SCOPUS 정보 검색 플랫폼

The Organic Chemistry of Drug Synthesis, Volume 7

Volumn , Issue , 2007, Pages 1-244

The Organic Chemistry of Drug Synthesis, Volume 7

(1) Lednicer, Daniel a

a NONE

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84890135407 PISSN: None EISSN: None Source Type: Book
DOI: 10.1002/9780470180679 Document Type: Book

Times cited : (61)

References (261)

1
- 0027465150
- D.P. Getman et al., J. Med. Chem. 36, 288 (1993).
- (1993) J. Med. Chem. , vol.36 , pp. 288
- Getman, D.P.¹

2
- 84890186137
- U.S. Patent 5,558,397, The scheme shown here is partly based on that used to prepare darunavir and phosamprenavir due to difficulty in deciphering the patent
- R.D. Tung, M.A. Murcko, G.R. Bhisetti, U.S. Patent 5,558,397 (1996). The scheme shown here is partly based on that used to prepare darunavir and phosamprenavir due to difficulty in deciphering the patent.
- (1996)
- Tung, R.D.¹ Murcko, M.A.² Bhisetti, G.R.³

3
- 0028798774
- A.K. Ghosh, Y. Chen, Tetrahedron Lett. 36, 505 (1995).
- (1995) Tetrahedron Lett. , vol.36 , pp. 505
- Ghosh, A.K.¹ Chen, Y.²

4
- 20144382495
- D.L.N.G. Surleraux et al., J. Med. Chem. 48, 1813 (2005).
- (2005) J. Med. Chem. , vol.48 , pp. 1813
- Surleraux, D.L.N.G.¹

5
- 84890213742
- L.A. Sobrera, L. Martin, J. Castaner, Drugs Future, 23, 22 (2001).
- (2001) Drugs Future , vol.23 , pp. 22
- Sobrera, L.A.¹ Martin, L.² Castaner, J.³

6
- 15144353143
- G. Bold et al., J. Med. Chem. 41, 3387 (1998).
- (1998) J. Med. Chem. , vol.41 , pp. 3387
- Bold, G.¹

7
- 0003940281
- The Organic Chemistry of Drug Synthesis
- For a scheme for this intermediate see, John Wiley & Sons, Inc., NY
- For a scheme for this intermediate see D. Lednicer,"The Organic Chemistry of Drug Synthesis", Vol. 6, John Wiley & Sons, Inc., NY 1999, pp. 12,13.
- (1999) , vol.6
- Lednicer, D.¹

8
- 0034374764
- E.J. Stoner et al., Org. Process Res. Dev. 4, 264 (2000).
- (2000) Org. Process Res. Dev. , vol.4 , pp. 264
- Stoner, E.J.¹

9
- 0033535596
- P.S. Dragovich et al., J. Med. Chem. 42, 1213 (1999).
- (1999) J. Med. Chem. , vol.42 , pp. 1213
- Dragovich, P.S.¹

10
- 4444352764
- A. Zask et al., J. Med. Chem. 47, 4774 (2004).
- (2004) J. Med. Chem. , vol.47 , pp. 4774
- Zask, A.¹

11
- 84890191665
- U.S. Patent 5,556,942
- L.M. Kauvar, M.H. Lyttle, A. Satyam, U.S. Patent 5,556,942 (1996).
- (1996)
- Kauvar, L.M.¹ Lyttle, M.H.² Satyam, A.³

12
- 0029863194
- A. Satyam, M.D. Hocker, K.A. Kane-Maguire, A.S. Morgan, H.O. Villar, M.H. Lyttle, J. Med. Chem. 39, 1736 (1996).
- (1996) J. Med. Chem. , vol.39 , pp. 1736
- Satyam, A.¹ Hocker, M.D.² Kane-Maguire, K.A.³ Morgan, A.S.⁴ Villar, H.O.⁵ Lyttle, M.H.⁶

13
- 11144242153
- J.A. McIntyre, J. Castaner, Drugs Future 29, 992 (2004).
- (2004) Drugs Future , vol.29 , pp. 992
- McIntyre, J.A.¹ Castaner, J.²

14
- 84890154510
- U.S. Patent 4,684,747
- A. Sartorelli, K. Shyam, U.S. Patent 4,684,747 (1987).
- (1987)
- Sartorelli, A.¹ Shyam, K.²

15
- 84890153319
- U.S. Patent 5,637,619
- A. Sartorelli, K. Shyam, P.G. Penketh, U.S. Patent 5,637,619 (1997).
- (1997)
- Sartorelli, A.¹ Shyam, K.² Penketh, P.G.³

16
- 84890191573
- U.S. Patent 4,355,043
- J.P. Durlach, U.S. Patent 4,355,043 (1982).
- (1982)
- Durlach, J.P.¹

17
- 84890150075
- U.S. Patent, 4,816,484
- S. Toyoshima, Y. Seto, U.S. Patent, 4,816,484 (1989).
- (1989)
- Toyoshima, S.¹ Seto, Y.²

18
- 84890147017
- U.S. Patent, 5,216,167
- W. Grell, R. Hurnaus, G. Griss, R. Sauter, M. Reiffen, E. Rupprecht, U.S. Patent, 5,216,167 (1993).
- (1993)
- Grell, W.¹ Hurnaus, R.² Griss, G.³ Sauter, R.⁴ Reiffen, M.⁵ Rupprecht, E.⁶

19
- 84890162837
- See Ref. 7, pp. 15-18
- See Ref. 7, pp. 15-18.

20
- 84890249815
- L.A. Sobrera, J. Castaner, Drugs Future, 27, 201 (2002).
- (2002) Drugs Future , vol.27 , pp. 201
- Sobrera, L.A.¹ Castaner, J.²

21
- 0032906160
- J.A. Robl et al., J. Med. Chem. 42, 305 (1999).
- (1999) J. Med. Chem. , vol.42 , pp. 305
- Robl, J.A.¹

22
- 84890156893
- Chemistry of the Prostaglandins and Leukotrienes
- See, for example, J.E. Pike, D.R. Morton, Eds., Raven Press, NY
- See, for example, Chemistry of the Prostaglandins and Leukotrienes, J.E. Pike, D.R. Morton, Eds., Raven Press, NY, 1985.
- (1985)

23
- 0343550409
- J. Castaner, L.A. Sobrera, Drugs Future 25, 41 (2000).
- (2000) Drugs Future , vol.25 , pp. 41
- Castaner, J.¹ Sobrera, L.A.²

24
- 0003940281
- The Organic Chemistry of Drug Synthesis
- John Wiley & Sons, Inc., NY
- See D. Lednicer, The Organic Chemistry of Drug Synthesis, Vol. 6, John Wiley & Sons, Inc., NY 1999, p. 98.
- (1999) , vol.6 , pp. 98
- Lednicer, D.¹

25
- 84890242284
- U.S. Patent 5,352,708
- D.A. Woodward, S.W. Andrews, R.M. Burk, M.E. Garst, U.S. Patent 5,352,708 (1994).
- (1994)
- Woodward, D.A.¹ Andrews, S.W.² Burk, R.M.³ Garst, M.E.⁴

26
- 2642517752
- L.A. Sobrera, J. Castaner, Drugs Future 29, 336 (2004).
- (2004) Drugs Future , vol.29 , pp. 336
- Sobrera, L.A.¹ Castaner, J.²

27
- 0031048319
- C.U. Kim et al., J. Am. Chem. Soc. 119, 681 (1997).
- (1997) J. Am. Chem. Soc. , vol.119 , pp. 681
- Kim, C.U.¹

28
- 15444353753
- C.U. Kim et al., J. Med. Chem. 41, 2451 (1998).
- (1998) J. Med. Chem. , vol.41 , pp. 2451
- Kim, C.U.¹

29
- 84890174137
- U.S. Patent 5,763,483
- N. Bischofberger, C.U. Kim, W. Lew, H. Liu M.A. Williams, U.S. Patent 5,763,483 (1998).
- (1998)
- Bischofberger, N.¹ Kim, C.U.² Lew, W.³ Liu, H.⁴ Williams, M.A.⁵

30
- 33646567839
- Y.-Y. Yeung, S. Hong, E.J. Corey, J. Am. Chem. Soc. 128, 6310 (2006).
- (2006) J. Am. Chem. Soc. , vol.128 , pp. 6310
- Yeung, Y.-Y.¹ Hong, S.² Corey, E.J.³

31
- 0034699492
- Y.S. Babu et al., J. Med. Chem. 43, 3482 (2000).
- (2000) J. Med. Chem. , vol.43 , pp. 3482
- Babu, Y.S.¹

32
- 14444268769
- S.B. Christensen et al., J. Med. Chem. 41, 821 (1998).
- (1998) J. Med. Chem. , vol.41 , pp. 821
- Christensen, S.B.¹

33
- 0028204762
- M.F. Boehm, M.R. McClurg, C. Pathirana, D. Mangelsdorf, S.K. White, J. Herbert, D. Winn, M.E. Goldman, R.A. Hayman, J. Med. Chem. 37, 408 (1994).
- (1994) J. Med. Chem. , vol.37 , pp. 408
- Boehm, M.F.¹ McClurg, M.R.² Pathirana, C.³ Mangelsdorf, D.⁴ White, S.K.⁵ Herbert, J.⁶ Winn, D.⁷ Goldman, M.E.⁸ Hayman, R.A.⁹

34
- 0024470505
- J. Bowler, T.J. Lilley, J.D. Pittman, A.E. Wakelin, Steroids 54, 71 (1989).
- (1989) Steroids , vol.54 , pp. 71
- Bowler, J.¹ Lilley, T.J.² Pittman, J.D.³ Wakelin, A.E.⁴

