17β-estradiol and estradiol fatty acyl esters and estrogen-Converting enzyme expression in adipose tissue in obese men and women

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 12, 2013, Pages 4923-4931

  Wang, Feng ^a,b,c   Vihma, Veera ^a,b,c   Soronen, Jarkko ^f   Turpeinen, Ursula ^d   Hämäläinen, Esa ^d   Savolainen Peltonen, Hanna ^a,e   Mikkola, Tomi S ^a,e   Naukkarinen, Jussi ^c,e   Pietiläinen, Kirsi H ^c,e   Jauhiainen, Matti ^f   Yki Järvinen, Hannele ^b   Tikkanen, Matti J ^b,c  

^a FOLKHÄLSAN RESEARCH CENTER   (Finland)

^b Institute of Clinical Medicine   (South Korea)

^c Research Programs Unit   (Finland)

^d Division of Cardiology   (Finland)

^e HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^f NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; ESTRADIOL; ESTRADIOL FATTY ACYL ESTER; ESTROGEN CONVERTING ENZYME; FATTY ACID ESTER; MESSENGER RNA; STERYL SULFATASE; TESTOSTERONE 17BETA DEHYDROGENASE; TESTOSTERONE 17BETA DEHYDROGENASE 1; TESTOSTERONE 17BETA DEHYDROGENASE 12; TESTOSTERONE 17BETA DEHYDROGENASE 7; UNCLASSIFIED DRUG;

ABDOMINAL SUBCUTANEOUS FAT; ADIPOSE TISSUE; ADULT; ARTICLE; BARIATRIC SURGERY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ESTRADIOL BLOOD LEVEL; ESTROGEN SYNTHESIS; FEMALE; FLUOROIMMUNOASSAY; GENE EXPRESSION; HORMONE DETERMINATION; HUMAN; HUMAN TISSUE; INTRAABDOMINAL FAT; LIQUID CHROMATOGRAPHY; MALE; MIDDLE AGED; OBESITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SEX DIFFERENCE; TANDEM MASS SPECTROMETRY; TISSUE LEVEL;

17-HYDROXYSTEROID DEHYDROGENASES; ACYLATION; ADULT; BODY MASS INDEX; ESTRADIOL; FATTY ACIDS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTRA-ABDOMINAL FAT; ISOENZYMES; MALE; MIDDLE AGED; OBESITY, MORBID; RNA, MESSENGER; SEX CHARACTERISTICS; STEREOISOMERISM; STERYL-SULFATASE; SUBCUTANEOUS FAT, ABDOMINAL;

EID: 84889818096     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-2605     Document Type: Article

References (35)

