Update on etio and immunopathogenesis of Kawasaki disease

Current Opinion in Rheumatology

Volumn 26, Issue 1, 2014, Pages 31-36

  Takahashi, Kei ^a   Oharaseki, Toshiaki ^a   Yokouchi, Yuki ^a  

^a TOHO UNIVERSITY OHASHI MEDICAL CENTER   (Japan)

Author keywords

genetic susceptibility; Kawasaki disease; microbiota; Th17 cell; TNF ; vasculitis model

Indexed keywords

CASPASE 3; CD40 LIGAND; DECTIN 2; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 2; INTERLEUKIN 20; INTERLEUKIN 23; INTERLEUKIN 6; INTERLEUKIN 8; SMAD3 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA2; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ANTIGEN ANTIBODY COMPLEX; AUTOIMMUNITY; CD8+ T LYMPHOCYTE; CHROMOSOME 20Q; DISEASE PREDISPOSITION; DISEASE SEVERITY; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; HEREDITY; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; IMMUNORECEPTOR TYROSINE BASED INHIBITION MOTIF; INTESTINE FLORA; LINKAGE ANALYSIS; MUCOCUTANEOUS LYMPH NODE SYNDROME; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; SEASONAL VARIATION; SINGLE NUCLEOTIDE POLYMORPHISM; TH17 CELL; UPREGULATION; VASCULITIS;

ACUTE DISEASE; ANIMALS; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MICE; MUCOCUTANEOUS LYMPH NODE SYNDROME; TH17 CELLS;

EID: 84890188000     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0000000000000010     Document Type: Review

References (41)