35
- 14744294664
- G. Schubert, W. Eiger, G. Kaufmann, B. Schneider, G. Reddersen, K. Chwalisz, Semin. Reprod. Med. 23, 58 (2005).
- (2005) Semin. Reprod. Med. , vol.23 , pp. 58
- Schubert, G.¹ Eiger, W.² Kaufmann, G.³ Schneider, B.⁴ Reddersen, G.⁵ Chwalisz, K.⁶

36
- 84890194574
- U.S. Patent 4,027,019
- A.P. Shroff, U.S. Patent 4,027,019 (1977).
- (1977)
- Shroff, A.P.¹

37
- 0025351402
- J.G. Reid, T. Debiak-Krook, Tetrahedron Lett. 31, 3669 (1990).
- (1990) Tetrahedron Lett. , vol.31 , pp. 3669
- Reid, J.G.¹ Debiak-Krook, T.²

38
- 33947464150
- S. Bernstein, R. Littell, J. Am. Chem. Soc. 81, 4573 (1959).
- (1959) J. Am. Chem. Soc. , vol.81 , pp. 4573
- Bernstein, S.¹ Littell, R.²

39
- 84890242998
- U.S. Patent 5,482,934
- J. Calatayud, J.R. Conde, M. Lunn, U.S. Patent 5,482,934 (1996).
- (1996)
- Calatayud, J.¹ Conde, J.R.² Lunn, M.³

40
- 84890173589
- U.S. Patent 5,565,467
- K.W. Batchelor, S.W. Frye, G.F. Dorsey, R.A. Mook, U.S. Patent 5,565,467 (1996).
- (1996)
- Batchelor, K.W.¹ Frye, S.W.² Dorsey, G.F.³ Mook, R.A.⁴

41
- 84890138012
- U.S. Patent 4,772,433
- R. Hesse, U.S. Patent 4,772,433 (1988).
- (1988)
- Hesse, R.¹

42
- 84890143268
- U.S. Patent 5,494,905
- R.H. Hesse, G.S. Reddy, S.K.S. Setty, U.S. Patent 5,494,905 (1996).
- (1996)
- Hesse, R.H.¹ Reddy, G.S.² Setty, S.K.S.³

43
- 0031053518
- T.C. McMorris, Y. Hu, M. Kellner, Chem. Commun. 315 (1997).
- (1997) Chem. Commun. , pp. 315
- McMorris, T.C.¹ Hu, Y.² Kellner, M.³

44
- 0842328956
- T.C. McMorris, M.D. Staake, M.J. Kellner, J. Org. Chem. 69, 619 (2004).
- (2004) J. Org. Chem. , vol.69 , pp. 619
- McMorris, T.C.¹ Staake, M.D.² Kellner, M.J.³

45
- 15144339410
- W.A. Kinney et al., J. Med. Chem. 41, 236 (1998).
- (1998) J. Med. Chem. , vol.41 , pp. 236
- Kinney, W.A.¹

46
- 84890146960
- U.S. Patent 5,712,298
- H. Amschler, U.S. Patent 5,712,298 (1998).
- (1998)
- Amschler, H.¹

47
- 84890147313
- U.S. Patent 5,081,112
- K. Tsutsumi, T. Sagimoto, Y. Tsuda, E. Uesaak, K. Shinomiya, Y. Shoji, A. Shima, U.S. Patent 5,081,112 (1989).
- (1989)
- Tsutsumi, K.¹ Sagimoto, T.² Tsuda, Y.³ Uesaak, E.⁴ Shinomiya, K.⁵ Shoji, Y.⁶ Shima, A.⁷

48
- 0025975893
- R.S. Randad, M.A. Mahran, A.S. Mehanna, D.J. Abraham, J. Med. Chem. 34, 752 (1991).
- (1991) J. Med. Chem. , vol.34 , pp. 752
- Randad, R.S.¹ Mahran, M.A.² Mehanna, A.S.³ Abraham, D.J.⁴

49
- 7844224790
- B.R. Henke et al., J. Med. Chem. 41, 5020 (1998).
- (1998) J. Med. Chem. , vol.41 , pp. 5020
- Henke, B.R.¹

50
- 20144370408
- P.V. Devasthale et al., J. Med. Chem. 48, 2248 (2005).
- (2005) J. Med. Chem. , vol.48 , pp. 2248
- Devasthale, P.V.¹

51
- 84890173988
- Anon U.S. Application 1992-903691
- Anon U.S. Application 1992-903691.

52
- 0037192458
- L.M. Coussens, B. Fingleton, L.M. Matrisian, Science 295, 2387 (2002).
- (2002) Science , vol.295 , pp. 2387
- Coussens, L.M.¹ Fingleton, B.² Matrisian, L.M.³

53
- 84890220722
- U.S. Patent 5,789,434
- H.C.E. Kluender et al., U.S. Patent 5,789,434 (1998).
- (1998)
- Kluender, H.C.E.¹

54
- 0028799247
- J.S. Sawyer et al., J. Med. Chem. 38, 4411 (1995).
- (1995) J. Med. Chem. , vol.38 , pp. 4411
- Sawyer, J.S.¹

55
- 84890220654
- U.S. Patent 6,251,925
- K.H. Donaldson, B.G. Shearer, D.E. Uehling, U.S. Patent 6,251,925 (2001).
- (2001)
- Donaldson, K.H.¹ Shearer, B.G.² Uehling, D.E.³

56
- 5744227334
- J. Malm, Curr. Pharm. Design 10, 3525 (2004).
- (2004) Curr. Pharm. Design , vol.10 , pp. 3525
- Malm, J.¹

57
- 0029044699
- N. Yokoyama et al., J. Med. Chem. 38, 695 (1995).
- (1995) J. Med. Chem. , vol.38 , pp. 695
- Yokoyama, N.¹

58
- 84890217878
- U.S. Patent 6,013,668
- K.S. Atwal, U.S. Patent 6,013,668 (2000).
- (2000)
- Atwal, K.S.¹

59
- 84890145053
- U.S. Patent 6,057,349
- R.L. Cournoyer, P.F. Keitz, C. O'Yang, D.M. Yasuda, U.S. Patent 6,057,349 (2000)
- (2000)
- Cournoyer, R.L.¹ Keitz, P.F.² O'Yang, C.³ Yasuda, D.M.⁴

60
- 84890248788
- L.A. Sobrera, P.A. Leeson, J.A. Castaner, M. del Fresno, Drugs Future 29, 240 (2002).
- (2002) Drugs Future , vol.29 , pp. 240
- Sobrera, L.A.¹ Leeson, P.A.² Castaner, J.A.³ Del Fresno, M.⁴

61
- 84890140679
- U.S. Patent 5,017,610
- K. Imaki, Y. Arai, T. Okegawa, U.S. Patent 5,017,610 (1991).
- (1991)
- Imaki, K.¹ Arai, Y.² Okegawa, T.³

62
- 84890191306
- U.S. Patent 5,753,653
- L. Bender, M.J. Melnick, U.S. Patent 5,753,653 (1998).
- (1998)
- Bender, L.¹ Melnick, M.J.²

63
- 0037413530
- N. Murugesan et al., J. Med. Chem. 46, 125 (2003).
- (2003) J. Med. Chem. , vol.46 , pp. 125
- Murugesan, N.¹

64
- 0030472785
- H.T. Lee et al., J. Med. Chem. 39, 5031 (1998).
- (1998) J. Med. Chem. , vol.39 , pp. 5031
- Lee, H.T.¹

65
- 84890198135
- U.S. Patent 5,591,754
- H.-J. Lang, A. Weichert, H.-W. Kleeman, H. Englert, W. Scholtz, U. Albus, U.S. Patent 5,591,754 (1997).
- (1997)
- Lang, H.-J.¹ Weichert, A.² Kleeman, H.-W.³ Englert, H.⁴ Scholtz, W.⁵ Albus, U.⁶

66
- 84890202491
- U.S. Patent 4,803,227
- L.J. Brandes, M.W. Hermonat, U.S. Patent 4,803,227 (1989).
- (1989)
- Brandes, L.J.¹ Hermonat, M.W.²

67
- 84890217828
- U.S. Patent 5,382,600
- N.A. Johnsson, B.A. Sparf, L. Mikiver, P. Moses, L. Nilvebrant, G. Glas, U.S. Patent 5,382,600 (1995).
- (1995)
- Johnsson, N.A.¹ Sparf, B.A.² Mikiver, L.³ Moses, P.⁴ Nilvebrant, L.⁵ Glas, G.⁶

68
- 0031746028
- S.T. Moe, D.L. Smith, K. By, J.A. Egan, C.N. Filer, J. Label. Comp. Radiopharm. 41, 535 (1998).
- (1998) J. Label. Comp. Radiopharm. , vol.41 , pp. 535
- Moe, S.T.¹ Smith, D.L.² By, K.³ Egan, J.A.⁴ Filer, C.N.⁵

69
- 0033535613
- R. Soyka, B.D. Guth, H.M. Weisenberger, P. Luger, T.H. Muller, J. Med. Chem. 42, 1235 (1999).
- (1999) J. Med. Chem. , vol.42 , pp. 1235
- Soyka, R.¹ Guth, B.D.² Weisenberger, H.M.³ Luger, P.⁴ Muller, T.H.⁵

70
- 84890182293
- U.S. Patent 5,840,736
- R. Zelle, M. Su, U.S. Patent 5,840,736 (1998).
- (1998)
- Zelle, R.¹ Su, M.²

71
- 15044347050
- E. Brenner, R.M. Baldwin, G. Tramagnan, Org. Lett. 7, 937 (2005).
- (2005) Org. Lett. , vol.7 , pp. 937
- Brenner, E.¹ Baldwin, R.M.² Tramagnan, G.³

