Biological characteristics of mesenchymal stem cells grown on different topographical nanofibrous poly-L-lactide meshes

Journal of Biomedical Nanotechnology

Volumn 9, Issue 10, 2013, Pages 1757-1767

  Zhu, Jingxian ^a   Cai, Qing ^c   Zhang, Xin ^a   Hu, Xiaoqing ^a   Li, La ^a   Wang, Weiping ^b   Shao, Zhenxing ^a   Dai, Linghui ^a   Cheng, Liyuan ^c   Yang, Xiaoping ^c   Zhou, Chunyan ^b   Ao, Yingfang ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

Author keywords

Extracellular matrix; Mesenchymal stem cell; Nanotopography; Osteogenesis; Signaling pathway

Indexed keywords

CELL ADHESION; CELL SIGNALING; CELLS; CYTOLOGY; ENZYME ACTIVITY; FLOWCHARTING; GENE EXPRESSION; GENES; NANOFIBERS; NANOTECHNOLOGY; PHOSPHATASES; PIGMENTS; PROTEINS; SCAFFOLDS (BIOLOGY); SIGNALING; STEM CELLS; TISSUE; TISSUE ENGINEERING; WEAVING;

EXTRACELLULAR MATRICES; MESENCHYMAL STEM CELL; NANOTOPOGRAPHIES; OSTEOGENESIS; SIGNALING PATHWAYS;

CELL CULTURE;

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALKALINE PHOSPHATASE; COLLAGEN; COPPER; F ACTIN; INTEGRIN; INTEGRIN SUBUNIT A5; INTEGRIN SUBUNIT B1; MITOGEN ACTIVATED PROTEIN KINASE; MOLECULAR SCAFFOLD; NANOFIBER; OSTEOCALCIN; OSTEOPONTIN; POLYLACTIC ACID; PROTEIN P160; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; BONE PROSTHESIS; POLYESTER; POLYLACTIDE;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL ADHESION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CELL SURFACE; CELLULAR DISTRIBUTION; COLORIMETRY; CYTOSKELETON; DOWN REGULATION; ELECTROSPINNING; ENZYME PHOSPHORYLATION; IMMUNOFLUORESCENCE; IN VITRO STUDY; LASER MICROSCOPY; MESENCHYMAL STEM CELL; NONHUMAN; OSTEOBLAST; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STRESS FIBER; UPREGULATION; WESTERN BLOTTING; ANIMAL; BONE PROSTHESIS; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DEVICE FAILURE ANALYSIS; EQUIPMENT DESIGN; MATERIALS TESTING; MECHANOTRANSDUCTION; MESENCHYMAL STROMA CELL; PHYSIOLOGY; SURFACE PROPERTY; SYNTHESIS; TISSUE SCAFFOLD; WISTAR RAT;

ANIMALS; BONE SUBSTITUTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; MATERIALS TESTING; MECHANOTRANSDUCTION, CELLULAR; MESENCHYMAL STROMAL CELLS; OSTEOBLASTS; OSTEOGENESIS; POLYESTERS; RATS; RATS, WISTAR; SURFACE PROPERTIES; TISSUE SCAFFOLDS;

EID: 84890071383     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2013.1661     Document Type: Article

References (45)