1. Kawasaki T. Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children [in Japanese]. Allergy 1967; 16:178-222.
2. Kawasaki T, Kosaki F, OkawaS, etal.Anewinfantileacutefebrilemucocutaneous lymph-node syndrome (MLNS) prevailing in Japan. Pediatrics 1974; 54:271- 276.
3. Ayusawa M, Sonobe T, Uemura S, et al. Revision of diagnostic guidelines for Kawasaki disease (the 5th revised edition). Pediatr Int 2005; 47:232-234.
4. Newburger JW, Takahashi M, Gerber MA, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: A statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 2004; 110:2747-2771.
5. Fujita Y, Nakamura Y, Sakata K, et al. Kawasaki disease in families. Pediatrics 1989; 84:666-669.
6. Uehara R, Yashiro M, Nakamura Y, Yanagawa H. Kawasaki disease in parents and children. Acta Paediatr 2003; 92:694-697.
7. Uehara R, Yashiro M, Nakamura Y, et al. Clinical features of patients with Kawasaki disease whose parents had the same disease. Arch Pediatr Adolesc Med 2004; 158:1166-1169.
8. Nakamura Y, Yashiro M, Uehara R, et al. Epidemiologic features of Kawasaki disease in Japan: Results of the 2009-2010 nationwide survey. J Epidemiol 2012; 3:216-221.
9. Holman RC, Belay ED, Christensen KY, et al. Hospitalizations for Kawasaki syndrome among children in the United States, 1997-2007. Pediatr Infect Dis J 2010; 29:483-488.
10. Park YW, Han JW, Hong YM, et al. Epidemiological features of Kawasaki disease in Korea, 2006-2008. Pediatr Int 2011; 53:36-39.
11. Huang WC, Huang LM, Chang IS, et al. Epidemiologic features of Kawasaki disease in Taiwan, 2003-2006. Pediatrics 2009; 123:e401-e405.
12. Onouchi Y, Gunji T, Burns JC, et al. ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Nat Genet 2008; 40:35-42.
13. Onouchi Y, Ozaki K, Burns JC, et al. Common variants in CASP3 confer susceptibility to Kawasaki disease. Hum Mol Genet 2010; 19:2898-2906.
14. Onouchi Y, Ozaki K, Burns JC, et al.A genome-wide association study identifies three new risk loci for Kawasaki disease. Nat Genet 2012; 44:517-521.
15. Lee YC, Kuo HC, Chang JS, et al. Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. Nat Genet 2012; 44:522-525.
16. Khor CC, Davila S, Breunis WB, et al. Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet 2011; 43:1241-1246.
17. Shimizu C, Jain S, Davila S, et al. Transforming growth factor-beta signaling pathway in patients with Kawasaki disease. Circ Cardiovasc Genet 2011; 4:16-25.
18. Laird RM, Laky K, Hayes SM. Unexpected role for the B cell-specific Src family kinase B lymphoid kinase in the development of IL-17-producing gd T cells. J Immunol 2010; 185:6518-6527.
19. Sohn MH, Noh SY, Chang W, et al. Circulating interleukin 17 is increased in the acute stage of Kawasaki disease. Scand J Rheumatol 2003; 32:364- 366.
20. Ikeda K, Yamaguchi K, Tanaka T, et al. Unique activation status of peripheral blood mononuclear cells at acute phase of Kawasaki disease. Clin Exp Immunol 2010; 160:246-255.
21. Wang CL, Wu YT, Liu CA, et al. Expression of CD40 ligand on CD4 T-cells and platelets correlated to the coronary artery lesion and disease progress in Kawasaki disease. Pediatrics 2003; 111:E140-E147.
22. Suzuki H, Terai M, Hamada H, et al. Cyclosporin a treatment for Kawasaki disease refractory to initial and additional intravenous immunoglobulin. Pediatr Infect Dis J 2011; 30:871-876.
23. Tremoulet AH, Pancoast P, Franco A, et al. Calcineurin inhibitor treatment of intravenous immunoglobulin-resistant Kawasaki disease. J Pediatr 2012; 161:506-512.
24. Wang Y, Wang W, Gong F, et al. Evaluation of intravenous immunoglobulin resistance and coronary artery lesions in relation to Th1/Th2 cytokine profiles in patients with Kawasaki disease. Arthr Rheum 2013; 65:805- 814.
25. Jia S, Li C, Wang G, et al. The T helper type 17/regulatory T cell imbalance in patients with acute Kawasaki disease. Clin Exp Immunol 2010; 162:131- 137.
26. Crome SQ, Wang AY, Levings MK. Translational mini-review series on Th17 cells: Function and regulation of human T helper 17 cells in health and disease. Clin Exp Immunol 2010; 159:109-119.
27. Afzali B, Mitchell P, Lechler RI, et al. Translational mini-review series on Th17 cells: Induction of interleukin-17 production by regulatory T cells. Clin Exp Immunol 2010; 159:120-130.
28. Choy E. Understanding the dynamics: Pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology 2012; 51 (Suppl 5):v3-v11.
29. Takahashi K, Oharaseki T, Wakayama M, et al. Histopathological features of murine systemic vasculitis caused by Candida albicans extract: An animal model of Kawasaki disease. Inflamm Res 2004; 53:72-74.
30. Miura NN, Komai M, Adachi Y, et al. IL-10 is a negative regulatory factor of CAWS-vasculitis in CBA/J mice as assessed by comparison with Bruton's tyrosine kinase-deficient CBA/N mice. J Immunol 2009; 183:3417-3424.
31. Oharaseki T, Kameoka Y, Kura F, et al. Susceptibility loci to coronary arteritis in animal model of Kawasaki disease induced with Candida albicans-derived substances. Microbiol Immunol 2005; 49:181-189.
32. Oharaseki T, Yokouchi Y, Yamada H, et al. The role of TNF-a in a murine model of Kawasaki disease arteritis induced with a Candida albicans cell wall polysaccharide. Mod Rheumatol 2013. [Epub ahead of print] Reveals that TNF-a is crucial in the course of development of CAWS-induced vasculitis
33. Martinez HG, Marlon P, Quinones MP, Fabio Jimenez F, et al. Important role of CCR2 in a murine model of coronary vasculitis. BMC Immunol 2012; 13:56. doi: 10.1186/1471-2172-13-56.
34. Saijo S, Ikeda S, Yamabe K, et al. Dectin-2 recognition of a-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity 2010; 32:681-691.
35. Saijo S, Iwakura Y. Dectin-1 and Dectin-2 in innate immunity against fungi. Int Immunol 2011; 23:467-472.
36. Zhu L.L., Zhao X.Q., Jiang C., et al. C-type lectin receptors dectin-3 and dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection. Immunity 2013; 39:324-334.
37. Ramirez-Velazquez C, Castillo EC, Guido-Bayardo L, Ortiz-Navarrete V. L-17-producing peripheral blood CD177 neutrophils increase in allergic asthmatic subjects. Allergy Asthma Clin Immunol 2013; 9:23. doi: 10.1186/ 1710-1492-9-23.
38. Shimizu C, Oharaseki T, Takahashi K, et al. The role of TGF-b and myofibroblasts in the arteritis of Kawasaki disease. Hum Pathol 2013; 44:189- 198.
39. Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science 2012; 336:1268-1273.
40. Lee YK, Menezes JS, Umesaki Y, et al. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 2011; 108 (Suppl 1):4615-4622.
41. Wu HJ, Ivanov II, Darce J, et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 2010; 32:815-827.