The nephronophthisis gene product NPHP2/Inversin interacts with Aurora A and interferes with HDAC6-mediated cilia disassembly

Nephrology Dialysis Transplantation

Volumn 28, Issue 11, 2013, Pages 2744-2753

  Mergen, Miriam ^a   Engel, Christina ^a   Müller, Barbara ^a   Follo, Marie ^a   Schäfer, Tobias ^a   Jung, Manfred ^b   Walz, Gerd ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Aurora A kinase; Cilary disassembly; HDAC6; NPHP2; Primary cilia

Indexed keywords

AURORA A KINASE; BINDING PROTEIN; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; HUMAN ENHANCER FILAMENTATION 1; INVERSIN; MEMBRANE PROTEIN; NEPHROCYSTIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CILIARY DISASSEMBLY; CONTROLLED STUDY; DOG; ENZYME ACTIVATION; ENZYME ASSAY; GENE; GENE FUNCTION; GENE IDENTIFICATION; GENE PRODUCT; IN VITRO STUDY; INVERSIN GENE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NEPHROCYSTIN GENE; NEPHRONOPHTHISIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

AURORA A KINASE; CILARY DISASSEMBLY; HDAC6; NPHP2; PRIMARY CILIA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; AURORA KINASE A; BLOTTING, WESTERN; CELLS, CULTURED; CILIA; DOGS; HISTONE DEACETYLASES; HUMANS; KIDNEY DISEASES, CYSTIC; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PHOSPHORYLATION; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS;

EID: 84890033642     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gft316     Document Type: Article

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