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Volumn 9, Issue 1, 2013, Pages 681-694

Linagliptin as add-on therapy to insulin for patients with type 2 diabetes

Author keywords

Dipeptidyl peptidase 4; Glucagon like peptide 1; Glycemic control; Hypoglycemia; Incretin; Renal impairment

Indexed keywords

ALOGLIPTIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GASTRIC INHIBITORY POLYPEPTIDE; GLIMEPIRIDE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCOSE; HEMOGLOBIN A1C; INSULIN; LINAGLIPTIN; METFORMIN; PIOGLITAZONE; PLACEBO; SAXAGLIPTIN; SITAGLIPTIN; VILDAGLIPTIN;

EID: 84889833566     PISSN: 11766344     EISSN: 11782048     Source Type: Journal    
DOI: 10.2147/VHRM.S40035     Document Type: Review
Times cited : (18)

References (102)
  • 1
    • 84873864348 scopus 로고    scopus 로고
    • Long-term efficacy and safety of linagliptin in patients with type 2 diabetes and severe renal impairment: A 1-year, randomized, double-blind, placebo-controlled study
    • McGill JB, Sloan L, Newman J, et al. Long-term efficacy and safety of linagliptin in patients with type 2 diabetes and severe renal impairment: a 1-year, randomized, double-blind, placebo-controlled study. Diabetes Care. 2013;36(2):237-244.
    • (2013) Diabetes Care , vol.36 , Issue.2 , pp. 237-244
    • McGill, J.B.1    Sloan, L.2    Newman, J.3
  • 2
    • 84886297885 scopus 로고    scopus 로고
    • Linagliptin for patients aged 70 years or older with type 2 diabetes inadequately controlled with common antidiabetes treatments: A randomised, double-blind, placebo-controlled trial
    • Epub, Aug 13
    • Barnett AH, Huisman H, Jones R, von Eynatten M, Patel S, Woerle HJ. Linagliptin for patients aged 70 years or older with type 2 diabetes inadequately controlled with common antidiabetes treatments: a randomised, double-blind, placebo-controlled trial. Lancet. Epub 2013 Aug 13.
    • (2013) Lancet
    • Barnett, A.H.1    Huisman, H.2    Jones, R.3    von Eynatten, M.4    Patel, S.5    Woerle, H.J.6
  • 3
    • 84889857731 scopus 로고    scopus 로고
    • Effects of Adding Linagliptin to Basal Insulin Regimen for Inadequately Controlled Type 2 Diabetes: A ≥ 52-week randomized, double-blind study
    • Epub 2013 Sep 23
    • Yki-Jarvinen H, Rosenstock J, Duran-Garcia S, et al. Effects of Adding Linagliptin to Basal Insulin Regimen for Inadequately Controlled Type 2 Diabetes: A ≥ 52-week randomized, double-blind study. Diabetes Care. 2013. Epub 2013 Sep 23.
    • (2013) Diabetes Care
    • Yki-Jarvinen, H.1    Rosenstock, J.2    Duran-Garcia, S.3
  • 4
    • 77953821528 scopus 로고    scopus 로고
    • Emerging Risk Factors Collaboration. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta-analysis of 102 prospective studies
    • Sarwar N, Gao P, Seshasai SR, et al; Emerging Risk Factors Collaboration. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet. 2010;375(9733):2215-2222.
    • (2010) Lancet , vol.375 , Issue.9733 , pp. 2215-2222
    • Sarwar, N.1    Gao, P.2    Seshasai, S.R.3
  • 5
    • 84889866052 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention. National Diabetes Fact Sheet: National Estimates and General Information on Diabetes and Prediabetes in the United States, 2011. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention; 2011. Available from, Accessed July 11
    • Centers for Disease Control and Prevention. National Diabetes Fact Sheet: National Estimates and General Information on Diabetes and Prediabetes in the United States, 2011. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention; 2011. Available from: http://www.cdc.gov/diabetes/pubs/pdf/ndfs_2011.pdf. Accessed July 11, 2013.
    • (2013)
  • 6
    • 84871995815 scopus 로고    scopus 로고
    • American Diabetes Association. Standards of medical care in diabetes-2013
    • American Diabetes Association. Standards of medical care in diabetes-2013. Diabetes Care. 2013;36 Suppl 1:S11-S66.
    • (2013) Diabetes Care , vol.36 , Issue.SUPPL. 1
  • 7
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007;132(6):2131-2157.
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 8
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet. 2006;368(9548):1696-1705.
    • (2006) Lancet , vol.368 , Issue.9548 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 9
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R, Gallwitz B, Schmidt WE. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem. 1993;214(3):829-835.
    • (1993) Eur J Biochem , vol.214 , Issue.3 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 10
    • 75549091263 scopus 로고    scopus 로고
    • Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: An algorithm for glycemic control
    • Rodbard HW, Jellinger PS, Davidson JA, et al. Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control. Endocr Pract. 2009;15(6):540-559.
    • (2009) Endocr Pract , vol.15 , Issue.6 , pp. 540-559
    • Rodbard, H.W.1    Jellinger, P.S.2    Davidson, J.A.3
  • 11
    • 84889771455 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence. Type 2 Diabetes: Newer Agents for Blood Glucose Control in Type 2 Diabetes. London: National Institute for Health and Clinical Excellence; 2009. Available from, Accessed May 29
    • National Institute for Health and Clinical Excellence. Type 2 Diabetes: Newer Agents for Blood Glucose Control in Type 2 Diabetes. London: National Institute for Health and Clinical Excellence; 2009. Available from: http://www.nice.org.uk/nicemedia/pdf/CG87ShortGuideline.pdf. Accessed May 29, 2013.
    • (2013)
  • 12
    • 33845405222 scopus 로고    scopus 로고
    • ADOPT Study Group. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    • Kahn SE, Haffner SM, Heise MA, et al; ADOPT Study Group. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med. 2006;355(23):2427-2443.
    • (2006) N Engl J Med , vol.355 , Issue.23 , pp. 2427-2443
    • Kahn, S.E.1    Haffner, S.M.2    Heise, M.A.3
  • 13
    • 33745006572 scopus 로고    scopus 로고
    • Treatment escalation and rise in HbA1c following successful initial metformin therapy
    • Nichols GA, Alexander CM, Girman CJ, Kamal-Bahl SJ, Brown JB. Treatment escalation and rise in HbA1c following successful initial metformin therapy. Diabetes Care. 2006;29(3):504-509.
