Malassezia yeasts in Seborrheic and Atopic Eczemas

Malassezia and the Skin: Science and Clinical Practice

Volumn , Issue , 2010, Pages 201-228

  Gaitanis, George ^a   Mayser, Peter ^b   Scheynius, Annika ^c   Crameri, Reto ^d  

^a UNIVERSITY HOSPITAL OF IOANNINA   (Greece)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c KAROLINSKA INSTITUTE   (Sweden)

^d SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84889864702     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-03616-3_7     Document Type: Chapter

References (174)

1. Hay RJ, Graham-Brown RAC (1997) Dandruff and seborrheic dermatitis: causes and management. Clin Exp Dermatol 22:3-6
2. Holden CA, Berth-Jones J (2004) Eczema, lichenification, prurigo and erythroderma. In: Burns T, Breathnach S, Cox N, et al Rook's textbook of dermatology, 7th edn. Blackwell, London, pp 17.1-17.55
3. Naldi L, Rebora A (2009) Seborrheic dermatitis. N Engl J Med 360:387-396
4. Plewig G, Jansen T (1999) Seborrheic dermatitis. In: Freedberg IM, Eisen AZ, Wolff K, et al (eds) Fitzpatrick's dermatology in general medicine. McGraw-Hill, New York, pp 1482-1489
5. Unna PG (1887) Seborrheic eczema. J Cut Dis 5:449-453
6. Shuster S (1984) The aetiology of dandruff and the mode of action of therapeutic agents. Br J Dermatol 111:235-242
7. Rook A, Wilkinson DS (1979) Eczema, lichen simplex and prurigo. In: Rook A, Wilkinson DS, Ebling FJG (eds) Rook's textbook of dermatology, 3rd edn. Blackwell, London, pp 308-312
8. Burton J, Rook A, Wilkinson DS (1986) Eczema, lichen simplex, erythroderma and prurigo. In: Rook A, Wilkinson DS, Ebling FJG (eds) Rook's textbook of dermatology, 4th edn. Blackwell, pp 375-381
9. Burton J, Holden CA (1999) Eczema, lichenification and prurigo. In: Champion RH, Burton JL, Burns DA et al (eds) Rook/Wilkinson/Ebling textbook of dermatology, 6th edn. Blackwell, pp 638-643
10. Shuster S, Blatchford N (1988) Seborrheic dermatitis and dandruff - a fungal disease. Royal Soc Med Serv 132:1-54
11. Kligman A (1979) Perspectives and problems in cutaneous gerontology. J Invest Dermatol 73:39-46
12. Binder RL, Jonelis FJ (1983) Seborrheic dermatitis in neuroleptic induced Parkinsonism. Arch Dermatol 119:473-475
13. Ahsbee HR (2007) Update on the genus Malassezia. Med Mycol 45:287-303
14. Tajima M, Sugita T, Nishikawa A et al (2008) Molecular analysis of Malassezia microflora in seborrheic dermatitis patients: comparison with other diseases and healthy subjects. J Invest Dermatol 128:345-351
15. Gaitanis G, Velegraki A, Alexopoulos EC et al (2009) Malassezia furfur fingerprints as possible markers for human phylogeography. ISME J 3:498-502
16. Parry ME, Sharpe GR (1998) Seborrheic dermatitis is not caused by an altered immune response to Malassezia yeast. Br J Dermatol 139:254-263
17. Faergemann J, Bergbrant IM, Dohsé M et al (2001) Seborrhoeic dermatitis and Pityrosporum (Malassezia) folliculitis: characterization of inflammatory cells and mediators in the skin by immunohistochemistry. Br J Dermatol 144:549-556
18. Thomas DS, Ingham E, Bojar RA et al (2008) In vitro modulation of human keratinocyte pro- and anti-inflammatory cytokine production by the capsule of Malassezia species. FEMS Immunol Med Microbiol 54:203-214
19. Mittag H (1995) Fine structural investigation of Malassezia furfur.II. The envelope of the yeast cells. Mycoses 38:13-21
20. Tolleson A, Frithz A, Stenlund K (1997) Malassezia furfur in infantile seborrheic dermatitis. Ped Dermatol 14:424-425
21. Watanabe S, Kano R, Sato H et al (2001) The effects of Malassezia yeasts on cytokine production by human keratinocytes. J Invest Dermatol 116:769-773
22. Ishibashi Y, Sugita T, Nishikawa A (2006) Cytokine secretion profile of human keratinocytes exposed to Malassezia yeasts. FEMS Immunol Med Microbiol 48:400-409
