Obesity-Related glomerulopathy and the nephron complement

Nephrology Dialysis Transplantation

Volumn 28, Issue SUPPL.4, 2013, Pages

  Tsuboi, Nobuo ^a   Utsunomiya, Yasunori ^a   Hosoya, Tatsuo ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Glomerular density; Glomerulomegaly; Hyperfiltration; Nephron number; Obesity

Indexed keywords

BODY MASS; CELL COUNT; CLINICAL FEATURE; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; END STAGE RENAL DISEASE; GLOMERULONEPHRITIS; GLOMERULOSCLEROSIS; GLOMERULUS FILTRATION RATE; HISTOPATHOLOGY; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; KIDNEY BIOPSY; KIDNEY BLOOD FLOW; KIDNEY MASS; NEPHRON; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW; RISK FACTOR; WEIGHT REDUCTION;

GLOMERULAR DENSITY; GLOMERULOMEGALY; HYPERFILTRATION; NEPHRON NUMBER; OBESITY;

ANIMALS; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; KIDNEY GLOMERULUS; NEPHRONS; OBESITY;

EID: 84890027558     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gft258     Document Type: Review

References (44)

1. Weisinger JR, Kempson RL, Eldridge FL et al. The nephrotic syndrome: a complication of massive obesity. Ann Intern Med 1974; 81: 440-447
2. Warnke RA, Kempson RL. The nephrotic syndrome in massive obesity. Arch Pathol Lab Med 1978; 102: 431-438
3. Kasiske BL, Crosson JT. Renal disease in patients with massive obesity. Arch Intern Med 1986; 146: 1107-1109
4. Jennette JC, Charles L, Grubb W. Glomerulomegaly and focal segmental glomerulosclerosis associated with obesity and sleep apnea syndrome. Am J Kidney Dis 1987; 10: 470-472
5. Verani RR. Obesity-associated focal segmental glomerulosclerosis: pathological features of the lesions and relationship with cardiomegaly and hyperlipidemia. Am J Kidney Dis 1992; 20: 629-634
6. Kambham N, Markowiz GS, Valeri AM et al. Obesity-related glomerulopathy: An emerging epidemic. Kidney Int 2001; 59: 1498-1509
7. Praga M, Hernandez E, Morales E et al. Clinical features and long-term outcome of obesity-associated focal segmental glomerulosclerosis. Nephrol Dial Transplant 2001; 16: 1790-1798
8. Chen HM, Li SJ, Chen HP et al. Obesity-related glomerulopathy in China: a case series of 90 patients. Am J Kidney Dis 2008; 52: 58-65
9. Tsuboi N, Koike K, Hirano K et al. Clinical features and longterm renal outcomes of Japanese patients with obesity-related glomerulopathy. Clin Exp Nephrol 2013; 17: 379-385
10. Danilewicz M, Wagrowska-Danielwicz M. Morphometric and immunohistochemical insight into focal segmental glomerulosclerosis in obese and non-obese patients. Nefrologia 2009; 29: 35-41
11. Praga M, Morales E, Herrero JC et al. Absence of hypoalbuminemia despite massive proteinuria in focal segmental glomerulosclerosis secondary to hyperfiltration. Am J Kidney Dis 1999; 33: 52-58
12. Morales E, Valero MA, León M et al. Beneficial effects of weight loss in overweight patients with chronic proteinuric nephropathies. Am J Kidney Dis. 41: 319-327
13. Chagnac A, Weinstein T, Herman M et al. The effects of weight loss on renal function in patients with severe obesity. J Am Soc Nephrol 2003; 14: 1480-1486
14. Fowler SM, Kon V, Ma L et al. Obesity-related focal and segmental glomerulosclerosis: normalization of proteinuria in an adolescent after bariatric surgery. Pediatr Nephrol 2009; 24: 851-855
15. Chagnac A, Weinstein T, Korzets A et al. Glomerular hemodynamics in severe obesity. Am J Physiol 2000; 278: F817-F822
16. Hall JE, Brands MW, Henegar JR et al. Abnormal kidney function as a cause and a consequence of obesity hypertension. Clin Exp Pharmacol Physiol 1998; 25: 58-64
17. Joles JA, Koomans HA. Causes and consequences of increased sympathetic activity in renal disease. Hypertension 2004; 43: 699-706
18. Griffin KA, Kramer H, Bidani AK. Adverse renal consequence of obesity. Am J Physiol 2008; 294: F685-F696
19. Wu Y, Liu Z, Xiang Z et al. Obesity-related glomerulopathy: insights from gene expression profiles of the glomeruli derived from renal biopsy samples. Endocrinology 2006; 147: 44-50
