Oral liquid levothyroxine treatment at breakfast: A mistake?

European Journal of Endocrinology

Volumn 170, Issue 1, 2014, Pages 95-99

  Cappelli, Carlo ^a   Pirola, Ilenia ^a   Gandossi, Elena ^a   Formenti, Annamaria ^a   Castellano, Maurizio ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOTHYROXINE; LIOTHYRONINE; THYROTROPIN; THYROXINE;

ADULT; ARTICLE; COFFEE; COHORT ANALYSIS; DRUG EFFECT; DRUG INDICATION; EUTHYROIDISM; FEMALE; FOOD DRUG INTERACTION; FOOD INTAKE; HEALTH CARE COST; HUMAN; HYPOTHYROIDISM; LIOTHYRONINE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MEAL; MIDDLE AGED; PRIORITY JOURNAL; TABLET FORMULATION; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

ADMINISTRATION, ORAL; ADULT; BREAKFAST; COFFEE; COHORT STUDIES; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOOD-DRUG INTERACTIONS; HORMONE REPLACEMENT THERAPY; HUMANS; HYPOTHYROIDISM; INTESTINAL ABSORPTION; ITALY; MALE; MIDDLE AGED; THYROTROPIN; THYROXINE; TIME FACTORS; TRIIODOTHYRONINE;

EID: 84890477767     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-13-0693     Document Type: Article

References (19)

1. tm. Use of Meds in the U.S. review of 2010 in http://www.imshealth.com.
2. Gkotsina M, Michalaki M, Mamali I, Markantes G, Sakellaropulos GC, Kalfarentzos F, Vagenakis A & Markou B. Improved levothyroxine pharmacokinetics after bariatric surgery. Thyroid 2013 4 414-419. (doi:10.1089/thy.2011.0526)
3. Lamson MJ, Pamplin CL, Rolleri RL & Klein I. Quantitation of a substantial reduction in levothyroxine (T4) absorption by food. Thyroid 2004 14 876.
4. Benvenga S, Bartolone L, Pappalardo MA, Russo A, Lapa D, Giorgianni G, Saraceno G & Trimarchi F. Altered intestinal absorption of L-thyroxine caused by coffee. Thyroid 2008 18 293-301. (doi:10.1089/thy.2007.0222)
5. Pacini F & Castagna MG. Approach to and treatment of differentiated thyroid carcinoma. Medical Clinics of North America 2012 96 369-383. (doi:10.1016/j.mcna.2012.01.002)
6. Almandoz JP & Gharib H. Hypothyroidism: etiology, diagnosis, and management. Medical Clinics of North America 2012 96 203-221. (doi:10.1016/j.mcna.2012.01.005)
7. Centanni M, Gargano L, Canettieri G, Viceconti N, Franchi A, Delle Fave G & Annibale B. Thyroxine in goiter, Helicobacter pylori infection, and chronic gastritis. New England Journal of Medicine 2006 354 1787-1795. (doi:10.1056/NEJMoa043903)
8. Bach-Huynh TG, Nayak B, Loh J, Soldin S & Jonklaas J. Timing of levothyroxine administration affects serum thyrotropin concentration. Journal of Clinical Endocrinology and Metabolism 2009 94 3905-3912. (doi:10.1210/jc.2009- 0860)
9. 4 malabsorption by coffee observed with traditional tablet formulations. Endocrine 2013 43 154-160. (doi:10.1007/s12020-012-9772-2)
10. Düsing R, Lottermoser K & Mengden T. Compliance with drug therapy - new answers to an old question. Nephrology, Dialysis, Transplantation 2001 16 1317-1321. (doi:10.1093/ndt/16.7.1317)
11. Perez CL, Araki FS, Graf H & de Carvalho GA. Serum thyrotropin levels following levothyroxine administration at breakfast. Thyroid 2013 23 779-784. (doi:10.1089/thy.2012.0435)
12. Yue CS, Scarsi C & Ducharme MP. Pharmacokinetics and potential advantages of a new oral solution of levothyroxine vs. other available dosage forms. Arzneimittel-Forschung 2012 62 631-636.
13. 4 tablets following bariatric surgery. Obesity Surgery 2013 23 1493-1496. (doi:10.1007/s11695-013-1015-y)
14. Zhang H, Zhang J & Streisand JB. Oralmucosal drug delivery: clinical pharmacokinetics and therapeutic applications. Clinical Pharmacokinetics 2002 41 661-680. (doi:10.2165/00003088-200241090-00003)
15. Won CM. Kinetics of degradation of levothyroxine in aqueous solution and in solid state. Pharmaceutical Research 1992 9 131-137. (doi:10.1023/A: 1018952415732)
16. Collier JW, Shah RB, Gupta A, Sayeed V, Habib MJ & Khan MA. Influence of formulation and processing factors on stability of levothyroxine sodium pentahydrate. AAPS PharmSciTech 2010 11 818-825. (doi:10.1208/s12249-010-9434-8)
17. Andueza S, Maeztu L, Pascual L, Ibanez C, Paz de Pena M & Cid C. Influence of extraction temperature on the final quality of espresso coffee. Journal of the Science of Food and Agriculture 2003 83 240-248. (doi:10.1002/jsfa.1304)
18. Boulton DW, Fawcett JP & Woods DJ. Stability of an extemporaneously compounded levothyroxine sodium oral liquid. American Journal of Health-System Pharmacy 1996 53 1157-1161.
19. Liwanpo L & Hershman J. Conditions and drugs interfering with thyroxine absorption. Best Practice & Research. Clinical Endocrinology & Metabolism 2009 23 781-792. (doi:10.1016/j.beem.2009.06.006)