Inflammation and hyponatremia: An underrecognized condition?

Korean Journal of Pediatrics

Volumn 56, Issue 12, 2013, Pages 519-522

  Park, Se Jin ^a   Shin, Jae Il ^b  

^a Ajou University School of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Critical condition; Cytokines; Hyponatremia; Inappropriate ADH syndrome; Inflammatory disease

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; ISOTONIC SOLUTION; LIPOPOLYSACCHARIDE; SODIUM; SODIUM CHANNEL; TECHNETIUM 99M; VASOPRESSIN;

ANTIDIURESIS; BACTEREMIA; BLOOD BRAIN BARRIER; DISEASE ASSOCIATION; ENDOTHELIUM CELL; HUMAN; HYPONATREMIA; INAPPROPRIATE VASOPRESSIN SECRETION; INFLAMMATION; NEUTROPHIL; NONHUMAN; PATHOPHYSIOLOGY; REVIEW; SCINTIGRAPHY; SMOOTH MUSCLE FIBER; URINARY TRACT INFECTION;

EID: 84890344488     PISSN: 17381061     EISSN: 20927258     Source Type: Journal    
DOI: 10.3345/kjp.2013.56.12.519     Document Type: Review

References (22)

1. Singhi S. Hyponatremia in hospitalized critically ill children: current concepts. Indian J Pediatr 2004;71:803-7.
2. Hoorn EJ, Lindemans J, Zietse R. Development of severe hyponatraemia in hospitalized patients: treatment-related risk factors and inadequate management. Nephrol Dial Transplant 2006;21:70-6.
3. Ellison DH, Berl T. Clinical practice: the syndrome of inappropriate antidiuresis. N Engl J Med 2007;356:2064-72.
4. Fenske W, Maier SK, Blechschmidt A, Allolio B, Stork S. Utility and limitations of the traditional diagnostic approach to hyponatremia: a diagnostic study. Am J Med 2010;123:652-7.
5. Swart RM, Hoorn EJ, Betjes MG, Zietse R. Hyponatremia and inflammation: the emerging role of interleukin-6 in osmoregulation. Nephron Physiol 2011;118:45-51.
6. Nielsen S, Frøkiaer J, Marples D, Kwon TH, Agre P, Knepper MA. Aquaporins in the kidney: from molecules to medicine. Physiol Rev 2002;82:205-44.
7. Ohta M, Ito S. Hyponatremia and inflammation. Rinsho Byori 1999;47:408-16.
8. Papanicolaou DA, Wilder RL, Manolagas SC, Chrousos GP. The pathophysiologic roles of interleukin-6 in human disease. Ann Intern Med 1998;128:127-37.
9. Landgraf R, Neumann I, Holsboer F, Pittman QJ. Interleukin-1 beta stimulates both central and peripheral release of vasopressin and oxytocin in the rat. Eur J Neurosci 1995;7:592-8.
10. Palin K, Moreau ML, Sauvant J, Orcel H, Nadjar A, Duvoid-Guillou A, et al. Interleukin-6 activates arginine vasopressin neurons in the supraoptic nucleus during immune challenge in rats. Am J Physiol Endocrinol Metab 2009;296:E1289-99.
11. Mastorakos G, Weber JS, Magiakou MA, Gunn H, Chrousos GP. Hypothalamic-pituitary-adrenal axis activation and stimulation of systemic vasopressin secretion by recombinant interleukin-6 in humans: potential implications for the syndrome of inappropriate vasopressin secretion. J Clin Endocrinol Metab 1994;79:934-9.
12. Fabry Z, Fitzsimmons KM, Herlein JA, Moninger TO, Dobbs MB, Hart MN. Production of the cytokines interleukin 1 and 6 by murine brain microvessel endothelium and smooth muscle pericytes. J Neuroimmunol 1993;47:23-34.
13. Reyes TM, Fabry Z, Coe CL. Brain endothelial cell production of a neuroprotective cytokine, interleukin-6, in response to noxious stimuli. Brain Res 1999;851:215-20.
14. Lim GW, Lee M, Kim HS, Hong YM, Sohn S. Hyponatremia and syndrome of inappropriate antidiuretic hormone secretion in kawasaki disease. Korean Circ J 2010;40:507-13.
15. Patwari AK, Singh BS, Manorama DE. Inappropriate secretion of antidiuretic hormone in acute bacterial meningitis. Ann Trop Paediatr 1995;15:179-83.
16. Riikonen P, Saarinen UM, Perkkio M, Hovi L, Siimes MA. Changing pattern of treatment policies invalidates the use of C-reactive protein level and hyponatremia as indicators of sepsis in children with malignancies. Pediatr Hematol Oncol 1992;9:365-72.
17. Watanabe T, Abe Y, Sato S, Uehara Y, Ikeno K, Abe T. Hyponatremia in Kawasaki disease. Pediatr Nephrol 2006;21:778-81.
18. Shin JI, Kim JH, Lee JS, Kim DS, Choi JY, Sul JH. Kawasaki disease and hyponatremia. Pediatr Nephrol 2006;21:1490-1.
19. Park SJ, Oh YS, Choi MJ, Shin JI, Kim KH. Hyponatremia may reflect severe inflammation in children with febrile urinary tract infection. Pediatr Nephrol 2012;27:2261-7.
20. Kaneko K, Shimojima T, Kaneko K. Risk of exacerbation of hyponatremia with standard maintenance fluid regimens. Pediatr Nephrol 2004;19:1185-6.
21. Halberthal M, Halperin ML, Bohn D. Lesson of the week: acute hyponatraemia in children admitted to hospital: retrospective analysis of factors contributing to its development and resolution. BMJ 2001;322:780-2.
22. Greenbaum LA. Maintenance and replacement therapy. In: Kliegman RM, Stanton BF, St. Geme JW III, Schor NF, Behrman RE, editors. Nelson textbook of pediatrics. 19th ed. Philadelphia: Elsevier/Saunders, 2012:242-5.