23. Yamamoto T, Tsuboi R (2008) Interleukin-2-induced seborrheic dermatitis-like eruption. J Eur Acad Dermatol Venereol 22:235-262
24. Baroni A, Orlando M, Donnarumma G et al (2006) Toll-like receptor 2 (TLR2) mediates intracellular signalling in human keratinocytes in response to Malassezia furfur. Arch Dermatol Res 297:280-288
25. Donnarumma G, Paoletti I, Buommino E et al (2004) Malassezia furfur induces the expression of beta-defensin-2 in human keratinocytes in a protein kinase C-dependent manner. Arch Dermatol Res 295:474-481
26. Marples RR, Heaton CL, Kligman AM (1973) Staphylococcus aureus in psoriasis. Arch Dermatol 107:568-570
27. Ong PY, Ohtake T, Brandt C et al (2002) Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 347:1151-1160
28. Gaitanis G, Magiatis P, Stathopoulou K et al (2008) AHR ligands, malassezin, and indolo[3,2-b]carbazole are selectively produced by Malassezia furfur strains isolated from seborrheic dermatitis. J Invest Dermatol 128:1620-1625
29. Veldhoen M, Hirota K, Christensen J et al (2009) Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. J Exp Med 206:43-49
30. Veldhoen M, Hirota K, Westendorf AM et al (2008) The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 453:106-109
31. Jansen PA, Rodijk-Olthuis D, Hollox EJ et al (2009) Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin. PLoS ONE 4:e4725
32. Hauben E, Gregori S, Draghici E et al (2008) Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell-mediated effects on regulatory T cells. Blood 112:1214-1222
33. Kerkvliet NI (2002) Recent advances in understanding the mechanism of TCDD immunotoxicity. Int Immunopharmacol 2:277-291
34. Tauchi M, Hida A, Negishi T et al (2005) Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions. Mol Cell Biol 25:9360-9368
35. Fritsche E, Schäfer C, Calles C et al (2007) Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation. Proc Natl Acad Sci USA 104:8851-8856
36. Tegner E (1983) Seborrhoeic dermatitis of the face induced by PUVA treatment. Acta Derm Venereol 63:335-339
37. Moehrle M, Dennenmoser B, Schlagenhauff B et al (2000) High prevalence of seborrhoeic dermatitis on the face and scalp in mountain guides. Dermatology 201:146-147
38. Burton J, Pye R (1983) Seborrhea is not a feature of seborrheic dermatitis. Br Med J 286:1169-1170
39. Atherton DJ, Gennery AR, Cant AJ (2004) The neonate. In: Burns T, Breathnach S, Cox N, Griffiths C (eds) Rook's textbook of dermatology, 7th edn. Blackwell, Oxford, pp 1422-1429
40. Foley P, Zuo Y, Plunkett A et al (2003) The frequency of commons skin conditions in preschool- aged children in Australia. Arch Dermatol 139:318-322
41. Cotterill J, Cunliffe W, Williamson B et al (1972) Age and sex variation in skin surface lipid composition and sebum excretion rate. Br J Dermatol 87:333-340
42. Gobulev W (2006) Antagonistic interactions among yeasts. In: Rosa C, Peter G (eds) Biodiversity and ecophysiology of yeasts. Springer, Berlin, pp 197-219
43. Youn SW, Na JI, Choi SY et al (2005) Regional and seasonal variations in facial sebum secretions: a proposal for the definition of combination skin type. Skin Res Technol 11:189-195
44. Cafarchia C, Otranto D (2004) Association between phospholipase production by Malassezia pachydermatis and skin lesions. J Clin Microbiol 42:4868-4869
45. Cafarchia C, Dell'Aquila ME, Capelli G et al (2007) Role of beta-endorphin on phospholipase production in Malassezia pachydermatis in dogs: new insights into the pathogenesis of this yeast. Med Mycol 45:11-15
46. Zouboulis CC, Baron JM, Böhm M et al (2008) Frontiers in sebaceous gland biology and pathology. Exp Dermatol 17:542-551
