메뉴 건너뛰기




Volumn 38, Issue 6, 2013, Pages 1472-1479

Brain iron MRI: A biomarker for amyotrophic lateral sclerosis

Author keywords

amyotrophic lateral sclerosis; biomarkers; brain iron; MRI

Indexed keywords

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CLINICAL ARTICLE; DISEASE SEVERITY; FEMALE; GRAY MATTER; HUMAN; IMAGE ANALYSIS; MAGNETISM; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL;

EID: 84890079933     PISSN: 10531807     EISSN: 15222586     Source Type: Journal    
DOI: 10.1002/jmri.24121     Document Type: Article
Times cited : (67)

References (56)
  • 1
    • 33750967363 scopus 로고    scopus 로고
    • The epidemiology of ALS and the role of population-based registries
    • Beghi E, Logroscino G, Chio A, et al. The epidemiology of ALS and the role of population-based registries. Biochim Biophys Acta 2006; 1762: 1150-1157.
    • (2006) Biochim Biophys Acta , vol.1762 , pp. 1150-1157
    • Beghi, E.1    Logroscino, G.2    Chio, A.3
  • 2
    • 3943102116 scopus 로고    scopus 로고
    • Unraveling the mechanisms involved in motor neuron degeneration in ALS
    • Bruijn LI, Miller TM, Cleveland DW,. Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci 2004; 27: 723-749.
    • (2004) Annu Rev Neurosci , vol.27 , pp. 723-749
    • Bruijn, L.I.1    Miller, T.M.2    Cleveland, D.W.3
  • 6
    • 0035331840 scopus 로고    scopus 로고
    • MRI-FLAIR images of the head show corticospinal tract alterations in ALS patients more frequently than T2-, T1- and proton-density-weighted images
    • Hecht MJ, Fellner F, Fellner C, Hilz MJ, Heuss D, Neundorfer B,. MRI-FLAIR images of the head show corticospinal tract alterations in ALS patients more frequently than T2-, T1- and proton-density-weighted images. J Neurol Sci 2001; 186: 37-44.
    • (2001) J Neurol Sci , vol.186 , pp. 37-44
    • Hecht, M.J.1    Fellner, F.2    Fellner, C.3    Hilz, M.J.4    Heuss, D.5    Neundorfer, B.6
  • 7
    • 0037964376 scopus 로고    scopus 로고
    • The diagnostic utility of FLAIR imaging in clinically verified amyotrophic lateral sclerosis
    • Zhang L, Ulug AM, Zimmerman RD, Lin MT, Rubin M, Beal MF,. The diagnostic utility of FLAIR imaging in clinically verified amyotrophic lateral sclerosis. J Magn Reson Imaging 2003; 17: 521-527.
    • (2003) J Magn Reson Imaging , vol.17 , pp. 521-527
    • Zhang, L.1    Ulug, A.M.2    Zimmerman, R.D.3    Lin, M.T.4    Rubin, M.5    Beal, M.F.6
  • 8
    • 33847091581 scopus 로고    scopus 로고
    • Hyperintensity of the precentral gyral subcortical white matter and hypointensity of the precentral gyrus on fluid-attenuated inversion recovery: Variation with age and implication for the diagnosis of amyotrophic lateral sclerosis
    • Ngai S, Tang YM, Du L, Stuckey S, Hyperintensity of the precentral gyral subcortical white matter and hypointensity of the precentral gyrus on fluid-attenuated inversion recovery: variation with age and implication for the diagnosis of amyotrophic lateral sclerosis, AJNR Am J Neuroradiol 2007; 28: 250-254.
    • (2007) AJNR Am J Neuroradiol , vol.28 , pp. 250-254
    • Ngai, S.1    Tang, Y.M.2    Du, L.3    Stuckey, S.4
  • 9
    • 0033595564 scopus 로고    scopus 로고
    • Diffusion tensor MRI assesses corticospinal tract damage in ALS
    • Elis CM, Simmons A, Jones DK, et al. Diffusion tensor MRI assesses corticospinal tract damage in ALS. Neurology 1999; 53: 1051-1058.