72
- 84890179012
- U.S. Patent 5,451,586
- J.A Lowe, U.S. Patent 5,451,586 (1995).
- (1995)
- Lowe, J.A.¹

73
- 84890228048
- U.S. Patent 5,807,867
- I. Fumitaka, H. Kondo, M. Nakane, K. Shimada, J.A. Lowe, T.J. Rosen, U.S. Patent 5,807,867 (1998).
- (1998)
- Fumitaka, I.¹ Kondo, H.² Nakane, M.³ Shimada, K.⁴ Lowe, J.A.⁵ Rosen, T.J.⁶

74
- 84890193445
- L.A. Sobrera, J.A. Castaner, Drugs Future 25, 196 (2000).
- (2000) Drugs Future , vol.25 , pp. 196
- Sobrera, L.A.¹ Castaner, J.A.²

75
- 84890145392
- U.S. Patent 5,034,419
- G.G. Aubard et al., U.S. Patent 5,034,419 (1991).
- (1991)
- Aubard, G.G.¹

76
- 0014573173
- D. Lednicer, D.E. Emmert, S.C. Lyster, G.W. Duncan, J. Med. Chem. 12, 881 (1969).
- (1969) J. Med. Chem. , vol.12 , pp. 881
- Lednicer, D.¹ Emmert, D.E.² Lyster, S.C.³ Duncan, G.W.⁴

77
- 0003940281
- The Organic Chemistry of Drug Synthesis
- JohnWiley & Sons, Inc., NY
- D. Lednicer, The Organic Chemistry of Drug Synthesis, Vol. 5, JohnWiley & Sons, Inc., NY, 1995, p. 33.
- (1995) , vol.5 , pp. 33
- Lednicer, D.¹

78
- 84890237525
- U.S. Patent 5,750,576
- M. DeGregorio, V. Wiebe, L. Kangas, P. Harkonen, K. Vaananen, A. Laine, U.S. Patent 5,750,576 (1998).
- (1998)
- DeGregorio, M.¹ Wiebe, V.² Kangas, L.³ Harkonen, P.⁴ Vaananen, K.⁵ Laine, A.⁶

79
- 0025334928
- R. Amstuz, M. Marzi, M. Boelsterli, M. Walsinshaw, Helv. Chim. Acta 73, 739 (1990).
- (1990) Helv. Chim. Acta , vol.73 , pp. 739
- Amstuz, R.¹ Marzi, M.² Boelsterli, M.³ Walsinshaw, M.⁴

80
- 0032169758
- W.D. Vaccaro, R. Sher, H.R. Davis, Bioorg. Med. Chem. 6, 1429 (1998).
- (1998) Bioorg. Med. Chem. , vol.6 , pp. 1429
- Vaccaro, W.D.¹ Sher, R.² Davis, H.R.³

81
- 84890179021
- U.S. Patent 6,313,322 B1
- A. Karjalainen, P. Huhtala, S. Wurster, M. Eloranta, M. Hillila, R. Saxlund, V. Cockroft, A. Karjalainen, U.S. Patent 6,313,322 B1 (2001).
- (2001)
- Karjalainen, A.¹ Huhtala, P.² Wurster, S.³ Eloranta, M.⁴ Hillila, M.⁵ Saxlund, R.⁶ Cockroft, V.⁷ Karjalainen, A.⁸

82
- 84890212220
- U.S. Patent 5,521,180
- M. Fuji, T. Suzuki, S. Hayashibe, S. Tsukamoto, S. Yatsugi, T. Yamaguchi, U.S. Patent 5,521,180 (1996).
- (1996)
- Fuji, M.¹ Suzuki, T.² Hayashibe, S.³ Tsukamoto, S.⁴ Yatsugi, S.⁵ Yamaguchi, T.⁶

83
- 0024390540
- Y. Imura, M. Mishima, M. Sugimoto, J. Label. Comp. Radiopharm 27, 835 (1989).
- (1989) J. Label. Comp. Radiopharm , vol.27 , pp. 835
- Imura, Y.¹ Mishima, M.² Sugimoto, M.³

84
- 84890217905
- U.S. Patent 6,462,222
- M. Chorev, T. Goren, Y. Herzig, J. Sterling, M. Weinstock-Rosin, M.B.H. Youdim, U.S. Patent 6,462,222 (2002).
- (2002)
- Chorev, M.¹ Goren, T.² Herzig, Y.³ Sterling, J.⁴ Weinstock-Rosin, M.⁵ Youdim, M.B.H.⁶

85
- 0347513102
- K. Chilma-Blair, J. Castaner, J.S. Silvestre, H. Bayes, Drugs Future 28, 950 (2003).
- (2003) Drugs Future , vol.28 , pp. 950
- Chilma-Blair, K.¹ Castaner, J.² Silvestre, J.S.³ Bayes, H.⁴

86
- 84890235357
- U.S. Patent 6,211,244
- B.C. Van Wagenen, S.T. Moe, M.F. Balandrin, E.G. DelMar, E.F. Nemeth, U.S. Patent 6,211,244 (2001).
- (2001)
- Van Wagenen, B.C.¹ Moe, S.T.² Balandrin, M.F.³ DelMar, E.G.⁴ Nemeth, E.F.⁵

87
- 0037019275
- J. Regan et al., J. Med. Chem. 45, 2994 (2002).
- (2002) J. Med. Chem. , vol.45 , pp. 2994
- Regan, J.¹

88
- 0027767734
- N.J. Cusack, J.V. Peck, Drugs Future 18, 1005 (1993).
- (1993) Drugs Future , vol.18 , pp. 1005
- Cusack, N.J.¹ Peck, J.V.²

89
- 84890202831
- U.S. Patent 5,214,202
- Y. Hamada, I. Yamada, M. Uenaka, T. Sakata, U.S. Patent 5,214,202 (1993).
- (1993)
- Hamada, Y.¹ Yamada, I.² Uenaka, M.³ Sakata, T.⁴

90
- 84890136719
- U.S. Patent 5,780,676
- M.F. Boehm, R.A. Heyman, L. Zhi, C.K. Hwang, S. White, A. Nadzan, U.S. Patent 5,780,676 (1998).
- (1998)
- Boehm, M.F.¹ Heyman, R.A.² Zhi, L.³ Hwang, C.K.⁴ White, S.⁵ Nadzan, A.⁶

91
- 0014573173
- D. Lednicer, D.E. Emmert, S.C. Lyster, G.W. Duncan, J. Med. Chem. 12, 881 (1969).
- (1969) J. Med. Chem. , vol.12 , pp. 881
- Lednicer, D.¹ Emmert, D.E.² Lyster, S.C.³ Duncan, G.W.⁴

92
- 84890201748
- U.S. Patent 5,552,412
- C.O. Cameron, P.A. Dasilva Jardine, R.L. Rosati, U.S. Patent 5,552,412 (1996).
- (1996)
- Cameron, C.O.¹ Dasilva Jardine, P.A.² Rosati, R.L.³

93
- 0028790019
- J.R. Pfister et al., Bioorg. Med. Chem. Lett. 5, 2473 (1995).
- (1995) Bioorg. Med. Chem. Lett. , vol.5 , pp. 2473
- Pfister, J.R.¹

94
- 84890174468
- U.S. Patent 4,306,075
- P.A. Aristoff, U.S. Patent 4,306,075 (1981).
- (1981)
- Aristoff, P.A.¹

95
- 84890162963
- U.S. Patent 4,649,689
- P.A. Aristoff, U.S. Patent 4,649,689 (1982).
- (1982)
- Aristoff, P.A.¹

96
- 84890204471
- U.S. Patent 4,683,330
- P.A. Aristoff, U.S. Patent 4,683,330 (1987).
- (1987)
- Aristoff, P.A.¹

97
- 0037777695
- E.B. Villhauer, J.A. Brinkman, G.B. Nader, B.F. Burkey, B.E. Dunning, K. Prasad, B.L. Mangold, M.E. Russel, T.A. Hughes, J. Med. Chem. 46, 2774 (2003).
- (2003) J. Med. Chem. , vol.46 , pp. 2774
- Villhauer, E.B.¹ Brinkman, J.A.² Nader, G.B.³ Burkey, B.F.⁴ Dunning, B.E.⁵ Prasad, K.⁶ Mangold, B.L.⁷ Russel, M.E.⁸ Hughes, T.A.⁹

98
- 0029946714
- S.J. Coutts et al., J. Med. Chem. 39, 2087 (1996).
- (1996) J. Med. Chem. , vol.39 , pp. 2087
- Coutts, S.J.¹

99
- 0033215464
- S.J. Wittenberger, M.A. McLaughlin. Tetrahedron Lett. 40, 7175 (1999).
- (1999) Tetrahedron Lett. , vol.40 , pp. 7175
- Wittenberger, S.J.¹ McLaughlin, M.A.²

100
- 84890207249
- U.S. Patent 5,096,890
- P.E. Cross, A.R. MacKenzie, U.S. Patent 5,096,890 (1992).
- (1992)
- Cross, P.E.¹ MacKenzie, A.R.²

101
- 0038676230
- M.M. Faul, E. Kobierski, M.E. Kopach, J. Org. Chem. 68, 5739 (2003).
- (2003) J. Org. Chem. , vol.68 , pp. 5739
- Faul, M.M.¹ Kobierski, E.² Kopach, M.E.³

102
- 84890203030
- U.S. Patent 5,672,618
- W.F. Heath, J.H. McDonald, M. Paal, T. Schotten, W. Stenzel, U.S. Patent 5,672,618 (1997).
- (1997)
- Heath, W.F.¹ McDonald, J.H.² Paal, M.³ Schotten, T.⁴ Stenzel, W.⁵