47. Kumar CP, Kumar SS, Menon T (2006) Phospholipase and proteinase activities of clinical isolates of Candida from immunocompromised patients. Mycopathologia 161:213-218
48. Juntachai W, Oura T, Murayama SY et al (2008) The lipolytic enzymes activities of Malassezia species. Med Mycol 16:1-8
49. Cafarchia C, Dell'Aquila ME, Traversa D et al (2009) Expression of the micro-opioid receptor on Malassezia pachydermatis and its effect on modulating phospholipase production. Med Mycol 19:1-6
50. Xue C, Hsueh YP, Heitman J (2008) Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi. FEMS Microbiol Rev 32:1010-1032
51. Giakoumaki D, Stathopoulou K, Melliou E et al (2008) Identification of indirubin as a metabolite of Malassezia furfur strains isolated from diseased skin. Planta Medica 74:PB166
52. Xu J, Saunders CW, Hu P et al (2007) Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens. Proc Natl Acad Sci U S A 104:18730-18735
53. Tschachler E, Bergstresser P, Stingl G (1996) HIV-related skin diseases. Lancet 348:659-663
54. Muñoz-Pérez MA, Rodriguez-Pichardo A, Camacho F et al (1998) Dermatological findings correlated with CD4 lymphocyte counts in a prospective 3 year study of 1161 patients with human immunodeficiency virus disease predominantly acquired through intravenous drug abuse. Br J Dermatol 139:33-39
55. Puig L, Fernandez-Figueras T, Ferrandiz C et al (1995) Epidermal expression of 65 and 72 kD heat shock proteins in psoriasis and AIDS-associated psoriasiform dermatitis. J Am Acad Dermatol 33:985-989
56. Pope M, Betjes MGC, Romani N et al (1994) Conjugates of dendritic cells and memory T-lymphocytes from skin facilitate productive infection with HIV-1. Cell 78:389-398
57. Pechere M, Krischer J, Remondat C et al (1999) Malassezia spp carriage in patients with seborrheic dermatitis. J Dermatol 26:558-561
58. Pechere M, Saurat J-H (1997) Malassezia yeast density in HIV-positive individuals. Br J Dermatol 136:138-139
59. Wikler JR, Nieboer C, Willemze R (1992) Quantitative skin cultures of Pityrosporum yeasts in patients seropositive for the human immunodeficiency virus with and without seborrheic dermatitis. J Am Acad Dermatol 27:37-39
60. Jing W, Ismail R (1999) Mucocutaneous manifestations of HIV infection: a retrospective analysis of 145 cases in a Chinese population in Malaysia. Int J Dermatol 38:457-463
61. Yates VM, Kerr RE, MacKie RM (1983) Early diagnosis of infantile seborrhoeic dermatitis and atopic dermatitis-clinical features. Br J Dermatol 108:633-638
62. Broberg A, Faergemann J (1989) Infantile seborrheic dermatitis and Pityrosporum ovale. Br J Dermatol 120:359-362
63. Ruiz-Maldonado R, Lopez-Matinez R, Perez Chavarria E et al (1989) Pityrosporum ovale in infantile seborrheic dermatitis. Ped Dermatol 6:16-20
64. Moises-Alfaro CB, Caceres-Rios HW, Rueda M et al (2002) Are infantile seborrheic and atopic dermatitis clinical variants of the same disease? Int J Dermatol 41:349-351
65. Johnson BA, Nunley JR (2000) Treatment of seborrheic dermatitis. Am Fam Physician 61:2703-2710
66. Elewski BE, Abramovits W, Kempers S et al (2007) A novel foam formulation of ketoconazole 2% for the treatment of seborrheic dermatitis on multiple body regions. J Drugs Dermatol 6:1001-1008
67. Elewski B, Ling MR, Phillips TJ (2006) Efficacy and safety of a new once-daily ketoconazole 2% gel in the treatment of seborrheic dermatitis: a phase III trial. J Drugs Dermatol 5:646-650
68. Peter RU, Richarz-Barthauer U (1995) Successful treatment and prophylaxis of scalp seborrhoeic dermatitis and dandruff with 2% ketoconazole shampoo: results of a multicentre, double-blind, placebo-controlled trial. Br J Dermatol 132:441-445