    • (1999) Neurology , vol.53 , pp. 1051-1058
    • Elis, C.M.1    Simmons, A.2    Jones, D.K.3
  • 10
    • 8544249121 scopus 로고    scopus 로고
    • Diffusion tensor MRI as a diagnostic tool of upper motor neuron involvement in amyotrophic lateral sclerosis
    • Hong YH, Lee KW, Sung JJ, Chang KH, Song IC,. Diffusion tensor MRI as a diagnostic tool of upper motor neuron involvement in amyotrophic lateral sclerosis. J Neurol Sci 2004; 227: 73-78.
    • (2004) J Neurol Sci , vol.227 , pp. 73-78
    • Hong, Y.H.1    Lee, K.W.2    Sung, J.J.3    Chang, K.H.4    Song, I.C.5
  • 11
    • 33744807191 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis: Diffusion-tensor imaging and chemical shift MR imaging at 3.0 T
    • Wang S, Poptani H, Woo JH, et al. Amyotrophic lateral sclerosis: diffusion-tensor imaging and chemical shift MR imaging at 3.0 T. Radiology 2006; 239: 831-838.
    • (2006) Radiology , vol.239 , pp. 831-838
    • Wang, S.1    Poptani, H.2    Woo, J.H.3
  • 12
    • 34347376390 scopus 로고    scopus 로고
    • Spatial profiling of the coricospinal tract in amyotrophic lateral sclerosis using diffusion tensor imaging
    • Wong JCT, Concha L, Beaulie C, Johnston W, Allen PS, Kaira S,. Spatial profiling of the coricospinal tract in amyotrophic lateral sclerosis using diffusion tensor imaging. J Neuroimaging 2007; 17: 234-240.
    • (2007) J Neuroimaging , vol.17 , pp. 234-240
    • Wong, J.C.T.1    Concha, L.2    Beaulie, C.3    Johnston, W.4    Allen, P.S.5    Kaira, S.6
  • 13
    • 70450179476 scopus 로고    scopus 로고
    • Structural and metabolic changes in the brain of patients with upper motor neuron disorders: A multiparametric study
    • Charil A, Corbo M, Filippi M, et al. Structural and metabolic changes in the brain of patients with upper motor neuron disorders: a multiparametric study. Amyotroph Lateral Scler 2009; 10: 269-279.
    • (2009) Amyotroph Lateral Scler , vol.10 , pp. 269-279
    • Charil, A.1    Corbo, M.2    Filippi, M.3
  • 14
    • 78149263085 scopus 로고    scopus 로고
    • MRI predictors of long-term evolution in amyotrophic lateral sclerosis
    • Agosta F, Pagani E, Petrolini M, et al. MRI predictors of long-term evolution in amyotrophic lateral sclerosis. Eur J Neurosci 2010; 32: 1490-1496.
    • (2010) Eur J Neurosci , vol.32 , pp. 1490-1496
    • Agosta, F.1    Pagani, E.2    Petrolini, M.3
  • 15
    • 77649277855 scopus 로고    scopus 로고
    • Combined structural and neurochemical evaluation of the corticospinal tract in amyotrophic lateral sclerosis
    • Pyra T, Hui B, Hanstock C, et al. Combined structural and neurochemical evaluation of the corticospinal tract in amyotrophic lateral sclerosis. Amyotrophic Lateral Scler 2010; 11: 157-165.
    • (2010) Amyotrophic Lateral Scler , vol.11 , pp. 157-165
    • Pyra, T.1    Hui, B.2    Hanstock, C.3
  • 17
    • 33847117590 scopus 로고    scopus 로고
    • Whole-brain and regional atrophy in amyotrophic lateral sclerosis
    • Mezzapesa DM, Ceccarelli A, Dicuonzo F, et al. Whole-brain and regional atrophy in amyotrophic lateral sclerosis. AJNR Am J Neuroradiol 2007; 28: 255-258.
    • (2007) AJNR Am J Neuroradiol , vol.28 , pp. 255-258
    • Mezzapesa, D.M.1    Ceccarelli, A.2    Dicuonzo, F.3
  • 18
    • 77949415405 scopus 로고    scopus 로고
    • Gray matter perfusion correlates with disease severity in ALS
    • Rule R, Schuff N, Miller R, Weiner M, Gray matter perfusion correlates with disease severity in ALS, Neurology 2010; 74: 821-827.