103
- 0038394537
- M.M. Faul, J.R. Gillig, M.R. Jirousek, L.M. Ballas, T. Schotten, A. Kahl, M. Mohr, Bioorg. Med. Chem. Lett. 13, 1857 (2003).
- (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 1857
- Faul, M.M.¹ Gillig, J.R.² Jirousek, M.R.³ Ballas, L.M.⁴ Schotten, T.⁵ Kahl, A.⁶ Mohr, M.⁷

104
- 0028884755
- C.D.W. Brooks et al., J. Med. Chem. 38, 4768 (1995).
- (1995) J. Med. Chem. , vol.38 , pp. 4768
- Brooks, C.D.W.¹

105
- 84890188072
- U.S. Patent 5,994,381
- J. Haruta, H. Hashimoto, M. Matsushita, U.S. Patent 5,994,381 (1999).
- (1999)
- Haruta, J.¹ Hashimoto, H.² Matsushita, M.³

106
- 85042289033
- J.J. Talley et al., J. Med. Chem. 43, 775 (2000).
- (2000) J. Med. Chem. , vol.43 , pp. 775
- Talley, J.J.¹

107
- 0034030366
- J.J. Talley et al., J. Med. Chem. 43, 1661 (2000).
- (2000) J. Med. Chem. , vol.43 , pp. 1661
- Talley, J.J.¹

108
- 84890204558
- U.S. Patent 5,949,511
- R.R. Bartlett, F.-J. Kammerer, U.S. Patent 5,949,511 (1996).
- (1996)
- Bartlett, R.R.¹ Kammerer, F.-J.²

109
- 84890182912
- U.S. Patent 4,892,963
- P.T. Gallagher, T.A. Hicks, G.W. Mullier, U.S. Patent 4,892,963 (1990).
- (1990)
- Gallagher, P.T.¹ Hicks, T.A.² Mullier, G.W.³

110
- 0023143916
- K. Thiele, L. Zimgibl, M.H. Pfeninger, M. Egli, M. Dobler, Helv. Chim. Acta 70, 441 (1987).
- (1987) Helv. Chim. Acta , vol.70 , pp. 441
- Thiele, K.¹ Zimgibl, L.² Pfeninger, M.H.³ Egli, M.⁴ Dobler, M.⁵

111
- 0346100541
- H. Liu, F.A. Kerdesky, L.A. Black, M. Fitzgerald, R. Henry, T.A. Ebenshade, A.A. Hancock, Y.L. Bennani, J. Org. Chem. 69, 192 (2004).
- (2004) J. Org. Chem. , vol.69 , pp. 192
- Liu, H.¹ Kerdesky, F.A.² Black, L.A.³ Fitzgerald, M.⁴ Henry, R.⁵ Ebenshade, T.A.⁶ Hancock, A.A.⁷ Bennani, Y.L.⁸

112
- 84890169453
- U.S. Patent 6,147,097
- H. Sugimoto, T. Fujiwara, U.S. Patent 6,147,097 (2000).
- (2000)
- Sugimoto, H.¹ Fujiwara, T.²

113
- 0042343839
- C. Almansa et al., J. Med. Chem. 46, 3463 (2003).
- (2003) J. Med. Chem. , vol.46 , pp. 3463
- Almansa, C.¹

114
- 84890142890
- U.S. Patent 5,719,280
- G.R. Martinez, O.W. Goodling, D.B. Repke, P.J. Teitelbaum, K.A.M. Walker, R.L. Whiting, U.S. Patent 5,719,280 (1998).
- (1998)
- Martinez, G.R.¹ Goodling, O.W.² Repke, D.B.³ Teitelbaum, P.J.⁴ Walker, K.A.M.⁵ Whiting, R.L.⁶

115
- 84890241475
- H.R. Wiltshire, K.J. Prior, J. Dhesi, G. Maile, J. Labelled Cpd. Radiopharm. 44, 149 (2001).
- (2001) J. Labelled Cpd. Radiopharm. , vol.44 , pp. 149
- Wiltshire, H.R.¹ Prior, K.J.² Dhesi, J.³ Maile, G.⁴

116
- 0030964706
- M.J. Broadhurst et al., Bioorg. Med. Chem. Lett. 7, 2299 (1997).
- (1997) Bioorg. Med. Chem. Lett. , vol.7 , pp. 2299
- Broadhurst, M.J.¹

117
- 84890202990
- U.S. Patent 5,624,940
- F. Barth, P. Casellas, C. Congy, S. Martinez, M. Rinaldi, G. Anne-Archard, U.S. Patent 5,624,940 (1997).
- (1997)
- Barth, F.¹ Casellas, P.² Congy, C.³ Martinez, S.⁴ Rinaldi, M.⁵ Anne-Archard, G.⁶

118
- 84890193418
- U.S. Patent 5,143,928
- W.A. Cetenko, D.T. Connor, J.C. Sircar, R.J. Sorenson, P.C. Unangst, U.S. Patent 5,143,928 (1992).
- (1992)
- Cetenko, W.A.¹ Connor, D.T.² Sircar, J.C.³ Sorenson, R.J.⁴ Unangst, P.C.⁵

119
- 84890206297
- U.S. Patent Appl. 2005/0075503
- T.A. Robbins, H. Zhu, J. Shan, U.S. Patent Appl. 2005/0075503 (2005).
- (2005)
- Robbins, T.A.¹ Zhu, H.² Shan, J.³

120
- 0029067662
- M. Chihiro et al., J. Med. Chem. 38, 353 (1995).
- (1995) J. Med. Chem. , vol.38 , pp. 353
- Chihiro, M.¹

121
- 84890192330
- U.S. Patent 3,950,351
- J-.F. Rossignol, R. Cavier, U.S. Patent 3,950,351 (1976).
- (1976)
- Rossignol, J.-F.¹ Cavier, R.²

122
- 84890165987
- L.A. Sobrera, J. Castaner, M. del Fresno, J. Silvestre, Drugs Future 27, 132 (2000).
- (2000) Drugs Future , vol.27 , pp. 132
- Sobrera, L.A.¹ Castaner, J.² Del Fresno, M.³ Silvestre, J.⁴

123
- 0029942358
- R.O. Fromtling, Drugs Future 21, 266 (1996).
- (1996) Drugs Future , vol.21 , pp. 266
- Fromtling, R.O.¹

124
- 0021239237
- J. Heeres, L. Backx, J. Van Custem, J. Med. Chem. 27, 894 (1984).
- (1984) J. Med. Chem. , vol.27 , pp. 894
- Heeres, J.¹ Backx, L.² Van Custem, J.³

125
- 15144354434
- J.J. Hale et al., J. Med. Chem. 41, 4607 (1998).
- (1998) J. Med. Chem. , vol.41 , pp. 4607
- Hale, J.J.¹

126
- 84890212199
- U.S. Patent 6,667,314
- M. Perros, D.A. Price, B.L.C. Stammen, A. Wood, U.S. Patent 6,667,314 (2003).
- (2003)
- Perros, M.¹ Price, D.A.² Stammen, B.L.C.³ Wood, A.⁴

127
- 84890209188
- L.A. Sobrera, P.A. Leeson, J. Castaner, Drugs Future 25, 1145 (1998).
- (1998) Drugs Future , vol.25 , pp. 1145
- Sobrera, L.A.¹ Leeson, P.A.² Castaner, J.³

128
- 84890166211
- U.S. Patent 6,716,863
- A. Tasaka, T. Hitaka, E. Matsutani, U.S. Patent 6,716,863 (2004).
- (2004)
- Tasaka, A.¹ Hitaka, T.² Matsutani, E.³

129
- 0027988563
- E.K. Moltzen, H. Pedersen, K.P. Bogeso, E. Meier, K. Frederiksen, C. Sanchez, H.L. Lambol, J. Med. Chem. 37, 4085 (1994).
- (1994) J. Med. Chem. , vol.37 , pp. 4085
- Moltzen, E.K.¹ Pedersen, H.² Bogeso, K.P.³ Meier, E.⁴ Frederiksen, K.⁵ Sanchez, C.⁶ Lambol, H.L.⁷

130
- 17044461438
- D.R. Armour et al., Bioorg. Med. Chem. Lett. 6, 1015 (1996).
- (1996) Bioorg. Med. Chem. Lett. , vol.6 , pp. 1015
- Armour, D.R.¹

131
- 0030049822
- H. Yanagisawa et al., J. Med. Chem. 39, 323 (1996).
- (1996) J. Med. Chem. , vol.39 , pp. 323
- Yanagisawa, H.¹

132
- 33750474100
- F.F. Wagner, D.L. Comins, J. Org. Chem. 71, 8673 (2006).
- (2006) J. Org. Chem. , vol.71 , pp. 8673
- Wagner, F.F.¹ Comins, D.L.²

133
- 0034670533
- I.W. Davies et al., J. Org. Chem. 65, 8415, (2000).
- (2000) J. Org. Chem. , vol.65 , pp. 8415
- Davies, I.W.¹

134
- 84890198162
- U.S. Patent 5,856,346
- K.H. Andersson, M. Norlander, R.C. Westerlund, U.S. Patent 5,856,346 (1999).
- (1999)
- Andersson, K.H.¹ Norlander, M.² Westerlund, R.C.³

135
- 84890202739
- U.S. Patent 6,350,877
- A. Mattson, C. Svensson, K. Thornblom, C. Odman, U.S. Patent 6,350,877 (2002).
- (2002)
- Mattson, A.¹ Svensson, C.² Thornblom, K.³ Odman, C.⁴

136
- 0000285698
- For a discussion of the stereochemistry in a related system see
- For a discussion of the stereochemistry in a related system see C.J. Barnett, C.R. Copley-Merriman, J. Maki, J. Org. Chem. 54, 4795 (1989).
- (1989) J. Org. Chem. , vol.54 , pp. 4795
- Barnett, C.J.¹ Copley-Merriman, C.R.² Maki, J.³