69. Zienicke H, Korting HC, Braun-Falco O et al (1993) Comparative efficacy and safety of bifonazole 1% cream and the corresponding base preparation in the treatment of seborrhoeic dermatitis. Mycoses 36:325-331
70. Segal R, David M, Ingber A et al (1992) Treatment with bifonazole shampoo for seborrhea and seborrheic dermatitis: a randomized, double-blind study. Acta Derm Venereol 72:454-455
71. Shuster S, Meynadier J, Kerl H et al (2005) Treatment and prophylaxis of seborrehic dermatitis of the scalp with antipityrosporal 1% ciclopirox shampoo. Arch Dermatol 141:47-52
72. Chosidow O, Maurette C, Dupuy P (2003) Randomized, open-labeled, non-inferiority study between ciclopiroxolamine 1% cream and ketoconazole 2% foaming gel in mild to moderate facial seborrheic dermatitis. Dermatology 206:233-240
73. Unholzer A, Varigos G, Nicholls D et al (2002) Ciclopiroxolamine cream for treating seborrheic dermatitis: a double-blind parallel group comparison. Infection 30:373-376
74. Faergemann J (1986) Seborrhoeic dermatitis and Pityrosporum orbiculare: treatment of seborrhoeic dermatitis of the scalp with miconazole-hydrocortisone (Daktacort), miconazole and hydrocortisone. Br J Dermatol 114:695-700
75. Stratigos JD, Antoniou C, Katsambas A et al (1988) Ketoconazole 2% cream versus hydrocortisone 1% cream in the treatment of seborrheic dermatitis: a double-blind comparative study. J Am Acad Dermatol 19:850-853
76. Danby FW, Maddin WS, Margesson LJ et al (1993) A randomized, double-blind, placebo controlled trial of ketoconazole 2% shampoo versus selenium sulfide 2.5% shampoo in the treatment of moderate to severe dandruff. J Am Acad Dermatol 29:1008-1012
77. Efalith Multicenter Trial Group (1992) A double-blind, placebo-controlled, multicenter trial of lithium succinate ointment in the treatment of seborrheic dermatitis. J Am Acad Dermatol 26:452-457
78. Langtry JA, Rowland Payne CM, Staughton RC et al (1997) Topical lithium succinate ointment (Efalith) in the treatment of AIDS-related seborrheic dermatitis. Clin Exp Dermatol 22:216-219
79. Dreno B, Chosidow O, Revuz J et al (2003) Lithium gluconate 8% vs ketoconazole 2% in the treatment of seborrhoeic dermatitis: a multicentre, randomized study. Br J Dermatol 148:1230-1236
80. Warshaw EM, Wohlhuter RJ, Liu A et al (2007) Results of a randomized, double-blind, vehicle-controlled efficacy trial of pimecrolimus cream 1% for the treatment of moderate to severe facial seborrheic dermatitis. J Am Acad Dermatol 57:257-264
81. Firooz A, Solhpour A, Gorouhi F et al (2006) Pimecrolimus cream, 1%, vs hydrocortisone acetate cream, 1%, in the treatment of facial seborrheic dermatitis: a randomized, investigator-blind, clinical trial. Arch Dermatol 142:1066-1067
82. Rigopoulos D, Ioannides D, Kalogeromitros D et al (2004) Pimecrolimus cream 1% versus. betamethasone 17-valerate 0.1% cream in the treatment of seborrhoeic dermatitis: a randomized open-label clinical trial. Br J Dermatol 151:1071-1075
83. Gambichler T, Breuckmann F, Boms S et al (2005) Narrowband UVB phototherapy in skin conditions beyond psoriasis. J Am Acad Dermatol 52:660-670
84. Pirkhammer D, Seeber A, Hönigsmann H et al (2000) Narrow-band ultraviolet B (ATL-01) phototherapy is an effective and safe treatment option for patients with severe seborrheic dermatitis. Br J Dermatol 143:964-968
85. Cömert A, Bekiroglu N, Gürbüz O et al (2007) Efficacy of oral fluconazole in the treatment of seborrheic dermatitis: a placebo-controlled study. Am J Clin Dermatol 8:235-238
86. Scaparro E, Quardi G, Virno G et al (2001) Evaluation of the efficacy and tolerability of oral terbinafine (Daskil®) in patients with seborrhoeic dermatitis. A multicentre, randomized, investigator-blinded, placebo-controlled trial. Br J Dermatol 144:854-857