1. R. Schofield, The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 4, 7 (1978).
2. S. J. Morrison and A. C. Spradling, Stem cells and niches: Mechanisms that promote stem cell maintenance throughout life. Cell 132, 598 (2008).
3. F. Guilak, D. M. Cohen, B. T. Estes, J. M. Gimble, W. Liedtke, and C. S. Chen, Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell 5, 17 (2009).
4. K. Mark, J. Park, S. Bauer, and P. Schmuki, Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix. Cell and Tissue Research 339, 131 (2009).
5. X. H. Zou, Y. L. Zhi, X. Chen, H. M. Jin, L. L. Wang, Y. Z. Jiang, Z. Yin, and H. W. Ouyang, Mesenchymal stem cell seeded knitted silk sling for the treatment of stress urinary incontinence. Biomaterials 31, 4872 (2010).
6. M. J. Dalby, N. Gadegaard, R. Tare, A. Andar, M. O. Riehle, P. Herzyk, C. D. Wilkinson, and R. O. Oreffo, The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder. Nat. Mater. 6, 997 (2007).
7. S. Agarwal, J. H. Wendorff, and A. Greiner, Use of electrospinning technique for biomedical applications. Polymer. 49, 5603 (2008).
8. M. M. Stevens and J. H. George, Exploring and engineering the cell surface interface. Science 310, 1135 (2005).
9. D. Li, G. Ouyang, J. T. McCann, and Y. Xia, Collecting electrospun nanofibers with patterned electrodes. Nano Lett. 5, 913 (2005).
10. D. Zhang and J. Chang, Patterning of electrospun fibers using electroconductive templates. Adv. Mater. 19, 3664 (2007).
11. D. Hoffman-Kim, J. A. Mitchel, and R. V. Bellamkonda, Topography, cell response, and nerve regeneration. Annu. Rev. Biomed. Eng. 12, 203 (2010).
12. T. K. Teh, S. L. Toh, and J. C. Goh, Aligned hybrid silk scaffold for enhanced differentiation of mesenchymal stem cells into ligament fibroblasts. Tissue Eng. Part. C Methods 17, 687 (2011).
13. Z. Yin, X. Chen, J. L. Chen, W. L. Shen, T. M. Hieu Nguyen, L. Gao, and H. W. Ouyang, The regulation of tendon stem cell differentiation by the alignment of nanofibers. Biomaterials 31, 2163 (2010).
14. J. Xie, M. R. MacEwan, X. Li, S. E. Sakiyama-Elbert, and Y. Xia, Neurite outgrowth on nanofiber scaffolds with different orders, structures, and surface properties. ACS Nano. 3, 1151 (2009).
15. A. Martins, M. L. Alves da Silva, S. Faria, A. P. Marques, R. L. Reis, and N. M. Neves, The influence of patterned nanofiber meshes on human mesenchymal stem cell osteogenesis. Macromol. Biosci. 11, 978 (2011).
16. B. Wang, Q. Cai, S. Zhang, X. Yang and X. Deng, The effect of poly (L-lactic acid) nanofiber orientation on osteogenic responses of human osteoblast-like MG63 cells. J. Mech. Behav. Biomed. Mater. 4, 600 (2011).
17. X. Zhou, Q. Cai, N. Yan, X. Deng, and X. Yang, In vitro hydrolytic and enzymatic degradation of nestlike-patterned electrospun poly(D,L-lactide-co-glycolide) scaffolds. J. Biomed. Mater. Res. A 95, 755 (2010).
18. C. H. Lee, H. J. Shin, I. H. Cho, Y. M. Kang, I. A. Kim, K. D. Park, and J. W. Shin, Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast. Biomaterials 26, 1261 (2005).
19. E. A. Cavalcanti-Adam, D. Aydin, V. C. Hirschfeld-Warneken, and J. P. Spatz, Cell adhesion and response to synthetic nanopatterned environments by steering receptor clustering and spatial location. HFSP J. 2, 276 (2008).
20. C. B. Khatiwala, P. D. Kim, S. R. Peyton, and A. J. Putnam, ECM compliance regulates osteogenesis by influencing MAPK signaling downstream of RhoA and ROCK. J. Bone. Miner. Res. 24, 886 (2009).
21. T. Kanno, T. Takahashi, T. Tsujisawa, W. Ariyoshi and T. Nishihara, Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts. J. Cell. Biochem. 101, 1266 (2007).
22. R. McBeath, D. M. Pirone, C. M. Nelson, K. Bhadriraju, and C. S. Chen, Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev. Cell. 6, 483 (2004).
23. Z. Hamidouche, O. Fromigue, J. Ringe, T. Haupl, P. Vaudin, J. C. Pages, S. Srouji, E. Livne, and P. J. Marie, Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis. Proc. Natl. Acad. Sci. U.S.A 106, 18587 (2009).
24. A. Shekaran and A. J. Garcia, Extracellular matrix-mimetic adhesive biomaterials for bone repair. J. Biomed. Mater. Res. A 96, 261 (2011).