137
- 84890204868
- L.A. Sobrera, J. Castaner, Drugs Future 28, 826 (2001).
- (2001) Drugs Future , vol.28 , pp. 826
- Sobrera, L.A.¹ Castaner, J.²

138
- 84890179455
- U.S. Patent 5,620,971
- D.M. Armistead, J.O. Saunders, J.S. Boger, U.S. Patent 5,620,971 (1997).
- (1997)
- Armistead, D.M.¹ Saunders, J.O.² Boger, J.S.³

139
- 0032538588
- K.S. Fors, R.F. Heier, R.C. Kelly, W.R. Perrault, N. Wicnienski, J. Org. Chem. 63, 7348 (1998).
- (1998) J. Org. Chem. , vol.63 , pp. 7348
- Fors, K.S.¹ Heier, R.F.² Kelly, R.C.³ Perrault, W.R.⁴ Wicnienski, N.⁵

140
- 84890209098
- U.S. Patent 6,252,076
- Y.W. Hong, Y.N. Lee, H.B. Kim, U.S. Patent 6,252,076 (2001).
- (2001)
- Hong, Y.W.¹ Lee, Y.N.² Kim, H.B.³

141
- 17944374798
- D.W. Ludovici et al., Bioorg. Med. Chem. Lett. 11, 2235 (2001).
- (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 2235
- Ludovici, D.W.¹

142
- 84890224636
- U.S. Patent 5,604,209
- M. Ubasawa, S. Yuasa, U.S. Patent 5,604,209 (1997).
- (1997)
- Ubasawa, M.¹ Yuasa, S.²

143
- 84890174406
- M. Watanabe, H. Koike, T. Ishiba, T. Okada, S. Seo, K. Hirai, Bioorg. Med. Chem. Lett. 5, 437 (1995).
- (1995) Bioorg. Med. Chem. Lett. , vol.5 , pp. 437
- Watanabe, M.¹ Koike, H.² Ishiba, T.³ Okada, T.⁴ Seo, S.⁵ Hirai, K.⁶

144
- 84890144580
- U.S. Patent, 5,773,449
- R. Masciardi, U.S. Patent, 5,773,449 (1998).
- (1998)
- Masciardi, R.¹

145
- 0029896933
- H. Riechers et al., J. Med. Chem. 39, 2123 (1996).
- (1996) J. Med. Chem. , vol.39 , pp. 2123
- Riechers, H.¹

146
- 84890238543
- U.S. Patent 6,797,709
- K. Yamada, K. Matsuki, K. Omori, K. Kikkawa, U.S. Patent 6,797,709 (2004).
- (2004)
- Yamada, K.¹ Matsuki, K.² Omori, K.³ Kikkawa, K.⁴

147
- 0027431466
- M. Hirohashi, M. Kido, Y. Yamamoto, Y. Kojima, K. Jitsikawa, S. Fujii, Chem. Pharm. Bull. 41, 1498 (1993).
- (1993) Chem. Pharm. Bull. , vol.41 , pp. 1498
- Hirohashi, M.¹ Kido, M.² Yamamoto, Y.³ Kojima, Y.⁴ Jitsikawa, K.⁵ Fujii, S.⁶

148
- 33745752826
- D. Russowsky, R.F.S. Canto, S.A.A. Sanches, M.G.M. D'Oca, A. de Fatima, R.A. Pilli, L.K. Kohn, M.A. Antonio, J.E. de Carvalho, Bioorg. Chem. 34, 173 (2006).
- (2006) Bioorg. Chem. , vol.34 , pp. 173
- Russowsky, D.¹ Canto, R.F.S.² Sanches, S.A.A.³ D'Oca, M.G.M.⁴ De Fatima, A.⁵ Pilli, R.A.⁶ Kohn, L.K.⁷ Antonio, M.A.⁸ De Carvalho, J.E.⁹

149
- 0022341203
- C.H. Tann, P.R. Brodfuehrer, S.P. Brundidge, C. Sapino, H.G. Howell, J. Org. Chem. 50, 3644 (1985).
- (1985) J. Org. Chem. , vol.50 , pp. 3644
- Tann, C.H.¹ Brodfuehrer, P.R.² Brundidge, S.P.³ Sapino, C.⁴ Howell, H.G.⁵

150
- 84890147182
- March 20
- Anon. New York Times, March 20, 2004.
- (2004) New York Times
- Anon¹

151
- 84890224956
- U.S. Patent 5,760,210
- J.R. Mccarthy, D.P. Mathews, J.S. Sabol, J.R. McConnell, R.E. Donaldson, R. Doguid, U.S. Patent 5,760,210 (1998).
- (1998)
- Mccarthy, J.R.¹ Mathews, D.P.² Sabol, J.S.³ McConnell, J.R.⁴ Donaldson, R.E.⁵ Doguid, R.⁶

152
- 0026485010
- B.R. Belleau, C.A. Evans, H.L.A. Tee, Tetrahedron Lett. 33, 6949 (1992).
- (1992) Tetrahedron Lett. , vol.33 , pp. 6949
- Belleau, B.R.¹ Evans, C.A.² Tee, H.L.A.³

153
- 0027408378
- L.S. Jeong et al., J. Med. Chem. 36, 181 (1993).
- (1993) J. Med. Chem. , vol.36 , pp. 181
- Jeong, L.S.¹

154
- 0028823452
- G. Van Lommen, M. De Bruyn, M. Schroven, W. Verschueren, W. Janssens, J. Verrelst, J. Leysen, Bioorg. Med. Chem. Lett. 5, 2649 (1995).
- (1995) Bioorg. Med. Chem. Lett. , vol.5 , pp. 2649
- Van Lommen, G.¹ De Bruyn, M.² Schroven, M.³ Verschueren, W.⁴ Janssens, W.⁵ Verrelst, J.⁶ Leysen, J.⁷

155
- 0032539702
- J. Adams et al., Bioorg. Med. Chem. Lett. 8, 333 (1998).
- (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 333
- Adams, J.¹

156
- 26444502561
- M. Alonso, F. Santacana, L. Rafecas, A. Riera, Org. Proc. Resea. Dev. 9, 690 (2005).
- (2005) Org. Proc. Resea. Dev. , vol.9 , pp. 690
- Alonso, M.¹ Santacana, F.² Rafecas, L.³ Riera, A.⁴

157
- 4644335577
- J.A. McIntire, J. Castaner, Drugs Future 29, 677 (2002).
- (2002) Drugs Future , vol.29 , pp. 677
- McIntire, J.A.¹ Castaner, J.²

158
- 84890200987
- U.S. Patent 6,608,195
- J.P. Rainville, T.G. Sinay, S.W. Wallinsky, U.S. Patent 6,608,195 (2003).
- (2003)
- Rainville, J.P.¹ Sinay, T.G.² Wallinsky, S.W.³

159
- 84890233497
- U.S. Patent 5,854,282, Note this patent describes the chemistry up to phenol 8. The alkylation step is conjectural though well precedented
- C. Mellin, U.S. Patent 5,854,282 (1998). Note this patent describes the chemistry up to phenol 8. The alkylation step is conjectural though well precedented.
- (1998)
- Mellin, C.¹

160
- 84890179953
- Anon, Drugs Future 25, 620 (2000).
- (2000) Drugs Future , vol.25 , pp. 620
- Anon¹

161
- 0028989793
- K.-H. Buchheit, R. Gamse, R. Giger, D. Hoyer, F. Klein, E. Klopner, H.-J. Pfannkuche, H. Mattes, J. Med. Chem. 38, 2331 (1995).
- (1995) J. Med. Chem. , vol.38 , pp. 2331
- Buchheit, K.-H.¹ Gamse, R.² Giger, R.³ Hoyer, D.⁴ Klein, F.⁵ Klopner, E.⁶ Pfannkuche, H.-J.⁷ Mattes, H.⁸

162
- 20244368524
- E.C. Haley et al., Stroke 36, 1006 (2005).
- (2005) Stroke , vol.36 , pp. 1006
- Haley, E.C.¹

163
- 0031951717
- R.D. Fabio, A. Cugola, D. Donati, A. Ferari, G. Gariraghi, E. Ratti, D.G. Trists, A. Reggiani, Drugs Future 23, 61, (1998).
- (1998) Drugs Future , vol.23 , pp. 61
- Fabio, R.D.¹ Cugola, A.² Donati, D.³ Ferari, A.⁴ Gariraghi, G.⁵ Ratti, E.⁶ Trists, D.G.⁷ Reggiani, A.⁸

164
- 12644262408
- S.D. Draheim et al., J. Med. Chem. 39, 5159 (1996).
- (1996) J. Med. Chem. , vol.39 , pp. 5159
- Draheim, S.D.¹

165
- 20944432343
- M.C. Van Zandt et al., J. Med. Chem. 48, 3141 (2005).
- (2005) J. Med. Chem. , vol.48 , pp. 3141
- Van Zandt, M.C.¹

166
- 0036244170
- C.P. Miller, H.A. Harris, B.S. Komm, Drugs Future 27, 117 (2002).
- (2002) Drugs Future , vol.27 , pp. 117
- Miller, C.P.¹ Harris, H.A.² Komm, B.S.³

167
- 0033061775
- Anon, Drugs Future 24, 367 (1999).
- (1999) Drugs Future , vol.24 , pp. 367
- Anon¹

168
- 0031450416
- P.R. Brodfuehrer et al., J. Org. Chem. 62, 9192 (1997).
- (1997) J. Org. Chem. , vol.62 , pp. 9192
- Brodfuehrer, P.R.¹

