Targeting the inward-rectifier potassium channel ROMK in cardiovascular disease

Current Opinion in Pharmacology

Volumn 15, Issue 1, 2014, Pages 1-6

  Garcia, Maria L ^a   Kaczorowski, Gregory J ^a  

^a Kanalis Consulting   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BIS(4 NITROPHENETHYL)PIPERAZINE; 5 [2 [4 [2 [4 (1H-TETRAZOL-1YL)PHENYL]ACETYL]PIPERAZIN 1 YL]ETHYL]ISOBENZOFURAN 1 [3H]ONE; 7,13 BIS(4 NITROBENZYL) 1,4,10 TRIOXA 7,13 DIAZACYCLOPENTADECANE; DIURETIC AGENT; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL ROMK; HYDROCHLOROTHIAZIDE; NEW DRUG; PLACEBO; POTASSIUM CHANNEL BLOCKING AGENT; TERTIAPIN; UNCLASSIFIED DRUG; VU 590;

ANTIHYPERTENSIVE ACTIVITY; ANTIHYPERTENSIVE THERAPY; BLOOD PRESSURE REGULATION; CONCENTRATION RESPONSE; DRUG BIOAVAILABILITY; DRUG DETERMINATION; DRUG EFFICACY; DRUG HALF LIFE; DRUG INDUSTRY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG RESEARCH; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; EXPERIMENTAL RAT; HUMAN; HYPERTENSION; IC 50; NONHUMAN; PATENT; PRIORITY JOURNAL; PROTEIN TARGETING; REVIEW; STRUCTURE ACTIVITY RELATION; VALIDATION STUDY;

ANIMALS; CARDIOVASCULAR DISEASES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR TARGETED THERAPY; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; SMALL MOLECULE LIBRARIES;

EID: 84889842454     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2013.11.005     Document Type: Review

References (30)