    • (2006) Diabetes Care , vol.29 , Issue.3 , pp. 504-509
    • Nichols, G.A.1    Alexander, C.M.2    Girman, C.J.3    Kamal-Bahl, S.J.4    Brown, J.B.5
  • 14
    • 77649254732 scopus 로고    scopus 로고
    • Secondary failure of metformin monotherapy in clinical practice
    • Brown JB, Conner C, Nichols GA. Secondary failure of metformin monotherapy in clinical practice. Diabetes Care. 2010;33(3):501-506.
    • (2010) Diabetes Care , vol.33 , Issue.3 , pp. 501-506
    • Brown, J.B.1    Conner, C.2    Nichols, G.A.3
  • 15
    • 84866268783 scopus 로고    scopus 로고
    • American Diabetes Association (ADA); European Association for the Study of Diabetes (EASD). Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • Inzucchi SE, Bergenstal RM, Buse JB, et al; American Diabetes Association (ADA); European Association for the Study of Diabetes (EASD). Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012;35(6):1364-1379.
    • (2012) Diabetes Care , vol.35 , Issue.6 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 16
    • 7444234167 scopus 로고    scopus 로고
    • Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of beta-cell function
    • Li Y, Xu W, Liao Z, et al. Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of beta-cell function. Diabetes Care. 2004;27(11):2597-2602.
    • (2004) Diabetes Care , vol.27 , Issue.11 , pp. 2597-2602
    • Li, Y.1    Xu, W.2    Liao, Z.3
  • 17
    • 55449096196 scopus 로고    scopus 로고
    • Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on beta-cell function in patients with type 2 diabetes: A model-based approach
    • Xu L, Man CD, Charbonnel B, et al. Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on beta-cell function in patients with type 2 diabetes: a model-based approach. Diabetes Obes Metab. 2008;10(12): 1212-1220.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.12 , pp. 1212-1220
    • Xu, L.1    Man, C.D.2    Charbonnel, B.3
  • 18
    • 0023903091 scopus 로고
    • Glyburide or insulin for metabolic control in non-insulin-dependent diabetes mellitus. A randomized, double-blind study
    • Nathan DM, Roussell A, Godine JE. Glyburide or insulin for metabolic control in non-insulin-dependent diabetes mellitus. A randomized, double-blind study. Ann Intern Med. 1988;108(3):334-340.
    • (1988) Ann Intern Med , vol.108 , Issue.3 , pp. 334-340
    • Nathan, D.M.1    Roussell, A.2    Godine, J.E.3
  • 19
    • 0141446274 scopus 로고    scopus 로고
    • Characterization of GLP-1 effects on beta-cell function after meal ingestion in humans
    • Ahrén B, Holst JJ, Mari A. Characterization of GLP-1 effects on beta-cell function after meal ingestion in humans. Diabetes Care. 2003;26(10):2860-2864.
    • (2003) Diabetes Care , vol.26 , Issue.10 , pp. 2860-2864
    • Ahrén, B.1    Holst, J.J.2    Mari, A.3
  • 20
    • 79961191559 scopus 로고    scopus 로고
    • Regulation of glucagon secretion by incretins
    • Holst JJ, Christensen M, Lund A, et al. Regulation of glucagon secretion by incretins. Diabetes Obes Metab. 2011;13 Suppl 1:89-94.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.SUPPL. 1 , pp. 89-94
    • Holst, J.J.1    Christensen, M.2    Lund, A.3
  • 21
    • 84866303239 scopus 로고    scopus 로고
    • The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice
    • Jelsing J, Vrang N, van Witteloostuijn SB, Mark M, Klein T. The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice. J Endocrinol. 2012;214(3):381-387.
    • (2012) J Endocrinol , vol.214 , Issue.3 , pp. 381-387
    • Jelsing, J.1    Vrang, N.2    van Witteloostuijn, S.B.3    Mark, M.4    Klein, T.5
  • 22
    • 83955161115 scopus 로고    scopus 로고
    • A novel long acting DPP-IV inhibitor PKF-275-055 stimulates β-cell proliferation resulting in improved glucose homeostasis in diabetic rats
    • Akarte AS, Srinivasan BP, Gandhi S. A novel long acting DPP-IV inhibitor PKF-275-055 stimulates β-cell proliferation resulting in improved glucose homeostasis in diabetic rats. Biochem Pharmacol. 2012;83(2):241-252.
    • (2012) Biochem Pharmacol , vol.83 , Issue.2 , pp. 241-252
    • Akarte, A.S.1    Srinivasan, B.P.2    Gandhi, S.3
  • 23
    • 33846796143 scopus 로고    scopus 로고
    • Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes
    • Brazg R, Xu L, Dalla Man C, Cobelli C, Thomas K, Stein PP. Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes. Diabetes Obes Metab. 2007;9(2):186-193.
    • (2007) Diabetes Obes Metab , vol.9 , Issue.2 , pp. 186-193
    • Brazg, R.1    Xu, L.2    Dalla Man, C.3    Cobelli, C.4    Thomas, K.5    Stein, P.P.6
  • 24
    • 77954515294 scopus 로고    scopus 로고
    • Time for testing incretin therapies in early type 1 diabetes?
    • Bosi E. Time for testing incretin therapies in early type 1 diabetes? J Clin Endocrinol Metab. 2010;95(6):2607-2609.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.6 , pp. 2607-2609
    • Bosi, E.1
  • 25
    • 79551615182 scopus 로고    scopus 로고
    • Use of twice-daily exenatide in Basal insulin-treated patients with type 2 diabetes: A randomized, controlled trial
    • Buse JB, Bergenstal RM, Glass LC, et al. Use of twice-daily exenatide in Basal insulin-treated patients with type 2 diabetes: a randomized, controlled trial. Ann Intern Med. 2011;154(2):103-112.
    • (2011) Ann Intern Med , vol.154 , Issue.2 , pp. 103-112
    • Buse, J.B.1    Bergenstal, R.M.2    Glass, L.C.3
  • 26
    • 79958700336 scopus 로고    scopus 로고
    • Clarifying the role of incretin-based therapies in the treatment of type 2 diabetes mellitus
    • Campbell RK. Clarifying the role of incretin-based therapies in the treatment of type 2 diabetes mellitus. Clin Ther. 2011;33(5):511-527.
