Chronic unilateral ureteral obstruction in the neonatal mouse delays maturation of both kidneys and leads to late formation of atubular glomeruli

American Journal of Physiology - Renal Physiology

Volumn 305, Issue 12, 2013, Pages

  Forbes, Michael S ^a   Thornhill, Barbara A ^a   Galarreta, Carolina I ^a   Minor, Jordan J ^a   Gordon, Katherine A ^a   Chevalier, Robert L ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Apoptosis; Atubular glomeruli; Autophagy; Mitochondria; Proliferation

Indexed keywords

4 HYDROXYNONENAL; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; FIBRONECTIN; LECTIN; MEGALIN; NITROBLUE TETRAZOLIUM; RENIN; SMOOTH MUSCLE ACTIN; SUPEROXIDE; TRANSCRIPTION FACTOR PAX2;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ATUBULAR GLOMERULI; AUTOPHAGY; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; GENERAL ANESTHESIA; IMMUNOHISTOCHEMISTRY; KIDNEY DEVELOPMENT; KIDNEY MALFORMATION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE DAMAGE; LOTUS; LOTUS TETRAGOLONOBUS; MITOCHONDRION; MOUSE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; UNILATERAL URETER OBSTRUCTION; URETER OBSTRUCTION;

APOPTOSIS; ATUBULAR GLOMERULI; AUTOPHAGY; MITOCHONDRIA; PROLIFERATION;

ACTINS; ANIMALS; ANIMALS, NEWBORN; CHRONIC DISEASE; COLLAGEN; DISEASE MODELS, ANIMAL; FEMALE; FIBRONECTINS; KIDNEY; KIDNEY GLOMERULUS; MALE; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; URETERAL OBSTRUCTION;

EID: 84890327425     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00152.2013     Document Type: Article

References (42)