169
- 84890197239
- U.S. Patent 6,797,708
- J.C. McKew, S.Y. Tam, K.L. Lee, L. Chen, P. Thakker, F.-W. Sum, M. Behnke, B. Hu, J.D. Clark, U.S. Patent 6,797,708 (2004).
- (2004)
- McKew, J.C.¹ Tam, S.Y.² Lee, K.L.³ Chen, L.⁴ Thakker, P.⁵ Sum, F.-W.⁶ Behnke, M.⁷ Hu, B.⁸ Clark, J.D.⁹

170
- 0032474915
- L. Sun, N. Tran, H. App, P. Hirth, G. McMahon, C. Tan, J. Med. Chem. 41, 2588 (1998).
- (1998) J. Med. Chem. , vol.41 , pp. 2588
- Sun, L.¹ Tran, N.² App, H.³ Hirth, P.⁴ McMahon, G.⁵ Tan, C.⁶

171
- 0037468875
- L. Sun et al., J. Med. Chem. 46, 1116 (2003).
- (2003) J. Med. Chem. , vol.46 , pp. 1116
- Sun, L.¹

172
- 84890205630
- U.S. Patent 5,962,465
- G.P. Stack, R.F. Mewshaw, B.A. Bravo, Y.H. Kang, U.S. Patent 5,962,465 (1999).
- (1999)
- Stack, G.P.¹ Mewshaw, R.F.² Bravo, B.A.³ Kang, Y.H.⁴

173
- 18344365176
- P. Hewawasam et al., Bioorg. Med. Chem. Lett. 12, 1023 (2002).
- (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 1023
- Hewawasam, P.¹

174
- 0033532557
- G.W. Muller, R. Chen, S.-Y. Huang, L.G. Corral, L.M.Wong, R.T. Patterson, Y. Chen, G. Kaplan, D.I. Stirling, Bioorg. Med. Chem. Lett. 9, 1625 (1999).
- (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 1625
- Muller, G.W.¹ Chen, R.² Huang, S.-Y.³ Corral, L.G.⁴ Wong, L.M.⁵ Patterson, R.T.⁶ Chen, Y.⁷ Kaplan, G.⁸ Stirling, D.I.⁹

175
- 15844421382
- D.C. Dean et al., J. Med. Chem. 39, 1767 (1996).
- (1996) J. Med. Chem. , vol.39 , pp. 1767
- Dean, D.C.¹

176
- 3242723963
- E. Comer, W.S. Murphy, ARKIVOC, 286 (2003).
- (2003) ARKIVOC , pp. 286
- Comer, E.¹ Murphy, W.S.²

177
- 0003630405
- A.D. Palkowitz et al., J. Med. Chem. 40, 1407 (1997).
- (1997) J. Med. Chem. , vol.40 , pp. 1407
- Palkowitz, A.D.¹

178
- 0037171819
- N.H. Hauel, H. Nar, H. Priepe, U. Ries, J.-M. Stassen, W. Wienen, J. Med. Chem. 45, 1757 (2002).
- (2002) J. Med. Chem. , vol.45 , pp. 1757
- Hauel, N.H.¹ Nar, H.² Priepe, H.³ Ries, U.⁴ Stassen, J.-M.⁵ Wienen, W.⁶

179
- 84890140544
- U.S. Patent 5,886,014 (1999) and T. Fujita, T. Yoshioka, T. Fujiwara, M. Ogichi, H. Yanagisawa H. Horikoshi, K. Wada, K. Fujimoto, U.S. Patent 6,117,893
- For general method see, T. Fujita, K. Wada, M. Oguchi, H. Yanagisawa, K. Fujimoto, T. Fujiwara, H. Horikoshi, T. Yoshioka, U.S. Patent 5,886,014 (1999) and T. Fujita, T. Yoshioka, T. Fujiwara, M. Ogichi, H. Yanagisawa H. Horikoshi, K. Wada, K. Fujimoto, U.S. Patent 6,117,893 (2000).
- (2000)
- Fujita, T.¹ Wada, K.² Oguchi, M.³ Yanagisawa, H.⁴ Fujimoto, K.⁵ Fujiwara, T.⁶ Horikoshi, H.⁷ Yoshioka, T.⁸

180
- 84890163835
- U.S. Patent 6,204,249
- S.D. Chamberlain, G.W. Koszalka, J.H. Tidwell, N.A. Vandraanen, U.S. Patent 6,204,249 (2001).
- (2001)
- Chamberlain, S.D.¹ Koszalka, G.W.² Tidwell, J.H.³ Vandraanen, N.A.⁴

181
- 84890160066
- U.S. Patent 5,576,318
- G. Bietti, F. Borsini, M. Turconi, E. Giraldo, M. Bignotti, U.S. Patent 5,576,318 (1996).
- (1996)
- Bietti, G.¹ Borsini, F.² Turconi, M.³ Giraldo, E.⁴ Bignotti, M.⁵

182
- 0035801722
- R.W. Feenstra, J. de Moes, J.J. Hofma, H. Kling, W. Kuipers, S.K. Long, M.T.M. Tulp, J.A.M. van der Heyden, C.G. Kruse, Bioorg. Med. Chem. Lett. 11, 2345 (2001).
- (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 2345
- Feenstra, R.W.¹ De Moes, J.² Hofma, J.J.³ Kling, H.⁴ Kuipers, W.⁵ Long, S.K.⁶ Tulp, M.T.M.⁷ Van Der Heyden, J.A.M.⁸ Kruse, C.G.⁹

183
- 84890213390
- U.S. Patent 4,861,785
- R.A. Stokbroekx, M.G.M. Luyckx, F.E. Janssens, U.S. Patent 4,861,785 (1989).
- (1989)
- Stokbroekx, R.A.¹ Luyckx, M.G.M.² Janssens, F.E.³

184
- 84890219030
- U.S. Patent 5,434,168
- R.A. Stokbroekx, G.A.J. Grauwels, U.S. Patent 5,434,168.
- Stokbroekx, R.A.¹ Grauwels, G.A.J.²

185
- 84890242131
- U.S. Patent 6,060,503
- F. Labrie, Y. Merand, S. Gauthier, U.S. Patent 6,060,503 (2000).
- (2000)
- Labrie, F.¹ Merand, Y.² Gauthier, S.³

186
- 0023030013
- V.A. Ashwood, R.E. Buckingham, F. Cassidy, J.M. Evans, E.A. Faruk, T.C. Hamilton, D.J. Nash, G. Stemp, K. Willcox, J. Med. Chem. 29, 2194 (1986).
- (1986) J. Med. Chem. , vol.29 , pp. 2194
- Ashwood, V.A.¹ Buckingham, R.E.² Cassidy, F.³ Evans, J.M.⁴ Faruk, E.A.⁵ Hamilton, T.C.⁶ Nash, D.J.⁷ Stemp, G.⁸ Willcox, K.⁹

187
- 84890170271
- U.S. Patent 5,760,074
- W.N. Chan, H.K.A. Morgan, M. Thompson, M. Evans, U.S. Patent 5,760,074 (1998).
- (1998)
- Chan, W.N.¹ Morgan, H.K.A.² Thompson, M.³ Evans, M.⁴

188
- 84890194394
- U.S. Patent 4,900,727
- S.L. Kattiger, R.G. Naik, A.D. Lakdawalla, A.N. Dohadwalla, R.H. Rupp, N.J. de Souza, U.S. Patent 4,900,727 (1990).
- (1990)
- Kattiger, S.L.¹ Naik, R.G.² Lakdawalla, A.D.³ Dohadwalla, A.N.⁴ Rupp, R.H.⁵ De Souza, N.J.⁶

189
- 84890206734
- U.S. Patent 5,284,856
- R.G. Naik, B. Lal, R.H. Rupp, H.H. Sedlack, G. Dickneite, U.S. Patent 5,284,856 (1994).
- (1994)
- Naik, R.G.¹ Lal, B.² Rupp, R.H.³ Sedlack, H.H.⁴ Dickneite, G.⁵

190
- 84890190793
- U.S. Patent 5,877,317
- R.E. TenBrink, M.D. Ennis, R.A. Lahti, U.S. Patent 5,877,317 (1999).
- (1999)
- TenBrink, R.E.¹ Ennis, M.D.² Lahti, R.A.³

191
- 0033593855
- M. Roe et al., Bioorg. Med. Chem. Lett. 9, 595 (1999).
- (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 595
- Roe, M.¹

192
- 0033827119
- C.J. Torrance, P.E. Jackson, E. Montgomery, A. Wissner, K.W. Kinzler, B. Vogelstein, P. Frost, C.M. Discafani, Nat. Med. 6, 1024 (2000).
- (2000) Nat. Med. , vol.6 , pp. 1024
- Torrance, C.J.¹ Jackson, P.E.² Montgomery, E.³ Wissner, A.⁴ Kinzler, K.W.⁵ Vogelstein, B.⁶ Frost, P.⁷ Discafani, C.M.⁸

193
- 21344449714
- S. Evangelista, Curr. Opin. Inevest. Drugs 6, 717 (2005).
- (2005) Curr. Opin. Inevest. Drugs , vol.6 , pp. 717
- Evangelista, S.¹

194
- 0033602522
- G.A.M. Giardina et al., J. Med. Chem. 42, 1053 (1999).
- (1999) J. Med. Chem. , vol.42 , pp. 1053
- Giardina, G.A.M.¹

195
- 84890182724
- U.S. Patent 6,313,142
- D.B. Damon, R.W. Dugger, U.S. Patent 6,313,142 (2001).
- (2001)
- Damon, D.B.¹ Dugger, R.W.²

196
- 0344562944
- N. Mealy, J. Castaner, Drugs Future 24, 871 (1999).
- (1999) Drugs Future , vol.24 , pp. 871
- Mealy, N.¹ Castaner, J.²