    • (2011) Clin Ther , vol.33 , Issue.5 , pp. 511-527
    • Campbell, R.K.1
  • 27
    • 81855194761 scopus 로고    scopus 로고
    • Safety of dipeptidyl peptidase-4 inhibitors: A meta-analysis of randomized clinical trials
    • Monami M, Dicembrini I, Martelli D, Mannucci E. Safety of dipeptidyl peptidase-4 inhibitors: a meta-analysis of randomized clinical trials. Curr Med Res Opin. 2011;27 Suppl 3:57-64.
    • (2011) Curr Med Res Opin , vol.27 , Issue.SUPPL. 3 , pp. 57-64
    • Monami, M.1    Dicembrini, I.2    Martelli, D.3    Mannucci, E.4
  • 28
    • 84889786340 scopus 로고    scopus 로고
    • diabetes.org [homepage on the Internet]. ADA/EASD/IDF Statement concerning the use of incretin therapy and pancreatic disease [ADA news release]. American Diabetes Association; 2013 [updated June 28, 2013; cited July 10, 2013]. Available from, Accessed September 25
    • diabetes.org [homepage on the Internet]. ADA/EASD/IDF Statement concerning the use of incretin therapy and pancreatic disease [ADA news release]. American Diabetes Association; 2013 [updated June 28, 2013; cited July 10, 2013]. Available from: http://www.diabetes.org/for-media/2013/recommendations-for.html. Accessed September 25, 2013.
    • (2013)
  • 29
    • 0036020278 scopus 로고    scopus 로고
    • Hypoglycaemia: The limiting factor in the glycaemic management of Type I and Type II diabetes
    • Cryer PE. Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes. Diabetologia. 2002;45(7): 937-948.
    • (2002) Diabetologia , vol.45 , Issue.7 , pp. 937-948
    • Cryer, P.E.1
  • 30
    • 82255185915 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide: A bifunctional glucose-dependent regulator of glucagon and insulin secretion in humans
    • Christensen M, Vedtofte L, Holst JJ, Vilsbøll T, Knop FK. Glucose-dependent insulinotropic polypeptide: a bifunctional glucose-dependent regulator of glucagon and insulin secretion in humans. Diabetes. 2011;60(12):3103-3109.
    • (2011) Diabetes , vol.60 , Issue.12 , pp. 3103-3109
    • Christensen, M.1    Vedtofte, L.2    Holst, J.J.3    Vilsbøll, T.4    Knop, F.K.5
  • 31
    • 78851471216 scopus 로고    scopus 로고
    • Clinical evidence and mechanistic basis for vildagliptin's action when added to metformin
    • Ahrén B, Foley JE, Bosi E. Clinical evidence and mechanistic basis for vildagliptin's action when added to metformin. Diabetes Obes Metab. 2011;13(3):193-203.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.3 , pp. 193-203
    • Ahrén, B.1    Foley, J.E.2    Bosi, E.3
  • 32
    • 36448968168 scopus 로고    scopus 로고
    • Bodyweight changes associated with antihyperglycaemic agents in type 2 diabetes mellitus
    • Hermansen K, Mortensen LS. Bodyweight changes associated with antihyperglycaemic agents in type 2 diabetes mellitus. Drug Saf. 2007;30(12):1127-1142.
    • (2007) Drug Saf , vol.30 , Issue.12 , pp. 1127-1142
    • Hermansen, K.1    Mortensen, L.S.2
  • 33
    • 77955456705 scopus 로고    scopus 로고
    • Pharmacokinetics of dipeptidylpeptidase-4 inhibitors
    • Scheen AJ. Pharmacokinetics of dipeptidylpeptidase-4 inhibitors. Diabetes Obes Metab. 2010;12(8):648-658.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.8 , pp. 648-658
    • Scheen, A.J.1
  • 34
    • 41149118550 scopus 로고    scopus 로고
    • (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3, 7-dihydro-purine-2, 6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors
    • Thomas L, Eckhardt M, Langkopf E, Tadayyon M, Himmelsbach F, Mark M. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3, 7-dihydro-purine-2, 6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors. J Pharmacol Exp Ther. 2008;325(1):175-182.
    • (2008) J Pharmacol Exp Ther , vol.325 , Issue.1 , pp. 175-182
    • Thomas, L.1    Eckhardt, M.2    Langkopf, E.3    Tadayyon, M.4    Himmelsbach, F.5    Mark, M.6
  • 35
    • 84889804943 scopus 로고    scopus 로고
    • Tradjenta® (linagliptin) tablets [package insert]. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc
    • Tradjenta® (linagliptin) tablets [package insert]. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc; 2011.
    • (2011)
  • 36
    • 84889874375 scopus 로고    scopus 로고
    • fda.gov [homepage on the internet]. Tradjenta (linagliptin) Prescribing Information September 2012; Available from, Accessed October 9
    • fda.gov [homepage on the internet]. Tradjenta (linagliptin) Prescribing Information September 2012; Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/201280s005lbl.pdf. Accessed October 9, 2013.
    • (2013)
  • 37
    • 84859438114 scopus 로고    scopus 로고
    • Safety and tolerability of linagliptin: A pooled analysis of data from randomized controlled trials in 3572 patients with type 2 diabetes mellitus
    • Schernthaner G, Barnett AH, Emser A, et al. Safety and tolerability of linagliptin: a pooled analysis of data from randomized controlled trials in 3572 patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2012;14(5):470-478.
    • (2012) Diabetes Obes Metab , vol.14 , Issue.5 , pp. 470-478
    • Schernthaner, G.1    Barnett, A.H.2    Emser, A.3
  • 38
    • 72049121944 scopus 로고    scopus 로고
    • Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes
    • Deacon CF, Holst JJ. Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes. Expert Opin Investig Drugs. 2010;19(1):133-140.
    • (2010) Expert Opin Investig Drugs , vol.19 , Issue.1 , pp. 133-140
    • Deacon, C.F.1    Holst, J.J.2
  • 39
    • 60449089649 scopus 로고    scopus 로고
    • American Diabetes Association; European Association for Study of Diabetes. Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB, et al; American Diabetes Association; European Association for Study of Diabetes. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2009;32(1):193-203.
    • (2009) Diabetes Care , vol.32 , Issue.1 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 40
    • 34247874561 scopus 로고    scopus 로고
    • Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes
    • Fonseca V, Schweizer A, Albrecht D, Baron MA, Chang I, Dejager S. Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes. Diabetologia. 2007;50(6):1148-1155.
