Cancer-associated fibroblasts and macrophages friendly conspirators for malignancy

OncoImmunology

Volumn 2, Issue 9, 2013, Pages

  Chiarugi, Paola ^a,b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Andrology Unit   (Italy)

Author keywords

Cancer associated fibroblasts; Endothelial precursor cells; Epithelila mesenchymal transition; M2 macrophages; Stemness; Tumor microenvironment

Indexed keywords

ARTICLE; CANCER ASSOCIATED FIBROBLAST; CANCER CELL; CANCER GROWTH; CELL ACTIVITY; CELL INTERACTION; CELL METABOLISM; EPITHELIAL MESENCHYMAL TRANSITION; FIBROBLAST; HUMAN; INFLAMMATION; MACROPHAGE; MACROPHAGE ACTIVATION; METASTASIS; TUMOR MICROENVIRONMENT;

EID: 84890285093     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.25563     Document Type: Article

References (10)

1. Cirri P, Chiarugi P. Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression. Cancer Metastasis Rev 2012; 31:195-208; PMID:22101652; http://dx.doi.org/10.1007/s10555- 011-9340-x
2. Fiaschi T, Marini A, Giannoni E, Taddei ML, Gandellini P, De Donatis A, et al. Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay. Cancer Res 2012; 72:5130-40; PMID:22850421; http://dx.doi. org/10.1158/0008-5472.CAN-12-1949
3. Giannoni E, Bianchini F, Masieri L, Serni S, Torre E, Calorini L, et al. Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. Cancer Res 2010; 70:6945-56; PMID:20699369; http://dx.doi.org/10.1158/0008-5472.CAN-10-0785
4. Giannoni E, Taddei ML, Parri M, Bianchini F, Santosuosso M, Grifantini R, et al. EphA2-mediated mesenchymal-amoeboid transition induced by endothelial progenitor cells enhances metastatic spread due to cancer-associated fibroblasts. J Mol Med (Berl) 2013; 91:103-15; PMID:22903544; http://dx.doi. org/10.1007/s00109-012-0941-9
5. Comito G, Giannoni E, Segura CP, Barcellos-de-Souza P, Raspollini MR, Baroni G, et al. Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression. Oncogene 2013; In press; PMID:23728338; http://dx.doi. org/10.1038/onc.2013.191.
6. Fiaschi T, Giannoni E, Taddei ML, Cirri P, Marini A, Pintus G, et al. Carbonic anhydrase IX from cancerassociated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells. Cell Cycle 2013 12:1791-801; PMID:23656776; http://dx.doi. org/10.4161/cc.24902
7. Duda DG, Duyverman AM, Kohno M, Snuderl M, Steller EJ, Fukumura D, et al. Malignant cells facilitate lung metastasis by bringing their own soil. Proc Natl Acad Sci U S A 2010; 107:21677-82; PMID:21098274; http://dx.doi.org/10.1073/pnas.1016234107
8. Toullec A, Gerald D, Despouy G, Bourachot B, Cardon M, Lefort S, et al. Oxidative stress promotes myofibroblast differentiation and tumour spreading. EMBO Mol Med 2010; 2:211-30; PMID:20535745; http://dx.doi.org/10.1002/emmm.201000073
9. Giannoni E, Bianchini F, Calorini L, Chiarugi P. Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness. Antioxid Redox Signal 2011; 14:2361-71; PMID:21235356; http://dx.doi.org/10.1089/ars.2010.3727
10. Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 2012; 122:787- 95; PMID:22378047; http://dx.doi.org/10.1172/ JCI59643