    • (2010) Neurology , vol.74 , pp. 821-827
    • Rule, R.1    Schuff, N.2    Miller, R.3    Weiner, M.4
  • 20
    • 9244231109 scopus 로고    scopus 로고
    • High-field magnetic resonance imaging of brain iron: Birth of biomarker?
    • Schenck JF, Zimmerman EA,. High-field magnetic resonance imaging of brain iron: birth of biomarker? NMR Biomed 2004; 17: 433-445.
    • (2004) NMR Biomed , vol.17 , pp. 433-445
    • Schenck, J.F.1    Zimmerman, E.A.2
  • 21
    • 0033981049 scopus 로고    scopus 로고
    • In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imaging
    • Bartzokis G, Sultzer D, Cummings J, et al. In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imaging. Arch Gen Psychiatry 2000; 57: 47-53.
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 47-53
    • Bartzokis, G.1    Sultzer, D.2    Cummings, J.3
  • 22
    • 77952840568 scopus 로고    scopus 로고
    • Mapping of iron deposition in conjunction with assessment of nerve fiber tract integrity in amyotrophic lateral sclerosis
    • Langkammer C, Enziger C, Quasthoff S, et al. Mapping of iron deposition in conjunction with assessment of nerve fiber tract integrity in amyotrophic lateral sclerosis. J Magn Reson Imaging 2010; 31: 1339-1345.
    • (2010) J Magn Reson Imaging , vol.31 , pp. 1339-1345
    • Langkammer, C.1    Enziger, C.2    Quasthoff, S.3
  • 23
    • 0027429573 scopus 로고
    • Amyotrophic lateral sclerosis: T2 shortening in motor cortex at MR imaging
    • Oba H, Araki T, Ohtomo H, et al. Amyotrophic lateral sclerosis: T2 shortening in motor cortex at MR imaging. Radiology 1993; 189: 843-846.
    • (1993) Radiology , vol.189 , pp. 843-846
    • Oba, H.1    Araki, T.2    Ohtomo, H.3
  • 24
    • 0027397903 scopus 로고
    • Signal loss in the motor cortex on magnetic resonance imaging in amyotrophic lateral sclerosis
    • Ishikawa K, Nagura H, Yokota T, Yamonauchi H,. Signal loss in the motor cortex on magnetic resonance imaging in amyotrophic lateral sclerosis. Ann Neurol 1993; 33: 218-222.
    • (1993) Ann Neurol , vol.33 , pp. 218-222
    • Ishikawa, K.1    Nagura, H.2    Yokota, T.3    Yamonauchi, H.4
  • 25
    • 0028924742 scopus 로고
    • Amyotrophic Lateral Sclerosis: Correlation of clinical and MR imaging findings
    • Cheung G, Gawal MJ, Cooper PW, Farb RI, Ang LC, Amyotrophic Lateral Sclerosis: correlation of clinical and MR imaging findings, Radiology 1995; 194: 263-270.
    • (1995) Radiology , vol.194 , pp. 263-270
    • Cheung, G.1    Gawal, M.J.2    Cooper, P.W.3    Farb, R.I.4    Ang, L.C.5
  • 26
    • 0036106207 scopus 로고    scopus 로고
    • Magnetic resonance imaging in amyotrophic lateral sclerosis
    • Basak M, Erturk M, Oflazoglu B, et al. Magnetic resonance imaging in amyotrophic lateral sclerosis. Acta Neurol Scand 2002; 105: 395-399.
    • (2002) Acta Neurol Scand , vol.105 , pp. 395-399
    • Basak, M.1    Erturk, M.2    Oflazoglu, B.3
  • 27
    • 0037099783 scopus 로고    scopus 로고
    • Hyperintense and hypointense MRI signals of the precentral gyruses and corticospinal tract in ALS: A follow-up examination including FLAIR images
    • Hecht MJ, Fellner F, Fellner C, et al. Hyperintense and hypointense MRI signals of the precentral gyruses and corticospinal tract in ALS: a follow-up examination including FLAIR images. J Neurol Sci 2002; 199: 59-65.
