A Guide to Measuring and Interpreting Φ-values

Protein Folding Handbook

Volumn 1, Issue , 2008, Pages 445-453

  Guydosh, Nicholas R ^a   Fersht, Alan R ^b  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Deletions; Measuring; Mutations; Thermodynamic data; Tools

Indexed keywords

EID: 84889792013     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527619498.ch13     Document Type: Chapter

References (19)

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8. Carroll, F. A. Perspectives on Structure and Mechanism in Organic Chemistry. Brooks/Cole Publishing, London (1998).
9. Jackson, S. E., Moracci, M., El Masry, N., Johnson, C. M. & Fersht, A. R. Effects of cavity-creating mutations in the hydrophobic core of chymotrypsin inhibitor 2. Biochemistry 32, 11259-11269 (1993).
10. Serrano, L., Neira, J.-L., Sancho, J. & Fersht, A. R. Effect of alanine versus glycine in a-helices on protein stability. Nature 356, 453-455 (1992).
11. Burton, R. E., Huang, G. S., Daugherty, M. A., Calderone, T. L. & Oas, T. G. The energy landscape of a fast-folding protein mapped by Ala-Gly Substitutions. Nature Struct. Biol. 4, 305-310 (1997).
12. Fersht, A. R., Itzhaki, L. S., ElMasry, N. F., Matthews, J. M. & Otzen, D. E. Single versus parallel pathways of protein folding and fractional formation of structure in the transition state. Proc. Natl Acad. Sci. USA 91, 10426-10429 (1994).
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14. Viguera, A. R., Vega, C. & Serrano, L. Unspecific hydrophobic stabilization of folding transition states. Proc. Natl Acad. Sci. USA 99, 5349-5354 (2001).
15. Ventura, S., Vega, M. C., Lacroix, E., Angrand, I., Spagnolo, L. & Serrano, L. Conformational strain in the hydrophobic core and its implications for protein folding and design. Nature Struct. Biol. 9, 485-493 (2002).
16. Bond, C. J., Wong, K. B., Clarke, J., Fersht, A. R. & Daggett, V. Characterization of residual structure in the thermally denatured state of barnase by simulation and experiment: description of the folding pathway. Proc. Natl Acad. Sci. USA 9, 13409-13413 (1997).
17. Fersht, A. Structure and Mechanism in Protein Science. W.H. Freeman and Company, New York (1998).
18. Matouschek, A., Otzen, D. E., Itzhaki, L. S., Jackson, S. E. & Fersht, A. R. Movement of the position of the transition state in protein folding. Biochemistry 17, 13656-13662 (1995).
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