87. Vena GA, Micali G, Santoianni P et al (2005) Oral terbinafine in the treatment of multi-site seborrheic dermatitis: a multicenter, double-blind placebo-controlled study. Int J Immunopathol Pharmacol 18:745-753
88. Baysal V, Yildirim M, Ozcanli C et al (2004) Itraconazole in the treatment of seborrheic dermatitis: a new treatment modality. Int J Dermatol 43:63-66
89. Kose O, Erbil H, Gur AR (2005) Oral itraconazole for the treatment of seborrhoeic dermatitis: an open, noncomparative trial. J Eur Acad Dermatol Venereol 19:172-175
90. Shemer A, Kaplan B, Nathansohn N et al (2008) Treatment of moderate to severe facial seborrheic dermatitis with itraconazole: an open non-comparative study. Isr Med Assoc J 10:417-418
91. Piérard GE, Ausma J, Henry F et al (2007) A pilot study on seborrheic dermatitis using pramiconazole as a potent oral anti-Malassezia agent. Dermatology 214:162-169
92. Geria AN, Scheinfeld NS (2008) Pramiconazole, a triazole compound for the treatment of fungal infections. IDrugs 11:661-670
93. Bieber T (2008) Mechanisms of disease. Atopic dermatitis. N Engl J Med 358:1483-1494
94. Akdis CA, Akdis M, Bieber T et al (2006) Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. J Allergy Clin Immunol 118:152-169
95. Altrichter S, Kriehuber E, Moser J et al (2008) Serum IgE autoantibodies target keratinocytes in patients with atopic dermatitis. J Invest Dermatol 128:2232-2239
96. Zeller S, Glaser AG, Vilhelmsson M et al (2008) Immunoglobulin E-mediated reactivity to self antigens: a controversial issue. Int Arch Allergy Immunol 145:87-93
97. Miska AE (2005) How microRNAs control cell division, differentiation and death. Curr Opin Gen Develop 15:563-568
98. Sonkoly E, Wei T, Janson PCJ et al (2007) MicroRNAs: novel regulators involved in the pathogenesis of psoriasis? PloS ONE 11:e610
99. Alfvén T, Braun-Fahrländer C, Brunekreef B et al (2006) Allergic diseases and atopic sensitisation in children related to farming and anthroposophic lifestyle in five European countries - the PARSIFAL study. Allergy 61:414-421
100. Vercelli D (2004) Genetics, epigenetics, and the environment: switching, buffering, releasing. J Allergy Clin Immunol 113:381-386
101. Vuillermin PJ, Ponsonby AL, Saffery R et al (2009) Microbial exposure, interferon gamma gene demethylation in naïve t-cells, and the risk of allergy disease. Allergy 64:343-353
102. Clemmensen OJ, Hjort N (1983) Treatment of dermatitis of the head and neck with ketoconazole in patients with type I hypersensitivity for Pityrosporum orbiculare. Semin Dermatol 2:26-29
103. Scheynius A, Johansson C, Buentke E et al (2002) Atopic eczema/dermatitis syndrome and Malassezia. Int Arch Allergy Immunol 127:161-169
104. Bäck O, Scheynius A, Johansson SG (1995) Ketoconazole in atopic dermatitis: therapeutic response is correlated with decrease in serum IgE. Arch Dermatol Res 287:448-451
105. Casagrande-Fischer B, Flückiger S, Linder MT et al (2006) Sensitization to the yeast Malassezia sympodialis is specific for extrinsic and intrinsic atopic eczema. J Invest Dermatol 126:2414-2421
106. Sandström Falk MH, Tengvall Linder M, Johansson C et al (2005) The prevalence of Malassezia yeasts in patients with atopic dermatitis, seborrhoeic dermatitis and healthy controls. Acta Derm Venereol 85:17-23
107. Steinman RM (2007) Dendritic cells: understanding immunogenicity. Eur J Immunol 37(suppl 1):S53-S60
108. Hiller R, Laffer S, Harwanegg C et al (2002) Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment. FASEB J 16:414-416
109. Schmid-Grendelmeier P, Crameri R (2001) Recombinant allergens for skin testing. Int Arch Allergy Immunol 125:96-111