1. Forney JP, Milewich L, Chen GT, et al. Aromatization of androstenedione to estrone by human adipose tissue in vitro. Correlation with adipose tissue mass, age, and endometrial neoplasia. J Clin Endocrinol Metab. 1981;53:192-199
2. Edman CD, MacDonald PC. Effect of obesity on conversion of plasma androstenedione to estrone in ovulatory and anovulatory young women. Am J Obstet Gynecol. 1978;130:456-461
3. Bellemare V, Laberge P, Noël S, Tchernof A, Luu-The V. Differential estrogenic 17β-hydroxysteroid dehydrogenase activity and type 12 17β-hydroxysteroid dehydrogenase expression levels in preadipocytes and differentiated adipocytes. J Steroid Biochem Mol Biol. 2009;114:129-134
4. Marchais-Oberwinkler S, Henn C, Möller G, et al. 17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development. J Steroid Biochem Mol Biol. 2011;125:66-82
5. Palin SL, McTernan PG, Anderson LA, Sturdee DW, Barnett AH, Kumar S. 17β-Estradiol and anti-estrogen ICI:Compound 182,780 regulate expression of lipoprotein lipase and hormone-sensitive lipase in isolated subcutaneous abdominal adipocytes. Metabolism. 2003;52:383-388
6. Cooke PS, Naaz A. Role of estrogens in adipocyte development and function. Exp Biol Med (Maywood). 2004;229:1127-1135
7. Kanji SS, Kuohung W, Labaree DC, Hochberg RB. Regiospecific esterification of estrogens by lecithin:cholesterol acyltransferase. J Clin Endocrinol Metab. 1999;84:2481-2488
8. Wang F, Vihma V, Badeau M, et al. Fatty acyl esterification and deesterification of 17β-estradiol in human breast subcutaneous adipose tissue. J Clin Endocrinol Metab. 2012;97:3349-3356
9. Larner JM, Shackleton CH, Roitman E, Schwartz PE, Hochberg RB. Measurement of estradiol-17-fatty acid esters in human tissues. J Clin Endocrinol Metab. 1992;75:195-200
10. Badeau M, Vihma V, Mikkola TS, Tiitinen A, Tikkanen MJ. Estradiol fatty acid esters in adipose tissue and serum of pregnant and pre- and postmenopausal women. J Clin Endocrinol Metab. 2007; 92:4327-4331
11. 3H]estradiol- 17β metabolites in calf perirenal fat. Analyst. 1994;119: 2623-2626
12. MaumeD, Deceuninck Y, Pouponneau K, Paris A, Le Bizec B, André F. Assessment of estradiol and its metabolites in meat.APMIS. 2001; 109:32-38
13. Pahuja SL, Hochberg RB. A comparison of the esterification of steroids by rat lecithin:cholesterol acyltransferase and acyl coenzyme A:cholesterol acyltransferase. Endocrinology. 1995;136:180-186
14. Höckerstedt A, Tikkanen MJ, Jauhiainen M. LCAT facilitates transacylation of 17β-estradiol in the presence of HDL3 subfraction. J Lipid Res. 2002;43:392-397
15. Vihma V, Tikkanen MJ. Fatty acid esters of steroids: synthesis and metabolism in lipoproteins and adipose tissue. J Steroid Biochem Mol Biol. 2011;124:65-76
16. Schneider G, Kirschner MA, Berkowitz R, Ertel NH. Increased estrogen production in obese men. J Clin Endocrinol Metab. 1979; 48:633-638
17. Zumoff B, Strain GW, Kream J, O'Connor J, Levin J, Fukushima DK. Obese young men have elevated plasma estrogen levels but obese premenopausal women do not. Metabolism. 1981;30:1011-1014
18. RohrmannS, ShielsMS,Lopez DS, et al. Body fatness and sex steroid hormone concentrations in US men: results fromNHANES 3. Cancer Causes Control. 2011;22:1141-1151
19. Deslypere JP, Verdonck L, Vermeulen A. Fat tissue: a steroid reservoir and site of steroid metabolism. J Clin Endocrinol Metab. 1985; 61:564-570
20. Blankenstein MA,Szymczak J, Daroszewski J, Milewicz A, Thijssen JH. Estrogens in plasma and fatty tissue from breast cancer patients and women undergoing surgery for non-oncological reasons. Gynecol Endocrinol. 1992;6:13-17
21. Falk RT, Gentzschein E, Stanczyk FZ, et al. Measurement of sex steroid hormones in breast adipocytes: methods and implications. Cancer Epidemiol Biomarkers Prev. 2008;17:1891-1895
22. Agarwal VR, Ashanullah CI, Simpson ER, Bulun SE. Alternatively spliced transcripts of the aromatase cytochrome P450 (CYP19) gene in adipose tissue of women. J Clin Endocrinol Metab. 1997;82:70-74
23. Bélanger C, Hould FS, Lebel S, Biron S, Brochu G, Tchernof A. Omental and subcutaneous adipose tissue steroid levels in obese men. Steroids. 2006;71:674-682
24. Vandesompele J,DePreter K, Pattyn F, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002;3:research0034.1-0034.11
25. Hurtado del Pozo C, Calvo RM, Vesperinas-García G, et al. IPO8 and FBXL10: New reference genes for gene expression studies in human adipose tissue. Obesity (Silver Spring). 2010;18:897-903
26. Vihma V, Adlercreutz H, Tiitinen A, Kiuru P, Wähälä K, Tikkanen MJ. Quantitative determination of estradiol fatty acid esters in humanpregnancy serum and ovarian follicular fluid. ClinChem. 2001; 47:1256-1262
27. Blouin K, Nadeau M, Mailloux J, et al. Pathways of adipose tissue androgen metabolism in women: depot differences and modulation by adipogenesis. Am J Physiol Endocrinol Metab. 2009;296:E244-E255
28. Ray H, Pinteur C, Frering V, Beylot M, Large V. Depot-specific differences in perilipin and hormone-sensitive lipase expression in lean and obese. Lipids Health Dis. 2009;8:58
29. Blouin K, Richard C, Brochu G, et al. Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men. J Endocrinol. 2006;191:637-649
30. Wake DJ, Strand M, Rask E, et al. Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity. Clin Endocrinol (Oxf). 2007;66:440-446
31. Quinkler M, Sinha B, Tomlinson JW, Bujalska IJ, Stewart PM, Arlt W. Androgen generation in adipose tissue in women with simple obesity-a site-specific role for 17β-hydroxysteroid dehydrogenase type 5. J Endocrinol. 2004;183:331-342
32. Wang L, Li S, Zhao A, et al. The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients. J Steroid Biochem Mol Biol. 2012;132:120-126
33. Sell H, Habich C, Eckel J. Adaptive immunity in obesity and insulin resistance. Nat Rev Endocrinol. 2012;8:709-716
34. Zhao Y, Nichols JE, Bulun SE, Mendelson CR, Simpson ER. Aromatase P450 gene expression in human adipose tissue. Role of a Jak/STAT pathway in regulation of the adipose-specific promoter. J Biol Chem. 1995;270:16449-16457
35. Lavallée B, Provost PR, Kahwash Z, Nestler JE, Bélanger A. Effect of insulin on serum levels of dehydroepiandrosterone metabolites in men. Clin Endocrinol (Oxf). 1997;46:93-100