25. M. M. Martino, M. Mochizuki, D. A. Rothenfluh, S. A. Rempel, J. A. Hubbell and T. H. Barker, Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability. Biomaterials 30, 1089 (2009).
26. L. A. Smith, X. Liu, J. Hu, and P. X. Ma, The enhancement of human embryonic stem cell osteogenic differentiation with nanofibrous scaffolding. Biomaterials 31, 5526 (2010).
27. J. M. Holzwarth and P. X. Ma, Biomimetic nanofibrous scaffolds for bone tissue engineering. Biomaterials 32, 9622 (2011).
28. A. Prasad, D. Berger and K. Popat, PCL nanopillars versus nanofibers: A contrast in progenitor cell morphology, proliferation, and fate determination. Adv. Engg. Mater. (Wiley-VCH Verlag), 14, B351 (2012).
29. G. Kaur, M. T. Valarmathi, J. D. Potts, E. Jabbari, T. Sabo-Attwood and Q. Wang, Regulation of osteogenic differentiation of rat bone marrow stromal cells on 2D nanorod substrates. Biomaterials 31, 1732 (2010).
30. P. Sitasuwan, L. A. Lee, P. Bo, E. N. Davis, Y. Lin, and Q. Wang, A plant virus substrate induces early upregulation of BMP2 for rapid bone formation. Integr. Biol. (Camb.) 4, 651 (2012).
31. J. Zhao, W. Han, H. Chen, M. Tu, S. Huan, G. Miao, R. Zeng, H. Wu, Z. Cha, and C. Zhou, Fabrication and in vivo osteogenesis of biomimetic poly(propylene carbonate) scaffold with nanofibrous chitosan network in macropores for bone tissue engineering. J. Mater. Sci. Mater. Med. 23, 517 (2012).
32. L. Zhao, L. Liu, Z. Wu, Y. Zhang, and P. K. Chu, Effects of micropitted/nanotubular titania topographies on bone mesenchymal stem cell osteogenic differentiation. Biomaterials 33, 2629 (2012).
33. Q. P. Pham, U. Sharma, and A. G. Mikos, Electrospinning of polymeric nanofibers for tissue engineering applications: A review. Tissue Eng. 12, 1197 (2006).
34. 2 nanotube surfaces: 15 nm-an optimal length scale of surface topography for cell adhesion and differentiation. Small 5, 666 (2009).
35. M. Arnold, E. A. Cavalcanti-Adam, R. Glass, J. Blummel, W. Eck, M. Kantlehner, H. Kessler, and J. P. Spatz, Activation of integrin function by nanopatterned adhesive interfaces. ChemPhysChem. 5, 383 (2004).
36. R. J. McMurray, N. Gadegaard, P. M. Tsimbouri, K. V. Burgess, L. E. McNamara, R. Tare, K. Murawski, E. Kingham, R. O. Oreffo, and M. J. Dalby, Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency. Nat. Mater. 10, 637 (2011).
37. B. M. Baker, A. S. Nathan, A. O. Gee, and R. L. Mauck, The influence of an aligned nanofibrous topography on human mesenchymal stem cell fibrochondrogenesis. Biomaterials 31, 6190 (2010).
38. W. J. Li, R. L. Mauck, J. A. Cooper, X. Yuan, and R. S. Tuan, Engineering controllable anisotropy in electrospun biodegradable nanofibrous scaffolds for musculoskeletal tissue engineering. J. Biomech. 40, 1686 (2007).
39. E. Kaivosoja, P. Suvanto, G. Barreto, S. Aura, A. Soininen, S. Franssila, and Y. T. Konttinen, Cell adhesion and osteogenic differentiation on three-dimensional pillar surfaces. J. Biomed. Mater. Res. A 101, 842 (2013).
40. P. C. Tseng, T. H. Young, T. M. Wang, H. W. Peng, S. M. Hou, and M. L. Yen, Spontaneous osteogenesis of MSCs cultured on 3D microcarriers through alteration of cytoskeletal tension. Biomaterials 33, 556 (2012).
41. R. K. Globus, S. B. Doty, J. C. Lull, E. Holmuhamedov, M. J. Humphries and C. H. Damsky, Fibronectin is a survival factor for differentiated osteoblasts. J. Cell. Sci. 111, 1385 (1998).
42. C. H. Seo, K. Furukawa, K. Montagne, H. Jeong, and T. Ushida, The effect of substrate microtopography on focal adhesion maturation and actin organization via the RhoA/ROCK pathway. Biomaterials 32, 9568 (2011).
43. K. A. Kilian, B. Bugarija, B. T. Lahn and M. Mrksich, Geometric cues for directing the differentiation of mesenchymal stem cells. Proc. Natl. Acad. Sci. U.S.A. 107, 4872 (2010).
44. K. Young, T. Samiric, J. Feller, and J. Cook, Extracellular matrix content of ruptured anterior cruciate ligament tissue. Knee. 18, 242 (2011).
45. L. Sun, Z. J. Ning, H. Zhang, M. Tian, and T. M. Ning, Multiple-ligament injured knee. Chinese Journal of Traumatology 9, 365 (2006).