110. Crameri R, Rhyner C (2007) Impact of native, recombinant, and cross-reactive allergens on humoral and T-cell-mediated immune responses. Immunol Allergy Clin North Am 27:65-68
111. Crameri R (2007) Allergy vaccines: dreams and reality. Exp Rev Vaccines 6:991-999
112. Valenta R, Niederberger V (2007) Recombinant allergens for immunotherapy. J Allergy Clin Immunol 119:826-830
113. Kodzius R, Rhyner C, Konthur Z et al (2003) Rapid identification of allergen-encoding cDNA clones by phage display and high-density arrays. Comb Chem High Throughput Screen 6:147-154
114. Vailes L, Sridhara S, Cromwell O et al (2001) Quantitation of the major fungal allergens, Alt a 1 and Asp f 1, in commercial allergenic products. J Allergy Clin Immunol 107:641-646
115. Crameri R, Weichel M, Flückiger S et al (2006) Fungal allergies: a yet unsolved problem. Chem Immunol Allergy 91:121-133
116. Crameri R, Kodzius R, Konthur Z et al (2001) Tapping allergen repertoires by advanced cloning technologies. Int Arch Allergy Immunol 124:43-47
117. Vilhelmsson M, Zargari A, Crameri R et al (2007) Crystal structure of the major Malassezia sympodialis allergen Mala s 1 reveals a beta-propeller fold: a novel fold among allergens. J Mol Biol 369:1079-1086
118. Glaser GA, Limacher A, Flückiger S et al (2006) Analysis of the cross-reactivity and of the 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family. Biochem J 396:41-49
119. Limacher A, Glaser AG, Meier C et al (2007) Cross-reactivity and 1.4 A crystal structure of Malassezia sympodialis thioredoxin (Mala s 13), a member of a new pan-allergen family. J Immunol 178:389-396
120. Flückiger S, Fijten H, Whitley P et al (2002) Cyclophilins, a new family of cross-reactive allergens. Eur J Immunol 32:10-17
121. Schmidt M, Zargari A, Holt P et al (1997) The complete cDNA sequence and expression of the first major allergenic protein of Malassezia furfur, Mal f 1. Eur J Biochem 246:181-185
122. Yasueda H, Hashida-Okado T, Saito A et al (1998) Identification and cloning of two novel allergens from the lipophilic yeast, Malassezia furfur. Biochem Biophys Res Comm 248:240-244
123. Onishi Y, Kuroda M, Yasueda H et al (1999) Two-dimensional electrophoresis of Malassezia allergens for atopic dermatitis and isolation of Mal f 4 homologs with mitochondrial malate dehydrogenase. Eur J Biochem 261:148-154
124. Moser M, Crameri R, Menz G et al (1992) Cloning and expression of recombinant Aspergillus fumigatus allergen I/a (rAsp f I/a) with IgE binding and type I skin test activity. J Immunol 149:454-460
125. De Vouge MW, Thaker AJ, Curran IH et al (1996) Isolation and expression of a cDNA clone encoding an Alternaria alternata Alt a 1 subunit. Int Arch Allergy Immunol 111:385-395
126. Bowyer P, Fraczek M, Denning DW (2006) Comparative genomics of fungal allergens and epitopes shows widespread distribution of closely related allergen and epitope orthologues. BMC Genomics 7:251
127. Martinez-Espinoza AD, Garcia-Pedrajas MD, Gold SE (2002) The Ustilaginales as plant pests and model systems. Fungal Genet Biol 35:1-20
128. Schisler DA, Khan NI, Boehm MJ (2002) Biological control of Fusarium head blight of wheat and deoxynivalenol levels in grain via use of microbial antagonists. Adv Exp Med Biol 504:53-69
129. Dyer RB, Plattner RD, Kendra DF et al (2005) Fusarium graminearum TRI14 is required for high virulence and DON production on wheat but not for DON synthesis in vitro. J Agric Food Chem 53:9281-9287
130. Zargari A, Emilson A, Halldén G et al (1997) Cell surface expression of two major yeast allergens in the Pityrosporum genus. Clin Exp Allergy 27:584-592
131. Dawson TL Jr (2007) Malassezia globosa and restricta: breakthrough understanding of the etiology and treatment of dandruff and seborrheic dermatitis through whole-genome analysis. J Investig Dermatol Symp Proc 12:15-19