    • (2002) J Neurol Sci , vol.199 , pp. 59-65
    • Hecht, M.J.1    Fellner, F.2    Fellner, C.3
  • 28
    • 28044447635 scopus 로고    scopus 로고
    • Cortical T2 signal shortening in amyotrophic lateral sclerosis is not due to iron deposits
    • Hecht MJ, Fellner C, Schmid A, Neundorfer B, Fellner FA,. Cortical T2 signal shortening in amyotrophic lateral sclerosis is not due to iron deposits. Neuroradiology 2005; 47: 805-808.
    • (2005) Neuroradiology , vol.47 , pp. 805-808
    • Hecht, M.J.1    Fellner, C.2    Schmid, A.3    Neundorfer, B.4    Fellner, F.A.5
  • 29
    • 34347376390 scopus 로고    scopus 로고
    • Spatial profiling of the corticospinal tract in amyotrophic lateral sclerosis using diffusion tensor imaging
    • Wong JCT, Concha L, Beaulleu C, Johnston W, Allen PS, Kalra S,. Spatial profiling of the corticospinal tract in amyotrophic lateral sclerosis using diffusion tensor imaging. J Neuroimaging 2007; 17: 234-240.
    • (2007) J Neuroimaging , vol.17 , pp. 234-240
    • Wong, J.C.T.1    Concha, L.2    Beaulleu, C.3    Johnston, W.4    Allen, P.S.5    Kalra, S.6
  • 31
    • 79955644655 scopus 로고    scopus 로고
    • High-field MRI of brain iron
    • Duyn JH,. High-field MRI of brain iron. Methods Mol Biol 2011; 711: 239-249.
    • (2011) Methods Mol Biol , vol.711 , pp. 239-249
    • Duyn, J.H.1
  • 33
    • 0141517633 scopus 로고    scopus 로고
    • Diffusion tensor imaging detects corticospinal tract involmenent at multiple levels in amyotrophic lateral sclerosis
    • Toosy AT, Werring DJ, Orrell, RW, et al. Diffusion tensor imaging detects corticospinal tract involmenent at multiple levels in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2003; 74: 1250-1257.
    • (2003) J Neurol Neurosurg Psychiatry , vol.74 , pp. 1250-1257
    • Toosy, A.T.1    Werring, D.J.2    Orrell, R.W.3
  • 35
    • 58249084223 scopus 로고    scopus 로고
    • A longitudinal diffusion tensor MRI study of the cervical cord and brain in ALS patients
    • Agosta F, Rocca MA, Valsasina P, et al. A longitudinal diffusion tensor MRI study of the cervical cord and brain in ALS patients. J Neurol Neurosurg Psychiatry 2009; 80: 53-55.
    • (2009) J Neurol Neurosurg Psychiatry , vol.80 , pp. 53-55
    • Agosta, F.1    Rocca, M.A.2    Valsasina, P.3
  • 36
    • 0035119074 scopus 로고    scopus 로고
    • Magnetic resonance imaging and (1)H-magnetic resonance spectroscopy in amyotrophic lateral sclerosis
    • Sarchielly P, Pelliccolli GP, Tarducci R, et al. Magnetic resonance imaging and (1)H-magnetic resonance spectroscopy in amyotrophic lateral sclerosis. Neuroradiology 2001; 43: 189-197.
    • (2001) Neuroradiology , vol.43 , pp. 189-197
    • Sarchielly, P.1    Pelliccolli, G.P.2    Tarducci, R.3
  • 37
    • 0031666673 scopus 로고    scopus 로고
    • A proton magnetic resonance spectroscopic study in ALS. Correlation with clinical findings
    • Elis CM, Simmons A, Andrews C, Dawson JM, Williams SCR, Leigh PN,. A proton magnetic resonance spectroscopic study in ALS. Correlation with clinical findings. Neurology 1998; 51: 1104-1109.
