Perineural invasion as a predictor of extraprostatic extension of prostate cancer: A systematic review and meta-analysis

Scandinavian Journal of Urology

Volumn 47, Issue 6, 2013, Pages 443-448

  Cozzi, Gabriele ^a   Rocco, Bernardo Maria ^a   Grasso, Angelica ^a   Rosso, Marco ^a   Abed El Rahman, Davide ^a   Oliva, Isabella ^a   Talso, Michele ^a   Costa, Beatrice ^a   Tafa, Ardit ^a   Palumbo, Carlotta ^a   Gadda, Franco ^a   Rocco, Francesco ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Extraprostatic extension; Perineural invasion; Positive surgical margins; Prostate cancer

Indexed keywords

CANCER INCIDENCE; HUMAN; META ANALYSIS; NEEDLE BIOPSY; PERINEURAL INVASION; PRIORITY JOURNAL; PROSTATE BIOPSY; PROSTATE CANCER; REVIEW; SYSTEMATIC REVIEW;

BIOPSY; HUMANS; MALE; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PERIPHERAL NERVES; PROSTATE; PROSTATIC NEOPLASMS;

EID: 84890467067     PISSN: 21681805     EISSN: 21681813     Source Type: Journal    
DOI: 10.3109/21681805.2013.776106     Document Type: Review

References (38)