132. Hemmann S, Blaser K, Crameri R (1997) Allergens of Aspergillus fumigatus and Candida boidinii share IgE-binding epitopes. Am J Respir Crit Care Med 156:1956-1962
133. Weichel M, Flückiger S, Crameri R (2002) Molecular characterization of mould allergens involved in respiratory complications. Recent Res Devel Resp Critical Care Med 2:29-45
134. Posch A, Chen Z, Dunn MJ et al (1997) Latex allergen database. Electrophoresis 18:2803-2810
135. Lindborg M, Magnusson CG, Zargari A et al (1999) Selective cloning of allergens from the skin colonizing yeast Malassezia furfur by phage surface display technology. J Invest Dermatol 113:156-161
136. Rasool O, Zargari A, Almqvist J et al (2000) Cloning, characterization and expression of complete coding sequences of three IgE binding Malassezia furfur allergens, Mala f 7, Mala f 8 and Mala f 9. Eur J Biochem 267:4355-4361
137. Wolfe KH (2006) Comparative genomics and genome evolution in yeasts. Philos Trans R Soc Lond B Biol Sci 361:403-412
138. Andersson A, Rasool O, Schmidt M et al (2004) Cloning, expression and characterization of two new IgE-binding proteins from the yeast Malassezia sympodialis with sequence similarities to heat shock proteins and manganese superoxide dismutase. Eur J Biochem 271: 1885-1894
139. Zargari A, Selander C, Rasool O et al (2007) Mala s 12 is a major allergen in patients with atopic eczema and has sequence similarities to the GMC oxidoreductase family. Allergy 62:695-703
140. Shen DH, Han SH (1998) Characterization of allergens of Penicillium and Aspergillus species. J Microbiol Immunol Infect 32:141-145
141. Johansson C, Eshaghi H, Tengvall Linder M et al (2002) Positive atopy patch test reaction to Malassezia furfur in atopic dermatitis patients correlates with a T h elper 2-like peripheral blood mononuclear cells response. J Invest Dermatol 118:1044-1051
142. Schmid-Grendelmeier P, Scheynius A, Crameri R (2006) The role of sensitization to Malassezia sympodialis in atopic eczema. Chem Immunol Allergy 91:98-109
143. Zargari A, Eshaghi H, Bäck O et al (2001) Serum IgE reactivity to Malassezia furfur extract and recombinant M. furfur allergens in patients with atopic dermatitis. Acta Derm Venereol 81:418-422
144. Selander C, Zargari A, Möllby R et al (2006) Higher pH level, corresponding to that on the skin of patients with atopic eczema, stimulates the release of Malassezia sympodialis allergens. Allergy 61:1002-1008
145. Ganz T (2003) Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 3:710-720
146. Ballardini N, Johansson C, Lilja G et al (2009) Enhanced expression of the antimicrobial peptide LL-37 in lesional skin of adults with atopic eczema. Br J Dermatol Mar 20:40-47
147. Novak N, Bieber T, Kraft S (2004) Immunoglobulin E-bearing antigen presenting cells in atopic dermatitis. Curr Allergy Asthma Rep 4:263-269
148. + dendritic cells. Clin Exp Allergy 30:1759-1770
149. Buentke E, Heffler LC, Wallin RP et al (2001) The allergenic yeast Malassezia furfur induces maturation of human dendritic cells. Clin Exp Allergy 31:1583-1593
150. Vilhelmsson M, Johansson C, Jacobsson-Ekman G et al (2007) The Malassezia sympodialis allergen Mala s 11 induces human dendritic cell maturation in contrast to its human homologue manganese superoxide dismutase. Int Arch Allergy Immunol 143:155-162
151. Gabrielsson S, Buentke E, Liedén A et al (2004) Malassezia sympodialis stimulation differently affects gene expression in dendritic cells from atopic dermatitis patients and healthy individuals. Acta Derm Venereol 84:339-345
152. Agerberth B, Buentke B, Bergman P et al (2006) Malassezia sympodialis differently affects the expression of LL-37 in dendritic cells from atopic eczema patients and healthy individuals. Allergy 61:422-430
