Stopping the carotene and retinol efficacy trial: The viewpoint of the safety and endpoint monitoring committee

Data Monitoring in Clinical Trials: A Case Studies Approach

Volumn , Issue , 2006, Pages 220-227

  Miller, Anthony B ^a   Buring, Julie ^b   Williams, O Dale ^c  

^a Harvard Medical School ^*

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84889847754     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/0-387-30107-0_20     Document Type: Chapter

References (6)

1. IARC Handbooks on Cancer Prevention. Volume 2 Carotenoids. 1998. Lyon, International Agency for Research on Cancer.
2. O'Brien PC, Fleming TR. 1979. A multiple testing procedure for clinical trials. Biometrics 35:549-556.
3. Bowen DJ, Thornqvist M, Anderson K, Barnett M, Powell C, Goodman G, Omenn G. 2003. Stopping the active intervention: CARET. Control Clin Trials 24:39-50.
4. The Alpha-Tocopherol Beta Carotene Prevention Study Group. 1994. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 330:1029-1035.
5. Hennekens CH Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, et al. 1996. Lack of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 334:1145-1149.
6. Miller AB, To T, Baines CJ, Wall C. 2000. Canadian National Breast Screening Study-2:13-year results of a randomized trial in women age 50-59 years. J Natl Cancer Inst 92:1490-1499.