The spectrum of BRCA1 and BRCA2 mutations in breast cancer patients in the Bahamas

Clinical Genetics

Volumn 85, Issue 1, 2014, Pages 64-67

  Akbari, M R ^a   Donenberg, T ^b   Lunn, J ^c   Curling, D ^d   Turnquest, T ^d   Krill Jackson, E ^e   Zhang, S ^a   Narod, S A ^a   Hurley, J ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF MIAMI   (United States)

^c Doctor's Hospital   (Bahamas)

^d Princess Margaret Hospital Nassau   (Bahamas)

^e Mount Sinai Comprehensive Cancer Center   (United States)

Author keywords

Bahamas; BRCA1; Breast cancer; Hereditary

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN;

ADULT; AGED; ARTICLE; BAHAMAS; BREAST CANCER; FAMILY HISTORY; FEMALE; GENE MUTATION; GENETIC SCREENING; HUMAN; MAJOR CLINICAL STUDY; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; PREVALENCE; PRIORITY JOURNAL;

BAHAMAS; BRCA1; BREAST CANCER; HEREDITARY;

ADULT; AGED; BAHAMAS; BREAST NEOPLASMS; DNA MUTATIONAL ANALYSIS; EXONS; FEMALE; FOUNDER EFFECT; GENES, BRCA1; GENES, BRCA2; GENETIC TESTING; HUMANS; MIDDLE AGED; MUTATION; MUTATION RATE; PREVALENCE; YOUNG ADULT;

EID: 84890195196     PISSN: 00099163     EISSN: 13990004     Source Type: Journal    
DOI: 10.1111/cge.12132     Document Type: Article

References (12)

1. Donenberg T, Lunn J, Curling D et al. A high prevalence of BRCA1 mutations among breast cancer patients from the Bahamas. Breast Cancer Res Treat 2011: 125 (2): 591-596.
2. Hall MJ, Reid JE, Burbidge LA et al. BRCA1 and BRCA2 mutations in women of different ethnicities undergoing testing for hereditary breast-ovarian cancer. Cancer 2009: 115 (10): 2222-2233.
3. Fackenthal JD, Zhang J, Zhang B et al. High prevalence of BRCA1 and BRCA2 mutations in unselected Nigerian breast cancer patients. Int J Cancer 2012: 131 (5): 1114-1123.
4. Walsh T, Casadei S, Coats KH et al. Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer. JAMA 2006: 295 (12): 1379-1388.
5. Breast Cancer Information Core (BIC). An open access online breast cancer mutation data base. Accessed on November 20, 2012, from http://www.nhgri.nih.gov/Intramural_research/Lab_transfer/BIC/
6. Warner E, Foulkes W, Goodwin P et al. Prevalence and penetrance of BRCA1 and BRCA2 gene mutations in unselected Ashkenazi Jewish women with breast cancer. J Natl Cancer Inst 1999: 91 (14): 1241-1247.
7. Tonin PN, Perret C, Lambert JA et al. Founder BRCA1 and BRCA2 mutations in early-onset French Canadian breast cancer cases unselected for family history. Int J Cancer 2001: 95 (3): 189-193.
8. Górski B, Byrski T, Huzarski T et al. Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. Am J Hum Genet 2000: 66 (6): 1963-1968.
9. Malone KE, Daling JR, Doody DR et al. Prevalence and Predictors of BRCA1 and BRCA2 mutations in a population based study of breast cancer in white and black American women ages 35 to 64 years. Cancer Res 2006: 66 (16): 8297-8308.
10. Metcalfe KA, Poll A, Royer R et al. Screening for founder mutations in BRCA1 and BRCA2 in unselected Jewish women. J Clin Oncol 2010: 28 (3): 387-391.
11. Gronwald J, Huzarski T, Byrski T et al. Direct-to-patient BRCA1 testing: the Twoj Styl experience. Breast Cancer Res Treat 2006: 100 (3): 239-245.
12. Metcalfe KA, Mian N, Enmore M et al. Long-term follow-up of Jewish women with a BRCA1 and BRCA2 mutation who underwent population genetic screening. Breast Cancer Res Treat 2012: 133 (2): 735-740.