Statistical design for biospecimen cohort size in proteomics-based biomarker discovery and verification studies

Journal of Proteome Research

Volumn 12, Issue 12, 2013, Pages 5383-5394

  Skates, Steven J ^a   Gillette, Michael A ^b   LaBaer, Joshua ^c   Carr, Steven A ^b   Anderson, Leigh ^d,e   Liebler, Daniel C ^f   Ransohoff, David ^g   Rifai, Nader ^h,i,j   Kondratovich, Marina ^k   Težak, Živana ^k   Mansfield, Elizabeth ^k   Oberg, Ann L ^l   Wright, Ian ^e   Barnes, Grady ^m   Gail, Mitchell ⁿ   Mesri, Mehdi ⁿ   Kinsinger, Christopher R ⁿ   Rodriguez, Henry ⁿ   Boja, Emily S ⁿ  

^a MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c ARIZONA STATE UNIVERSITY   (United States)

^d The Plasma Proteome Institute   (United States)

^e SISCAPA Assay Technologies Inc   (United States)

^f VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^h BOSTON CHILDREN S HOSPITAL   (United States)

ⁱ HARVARD MEDICAL SCHOOL   (United States)

^j KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^k CENTER FOR DEVICES AND RADIOLOGICAL HEALTH   (United States)

^l MAYO CLINIC   (United States)

^m FUJIREBIO INC   (Japan)

ⁿ NATIONAL CANCER INSTITUTE   (United States)

more..

Author keywords

biomarker; power calculation; proteomics; statistical experiment design; unbiasedness

Indexed keywords

BIOLOGICAL MARKER; CA 125 ANTIGEN; PROTEIN; TUMOR MARKER; PLASMA PROTEIN; TUMOR PROTEIN;

ARTICLE; CLINICAL DECISION MAKING; COHORT ANALYSIS; CONCEPTUAL FRAMEWORK; CONTROLLED STUDY; EARLY DIAGNOSIS; HUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEOMICS; QUANTITATIVE ANALYSIS; SAMPLE SIZE; SENSITIVITY AND SPECIFICITY; STATISTICAL ANALYSIS; STATISTICAL MODEL; ALGORITHM; CONSENSUS DEVELOPMENT; GENE EXPRESSION REGULATION; GENETICS; LABORATORY DIAGNOSIS; METABOLISM; METHODOLOGY; NEOPLASMS; STATISTICS AND NUMERICAL DATA;

ALGORITHMS; BLOOD PROTEINS; COHORT STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM PROTEINS; NEOPLASMS; PROTEOMICS; RESEARCH DESIGN; SAMPLE SIZE; SENSITIVITY AND SPECIFICITY; SPECIMEN HANDLING; TUMOR MARKERS, BIOLOGICAL;

EID: 84890023096     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr400132j     Document Type: Article

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