1. R.P. Lifton, A.G. Gharavi, and D.S. Geller Molecular mechanisms of human hypertension Cell 104 2001 545 556 (Pubitemid 32201949)
2. L.K.M. De Bruyne Mechanisms and management of diuretic resistance in congestive heart failure Postgrad Med J 79 2003 268 271 (Pubitemid 36724235)
3. B.F. Palmer, and A.S. Naderi Metabolic complications associated with use of thiazide diuretics J Am Soc Hypertens 1 2007 381 392 (Pubitemid 350182999)
4. C.G. Nichols, and A.N. Lopatin Inward rectifier potassium channels Annu Rev Physiol 59 1997 171 191 (Pubitemid 27142438)
5. W. Wang Renal potassium channels: recent developments Curr Opin Nephrol Hypertens 13 2004 549 555 (Pubitemid 39150082)
6. S.C. Herbert, G. Desir, G. Giebisch, and W. Wang Molecular diversity and regulation of renal potassium channels Physiol Rev 85 2005 319 371 (Pubitemid 40173996)
7. T. Rieg, V. Vallon, M. Sausbier, U. Sausbier, B. Kaissling, P. Ruth, and H. Osswald The role of the BK channel in potassium homeostasis and flow-induced renal potassium excretion Kidney Int 72 2007 566 573 (Pubitemid 47312793)
8. + channel, ROMK Nat Genet 14 1996 152 156 (Pubitemid 26338794)
9. W. Ji, J.N. Foo, B.J. O'Roak, H. Zhao, M.G. Larson, D.B. Simon, C. Newton-Cheh, M.W. State, D. Levy, and R.P. Lifton Rare independent mutations in renal salt handling genes contribute to blood pressure variation Nat Genet 40 2008 592 599 (Pubitemid 351601207)
10. J.N. Lorenz, N.R. Baird, L.M. Judd, W.T. Noonan, A. Andringa, T. Doetschman, P.A. Manning, L.H. Liu, M.L. Miller, and G.E. Shull Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome J Biol Chem 277 2002 37871 37880
11. + channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice J Biol Chem 277 2002 37881 37887 (Pubitemid 35153514)
12. X. Zhou, Z. Zhang, M.K. Shin, S.B. Horwitz, J.M. Levorse, L. Zhu, W. Sharif-Rodriguez, D.Y. Streltsov, M. Dajee, and M. Hernandez Heterozygous disruption of renal outer medullary potassium channel in rats is associated with reduced blood pressure Hypertension 62 2013 288 294
13. + channel modulators for the treatment of neurological disorders and autoimmune diseases Chem Rev 108 2008 1744 1773 (Pubitemid 351796408)
14. + channels Biochemistry 37 1998 13291 13299 (Pubitemid 28449574)
15. J.P. Felix, J. Liu, W.A. Schmalhofer, T. Bailey, M.A. Bednarek, S. Kinkel, A.B. Weinglass, M. Kohler, G.J. Kaczorowski, B.T. Priest, and M.L. Garcia Characterization of Kir1.1 channels with the use of a radiolabeled derivative of tertiapin Biochemistry 45 2006 10129 10139 (Pubitemid 44257407)
16. K. Solly, J. Cassaday, J.P. Felix, M.L. Garcia, M. Ferrer, B. Strulovici, and L. Kiss Miniaturization and HTS of a FRET-based membrane potential assay for Kir channel inhibitors Assay Drug Dev Technol 6 2008 225 234 (Pubitemid 351670379)
17. L.M. Lewis, G. Bhave, B.A. Chauder, S. Banerjee, K.A. Lornsen, R. Redha, K. Fallen, C.W. Lindsley, C.D. Weaver, and J.S. Denton High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1 Mol Pharmacol 76 2009 1094 1103
18. J.P. Felix, B.T. Priest, K. Solly, T. Bailey, R.M. Brochu, C.J. Liu, M.G. Kohler, L. Kiss, M. Alonso-Galicia, and H. Tang The inwardly rectifying potassium channel Kir1.1: development of functional assays to identify and characterize channel inhibitors Assay Drug Dev Technol 10 2012 417 431
19. G. Bhave, B.A. Chauder, W. Liu, E.S. Dawson, R. Kadakia, T.T. Nguyen, L.M. Lewis, J. Meiler, C.D. Weaver, and L.M. Satlin Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel Mol Pharmacol 79 2011 42 50
20. K1) controls cardiac excitability and is involved in arrhythmogenesis Heart Rhythm 2 2005 316 324 (Pubitemid 40309834)
21. H. Tang, S.P. Walsh, Y. Yan, R.K. de Jesus, A. Shahripour, N. Teumelsan, Y. Zhu, S. Ha, K.A. Owens, and B. Thomas-Fowlkes Discovery of selective small molecule ROMK inhibitors as potential new mechanism diuretics ACS Med Chem Lett 3 2012 367 372
22. M.E. Curran, I. Splawski, K.W. Timothy, G.M. Vincent, E.D. Green, and M.T. Keating A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome Cell 80 1995 795 803
23. H. Tang, R.K. de Jesus, S.P. Walsh, Y. Zhu, Y. Yan, B.T. Priest, A.M. Swensen, M. Alonso-Galicia, J.P. Felix, and R.M. Brochu Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-tetrazol-1- yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one Bioorg Med Chem Lett 23 2013 5829 5832
24. M.L. Garcia, B.T. Priest, M. Alonso-Galicia, X. Zhou, J.P. Felix, R.M. Brochu, T. Bailey, B. Thomas-Fowlkes, J. Liu, and A. Swensen Pharmacological inhibition of the renal outer medullary potassium channel causes diuresis and natriuresis in the absence of kaliuresis J Pharmacol Exp Therap 2013 10.1124/jpet.113.208603
25. Merck & Co. Inhibitors of the renal outer medullary potassium channel, US Patent Application: US2010/0286123A1; 2010
26. Merck & Co. Inhibitors of the renal outer medullary potassium channel, WIPO Patent Application: PCT/US2011/057346; 2011
27. Merck & Co. Inhibitors of the renal outer medullary potassium channel, WIPO Patent Application: PCT/US2012/054354; 2012
28. Merck & Co. Inhibitors of the renal outer medullary potassium channel, WIPO Patent Application: PCT/US2012/061274; 2012
29. Merck & Co. Inhibitors of the renal outer medullary potassium channel, WIPO Patent Application: PCT/US2012/061896; 2012
30. N. Sood, K.M. Reinhart, and W.L. Baker Combination therapy for the management of hypertension: a review of the evidence Am J Health Syst Pharm 67 2010 885 894