    • (1998) Neurology , vol.51 , pp. 1104-1109
    • Elis, C.M.1    Simmons, A.2    Andrews, C.3    Dawson, J.M.4    Williams, S.C.R.5    Leigh, P.N.6
  • 39
    • 0035015381 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy of the motor cortex in 70 patients with amyotrophic lateral sclerosis
    • Pohl C, Block W, Karitzky J, et al. Proton magnetic resonance spectroscopy of the motor cortex in 70 patients with amyotrophic lateral sclerosis. Arch Neurol 2001; 58: 729-735.
    • (2001) Arch Neurol , vol.58 , pp. 729-735
    • Pohl, C.1    Block, W.2    Karitzky, J.3
  • 40
    • 8744291752 scopus 로고    scopus 로고
    • Combined MR spectroscopic imaging and diffusion tensor MRI visualizes corticospinal tract degeneration in amyotrophic lateral sclerosis
    • Yin H, Lim CCT, Ma L, et al. Combined MR spectroscopic imaging and diffusion tensor MRI visualizes corticospinal tract degeneration in amyotrophic lateral sclerosis. J Neurol 2004; 251: 1249-1254.
    • (2004) J Neurol , vol.251 , pp. 1249-1254
    • Yin, H.1    Lim, C.C.T.2    Ma, L.3
  • 41
    • 0037066081 scopus 로고    scopus 로고
    • Early detection and longitudinal changes in amyotrophic lateral sclerosis by (1)H MRSI
    • Suhy J, Miller RG, Rule R, et al. Early detection and longitudinal changes in amyotrophic lateral sclerosis by (1)H MRSI. Neurology 2002; 58: 773-779.
    • (2002) Neurology , vol.58 , pp. 773-779
    • Suhy, J.1    Miller, R.G.2    Rule, R.3
  • 42
    • 0034115380 scopus 로고    scopus 로고
    • MR imaging and localized proton spectroscopy of the precentral gyrus in amyotrophic lateral sclerosis
    • Bowen BC, Pattany PM, Bradley WG, et al. MR imaging and localized proton spectroscopy of the precentral gyrus in amyotrophic lateral sclerosis. AJNR Am J Neuroradiol 2000; 21: 647-658.
    • (2000) AJNR Am J Neuroradiol , vol.21 , pp. 647-658
    • Bowen, B.C.1    Pattany, P.M.2    Bradley, W.G.3
  • 43
    • 77958574421 scopus 로고    scopus 로고
    • Quantitative imaging of brain iron: A postmortem validation study
    • Langkammer C, Krebs N, Goessler W, et al. Quantitative imaging of brain iron: a postmortem validation study. Radiology 2010; 257: 455-462.
    • (2010) Radiology , vol.257 , pp. 455-462
    • Langkammer, C.1    Krebs, N.2    Goessler, W.3
  • 44
    • 0033639207 scopus 로고    scopus 로고
    • Brain iron deposition in Parkinson's disease imaged using the PRIME magnetic resonance sequence
    • Graham JM, Paley MN, Grunewald RA, Hoggard N, Griffiths PD,. Brain iron deposition in Parkinson's disease imaged using the PRIME magnetic resonance sequence. Brain 2000; 123: 2423-2431.
    • (2000) Brain , vol.123 , pp. 2423-2431
    • Graham, J.M.1    Paley, M.N.2    Grunewald, R.A.3    Hoggard, N.4    Griffiths, P.D.5
  • 45
    • 34147107527 scopus 로고    scopus 로고
    • Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts
    • Michaeli S, Oz G, Sorce DJ, et al. Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts. Mov Disord 2007; 22: 334-340.
    • (2007) Mov Disord , vol.22 , pp. 334-340
    • Michaeli, S.1    Oz, G.2    Sorce, D.J.3
  • 46
  • 47
    • 0032985259 scopus 로고    scopus 로고
    • Three generations of amyotrophic lateral sclerosis in a family: SPECT brain perfusion findings
    • Kumar M, Abdel-Dayem HM, Three generations of amyotrophic lateral sclerosis in a family: SPECT brain perfusion findings. Clin Nucl Med 1999; 24: 539-540.