197
- 84890148280
- U.S. Patent 6,037,350
- M.G. Venet, P.R. Angibaud, P. Muller, G.C. Sanz, U.S. Patent 6,037,350 (2000).
- (2000)
- Venet, M.G.¹ Angibaud, P.R.² Muller, P.³ Sanz, G.C.⁴

198
- 12444338814
- P. Angibaud et al., Bioorg. Med. Chem. Lett. 13, 1543 (2003).
- (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 1543
- Angibaud, P.¹

199
- 0026738681
- T. Fujioka, S. Teramoto, T. Mori, T. Hosokawa, T. Sumida, M. Tominaga, Y. Yabuuchi, J. Med. Chem. 35, 3607 (1992).
- (1992) J. Med. Chem. , vol.35 , pp. 3607
- Fujioka, T.¹ Teramoto, S.² Mori, T.³ Hosokawa, T.⁴ Sumida, T.⁵ Tominaga, M.⁶ Yabuuchi, Y.⁷

200
- 84890160936
- U.S. Patent 4,980,470
- K. Masuzawa, S. Suzue, K. Hirai, T. Ishizaki, U.S. Patent 4,980,470 (1990).
- (1990)
- Masuzawa, K.¹ Suzue, S.² Hirai, K.³ Ishizaki, T.⁴

201
- 0028028286
- J. Prous, J. Graul, J. Castaner, Drugs Future 19, 827 (1994).
- (1994) Drugs Future , vol.19 , pp. 827
- Prous, J.¹ Graul, J.² Castaner, J.³

202
- 0033380623
- A. Graul, X. Rabasseda, J. Castaner, Drugs Future 24, 1324 (1999).
- (1999) Drugs Future , vol.24 , pp. 1324
- Graul, A.¹ Rabasseda, X.² Castaner, J.³

203
- 0028788312
- A.S. Thompson, E.G. Corley, M.F. Huntington, E.J.J. Grabowski, Tetrahedron Lett. 36, 8937 (1995).
- (1995) Tetrahedron Lett. , vol.36 , pp. 8937
- Thompson, A.S.¹ Corley, E.G.² Huntington, M.F.³ Grabowski, E.J.J.⁴

204
- 23444440846
- A. Fensome et al., J. Med. Chem. 48, 5092 (2005).
- (2005) J. Med. Chem. , vol.48 , pp. 5092
- Fensome, A.¹

205
- 0022569222
- D.M. Manoury, J.L. Binet, A.P.D. Dumas, F. Lefevre-Borg, I. Cavero, J. Med. Chem. 29, 19 (1986).
- (1986) J. Med. Chem. , vol.29 , pp. 19
- Manoury, D.M.¹ Binet, J.L.² Dumas, A.P.D.³ Lefevre-Borg, F.⁴ Cavero, I.⁵

206
- 84890199878
- U.S. Patent 5,747,498
- R.C. Schnuur, L.D. Arnold, U.S. Patent 5,747,498 (1998).
- (1998)
- Schnuur, R.C.¹ Arnold, L.D.²

207
- 0034611617
- J.B. Small et al., J. Med. Chem. 43, 1380 (2000).
- (2000) J. Med. Chem. , vol.43 , pp. 1380
- Small, J.B.¹

208
- 0035939330
- A.J. Barker et al., Bioorg. Med. Chem. Lett. 11, 1911 (2001).
- (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 1911
- Barker, A.J.¹

209
- 0037075812
- L.F. Henenquin et al., J. Med. Chem. 45, 1300 (2002).
- (2002) J. Med. Chem. , vol.45 , pp. 1300
- Henenquin, L.F.¹

210
- 33746196584
- K.G. Petrov et al., Bioorg. Med. Chem. Lett. 16, 4686, (2006).
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 4686
- Petrov, K.G.¹

211
- 0037103166
- A. Pandey et al., J. Med. Chem. 45, 3772 (2002).
- (2002) J. Med. Chem. , vol.45 , pp. 3772
- Pandey, A.¹

212
- 84890202120
- U.S. Patent 4,734,419
- M. Hashimoto, T. Oku, Y. Ito, T. Namiki, K. Sawada, C. Kasahara, Y. Baba, U.S. Patent 4,734,419 (1988).
- (1988)
- Hashimoto, M.¹ Oku, T.² Ito, Y.³ Namiki, T.⁴ Sawada, K.⁵ Kasahara, C.⁶ Baba, Y.⁷

213
- 0032811742
- K. Kondo et al., Bioor. Med. Chem. 7, 1743 (1999).
- (1999) Bioor. Med. Chem. , vol.7 , pp. 1743
- Kondo, K.¹

214
- 84890160364
- U.S. Patent 4,424,356
- J.-P. Maffrand, N. Suzuki, K. Matsubayashi, S. Ashida, U.S. Patent 4,424,356 (1984).
- (1984)
- Maffrand, J.-P.¹ Suzuki, N.² Matsubayashi, K.³ Ashida, S.⁴

215
- 84890232893
- World Patent 2004/098713
- J. Brandt, N.A. Farid, J.A. Jakubowski, K.J. Winters, World Patent 2004/098713 (2004).
- (2004)
- Brandt, J.¹ Farid, N.A.² Jakubowski, J.A.³ Winters, K.J.⁴

216
- 84890157949
- U.S. Patent 4,301,287
- P. Krogsgaard-Larsen, U.S. Patent 4,301,287 (1981).
- (1981)
- Krogsgaard-Larsen, P.¹

217
- 84890180990
- U.S. Patent 6,162,913
- J.L. Moniot et al., U.S. Patent 6,162,913.
- Moniot, J.L.¹

218
- 84890240496
- U.S. Patent 6,472,528
- R.S. Gross, K.M. Wilcoxen, R. Ogelsby, U.S. Patent 6,472,528.
- Gross, R.S.¹ Wilcoxen, K.M.² Ogelsby, R.³

219
- 2542531592
- G.B. Evans, R.H. Fourneaux, V.L. Schramm, V. Singh, P.C. Tyler, J. Med. Chem. 47, 3275 (2004).
- (2004) J. Med. Chem. , vol.47 , pp. 3275
- Evans, G.B.¹ Fourneaux, R.H.² Schramm, V.L.³ Singh, V.⁴ Tyler, P.C.⁵

220
- 0026494947
- E.C. Taylor, D. Kuhnt, C. Shih, M. Rinzel, G.B. Grindey, J. Barredo, M. Jannatipour, R.G. Moran, J. Med. Chem. 35, 4450 (1992).
- (1992) J. Med. Chem. , vol.35 , pp. 4450
- Taylor, E.C.¹ Kuhnt, D.² Shih, C.³ Rinzel, M.⁴ Grindey, G.B.⁵ Barredo, J.⁶ Jannatipour, M.⁷ Moran, R.G.⁸

221
- 84890226252
- U.S. Patent 5,789,416
- R.T. Lum, J.R. Pfister, S.R. Schow, M.M. Wick, M.G. Nelson, G.F. Schreiner, U.S. Patent 5,789,416 (1998).
- (1998)
- Lum, R.T.¹ Pfister, J.R.² Schow, S.R.³ Wick, M.M.⁴ Nelson, M.G.⁵ Schreiner, G.F.⁶

222
- 84890231238
- U.S. Patent 4,868,160
- H.C. Williams, W.C. Patt, U.S. Patent 4,868,160 (1989).
- (1989)
- Williams, H.C.¹ Patt, W.C.²

223
- 84890145481
- U.S. Patent 6,403,567
- J.A. Zabocki, E.O. Elzein, V.P. Palle, U.S. Patent 6,403,567.
- Zabocki, J.A.¹ Elzein, E.O.² Palle, V.P.³

224
- 0032445789
- L.A. Sobrera, J. Castaner, Drugs Future 23, 1279 (1998).
- (1998) Drugs Future , vol.23 , pp. 1279
- Sobrera, L.A.¹ Castaner, J.²

225
- 84890227222
- U.S. Patent 5,444,063
- R.F. Shinazi, U.S. Patent 5,444,063 (1995).
- (1995)
- Shinazi, R.F.¹

226
- 84890234536
- U.S. Patent 5,869,493
- P. Engelhardt, M. Hogberg, N.-G. Johanssen, X.-X. Zhou, B. Lindborg, U.S. Patent 5,869,493 (1999).
- (1999)
- Engelhardt, P.¹ Hogberg, M.² Johanssen, N.-G.³ Zhou, X.-X.⁴ Lindborg, B.⁵

227
- 85015431491
- R.N. Patel, Curr. Opin. Drug Disc. Dev. 9, 744 (2006).
- (2006) Curr. Opin. Drug Disc. Dev. , vol.9 , pp. 744
- Patel, R.N.¹

228
- 1642417544
- K. Chilman-Blair, N.E. Mealy, J. Castaner, Drugs Future 29, 112 (2004).
- (2004) Drugs Future , vol.29 , pp. 112
- Chilman-Blair, K.¹ Mealy, N.E.² Castaner, J.³

229
- 1842373335
- A. Graul, J. Castaner, Drugs Future 22, 945 (1997).
- (1997) Drugs Future , vol.22 , pp. 945
- Graul, A.¹ Castaner, J.²

230
- 84890135131
- U.S. Patent 5,223,504
- A.V. Averola, J.M.P. Soto, J.M. Mauri, R.W. Gristwood, U.S. Patent 5,223,504 (1993).
- (1993)
- Averola, A.V.¹ Soto, J.M.P.² Mauri, J.M.³ Gristwood, R.W.⁴