20. Nyengaard J.R. Number and dimensions of rat glomerular capillaries in normal development and after nephrectomy. Kidney Int 1993; 43: 1049-1057
21. Shimamura T, Morrison AB. A progressive glomerulosclerosis occurring in partial five-sixths nephrectomized rats. Am J Pathol 1975; 79: 95-106
22. Hostetter TH, Olson JL, Rennke HG et al. Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation. Am J Physiol 1981; 241: F85-F93
23. Wahba IM, Mak RH. Obesity and obesity-initiated metabolic syndrome: Mechanistic links to chronic kidney disease. Clin J Am Soc Nephrol 2007; 2: 550-562
24. Praga M, Hernández E, Herrero JC et al. Influence of obesity on the appearance of proteinuria and renal insufficiency after unilateral nephrectomy. Kidney Int 2000; 58: 2111-2118
25. Gonzalez E, Gutierrz E, Morales E et al. Factor influencing the progression of renal damage in patients with unilateral renal agenesis and remnant kidney. Kidney Int 2005; 68: 263-270
26. Fukuda A, Chowdhury MA, Venkatareddy MP et al. Growth-dependent podocyte failure causes glomerulosclerosis. J Am Soc Nephrol 2012; 23: 1351-1363
27. Chen HM, Liu ZH, Zeng CH et al. Podocyte lesions in patients with obesity-related glomerulopathy. Am J Kidney Dis 2006; 48: 772-779
28. Tsuboi N, Kawamura T, Koike K et al. Glomerular density in renal biopsy specimens predicts the long-term prognosis of IgA nephropathy. Clin J Am Soc Nephrol 2010; 5: 39-44
29. Tsuboi N, Kawamura T, Miyazaki Y et al. Low glomerular density is a risk factor for progression in idiopathic membranous nephropathy. Nephrol Dial Transplant 2011; 26: 3555-3560
30. Koike K, Tsuboi N, Utsunomiya Y et al. Glomerular densityassociated changes in clinicopathological features of minimal change nephrotic syndrome in adults. Am J Nephrol 2011; 34: 542-548
31. Tsuboi N, Utsunomiya Y, Kanzaki G et al. Low glomerular density with glomerulomegaly in obesity-related glomerulopathy. Clin J Am Soc Nephrol 2012; 7: 735-741
32. Hoy WE, Hughson MD, Zimanyi M et al. Distribution of volumes of individual glomeruli in kidneys at autopsy: association with age, nephron number, birth weight and body mass index. Clin Nephrol 2010; 74: S105-S112
33. Tsuboi N, Utsunomiya Y, Koike K et al. Factors related to the glomerular size in renal biopsies of chronic kidney disease patients. Clin Nephrol 2013; 79: 277-284
34. Herlitz LC, Markowitz GS, Farris AB et al. Development of focal segmental glomerulosclerosis after anabolic steroid abuse. J Am Soc Nephrol 2010; 21: 163-172
35. Hughson M, Farris AB, 3rd, Douglas-Denton R et al. Glomerular number and size in autopsy kidneys: the relationship to birth weight. Kidney Int 2003; 83: S32-S37
36. Nyengaard JR, Bendtsen TF. Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec 1992; 232: 194-201
37. Brenner BM. Brenner and Rector's the Kidney, 8th edn. Philadelphia: Saunders Elsevier, 2008, pp. 3-24
38. Zanndi-Nejad K, Luyckx VA, Brenner BM. Adult hypertension and kidney disease: the role of fetal programming. Hypertension 2006; 47: 1-7
39. Lackland DT, Bendall HE, Clive O et al. Low birth weights contribute to the high rates of early-onset chronic renal failure in Southeastern United States. Arch Intern Med 2000; 160: 1472-1476
40. Vickers MH, Breier BH, Cutfield WS et al. Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition. Am J Physiol 2000; 279: E83-E87
41. Bonet F, Deprele C, Sassolas A et al. Excessive body weight as a new independent risk factor for clinical and pathological progression in primary IgA nephritis. Am J Kidney Dis 2003; 37: 720-727
42. Morales E, Valero MA, Léon M et al. Benefical effects of weight loss in overweight patients with chronic proteinuric nephropathies. Am J Kidney Dis 2003; 41: 319-327
43. Fox CS, Larson MG, Leip EP et al. Predictors of new-onset kidney disease in a community-based population. JAMA 2004; 291: 844-850
44. Gelber RP, Kurth T, Kausz AT et al. Association between body mass index and CKD in apparently healthy men. Am J Kidney Dis 2005; 46: 871-880