153. Tengvall Linder M, Johansson C, Zargari A et al (1996) Detection of Pityrosporum orbiculare reactive T cells from skin and blood in atopic dermatitis and characterization of their cytokine profiles. Clin Exp Allergy 26:1286-1297
154. Tengvall Linder M, Johansson C, Bengtsson A et al (1998) Pityrosporum orbiculare-reactive T-cell lines in atopic dermatitis patients and healthy individuals. Scand J Immunol 47:152-158
155. Walzer T, Dalod M, Robbins SH et al (2005) Natural-killer cells and dendritic cells: "l'union fait la force". Blood 106:2252-2258
156. Buentke E, Heffler LC, Wilson JL et al (2002) Natural killer and dendritic cell contact in lesional atopic dermatitis skin Malassezia-influenced cell interaction. J Invest Dermatol 119:850-857
157. Buentke E, D'Amoto M, Scheynius A (2004) Malassezia enhances natural killer cell-induced dendritic cell maturation. Scand J Immunol 59:511-516
158. Olynych TJ, Jakeman DL, Marshall JS (2006) Fungal zymosan induces leukotriene production by human mast cells through a dectin-1-dependent mechanism. J Allergy Clin Immunol 118:837-843
159. Henz BM, Maurer M, Lippert U et al (2001) Mast cells as initiators of immunity and host defense. Exp Dermatol 10:1-10
160. Selander C, Engblom C, Nilsson G et al (2009) TLR2/MyD88-depedent and -independent activation of mast cell IgE responses by the skin commensal yeast Malassezia sympodialis. J Immunol 182:4208-4216
161. Schmid-Grendelmeier P, Flückiger S, Disch R et al (2005) IgE-mediated and T-cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis. J Allergy Clin Immunol 115:1068-1075
162. Crameri R, Faith A, Hemmann S et al (1996) Humoral and cell-mediated autoimmunity in allergy to Aspergillus fumigatus. J Exp Med 184:265-270
163. Mayer C, Appenzeller U, Seelbach H et al (1999) Humoral and cell-mediated autoimmune reaction to human acidic ribosomal P2 protein in individuals sensitized to Aspergillus fumigatus P2 protein. J Exp Med 189:1507-1512
164. Stadler JF, Taieb A, Atherton DJ (1993) Severity scoring of atopic dermatitis: the SCORAD index. Consensus report of the European task force on atopic dermatitis. Dermatology 186:23-31
165. Andersson A, Scheynius A, Rasool O (2003) Detection of Mala f and Mala s allergen sequences within the genus Malassezia. Med Mycol 41:479-485
166. Zargari A, Midgley G, Bäck O et al (2003) IgE-reactivity to seven Malassezia species. Allergy 58:306-311
167. Zargari A, Doekes G, van Ieperen-van Dijk AG et al (1995) Influence of culture period on the allergenic composition of Pityrosporum orbiculare extracts. Clin Exp Allergy 25: 1235-1245
168. Johansson C, Sandström MH, Bartosik J et al (2003) Atopy patch test reactions to Malassezia allergens differentiate subgroups of atopic dermatitis patients. Br J Dermatol 148:479-488
169. Tengvall Linder M, Johansson C, Scheynius A et al (2000) Positive atopy patch test reactions to Pityrosporum orbiculare in atopic dermatitis patients. Clin Exp Allergy 30:122-131
170. Johansson C, Ahlborg N, Andersson A et al (2009) Elevated peripheral allergen-specific T cell response is crucial for a positive atopy patch test reaction. Int Arch Allergy Immunol 150:51-58
171. Elias PM, Steinhoff M (2008) "Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis. J Invest Dermatol 128:1067-1070
172. Müller UR (2003) Recent developments and future strategies for immunotherapy of insect venom allergy. Curr Opin Allergy Clin Immunol 3:299-303
173. Wallner M, Briza P, Thalhamer J et al (2007) Specific immunotherapy in pollen allergy. Curr Opin Mol Ther 9:160-167
174. Helbling A, Reimes A (2003) Immunotherapy in fungal allergy. Curr Allergy Asthma Rep 3:447-453