The effects of H2s on the activities of CYP2B6, CYP2D6, CYP3A4, CYP2C19 and CYP2C9 in vivo in rat

International Journal of Molecular Sciences

Volumn 14, Issue 12, 2013, Pages 24055-24063

  Wang, Xianqin ^a   Han, Anyue ^a   Wen, Congcong ^a   Chen, Mengchun ^a   Chen, Xinxin ^a   Yang, Xuezhi ^a   Ma, Jianshe ^a   Lin, Guanyang ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Cocktail; CYP450; H2S; LC MS

Indexed keywords

AMFEBUTAMONE; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; HYDROGEN SULFIDE; INORGANIC COMPOUND; METOPROLOL; MIDAZOLAM; OMEPRAZOLE; SODIUM HYDROSULFIDE; TOLBUTAMIDE; UNCLASSIFIED DRUG; CYP2C9 PROTEIN, RAT; CYP3A2 PROTEIN, RAT; CYTOCHROME P 450 CYP2B6; CYTOCHROME P-450 CYP2B6; CYTOCHROME P450; CYTOCHROME P450 3A; ENZYME INHIBITOR; UNSPECIFIC MONOOXYGENASE;

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG METABOLISM; IN VIVO STUDY; LIMIT OF QUANTITATION; LINEARITY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MEASUREMENT ACCURACY; MEASUREMENT PRECISION; NONHUMAN; RANGE; RAT; VALIDATION PROCESS; ANIMAL; AREA UNDER THE CURVE; BLOOD; CHEMISTRY; DRUG EFFECT; ENZYME ACTIVATION; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; AREA UNDER CURVE; ARYL HYDROCARBON HYDROXYLASES; BUPROPION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME ACTIVATION; ENZYME INHIBITORS; HALF-LIFE; HYDROGEN SULFIDE; MALE; MASS SPECTROMETRY; MIDAZOLAM; OMEPRAZOLE; RATS; RATS, SPRAGUE-DAWLEY; TOLBUTAMIDE;

EID: 84890132020     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms141224055     Document Type: Article

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