    • (2007) Diabetologia , vol.50 , Issue.6 , pp. 1148-1155
    • Fonseca, V.1    Schweizer, A.2    Albrecht, D.3    Baron, M.A.4    Chang, I.5    Dejager, S.6
  • 41
    • 73349119110 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes
    • Vilsbøll T, Rosenstock J, Yki-Järvinen H, et al. Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes. Diabetes Obes Metab. 2010;12(2):167-177.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.2 , pp. 167-177
    • Vilsbøll, T.1    Rosenstock, J.2    Yki-Järvinen, H.3
  • 42
    • 84859731126 scopus 로고    scopus 로고
    • Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin
    • Barnett AH, Charbonnel B, Donovan M, Fleming D, Chen R. Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin. Curr Med Res Opin. 2012;28(4):513-523.
    • (2012) Curr Med Res Opin , vol.28 , Issue.4 , pp. 513-523
    • Barnett, A.H.1    Charbonnel, B.2    Donovan, M.3    Fleming, D.4    Chen, R.5
  • 43
    • 77950197593 scopus 로고    scopus 로고
    • The metabolism and disposition of the oral dipeptidyl peptidase-4 inhibitor, linagliptin, in humans
    • Blech S, Ludwig-Schwellinger E, Gräfe-Mody EU, Withopf B, Wagner K. The metabolism and disposition of the oral dipeptidyl peptidase-4 inhibitor, linagliptin, in humans. Drug Metab Dispos. 2010;38(4):667-678.
    • (2010) Drug Metab Dispos , vol.38 , Issue.4 , pp. 667-678
    • Blech, S.1    Ludwig-Schwellinger, E.2    Gräfe-Mody, E.U.3    Withopf, B.4    Wagner, K.5
  • 44
    • 78649686908 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: A comparative review
    • Deacon CF. Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review. Diabetes Obes Metab. 2011;13(1): 7-18.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.1 , pp. 7-18
    • Deacon, C.F.1
  • 45
    • 80052530183 scopus 로고    scopus 로고
    • Effect of renal impairment on the pharmacokinetics of the dipeptidyl peptidase-4 inhibitor linagliptin(*)
    • Graefe-Mody U, Friedrich C, Port A, et al. Effect of renal impairment on the pharmacokinetics of the dipeptidyl peptidase-4 inhibitor linagliptin(*). Diabetes Obes Metab. 2011;13(10):939-946.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.10 , pp. 939-946
    • Graefe-Mody, U.1    Friedrich, C.2    Port, A.3
  • 46
    • 77950930001 scopus 로고    scopus 로고
    • CDC CKD Surveillance Team. Prevalence of chronic kidney disease in US adults with undiagnosed diabetes or prediabetes
    • Plantinga LC, Crews DC, Coresh J, et al; CDC CKD Surveillance Team. Prevalence of chronic kidney disease in US adults with undiagnosed diabetes or prediabetes. Clin J Am Soc Nephrol. 2010;5(4):673-682.
    • (2010) Clin J Am Soc Nephrol , vol.5 , Issue.4 , pp. 673-682
    • Plantinga, L.C.1    Crews, D.C.2    Coresh, J.3
  • 47
    • 84904379996 scopus 로고    scopus 로고
    • Renal Impairment Has No Clinically Relevant Effect on the Long-Term Exposure of Linagliptin in Patients With Type 2 Diabetes
    • Epub 2013 Feb 13
    • Friedrich C, Emser A, Woerle H-J, Graefe-Mody U. Renal Impairment Has No Clinically Relevant Effect on the Long-Term Exposure of Linagliptin in Patients With Type 2 Diabetes. Am J Ther. 2013. Epub 2013 Feb 13
    • (2013) Am J Ther
    • Friedrich, C.1    Emser, A.2    Woerle, H.-J.3    Graefe-Mody, U.4
  • 48
    • 84876543147 scopus 로고    scopus 로고
    • Managing diabetic patients with moderate or severe renal impairment using DPP-4 inhibitors: Focus on vildagliptin
    • Russo E, Penno G, Del Prato S. Managing diabetic patients with moderate or severe renal impairment using DPP-4 inhibitors: focus on vildagliptin. Diabetes Metab Syndr Obes. 2013;6:161-170.
    • (2013) Diabetes Metab Syndr Obes , vol.6 , pp. 161-170
    • Russo, E.1    Penno, G.2    Del Prato, S.3
  • 50
    • 45449105789 scopus 로고    scopus 로고
    • Safety and efficacy of sitagliptin in patients with type 2 diabetes and chronic renal insufficiency
    • Chan JC, Scott R, Arjona Ferreira JC, et al. Safety and efficacy of sitagliptin in patients with type 2 diabetes and chronic renal insufficiency. Diabetes Obes Metab. 2008;10(7):545-555.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.7 , pp. 545-555
    • Chan, J.C.1    Scott, R.2    Arjona Ferreira, J.C.3
  • 51
    • 81755181497 scopus 로고    scopus 로고
    • Long-term treatment with the dipeptidyl peptidase-4 inhibitor saxagliptin in patients with type 2 diabetes mellitus and renal impairment: A randomised controlled 52-week efficacy and safety study
    • Nowicki M, Rychlik I, Haller H, et al. Long-term treatment with the dipeptidyl peptidase-4 inhibitor saxagliptin in patients with type 2 diabetes mellitus and renal impairment: a randomised controlled 52-week efficacy and safety study. Int J Clin Pract. 2011;65(12):1230-1239.
    • (2011) Int J Clin Pract , vol.65 , Issue.12 , pp. 1230-1239
    • Nowicki, M.1    Rychlik, I.2    Haller, H.3
  • 52
    • 0033631547 scopus 로고    scopus 로고
    • Impact of end-stage renal disease and dialysis on glycemic control
    • Mak RH. Impact of end-stage renal disease and dialysis on glycemic control. Semin Dial. 2000;13(1):4-8.
