Discovery of potent and selective inhibitors of toxoplasma gondii thymidylate synthase for opportunistic infections

ACS Medicinal Chemistry Letters

Volumn 4, Issue 12, 2013, Pages 1148-1151

  Zaware, Nilesh ^a   Sharma, Hitesh ^b   Yang, Jie ^a   Devambatla, Ravi Kumar Vyas ^a   Queener, Sherry F ^c   Anderson, Karen S ^b   Gangjee, Aleem ^a  

^a DUQUESNE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

active site inhibitors; crystal structure; Opportunistic infection; thymidylate synthase inhibitors; Toxoplasma gondii

Indexed keywords

DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; INDOLE DERIVATIVE; PYRIMETHAMINE; SULFADIAZINE; SULFONAMIDE; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR;

ARTICLE; CELL CULTURE; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HYDROGEN BOND; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; TOXOPLASMOSIS;

EID: 84890486360     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400208v     Document Type: Article

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