1. Bascands JL, Schanstra JP. Obstructive nephropathy: insights from genetically engineered animals. Kidney Int 68: 925-937, 2005.
2. Bialestock D. Microdissection of specimen of hydronephrosis with comparative nephron measurements. Aust N Z J Surg 29: 211-226, 1960.
3. Cachat F, Lange-Sperandio B, Chang AY, Kiley SC, Thornhill BA, Forbes MS, Chevalier RL. Ureteral obstruction in neonatal mice elicits segment-specific tubular cell responses leading to nephron loss. Kidney Int 63: 564-575, 2003.
4. Castellanos Rivera RM, Monteagudo MC, Pentz ES, Glenn ST, Gross KW, Carretero O, Sequeira Lopez ML, Gomez RA. Transcriptional regulator RBP-J regulates the number and plasticity of renin cells. Physiol Genomics 43: 1021-1028, 2011.
5. Cebrian C, Borodo K, Charles N, Herzlinger DA. Morphometric index of the developing murine kidney. Dev Dyn 231: 601-608, 2004.
6. Chevalier RL, Chung KH, Smith CD, Ficenec M, Gomez RA. Renal apoptosis and clusterin following ureteral obstruction: the role of maturation. J Urol 156: 1474-1479, 1996.
7. Chevalier RL, Forbes MS. Generation and evolution of atubular glom-eruli in the progression of renal disorders. J Am Soc Nephrol 19: 197-206, 2008.
8. Chevalier RL, Forbes MS, Thornhill BA. Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy. Kidney Int 75: 1145-1152, 2009.
9. Chien CT, Lee PH, Chen CF, Ma MC, Lai MK, Hsu SM. De novo demonstration and co-localization of free-radical production and apoptosis formation in rat kidney subjected to ischemia/reperfusion. J Am Soc Nephrol 12: 973-982, 2001.
10. Chung KH, Chevalier RL. Arrested development of the neonatal kidney following chronic ureteral obstruction. J Urol 155: 1139-1144, 1996.
11. Crabtree C. The structure of Bowman's capsule as an index of age and sex variations in normal mice. Anat Rec 79: 395-413, 1941.
12. Dicker SE, Shirley DG. Rates of oxygen consumption and of anaerobic glycolysis in renal cortex and medulla of adult and new-born rats and guinea-pigs. J Physiol 212: 235-243, 1971.
13. Eddy AA. Molecular basis of renal fibrosis. Pediatr Nephrol 15: 290-301, 2000.
14. Fetterman GH, Shuplock NA, Philipp FJ, Gregg HS. The growth and maturation of human glomeruli and proximal convolutions from term to adulthood. Studies by microdissection. Pediatrics 35: 601-619, 1965.
15. Forbes MS, Ghribi O, Herman MM, Savory J. Aluminum-induced dendritic pathology revisited: cytochemical and electron microscopic studies of rabbit cortical pyramidal neurons. Ann Clin Lab Sci 32: 75-86, 2002.
16. Forbes MS, Thornhill BA, Chevalier RL. Proximal tubular injury and rapid formation of atubular glomeruli in mice with unilateral ureteral obstruction: a new look at an old model. Am J Physiol Renal Physiol 301: F110-F117, 2011.
17. Forbes MS, Thornhill BA, Minor JJ, Gordon KA, Galarreta CI, Chevalier RL. Fight-or-flight: murine unilateral ureteral obstruction causes extensive proximal tubular degeneration, collecting duct dilatation, and minimal fibrosis. Am J Physiol Renal Physiol 303: F120-F129, 2012.
18. Friis C. Postnatal development of the pig kidney: ultrastructure of the glomerulus and the proximal tubule. J Anat 130: 513-526, 1980.
19. Frokiær J, Flyvbjerg A, Knudsen L. Obstructive nephropathy in the pig. Possible roles for insulin-like growth factor I. Urol Res 20: 335-339, 1992.
20. Garcia CH, Krueger K, Landing BH, Wells TR. Microdissection demonstration of the lesion of the endocrine kidney in children. Pediatr Pathol 5: 45-54, 1986.
21. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119: 493-501, 1992.
22. Goeckermann JA, Vigil EL. Peroxisome development in the metanephric kidney of mouse. J Histochem Cytochem 23: 957-973, 1975.
23. Hanai T, Usuda N, Morita T, Nagata T. Light microscopic lectin histochemistry in aging mouse kidney: study of compositional changes in glycoconjugates. J Histochem Cytochem 42: 897-906, 1994.
24. Hartman HA, Lai HL, Patterson P. Cessation of renal morphogenesis in mice. Dev Biol 310: 379-387, 2007.
25. Hilgers KF, Reddi V, Krege JH, Smithies O, Gomez RA. Aberrant renal vascular morphology and renin expression in mutant mice lacking angiotensin-converting enzyme. Hypertension 29: 216-221, 1997.
26. Huang WY, Peters CA, Zurakowski D, Borer JG, Diamond DA, Bauer SB, McLellan DL, Rosen S. Renal biopsy in congenital uretero-pelvic junction obstruction: evidence for parenchymal maldevelopment. Kidney Int 69: 137-143, 2006.
27. Kaissling B, Le Hir M. The renal cortical interstitium: morphological and functional aspects. Histochem Cell Biol 130: 247-262, 2008.
28. Kim WY, Nam SA, Song HC, Ko JS, Park SH, Kim HL, Choi EJ, Kim YS, Kim J, Kim YK. The role of autophagy in unilateral ureteral obstruction rat model. Nephrology 17: 148-159, 2012.
29. Levine B, Yuan J. Autophagy in cell death: an innocent convict? J Clin Invest 115: 2679-2688, 2005.
30. Matsell DG, Tarantal AF. Experimental models of fetal obstructive nephropathy. Pediatr Nephrol 17: 470-476, 2002.
31. McDill BW, Li SZ, Kovach PA, Ding L, Chen F. Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation. Proc Natl Acad Sci USA 103: 6952-6957, 2006.
32. Mesrobian HO, Laud PW, Todd E, Gregg DC. The normal kidney growth rate during year 1 of life is variable and age dependent. J Urol 160: 989-993, 1998.
33. Murer L, Benetti E, Centi S, Della VM, Artifoni L, Capizzi A, Zucchetta P, Del PD, Carasi C, Montini G, Rigamonti W, Zaccello G. Clinical and molecular markers of chronic interstitial nephropathy in congenital unilateral ureteropelvic junction obstruction. J Urol 176: 2668-2673, 2006.
34. Periyasamy-Thandavan S, Jiang M, Schoenlein P, Dong Z. Autophagy: molecular machinery, regulation, and implications for renal pathophysi-ology. Am J Physiol Renal Physiol 297: F244-F256, 2009.
35. Song R, Preston G, Khalili A, El-Dahr SS, Yosypiv IV. Angiotensin II regulates growth of the developing papilla ex vivo. Am J Physiol Renal Physiol 302: F1112-F1120, 2012.
36. Takahashi N, Lopez ML, Cowhig JE Jr, Taylor MA, Hatada T, Riggs E, Lee G, Gomez RA, Kim HS, Smithies O. Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type. J Am Soc Nephrol 16: 125-132, 2005.
37. Thornhill BA, Forbes MS, Marcinko ES, Chevalier RL. Glomerulotu-bular disconnection in neonatal mice after relief of partial ureteral obstruction. Kidney Int 72: 1103-1112, 2007.
38. Tsigeiny IF, Kouznetsova VL, Sweeney DE, Wu W, Bush KT, Nigam SK. Analysis of metagene portraits reveals distinct transitions during kidney organogenesis. Science Signaling 1: 1-9, 2008.
39. Tsuchida S, Matsuzaka T, Chen X, Okubo S, Nimura F, Nishimura H, Fogo A, Utsunomiya H, Inagami T, Ichikawa I. Murine double nullizy-gotes of the angiotensin type 1A and 1B receptor genes have all the major abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest 101: 755-760, 1998.
40. Venkatachalam MA, Griffin KA, Lan R, Geng H, Saikumanr P, Bidani AK. Acute kidney injury: a springboard for progression in chronic kidney disease. Am J Physiol Renal Physiol 298: F1078-F1094, 2010.
41. Woolf AS, Price KL, Scambler PJ, Winyard PJD. Evolving concepts in human renal dysplasia. J Am Soc Nephrol 15: 998-1007, 2004.
42. Yoo KH, Thornhill BA, Forbes MS, Chevalier RL. Compensatory renal growth due to neonatal ureteral obstruction: implications for clinical studies. Pediatr Nephrol 21: 368-375, 2006.