    • (2000) Semin Dial , vol.13 , Issue.1 , pp. 4-8
    • Mak, R.H.1
  • 53
    • 80052551137 scopus 로고    scopus 로고
    • Safety and efficacy of vildagliptin versus placebo in patients with type 2 diabetes and moderate or severe renal impairment: A prospective 24-week randomized placebo-controlled trial
    • Lukashevich V, Schweizer A, Shao Q, Groop PH, Kothny W. Safety and efficacy of vildagliptin versus placebo in patients with type 2 diabetes and moderate or severe renal impairment: a prospective 24-week randomized placebo-controlled trial. Diabetes Obes Metab. 2011;13(10):947-954.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.10 , pp. 947-954
    • Lukashevich, V.1    Schweizer, A.2    Shao, Q.3    Groop, P.H.4    Kothny, W.5
  • 54
    • 84867136387 scopus 로고    scopus 로고
    • Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice
    • Rieg T, Gerasimova M, Murray F, et al. Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice. Am J Physiol Renal Physiol. 2012;303(7):F963-F971.
    • (2012) Am J Physiol Renal Physiol , vol.303 , Issue.7
    • Rieg, T.1    Gerasimova, M.2    Murray, F.3
  • 55
    • 84869238002 scopus 로고    scopus 로고
    • DPP-4 inhibition on top of angiotensin receptor blockade offers a new therapeutic approach for diabetic nephropathy
    • Alter ML, Ott IM, von Websky K, et al. DPP-4 inhibition on top of angiotensin receptor blockade offers a new therapeutic approach for diabetic nephropathy. Kidney Blood Press Res. 2012;36(1):119-130.
    • (2012) Kidney Blood Press Res , vol.36 , Issue.1 , pp. 119-130
    • Alter, M.L.1    Ott, I.M.2    von Websky, K.3
  • 57
    • 84889859662 scopus 로고    scopus 로고
    • Boehringer Ingelheim Pharmaceutic. MARLINA: efficacy, safety and modification of albuminuria in type 2 diabetes subjects with renal disease with linagliptin. Available from, NLM identifier: NCT01792518. Accessed May 29
    • Boehringer Ingelheim Pharmaceutic. MARLINA: efficacy, safety and modification of albuminuria in type 2 diabetes subjects with renal disease with linagliptin. Available from: http://www.clinicaltrials.gov/ct2/show/NCT01792518. NLM identifier: NCT01792518. Accessed May 29, 2013
    • (2013)
  • 58
    • 30844463269 scopus 로고    scopus 로고
    • Burden of diabetes in an aging population: Prevalence, incidence, mortality, characteristics and quality of care
    • Spec No 2
    • Fagot-Campagna A, Bourdel-Marchasson I, Simon D. Burden of diabetes in an aging population: prevalence, incidence, mortality, characteristics and quality of care. Diabetes Metab. 2005;31 Spec No 2:S535-S552.
    • (2005) Diabetes Metab , vol.31
    • Fagot-Campagna, A.1    Bourdel-Marchasson, I.2    Simon, D.3
  • 59
    • 33745400514 scopus 로고    scopus 로고
    • Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: A population-based retrospective cohort study
    • Booth GL, Kapral MK, Fung K, Tu JV. Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study. Lancet. 2006;368(9529):29-36.
    • (2006) Lancet , vol.368 , Issue.9529 , pp. 29-36
    • Booth, G.L.1    Kapral, M.K.2    Fung, K.3    Tu, J.V.4
  • 60
    • 0031024007 scopus 로고    scopus 로고
    • Altered hierarchy of protective responses against severe hypoglycemia in normal aging in healthy men
    • Matyka K, Evans M, Lomas J, Cranston I, Macdonald I, Amiel SA. Altered hierarchy of protective responses against severe hypoglycemia in normal aging in healthy men. Diabetes Care. 1997;20(2):135-141.
    • (1997) Diabetes Care , vol.20 , Issue.2 , pp. 135-141
    • Matyka, K.1    Evans, M.2    Lomas, J.3    Cranston, I.4    Macdonald, I.5    Amiel, S.A.6
  • 61
    • 84882932426 scopus 로고    scopus 로고
    • Avoiding hypoglycemia: A key to success for glucose-lowering therapy in type 2 diabetes
    • Ahrén B. Avoiding hypoglycemia: a key to success for glucose-lowering therapy in type 2 diabetes. Vasc Health Risk Manag. 2013;9: 155-163.
    • (2013) Vasc Health Risk Manag , vol.9 , pp. 155-163
    • Ahrén, B.1
  • 64
    • 84883329490 scopus 로고    scopus 로고
    • Safety and efficacy of linagliptin in elderly patients with type 2 diabetes: Evidence from 1331 individuals aged ≥65 years [abstract]
    • Patel S, Schernthaner G, Barnett AH, Emser A, von Eynatten M, Woerle HJ. Safety and efficacy of linagliptin in elderly patients with type 2 diabetes: evidence from 1331 individuals aged ≥65 years [abstract]. Diabetologia. 2012;55(Suppl 1):S351.
    • (2012) Diabetologia , vol.55 , Issue.SUPPL. 1
    • Patel, S.1    Schernthaner, G.2    Barnett, A.H.3    Emser, A.4    von Eynatten, M.5    Woerle, H.J.6
  • 65
    • 84858708626 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors in the elderly: More benefits or risks?
    • Paolisso G, Monami M, Marfella R, Rizzo MR, Mannucci E. Dipeptidyl peptidase-4 inhibitors in the elderly: more benefits or risks? Adv Ther. 2012;29(3):218-233.
    • (2012) Adv Ther , vol.29 , Issue.3 , pp. 218-233
    • Paolisso, G.1    Monami, M.2    Marfella, R.3    Rizzo, M.R.4    Mannucci, E.5
  • 66
    • 59149099759 scopus 로고    scopus 로고
    • The 10-year post-trial follow-up of the United Kingdom Prospective Diabetes Study (UKPDS): Cardiovascular observations in context
    • Gore MO, McGuire DK. The 10-year post-trial follow-up of the United Kingdom Prospective Diabetes Study (UKPDS): cardiovascular observations in context. Diab Vasc Dis Res. 2009;6(1):53-55.
    • (2009) Diab Vasc Dis Res , vol.6 , Issue.1 , pp. 53-55
    • Gore, M.O.1    McGuire, D.K.2
  • 67
    • 21744437313 scopus 로고    scopus 로고
    • ADVANCE: Action in diabetes and vascular disease
    • Patel A, Chalmers J, Poulter N. ADVANCE: action in diabetes and vascular disease. J Hum Hypertens. 2005;19 Suppl 1:S27-S32.
