A study of microemulsions as prolonged-release injectables through in-situ phase transition

Journal of Controlled Release

Volumn 174, Issue 1, 2014, Pages 188-194

  Wu, Zimei ^a   Alany, Raid G ^a,b   Tawfeek, Noor ^a   Falconer, James ^a   Zhang, Wenli ^a   Hassan, Ibrahim M ^c   Rutland, Michael ^c   Svirskis, Darren ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b KINGSTON UNIVERSITY   (United Kingdom)

^c AUCKLAND CITY HOSPITAL   (New Zealand)

Author keywords

Gamma scintigraphy; Liquid crystal; Microemulsion; Phase transition; Prolonged drug release; Subcutaneous injection

Indexed keywords

DRUG DELIVERY SYSTEM; DRUG DELIVERY VEHICLES; DRUG RELEASE; GAMMA-SCINTIGRAPHY; POLARIZED MICROSCOPY; PSEUDOTERNARY PHASE DIAGRAMS; RAPID PHASE TRANSITIONS; TRANSITION BEHAVIOR;

DRUG DELIVERY; DRUG PRODUCTS; EMULSIFICATION; LIQUID CRYSTALS; NUCLEAR MEDICINE; PHASE TRANSITIONS; VISCOSITY;

MICROEMULSIONS;

EMLA; OIL; PERTECHNETIC ACID TC 99M; WATER; WATER OIL CREAM;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL COMPOSITION; COARSE EMULSION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; EMULSION; GAMMA SCINTIGRAPHY; IN VITRO STUDY; IN VIVO STUDY; INJECTION; INJECTION SITE; ISOTOPE LABELING; MICROEMULSION; NONHUMAN; POLARIZATION MICROSCOPY; PRIORITY JOURNAL; RABBIT; SHEAR RATE; SUSTAINED DRUG RELEASE; THICKNESS; VISCOSITY;

GAMMA-SCINTIGRAPHY; LIQUID CRYSTAL; MACROGOL (15)-HYDROXYSTEARATE (CID 71311956); MICROEMULSION; MOLYBDENUM (CID 23932); NILE RED (CID 65182); PHASE TRANSITION; PROLONGED DRUG RELEASE; SODIUM PERTECHNETATE ((99M)TC) (CID 23689036); SORBITAN MONOOLEATE (CID 9920342); SUBCUTANEOUS INJECTION;

ANIMALS; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; EMULSIONS; INJECTIONS, SUBCUTANEOUS; LIQUID CRYSTALS; PHASE TRANSITION; RABBITS; TECHNETIUM; WATER;

EID: 84890286070     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.11.022     Document Type: Article

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