231
- 0037375621
- J.P. Petzer, S. Steyn, K.P. Castagnoli, J.-F. Chen, M.A. Schwartzschild, C.J. Van der Schyf, N. Castagnoli, Bioor. Med. Chem. 11, 1299 (2003).
- (2003) Bioor. Med. Chem. , vol.11 , pp. 1299
- Petzer, J.P.¹ Steyn, S.² Castagnoli, K.P.³ Chen, J.-F.⁴ Schwartzschild, M.A.⁵ Van Der Schyf, C.J.⁶ Castagnoli, N.⁷

232
- 84890236648
- U.S. Patent 5,466,046
- L. Belardinelli, R. Olsson, S. Baker, P.J. Scammells, U.S. Patent 5,466,046 (1995).
- (1995)
- Belardinelli, L.¹ Olsson, R.² Baker, S.³ Scammells, P.J.⁴

233
- 84890133514
- U.S. Patent 7,074,923
- V.A. Dahanukar, H.A. Nguyen, C.A. Orr, F. Zhang, A. Zavialov, U.S. Patent 7,074,923 (2006).
- (2006)
- Dahanukar, V.A.¹ Nguyen, H.A.² Orr, C.A.³ Zhang, F.⁴ Zavialov, A.⁵

234
- 0037170832
- H. Haning, U. Niewohner, T. Schlenke, M. Es-Sayed, G. Schmidt, T. Lampe, E. Bischoff, Bioorg. Med. Chem. Lett. 12, 865 (2002).
- (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 865
- Haning, H.¹ Niewohner, U.² Schlenke, T.³ Es-Sayed, M.⁴ Schmidt, G.⁵ Lampe, T.⁶ Bischoff, E.⁷

235
- 13844272010
- For alternate methods, see P.J. Dunn, Org. Proc. Res. Dev. 9, 88 (2005).
- (2005) Org. Proc. Res. Dev. , vol.9 , pp. 88
- Dunn, P.J.¹

236
- 19944427998
- D. Kim et al., J. Med. Chem. 48, 141 (2005).
- (2005) J. Med. Chem. , vol.48 , pp. 141
- Kim, D.¹

237
- 84890205456
- U.S. Patent 5,166,141
- M.G. Goodman, E.P. Gamson U.S. Patent 5,166,141 (1992).
- (1992)
- Goodman, M.G.¹ Gamson, E.P.²

238
- 84890216015
- U.S. Patent 5,122,525
- G.N. Bright, K.A. Desai, U.S. Patent 5,122,525 (1992).
- (1992)
- Bright, G.N.¹ Desai, K.A.²

239
- 0003940281
- The Organic Chemistry of Drug Synthesis
- John Wiley & Sons, Inc., NY
- D. Lednicer, "The Organic Chemistry of Drug Synthesis", Volume 5, John Wiley & Sons, Inc., NY, 1995, p. 151.
- (1995) , vol.5 , pp. 151
- Lednicer, D.¹

240
- 84890172777
- U.S. Patent 5,158,952
- C.G.M. Janssen, A.G. Knaeps, E.J. Kennis, J. Vandenberk, U.S. Patent 5,158,952 (1992).
- (1992)
- Janssen, C.G.M.¹ Knaeps, A.G.² Kennis, E.J.³ Vandenberk, J.⁴

241
- 0001765560
- C.Y. Hong, Y.K. Kim, J.H. Chang, S.H. Kim, H. Choi, D.H. Nam, Y.Z. Kim, J.H. Kwak, J. Med. Chem. 40, 3584 (1997).
- (1997) J. Med. Chem. , vol.40 , pp. 3584
- Hong, C.Y.¹ Kim, Y.K.² Chang, J.H.³ Kim, S.H.⁴ Choi, H.⁵ Nam, D.H.⁶ Kim, Y.Z.⁷ Kwak, J.H.⁸

242
- 0027304579
- J.I. DeGraw, W.T. Colewell, J.R. Piper, F.M. Sirotnak, J. Med. Chem. 36, 2228 (1993).
- (1993) J. Med. Chem. , vol.36 , pp. 2228
- DeGraw, J.I.¹ Colewell, W.T.² Piper, J.R.³ Sirotnak, F.M.⁴

243
- 84890249424
- World Patent, WO2004113337
- E.Z. Dovalsantos, J.E. Flahive, J.B. Halden, M.B. Mitchell, W.R.L. Notz, Q. Tian, S.A. O'Neil-Slawecki, World Patent, WO2004113337 (2004).
- (2004)
- Dovalsantos, E.Z.¹ Flahive, J.E.² Halden, J.B.³ Mitchell, M.B.⁴ Notz, W.R.L.⁵ Tian, Q.⁶ O'Neil-Slawecki, S.A.⁷

244
- 33646451314
- S. Hu, S. Kelly, S. Lee, J. Tao, E. Flahive, Org. Lett. 8, 1653 (2006).
- (2006) Org. Lett. , vol.8 , pp. 1653
- Hu, S.¹ Kelly, S.² Lee, S.³ Tao, J.⁴ Flahive, E.⁵

245
- 84890242783
- U.S. Patent 6,504,025
- P. Hebeisen, H. Hilpert, R. Humm, U.S. Patent 6,504,025 (2003).
- (2003)
- Hebeisen, P.¹ Hilpert, H.² Humm, R.³

246
- 0037067333
- K.M. Brands et al., J. Org. Chem. 67, 4771 (2002).
- (2002) J. Org. Chem. , vol.67 , pp. 4771
- Brands, K.M.¹

247
- 84890164117
- D. Cook, J.E. Meritt, A. Nerio, H. Rapoport, A. Stassinopoulos, S. Wolowitz, J. Matejovic, W.A. Denny, U.S. Patent 6,514,987
- D. Cook, J.E. Meritt, A. Nerio, H. Rapoport, A. Stassinopoulos, S. Wolowitz, J. Matejovic, W.A. Denny, U.S. Patent 6,514,987 (2003).
- (2003)

248
- 84890134215
- U.S. Patent 6,251,936
- J.E. Wrobel, A.J. Dietrich, M.M. Antane, U.S. Patent 6,251,936 (2001).
- (2001)
- Wrobel, J.E.¹ Dietrich, A.J.² Antane, M.M.³

249
- 0037431401
- S. Ebdrup et al., J. Med. Chem. 46, 1306 (2003).
- (2003) J. Med. Chem. , vol.46 , pp. 1306
- Ebdrup, S.¹

250
- 0034903671
- M. Fedouloff, F. Hossner, M. Voyle, J. Ranson, J. Powles, G. Riley, G. Sanger, Bioorg. Med. Chem. 9, 2119 (2001).
- (2001) Bioorg. Med. Chem. , vol.9 , pp. 2119
- Fedouloff, M.¹ Hossner, F.² Voyle, M.³ Ranson, J.⁴ Powles, J.⁵ Riley, G.⁶ Sanger, G.⁷

251
- 85069256931
- J.D. Albright et al., J. Med. Chem. 41, 2442 (1998).
- (1998) J. Med. Chem. , vol.41 , pp. 2442
- Albright, J.D.¹

252
- 0030059087
- B.A. Astelford, J.E. Audia, J. Deeter, P.C. Heath, S.K. Janisse, T.J. Kress, J.P. Wepsiec, L.O. Weigel, J. Org. Chem. 61, 4450 (1996).
- (1996) J. Org. Chem. , vol.61 , pp. 4450
- Astelford, B.A.¹ Audia, J.E.² Deeter, J.³ Heath, P.C.⁴ Janisse, S.K.⁵ Kress, T.J.⁶ Wepsiec, J.P.⁷ Weigel, L.O.⁸

253
- 84890200319
- U.S. Patent 5,662,962
- J.R. Audia, L.A. McQuaid, B.L. Neubauer, V.P. Rocco, U.S. Patent 5,662,962 (1997).
- (1997)
- Audia, J.R.¹ McQuaid, L.A.² Neubauer, B.L.³ Rocco, V.P.⁴

254
- 0023928369
- K.H. Weber, Drugs Future 13, 242 (1988).
- (1988) Drugs Future , vol.13 , pp. 242
- Weber, K.H.¹

255
- 10044254548
- A.R. Haight et al., Org. Proc. Res. Devel. 8, 897 (2004).
- (2004) Org. Proc. Res. Devel. , vol.8 , pp. 897
- Haight, A.R.¹

256
- 84890130942
- U.S. Patent 5,596,097
- A.P. Krapcho, E. Menta, A. Oliva, S. Spinelli, U.S. Patent 5,596,097 (1997).
- (1997)
- Krapcho, A.P.¹ Menta, E.² Oliva, A.³ Spinelli, S.⁴

257
- 0035185399
- D. Hou, D. Schumacher, Curr. Opinion Drug Res. Devel. 4, 792 (2001).
- (2001) Curr. Opinion Drug Res. Devel. , vol.4 , pp. 792
- Hou, D.¹ Schumacher, D.²

258
- 84890194616
- U.S. Patent 4,145,434
- J. van der Burg, U.S. Patent 4,145,434.
- Van der Burg, J.¹

259
- 13844272010
- P.J. Dunn, Org. Proc. Res. Devel. 9, 88 (2005).
- (2005) Org. Proc. Res. Devel. , vol.9 , pp. 88
- Dunn, P.J.¹

260
- 0023034927
- M. Wani, A.W. Nicholas, M.E. Wall, J. Med. Chem. 29, 2358 (1986).
- (1986) J. Med. Chem. , vol.29 , pp. 2358
- Wani, M.¹ Nicholas, A.W.² Wall, M.E.³

261
- 84890242422
- U.S. Patent 5,834,476
- H. Terasawa, A. Ejima, S. Ohsuki, K. Uoto, U.S. Patent 5,834,476 (1998).
- (1998)
- Terasawa, H.¹ Ejima, A.² Ohsuki, S.³ Uoto, K.⁴

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.