    • (2005) J Hum Hypertens , vol.19 , Issue.SUPPL. 1
    • Patel, A.1    Chalmers, J.2    Poulter, N.3
  • 68
    • 58149389215 scopus 로고    scopus 로고
    • VADT Investigators. Glucose control and vascular complications in veterans with type 2 diabetes
    • Duckworth W, Abraira C, Moritz T, et al; VADT Investigators. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009;360(2):129-139.
    • (2009) N Engl J Med , vol.360 , Issue.2 , pp. 129-139
    • Duckworth, W.1    Abraira, C.2    Moritz, T.3
  • 69
    • 45149131667 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering in type 2 diabetes
    • Action to Control Cardiovascular Risk in Diabetes Study Group; Gerstein HC
    • Action to Control Cardiovascular Risk in Diabetes Study Group; Gerstein HC, Miller ME, Byington RP, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358(24):2545-2559.
    • (2008) N Engl J Med , vol.358 , Issue.24 , pp. 2545-2559
    • Miller, M.E.1    Byington, R.P.2
  • 70
    • 77956069166 scopus 로고    scopus 로고
    • Hypoglycemia, diabetes, and cardiovascular events
    • Desouza CV, Bolli GB, Fonseca V. Hypoglycemia, diabetes, and cardiovascular events. Diabetes Care. 2010;33(6):1389-1394.
    • (2010) Diabetes Care , vol.33 , Issue.6 , pp. 1389-1394
    • Desouza, C.V.1    Bolli, G.B.2    Fonseca, V.3
  • 71
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med. 2007;356(24):2457-2471.
    • (2007) N Engl J Med , vol.356 , Issue.24 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 72
    • 77956570029 scopus 로고    scopus 로고
    • Effects of oral glucose-lowering drugs on long term outcomes in patients with diabetes mellitus following myocardial infarction not treated with emergent percutaneous coronary intervention-a retrospective nationwide cohort study
    • Jørgensen CH, Gislason GH, Andersson C, et al. Effects of oral glucose-lowering drugs on long term outcomes in patients with diabetes mellitus following myocardial infarction not treated with emergent percutaneous coronary intervention-a retrospective nationwide cohort study. Cardiovasc Diabetol. 2010;9:54.
    • (2010) Cardiovasc Diabetol , vol.9 , pp. 54
    • Jørgensen, C.H.1    Gislason, G.H.2    Andersson, C.3
  • 73
    • 31544482787 scopus 로고    scopus 로고
    • Dose-response relation between sulfonylurea drugs and mortality in type 2 diabetes mellitus: A population-based cohort study
    • Simpson SH, Majumdar SR, Tsuyuki RT, Eurich DT, Johnson JA. Dose-response relation between sulfonylurea drugs and mortality in type 2 diabetes mellitus: a population-based cohort study. CMAJ. 2006;174(2):169-174.
    • (2006) CMAJ , vol.174 , Issue.2 , pp. 169-174
    • Simpson, S.H.1    Majumdar, S.R.2    Tsuyuki, R.T.3    Eurich, D.T.4    Johnson, J.A.5
  • 74
    • 84889857113 scopus 로고    scopus 로고
    • US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER). Guidance for Industry: Diabetes Mellitus-Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes. Silver Spring, MD: US Department of Health and Human Services; 2008. Available from, Accessed September 25
    • US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER). Guidance for Industry: Diabetes Mellitus-Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes. Silver Spring, MD: US Department of Health and Human Services; 2008. Available from: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm071627.pdf. Accessed September 25, 2013.
    • (2013)
  • 75
    • 84855481995 scopus 로고    scopus 로고
    • Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: A pre-specified, prospective, and adjudicated meta-analysis of a phase 3 programme
    • Johansen OE, Neubacher D, von Eynatten M, Patel S, Woerle HJ. Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: a pre-specified, prospective, and adjudicated meta-analysis of a phase 3 programme. Cardiovasc Diabetol. 2012;11:3.
    • (2012) Cardiovasc Diabetol , vol.11 , pp. 3
    • Johansen, O.E.1    Neubacher, D.2    von Eynatten, M.3    Patel, S.4    Woerle, H.J.5
  • 76
    • 84875907876 scopus 로고    scopus 로고
    • Efficacy and safety of linagliptin in type 2 diabetes subjects at high risk for renal and cardiovascular disease: A pooled analysis of six phase III clinical trials
    • von Eynatten M, Gong Y, Emser A, Woerle HJ. Efficacy and safety of linagliptin in type 2 diabetes subjects at high risk for renal and cardiovascular disease: a pooled analysis of six phase III clinical trials. Cardiovasc Diabetol. 2013;12:60.
    • (2013) Cardiovasc Diabetol , vol.12 , pp. 60
    • von Eynatten, M.1    Gong, Y.2    Emser, A.3    Woerle, H.J.4
  • 77
    • 84864757433 scopus 로고    scopus 로고
    • 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: A randomised, double-blind, non-inferiority trial
    • Gallwitz B, Rosenstock J, Rauch T, et al. 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial. Lancet. 2012;380(9840):475-483.
    • (2012) Lancet , vol.380 , Issue.9840 , pp. 475-483
    • Gallwitz, B.1    Rosenstock, J.2    Rauch, T.3
  • 78
    • 77953108350 scopus 로고    scopus 로고
    • A systematic assessment of cardiovascular outcomes in the saxagliptin drug development program for type 2 diabetes
    • Frederich R, Alexander JH, Fiedorek FT, et al. A systematic assessment of cardiovascular outcomes in the saxagliptin drug development program for type 2 diabetes. Postgrad Med. 2010;122(3):16-27.
    • (2010) Postgrad Med , vol.122 , Issue.3 , pp. 16-27
    • Frederich, R.1    Alexander, J.H.2    Fiedorek, F.T.3
  • 79
    • 77951069227 scopus 로고    scopus 로고
    • Safety and tolerability of sitagliptin in clinical studies: A pooled analysis of data from 10, 246 patients with type 2 diabetes
    • Williams-Herman D, Engel SS, Round E, et al. Safety and tolerability of sitagliptin in clinical studies: a pooled analysis of data from 10, 246 patients with type 2 diabetes. BMC Endocr Disord. 2010;10:7.