    • (1999) Clin Nucl Med , vol.24 , pp. 539-540
    • Kumar, M.1    Abdel-Dayem, H.M.2
  • 48
    • 77649257562 scopus 로고    scopus 로고
    • Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast
    • Fukunaga M, Li TQ, van Gelderen P, et al. Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast. Proc Natl Acad Sci U S A 2010; 107: 3834-3839.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 3834-3839
    • Fukunaga, M.1    Li, T.Q.2    Van Gelderen, P.3
  • 49
    • 0027378141 scopus 로고
    • Oxygen tension in murine tumor: A combined EPR and MRI study
    • Bačić G, Liu KJ, O'Hara JA, et al. Oxygen tension in murine tumor: a combined EPR and MRI study. Magn Reson Med 1993; 30: 568-572.
    • (1993) Magn Reson Med , vol.30 , pp. 568-572
    • Bačić, G.1    Liu, K.J.2    O'Hara, J.A.3
  • 50
    • 0028981429 scopus 로고
    • Assessment of cerebral pO2 by EPR oximetry in rodents: Effects of anesthesia, ischemia, and breathing gas
    • Liu KJ, Bačić G, Hoopes PJ, et al. Assessment of cerebral pO2 by EPR oximetry in rodents: effects of anesthesia, ischemia, and breathing gas. Brain Res 1995; 685: 91-98.
    • (1995) Brain Res , vol.685 , pp. 91-98
    • Liu, K.J.1    Bačić, G.2    Hoopes, P.J.3
  • 51
    • 80051660738 scopus 로고    scopus 로고
    • Iron chelation and neuroprotection in neurodegenerative diseases
    • Li X, Jankovic J, Le W,. Iron chelation and neuroprotection in neurodegenerative diseases. J Neural Transm 2011; 118: 473-477.
    • (2011) J Neural Transm , vol.118 , pp. 473-477
    • Li, X.1    Jankovic, J.2    Le, W.3
  • 52
    • 0028917342 scopus 로고
    • Activated microglia cause superoxide-mediated release of iron from ferritin
    • Toshihiko Y, Makoto T, Akemi S, Shunsaku H,. Activated microglia cause superoxide-mediated release of iron from ferritin. Neurosci Lett 1995; 190: 21-24.
    • (1995) Neurosci Lett , vol.190 , pp. 21-24
    • Toshihiko, Y.1    Makoto, T.2    Akemi, S.3    Shunsaku, H.4
  • 53
    • 59649091603 scopus 로고    scopus 로고
    • Iron chelators as potential therapeutic agents for Parkinson's disease
    • Perez CA, Tong Y, Guo M,. Iron chelators as potential therapeutic agents for Parkinson's disease. Curr Bioact Compd 2008; 4: 150-158.
    • (2008) Curr Bioact Compd , vol.4 , pp. 150-158
    • Perez, C.A.1    Tong, Y.2    Guo, M.3
  • 54
    • 70350521966 scopus 로고    scopus 로고
    • Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis
    • Kupershmidt L, Weinreb O, Amit T, et al. Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis. FASEB J 2009; 23: 3766-3779.
    • (2009) FASEB J , vol.23 , pp. 3766-3779
    • Kupershmidt, L.1    Weinreb, O.2    Amit, T.3
  • 55
    • 79958787596 scopus 로고    scopus 로고
    • Prevention of motor neuron degeneration by novel iron chelators in SOD1(G93A) transgenic mice of amyotrophic lateral sclerosis
    • Wang Q, Zhang X, Chen S, Zhang S, Youdium M, et al. Prevention of motor neuron degeneration by novel iron chelators in SOD1(G93A) transgenic mice of amyotrophic lateral sclerosis. Neurodegener Dis 2011; 8: 310-321.
    • (2011) Neurodegener Dis , vol.8 , pp. 310-321
    • Wang, Q.1    Zhang, X.2    Chen, S.3    Zhang, S.4    Youdium, M.5
  • 56
    • 84859880865 scopus 로고    scopus 로고
    • Iron Accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: Correlating 7 Tesla MRI and pathology
    • Kwan JY, Jeong SY, van Gelderen P, et al. Iron Accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 Tesla MRI and pathology. PLoS ONE 2012; 7: e35241.
    • (2012) PLoS ONE , vol.7
    • Kwan, J.Y.1    Jeong, S.Y.2    Van Gelderen, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.