Radiolabeling, quality control and kit formulation of a new 99m Tc-labeled antibiotic: 99m Tc-doxycycline hyclate

Journal of Radioanalytical and Nuclear Chemistry

Volumn 298, Issue 3, 2013, Pages 1635-1642

  İlem Özdemir, Derya ^a   Aşıkoğlu, Makbule ^a   Özkılıç, Hayal ^a  

^a EGE UNIVERSITY   (Turkey)

Author keywords

99m Technetium; 99mTc doxycycline hyclate; Doxycycline hyclate; Radiolabelling; Radiopharmaceutical

Indexed keywords

ANTIINFECTIVE AGENT; DOXYCYCLINE HYCLATE; DOXYCYCLINE HYCLATE TC 99M; RADIOISOTOPE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG FORMULATION; FREEZE DRYING; ISOTOPE LABELING; PH; QUALITY CONTROL; RADIOACTIVITY;

EID: 84890311009     PISSN: 02365731     EISSN: 15882780     Source Type: Journal    
DOI: 10.1007/s10967-013-2547-2     Document Type: Article

References (24)

1. Sharmila B, Maroor R, Ambikalmajan P, Natesan R (2001) Evolution of Tc-99m in diagnosticradiopharmaceuticals. Mumbai. India: radiopharmaceuticals division. Isotope Group, Bhabha Atomic Research Center, Seminars in Nuclear Medicine XXXl (4):266-277
2. Muhammad J, Irfan UK, Saima M, Ume-Kalsoom D, Syed WH (2012) Synthesis, characterization and biodistribution of novel amine thiophene 99mTc labeled complex. Pak J Pharm Sci 25:381-387
3. Boerman OC, Dams EM, Oyen WJG, Corstens FHM, Storm G (2001) Radiopharmaceuticals for scintigraphic imaging of infection. Inflamm Res 50:55-64
4. Seyedeh FM, Mostafa E, Seyed E, Mohammad HT, Farhad HH (2010) Freeze-dried cold kit for preparation of 99mTc-ciprofloxacin as an infection imaging agent. Iran J Nucl Med 18:45-51
5. 3 ] core: evaluation of their efficacy as infection imaging agents. Metallomics 1041-1048
6. Britton KE, Vinjamuri S, Hall AV, Solanki K, Siraj QH, Bomanji J, Das S (1997) Clinical evaluation of technetium-99m infecton for the localisation of bacterial infection. Eur J Nucl Med 24:553-556
7. Britton KE, Soroa V, Amaral H (1998) 99mTc "infecton", preliminary evaluation in over 500 patients through an IAEA coordinate research program. Eur J Nucl Med 25:874
8. Britton KE, Wareham DW, Das SS, Solanki KK, Amaral H, Bhatnagar A, Katamihardja AH, Malamitsi J, Moustafa HM, Soroa VE, Sundram FX, Padhy AK (2002) Imaging bacterial infection with (99m)Tc-ciprofloxacin (infecton). J Clin Pathol 55(11):817-823
9. Siaens RH, Rennen HJ, Otto C, Boerman R, Guido S (2004) Synthesis and comparison of 99mTc-enrofloxacin and 99mTc ciprofloxacin. J Nucl Med 45:2088-2094
10. Sankha C, Sujata SD, Susmita C, Kakali D, Mridula M, Bharat RS, Samarendu S, Shantanu G (2010) Synthesis and evaluation of 99mTc-moxifloxacin, a potential infection specific imaging agent. Appl Radiat Isot 68:314-316
11. Roohi S, Mustaq A, Jehangir M, Malik SA (2006) Synthesis, quality control and biodistribution of 99mTc-kanamycin. J Radioanal Nucl Chem 267(3):561-566
12. Motaleb MA (2007) Preparation and biodistrubition of 99mTc-lomefloxacin and 99mTc-ofloxacin complexes. J Radioanal Nucl Chem 272(1):95-99
13. Motaleb MA (2007) Preparation of 99mTc-Cefoperazone complex, a novel agent for detecting sites of infection. J Radioanal Nucl Chem 272(1):167-171
14. El-Ghany EA, El-Kolaly MT, Amine AM, El-Sayed AS, Abdel-Gelil F (2005) Synthesis of 99mTc-pefloxacin: a new targeting agent for infectious foci. J Radioanal Nucl Chem 266(1):131-139
15. Rizvi FA, Bokhari TH, Roohi S, Mustaq A (2012) Direct labeling of doxorubicin with technetium-99m: its optimization, characterization and quality. J Radioanal Nucl Chem 293(1):303-307
16. Örümlü O (2009) Development of new radiopharmaceuticals fo imaging acute inflammation and infection. PhD Thesis. Ege University, Faculty of Pharmacy
17. Thawatchai P, Juree C (2008) Antibacterial activity and drug release of chitosan sponge containing doxycycline hyclate. AAPS PharmSciTech 9:829-836
18. Luis JC, Ana MS, Jose D, Nelida F, Matilde S, Juan JG (2009) Pharmacokinetics of doxycycline in sheep after intravenous and oral administration. Vet J 180:389-395
19. Saleh TB (2011) Basic sciences of nuclear medicine. Springer, London, pp 10-30
20. Fred A, Jr M, Milton JG (2012) Radioactivity, radionuclides and radiopharmaceuticals. Essentials of nuclear medicine Imaging. Elsvier Saunders, Philedelphia, pp 1-11
21. Ahlgren S, Andersson K, Tolmachev V (2010) Kit formulation for 99mTc-labeling of recombinant anti-HER2 affibody molecules with a C-terminally engineered cysteine. Nucl Med Biol 37(5):539-544
22. Technical Report Series No: 466 (2008) Technetium-99m radiopharmaceuticals: manufacture of kits. International Atomic Energy Agency, Vienna
23. Liu S (2005) 6-Hydrazinonicotinamide derivatives as bifunctional coupling agents for 99mTc-labeling of small biomolecules. Top Curr Chem 252:117-153
24. Xiaolin T, Michael JP (2004) Design of freeze-drying processes for pharmaceuticals: practical advice. Pharm Res 21:191-199