    • (2010) BMC Endocr Disord , vol.10 , pp. 7
    • Williams-Herman, D.1    Engel, S.S.2    Round, E.3
  • 80
    • 77953182696 scopus 로고    scopus 로고
    • Assessing the cardio-cerebrovascular safety of vildagliptin: Meta-analysis of adjudicated events from a large Phase III type 2 diabetes population
    • Schweizer A, Dejager S, Foley JE, Couturier A, Ligueros-Saylan M, Kothny W. Assessing the cardio-cerebrovascular safety of vildagliptin: meta-analysis of adjudicated events from a large Phase III type 2 diabetes population. Diabetes Obes Metab. 2010;12(6):485-494.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.6 , pp. 485-494
    • Schweizer, A.1    Dejager, S.2    Foley, J.E.3    Couturier, A.4    Ligueros-Saylan, M.5    Kothny, W.6
  • 81
    • 84889821480 scopus 로고    scopus 로고
    • Boehringer Ingelheim Pharmaceuticals. CAROLINA: cardiovascular outcome study of linagliptin versus glimepiride in patients with type 2 diabetes. Available from, NLM identifier: NCT01243424. Accessed May 29
    • Boehringer Ingelheim Pharmaceuticals. CAROLINA: cardiovascular outcome study of linagliptin versus glimepiride in patients with type 2 diabetes. Available from: http://www.clinicaltrials.gov/ct2/show/NCT01243424?term=NCT01243424&rank=1. NLM identifier: NCT01243424. Accessed May 29, 2013.
    • (2013)
  • 82
    • 84889841440 scopus 로고    scopus 로고
    • Takeda Global Research and Development Center, Inc. Cardiovascular outcomes study of alogliptin in subjects with type 2 diabetes and acute coronary syndrome (EXAMINE). Available from, NLM identifier: NCT00968708. Accessed May 29
    • Takeda Global Research and Development Center, Inc. Cardiovascular outcomes study of alogliptin in subjects with type 2 diabetes and acute coronary syndrome (EXAMINE). Available from: http://clinicaltrials.gov/ct2/show/NCT00968708?term=NCT00968708&rank=1. NLM identifier: NCT00968708. Accessed May 29, 2013.
    • (2013)
  • 83
    • 84855770694 scopus 로고    scopus 로고
    • Saxagliptin for the treatment of type 2 diabetes mellitus: Assessing cardiovascular data
    • Cobble ME, Frederich R. Saxagliptin for the treatment of type 2 diabetes mellitus: assessing cardiovascular data. Cardiovasc Diabetol. 2012;11:6.
    • (2012) Cardiovasc Diabetol , vol.11 , pp. 6
    • Cobble, M.E.1    Frederich, R.2
  • 84
    • 84889775340 scopus 로고    scopus 로고
    • Amylin Pharmaceuticals, LLC. Exenatide study of cardiovascular event lowering trial (EXSCEL): a trial to evaluate cardiovascular outcomes after treatment with exenatide once weekly in patients with type 2 diabetes mellitus. Available from, NLM identifier: NCT01144338. Accessed May 29
    • Amylin Pharmaceuticals, LLC. Exenatide study of cardiovascular event lowering trial (EXSCEL): a trial to evaluate cardiovascular outcomes after treatment with exenatide once weekly in patients with type 2 diabetes mellitus. Available from: http://www.clinicaltrials.gov/ct2/show/NCT01144338?term=ExenatideStudyofCardiovascularEventLoweringTrial(EXSCEL)&rank=1. NLM identifier: NCT01144338. Accessed May 29, 2013.
    • (2013)
  • 85
    • 84889765191 scopus 로고    scopus 로고
    • Novo Nordisk. Liraglutide effect and action in diabetes: evaluation of cardiovascular outcome results-a long term evaluation (LEADER®). Available from, NLM identifier: NCT01179048. Accessed May 29
    • Novo Nordisk. Liraglutide effect and action in diabetes: evaluation of cardiovascular outcome results-a long term evaluation (LEADER®). Available from: http://www.clinicaltrials.gov/ct2/show/NCT01179048?term=LiraglutideEffectandActioninDiabets(LEADER)&rank=1. NLM identifier: NCT01179048. Accessed May 29, 2013.
    • (2013)
  • 86
    • 84889847563 scopus 로고    scopus 로고
    • SAVOR TIMI 53 Steering Committee and Investigators. Saxagliptin assessment of vascular outcomes recorded in patients with diabetes mellitus (SAVOR)-TIMI 53 study
    • August 30-September 3; 2013; Amsterdam, The Netherlands. Available from, Accessed September 25
    • Bhatt DL; SAVOR TIMI 53 Steering Committee and Investigators. Saxagliptin assessment of vascular outcomes recorded in patients with diabetes mellitus (SAVOR)-TIMI 53 study. Presented at the European Society of Cardiology Congress; August 30-September 3; 2013; Amsterdam, The Netherlands. Available from: http://www.escardio.org/about/press/esc-congress-2013/press-conferences/Documents/slides/bhatt.pdf. Accessed September 25, 2013.
    • (2013) Presented At the European Society of Cardiology Congress
    • Bhatt, D.L.1
  • 87
    • 84878587722 scopus 로고    scopus 로고
    • The novel DPP-4 inhibitors linagliptin and BI 14361 reduce infarct size after myocardial ischemia/reperfusion in rats
    • Hocher B, Sharkovska Y, Mark M, Klein T, Pfab T. The novel DPP-4 inhibitors linagliptin and BI 14361 reduce infarct size after myocardial ischemia/reperfusion in rats. Int J Cardiol. 2013;167(1): 87-93.
    • (2013) Int J Cardiol , vol.167 , Issue.1 , pp. 87-93
    • Hocher, B.1    Sharkovska, Y.2    Mark, M.3    Klein, T.4    Pfab, T.5
  • 88
    • 81355124070 scopus 로고    scopus 로고
    • Effects of DPP-4 inhibitors on the heart in a rat model of uremic cardiomyopathy
    • Chaykovska L, von Websky K, Rahnenführer J, et al. Effects of DPP-4 inhibitors on the heart in a rat model of uremic cardiomyopathy. PLoS One. 2011;6(11):e27861.
    • (2011) PLoS One , vol.6 , Issue.11
    • Chaykovska, L.1    von Websky, K.2    Rahnenführer, J.3
  • 89
    • 77953639418 scopus 로고    scopus 로고
    • Translating comparative effectiveness into practice: The case of diabetes medications
    • Shah ND, Mullan RJ, Breslin M, Yawn BP, Ting HH, Montori VM. Translating comparative effectiveness into practice: the case of diabetes medications. Med Care. 2010;48(Suppl 6):S153-S158.
