo imaging of the cranial perineural lymphatic pathway. Am J Neuroradiol 1984, 5:539-545.
8. Hunter JV, Batchelder KF, Lo EH, Wolf GL. Imaging techniques for in vivo quantitation of extracranial lymphatic drainage of the brain. Neuropathol Appl Neurobiol 1995, 21:185-188. 10.1111/j.1365-2990.1995.tb01049.x, 7477726.
9. Moinuddin SM, Tada T. Study of cerebrospinal fluid flow dynamics in TGF-beta1 induced chronic hydrocephalic mice. Neurol Res 2000, 22:215-222.
10. Kobayashi H, Hama Y, Koyama Y, Barrett T, Regino CA, Urano Y, Choyke PL. Simultaneous multicolor imaging of five different lymphatic basins using quantum dots. Nano Lett 2007, 7:1711-1716. 10.1021/nl0707003, 17530812.
11. Tam AL, Gupta N, Zhang Z, Yücel YH. Quantum dots trace lymphatic drainage from the mouse eye. Nanotechnology 2011, 22:425101. doi: 10.1088/0957-4484/22/42/425101, 10.1088/0957-4484/22/42/425101, 21934199.
12. Tam AL, Gupta N, Zhang Z, Yücel YH. Latanoprost stimulates ocular lymphatic drainage: An in vivo nanotracer study. Trans Vis Sci Technol 2013, 2:3. Available from: http://tvstjournal.org/doi/pdf/10.1167/tvst.2.5.3.
13. Swart PJ, Beljaars L, Kuipers ME, Smit C, Nieuwenhuis P, Meijer DK. Homing of negatively charged albumins to the lymphatic system: general implications for drug targeting to peripheral tissues and viral reservoirs. Biochem Pharmacol 1999, 58:1425-1435. 10.1016/S0006-2952(99)00224-5, 10513986.
14. Van den Broeck W, Derore A, Simoens P. Anatomy and nomenclature of murine lymph nodes : Descriptive study and nomenclatory standardization in BALB/cAnNCrl mice. J Immunol Methods 2006, 312:12-19. 10.1016/j.jim.2006.01.022, 16624319.
15. Harling-Berg CJ, Knopf PM, Merriam J, Cserr HF. Role of cervical lymph nodes in the systemic humoral immune response to human serum albumin microinfused into rat CSF. J Neuroimmunol 1989, 25:185-193. 10.1016/0165-5728(89)90136-7, 2584396.
16. Tilney NL. Patterns of lymphatic drainage in the adult laboratory rat. J Anat 1971, 109:369-383. 1270981, 5153800.
17. Hauck TS, Anderson RE, Fischer HC, Newbigging S, Chan WC. In vivo quantum-dot toxicity assessment. Small 2010, 6:138-144. 10.1002/smll.200900626, 19743433.
18. Rosenblum LT, Kosaka N, Mitsunaga M, Choyke PL, Kobayashi H. Optimizing quantitiative in vivo fluorescence imaging with near infrared quantum dots. Contrast Media Mol Imaging 2011, 6:148-152. 10.1002/cmmi.409, 20936710.
19. Wagshul ME, Johnston M. The brain and the lymphatic system. Immunology of the Lymphatic System 2013, 143-164. New York: Springer, Santambroglio L, 1.
20. Schmid-Schönbein GW. Microlymphatics and lymph flow. Physiol Rev 1990, 70:987-1028.