1. Grossklaus DJ, Coffey CS, Shappell SB, Jack GS, Chang SS, Cookson MS. Percent of cancer in the biopsy set predicts pathological findings after prostatectomy. J Urol 2002;167: 2032-5.
2. Heidenreich A, Bellmunt J, Bolla M, Joniau S, Mason M, Matveev V, et al. European Association of Urology. EAU guidelines on prostate cancer. Part 1: Screening, diagnosis, and treatment of clinically localised disease. Eur Urol 2011; 59:61-71.
3. Swanson GP, Lerner SP. Positive margins after radical prostatectomy: implications for failure and role of adjuvant treatment. Urol Oncol 2011;Epub ahead of print.
4. Liebig C, Ayala G, Wilks JA, Berger DH, Albo D. Perineural invasion in cancer: a review of the literature. Cancer 2009; 115:3379-91.
5. Villers A, McNeal JE, Redwine EA, Freiha FS, Stamey TA. The role of perineural space invasion in the local spread of prostatic adenocarcinoma. J Urol 1989;142:763-8.
6. Powell MS, Li R, Dai H, Sayeeduddin M, Wheeler TM, Ayala GE. Neuroanatomy of the normal prostate. Prostate 2005;65:52-7.
7. Fromont G, Godet J, Pires C, Yacoub M, Dore B, Irani J. Biological significance of perineural invasion (PNI) in prostate cancer. Prostate 2012;72:542-8.
8. Javidan J, Wood DP. Clinical interpretation of the prostate biopsy. Urol Oncol 2003;21:141-4.
9. Egan AJ, Bostwick DG. Prediction of extraprostatic extension of prostate cancer based on needle biopsy findings: perineural invasion lacks significance on multivariate analysis. Am J Surg Pathol 1997;21:1496-500.
10. Bismar TA, Lewis JS Jr, Vollmer RT, Humphrey PA. Multiple measures of carcinoma extent versus perineural invasion in prostate needle biopsy tissue in prediction of pathologic stage in a screening population. Am J Surg Pathol 2003;27:432-40.
11. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009;339:b2700.
12. Aumayr K, Breitegger M, Mazal PR, Koller A, Marberger M, Susani M, et al. Quantification of extraprostatic perineural spread and its prognostic value in pT3a pN0 M0 R0 prostate cancer patients. Prostate 2011;71:1790-5.
13. Endrizzi J, Seay T. The relationship between early biochemical failure and perineural invasion in pathological T2 prostate cancer. BJU Int 2000;85:696-8.
14. Ficarra V, Novara G, Secco S, D'Elia C, Boscolo-Berto R, Gardiman M, et al. Predictors of positive surgical margins after laparoscopic robot assisted radical prostatectomy. J Urol 2009;182:2682-8.
15. Holmes GF,Walsh PC, Pound CR, Epstein JI. Excision of the neurovascular bundle at radical prostatectomy in cases with perineural invasion on needle biopsy. Urology 1999;53:752-6.
16. Jeon HG, Bae J, Yi JS, Hwang IS, Lee SE, Lee E. Perineural invasion is a prognostic factor for biochemical failure after radical prostatectomy. Int J Urol 2009;16:682-6.
17. Lee JT, Lee S, Yun CJ, Jeon BJ, Kim JM, Ha HK, et al. Prediction of perineural invasion and its prognostic value in patients with prostate cancer. Korean J Urol 2010;51:745-51.
18. Merrilees AD, Bethwaite PB, Russell GL, Robinson RG, Delahunt B. Parameters of perineural invasion in radical prostatectomy specimens lack prognostic significance. Mod Pathol 2008;21:1095-100.
19. Moussa AS, Li J, Soriano M, Klein EA, Dong F, Jones JS. Prostate biopsy clinical and pathological variables that predict significant grading changes in patients with intermediate and high grade prostate cancer. BJU Int 2009;103:43-8.
20. Passavanti G, Pizzuti V, Costantini FM, Nucciotti R, Stumpo M, Paolini R. Perineural invasion in prostatic carcinoma treated with radical prostatectomy: the role of TR systematic biopsy. Arch Ital Urol Androl 2007;79:23-5.
21. Quinn DI, Henshall SM, Brenner PC, Kooner R, Golovsky D, O'Neill GF, et al. Prognostic significance of preoperative factors in localized prostate carcinoma treated with radical prostatectomy: importance of percentage of biopsies that contain tumor and the presence of biopsy perineural invasion. Cancer 2003;97:1884-93.
22. Sankin A, Tareen B, Lepor H. Side-specific factors associated with extracapsular extension and seminal vesicular invasion in men undergoing open radical retropubic prostatectomy. Prostate Cancer Prostatic Dis 2009;12:204-8.
23. Sebo TJ, Cheville JC, Riehle DL, Lohse CM, Pankratz VS, Myers RP, et al. Predicting prostate carcinoma volume and stage at radical prostatectomy by assessing needle biopsy specimens for percent surface area and cores positive for carcinoma, perineural invasion, Gleason score, DNA ploidy and proliferation, and preoperative serum prostate specific antigen: a report of 454 cases. Cancer 2001;91:2196-204.
24. Sebo TJ, Cheville JC, Riehle DL, Lohse CM, Pankratz VS, Myers RP, et al. Perineural invasion and MIB-1 positivity in addition to Gleason score are significant preoperative predictors of progression after radical retropubic prostatectomy for prostate cancer. Am J Surg Pathol 2002;26:431-9.
25. Algaba F, Arce Y, Oliver A, Barandica C, Santaularia JM, Montañés R. Prognostic parameters other than Gleason score for the daily evaluation of prostate cancer in needle biopsy. Eur Urol 2005;48:566-71.
26. Cannon GM Jr, Pound CR, Landsittel DP, Bastacky SI, Dhir R, Becich MJ, et al. Perineural invasion in prostate cancer biopsies is not associated with higher rates of positive surgical margins. Prostate 2005;63:336-40.
27. de la Taille A, Katz A, Bagiella E, Olsson CA, O'Toole KM, Rubin MA. Perineural invasion on prostate needle biopsy: an independent predictor of final pathologic stage. Urology 1999;54:1039-43.
28. Katz B, Srougi M, Dall'oglio M, Nesrallah AJ, Sant'anna AC, Pontes J Jr, et al. Perineural invasion detection in prostate biopsy is related to recurrence-free survival in patients submitted to radical prostatectomy. Urol Oncol 2011; Epub ahead of print.
29. Kryvenko ON, Diaz M, Meier FA, Ramineni M, Menon M, Gupta NS. Findings in 12-core transrectal ultrasound - guided prostate needle biopsy that predict more advanced cancer at prostatectomy: analysis of 388 biopsy-prostatectomy pairs. Am J Clin Pathol 2012;137:739-46.
30. Lee IH, Roberts R, Shah RB, Wojno KJ, Wei JT, Sandler HM. Perineural invasion is a marker for pathologically advanced disease in localized prostate cancer. Int J Radiat Oncol Biol Phys 2007;68:1059-64.
31. Loeb S, Epstein JI, Humphreys EB, Walsh PC. Does perineural invasion on prostate biopsy predict adverse prostatectomy outcomes? BJU Int 2010;105:1510-13.
32. O'Malley KJ, Pound CR, Walsh PC, Epstein JI, Partin AW. Influence of biopsy perineural invasion on long-term biochemical disease-free survival after radical prostatectomy. Urology 2002;59:85-90.
33. Tsuzuki T, Hernandez DJ, Aydin H, Trock B, Walsh PC, Epstein JI. Prediction of extraprostatic extension in the neurovascular bundle based on prostate needle biopsy pathology, serum prostate specific antigen and digital rectal examination. J Urol 2005;173:450-3.
34. Freeman A. Perineural and lymphovascular invasion on prostatic biopsy: pathological assessment and significance. Surg Oncol 2009;18:200-2.
35. Partin AW, Yoo J, Carter HB, Pearson JD, Chan DW, Epstein JI, et al. The use of prostate specific antigen, clinical stage and Gleason score to predict pathological stage in men with localized prostate cancer. J Urol 1993;150:110-14.
36. Ohori M, Kattan MW, Koh H, Maru N, Slawin KM, Shariat S, et al. Predicting the presence and side of extracapsular extension: a nomogram for staging prostate cancer. J Urol 2004;171:1844-9.
37. Harnden P, Shelley MD, Clements H, Coles B, Tyndale-Biscoe RS, Naylor B, et al. The prognostic significance of perineural invasion in prostatic cancer biopsies: a systematic review. Cancer 2007;109:13-24.
38. Ng JC, Koch MO, Daggy JK, Cheng L. Perineural invasion in radical prostatectomy specimens: lack of prognostic significance. J Urol 2004;172:2249-51.