    • (2010) Med Care , vol.48 , Issue.SUPPL. 6
    • Shah, N.D.1    Mullan, R.J.2    Breslin, M.3    Yawn, B.P.4    Ting, H.H.5    Montori, V.M.6
  • 90
    • 33745047332 scopus 로고    scopus 로고
    • Diabetes-specific emotional distress among African Americans and Hispanics with type 2 diabetes
    • Spencer MS, Kieffer EC, Sinco BR, et al. Diabetes-specific emotional distress among African Americans and Hispanics with type 2 diabetes. J Health Care Poor Underserved. 2006;17(Suppl 2):88-105.
    • (2006) J Health Care Poor Underserved , vol.17 , Issue.SUPPL. 2 , pp. 88-105
    • Spencer, M.S.1    Kieffer, E.C.2    Sinco, B.R.3
  • 91
    • 53249142132 scopus 로고    scopus 로고
    • DURATION-1 Study Group. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study
    • Drucker DJ, Buse JB, Taylor K, et al; DURATION-1 Study Group. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet. 2008;372(9645):1240-1250.
    • (2008) Lancet , vol.372 , Issue.9645 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3
  • 92
    • 84889850193 scopus 로고    scopus 로고
    • Boehringer Ingelheim Pharmaceuticals. Safety and efficacy in type 2 diabetic patients with severe chronic renal impairment, 5 mg BI 1356 (Linagliptin) vs placebo, insulin background inclusive. Available from, NLM identifier NCT00800683. Accessed May 29
    • Boehringer Ingelheim Pharmaceuticals. Safety and efficacy in type 2 diabetic patients with severe chronic renal impairment, 5 mg BI 1356 (Linagliptin) vs placebo, insulin background inclusive. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00800683?term=NCT00800683&rank=1. NLM identifier: NCT00800683. Accessed May 29, 2013.
    • (2013)
  • 93
    • 84889803141 scopus 로고    scopus 로고
    • Boehringer Ingelheim Pharmaceuticals. Efficacy and safety of linagliptin in elderly patients with type 2 diabetes. Available from, NLM identifier: NCT01084005. Accessed May 29
    • Boehringer Ingelheim Pharmaceuticals. Efficacy and safety of linagliptin in elderly patients with type 2 diabetes. Available from: http://www.clinicaltrials.gov/ct2/show/NCT01084005?term=NCT01084005&rank=1. NLM identifier: NCT01084005. Accessed May 29, 2013.
    • (2013)
  • 94
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • Exenatide-113 Clinical Study Group
    • Buse JB, Henry RR, Han J, Kim DD, Fineman MS, Baron AD; Exenatide-113 Clinical Study Group. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care. 2004;27(11):2628-2635.
    • (2004) Diabetes Care , vol.27 , Issue.11 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 95
    • 34547650859 scopus 로고    scopus 로고
    • Comparison of extended-release metformin in combination with a sulfonylurea (glyburide) to sulfonylurea monotherapy in adult patients with type 2 diabetes: A multicenter, double-blind, randomized, controlled, phase III study
    • Lewin A, Lipetz R, Wu J, Schwartz S. Comparison of extended-release metformin in combination with a sulfonylurea (glyburide) to sulfonylurea monotherapy in adult patients with type 2 diabetes: a multicenter, double-blind, randomized, controlled, phase III study. Clin Ther. 2007;29(5):844-855.
    • (2007) Clin Ther , vol.29 , Issue.5 , pp. 844-855
    • Lewin, A.1    Lipetz, R.2    Wu, J.3    Schwartz, S.4
  • 96
    • 84889805980 scopus 로고    scopus 로고
    • ONGLYZA® (saxagliptin) tablets [package insert]. Princeton, NJ: Bristol-Myers Squibb
    • ONGLYZA® (saxagliptin) tablets [package insert]. Princeton, NJ: Bristol-Myers Squibb; 2011.
    • (2011)
  • 97
    • 84889853611 scopus 로고    scopus 로고
    • JANUVIA® (sitagliptin) tablets [package insert]. Whitehouse Station, NJ: Merck Sharp and Dohme Corp
    • JANUVIA® (sitagliptin) tablets [package insert]. Whitehouse Station, NJ: Merck Sharp and Dohme Corp; 2006.
    • (2006)
  • 98
    • 84873873967 scopus 로고    scopus 로고
    • Improved glycaemic control with vildagliptin added to insulin, with or without metformin, in patients with type 2 diabetes mellitus
    • Kothny W, Foley J, Kozlovski P, Shao Q, Gallwitz B, Lukashevich V. Improved glycaemic control with vildagliptin added to insulin, with or without metformin, in patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2013;15(3):252-257.
    • (2013) Diabetes Obes Metab , vol.15 , Issue.3 , pp. 252-257
    • Kothny, W.1    Foley, J.2    Kozlovski, P.3    Shao, Q.4    Gallwitz, B.5    Lukashevich, V.6
  • 99
    • 70450173642 scopus 로고    scopus 로고
    • Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemia
    • Rosenstock J, Rendell MS, Gross JL, Fleck PR, Wilson CA, Mekki Q. Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemia. Diabetes Obes Metab. 2009;11(12):1145-1152.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.12 , pp. 1145-1152
    • Rosenstock, J.1    Rendell, M.S.2    Gross, J.L.3    Fleck, P.R.4    Wilson, C.A.5    Mekki, Q.6
  • 101
    • 65249095686 scopus 로고    scopus 로고
    • Vildagliptin enhances islet responsiveness to both hyper-and hypoglycemia in patients with type 2 diabetes
    • Ahrén B, Schweizer A, Dejager S, et al. Vildagliptin enhances islet responsiveness to both hyper-and hypoglycemia in patients with type 2 diabetes. J Clin Endocrinol Metab. 2009;94(4):1236-1243.
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.4 , pp. 1236-1243
    • Ahrén, B.1    Schweizer, A.2    Dejager, S.3
  • 102
    • 0036959991 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers
    • Nauck MA, Heimesaat MM, Behle K, et al. Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. J Clin Endocrinol Metab. 2002;87(3):1239-1246.
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.3 , pp. 1239-1246
    • Nauck, M.A.1    Heimesaat, M.M.2    Behle, K.3


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