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Volumn 2, Issue , 2008, Pages 619-640

Skeletal Development

Author keywords

Endochondral skeletal development; Growth plate structure; Linear growth; Membranous skeletal development; Skeletal morphogenesis

Indexed keywords


EID: 84889782793     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527619689.ch16     Document Type: Chapter
Times cited : (4)

References (114)
  • 1
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • Lander, E.S., Linton, L.M., Birren, B., Nusbaum, C., Zody, M.C.,. et al., Initial sequencing and analysis of the human genome. Nature 2001; 409: 860-921.
    • (2001) Nature , vol.409 , pp. 860-921
    • Lander, E.S.1    Linton, L.M.2    Birren, B.3    Nusbaum, C.4    Zody, M.C.5
  • 3
    • 0029787411 scopus 로고    scopus 로고
    • Molecular genetic basis of the human chondrodysplasias
    • Horton, W.A., Molecular genetic basis of the human chondrodysplasias. Endocrinol Metab Clin North Am 1996; 25: 683-697.
    • (1996) Endocrinol Metab Clin North Am , vol.25 , pp. 683-697
    • Horton, W.A.1
  • 4
    • 0011344831 scopus 로고    scopus 로고
    • Chondrodysplasias
    • (4th edn), Rimoin, D.L., Connor, J.M., Pyeritz, R. E. and Korf, B. R. (Eds). Churchill Livingstone: New York
    • Rimoin, D.L., Lachman, R. S. and Unger, S., Chondrodysplasias. In Emery and Remoin's Principles and Practice of Medical Genetics (4th edn), Rimoin, D.L., Connor, J.M., Pyeritz, R. E. and Korf, B. R. (Eds). Churchill Livingstone: New York, 2002, pp. 4071-4115.
    • (2002) Emery and Remoin's Principles and Practice of Medical Genetics , pp. 4071-4115
    • Rimoin, D.L.1    Lachman, R.S.2    Unger, S.3
  • 5
    • 0038688357 scopus 로고    scopus 로고
    • The genetic basis for skeletal diseases
    • Zelzer, E. and Olsen, B.R., The genetic basis for skeletal diseases. Nature 2003; 423: 343-348.
    • (2003) Nature , vol.423 , pp. 343-348
    • Zelzer, E.1    Olsen, B.R.2
  • 6
    • 0028836022 scopus 로고
    • Toward a molecular understanding of skeletal development
    • Erlebacher, A., Filvaroff, E.H., Gitelman, S. E. and Derynck, R., Toward a molecular understanding of skeletal development. Cell 1995; 80: 371-378.
    • (1995) Cell , vol.80 , pp. 371-378
    • Erlebacher, A.1    Filvaroff, E.H.2    Gitelman, S.E.3    Derynck, R.4
  • 8
    • 0037673939 scopus 로고    scopus 로고
    • Cranial skeletal biology
    • Helms, J. A. and Schneider, R.A., Cranial skeletal biology. Nature 2003; 423: 326-331.
    • (2003) Nature , vol.423 , pp. 326-331
    • Helms, J.A.1    Schneider, R.A.2
  • 9
    • 84973527201 scopus 로고    scopus 로고
    • Development of bone and cartilage
    • Epstein, C.J., Erickson, R. P. and Winshaw-Boris, A. (Eds). Oxford University Press: New York
    • Murakami, S., Akiyama, H. and de Crombrugghe, B., Development of bone and cartilage. In Inborn Errors of Development, Epstein, C.J., Erickson, R. P. and Winshaw-Boris, A. (Eds). Oxford University Press: New York, 2004, pp. 133-147.
    • (2004) Inborn Errors of Development , pp. 133-147
    • Murakami, S.1    Akiyama, H.2    De Crombrugghe, B.3
  • 10
    • 0033973655 scopus 로고    scopus 로고
    • All for one and one for all: condensations and the initiation of skeletal development
    • Hall, B. K. and Miyake, T., All for one and one for all: condensations and the initiation of skeletal development. Bioessays 2000; 22: 138-147.
    • (2000) Bioessays , vol.22 , pp. 138-147
    • Hall, B.K.1    Miyake, T.2
  • 11
    • 0038011840 scopus 로고    scopus 로고
    • Deciphering skeletal patterning: clues from the limb
    • Mariani, F. V. and Martin, G.R., Deciphering skeletal patterning: clues from the limb. Nature 2003; 423: 319-325.
    • (2003) Nature , vol.423 , pp. 319-325
    • Mariani, F.V.1    Martin, G.R.2
  • 12
    • 0033835868 scopus 로고    scopus 로고
    • Cellular interactions and signaling in cartilage development
    • DeLise, A.M., Fischer, L. and Tuan, R.S., Cellular interactions and signaling in cartilage development. Osteoarthritis Cartilage 2000; 8: 309-334.
    • (2000) Osteoarthritis Cartilage , vol.8 , pp. 309-334
    • DeLise, A.M.1    Fischer, L.2    Tuan, R.S.3
  • 13
    • 0026757845 scopus 로고
    • The membranous skeleton: the role of cell condensations in vertebrate skeletogenesis
    • Hall, B. K. and Miyake, T., The membranous skeleton: the role of cell condensations in vertebrate skeletogenesis. Anat Embryol (Berl) 1992; 186: 107-124.
    • (1992) Anat Embryol (Berl) , vol.186 , pp. 107-124
    • Hall, B.K.1    Miyake, T.2
  • 14
    • 0029551439 scopus 로고
    • Divide, accumulate, differentiate: cell condensation in skeletal development revisited
    • Hall, B. K. and Miyake, T., Divide, accumulate, differentiate: cell condensation in skeletal development revisited. Int J Dev Biol 1995; 39: 881-893.
    • (1995) Int J Dev Biol , vol.39 , pp. 881-893
    • Hall, B.K.1    Miyake, T.2
  • 15
    • 0034858568 scopus 로고    scopus 로고
    • Derivation of the mammalian skull vault
    • Morriss-Kay, G.M., Derivation of the mammalian skull vault. J Anat 2001; 199: 143-151.
    • (2001) J Anat , vol.199 , pp. 143-151
    • Morriss-Kay, G.M.1
  • 16
    • 0035865852 scopus 로고    scopus 로고
    • Development of the clavicles in birds and mammals
    • Hall, B.K., Development of the clavicles in birds and mammals. J Exp Zool 2001; 289: 153-161.
    • (2001) J Exp Zool , vol.289 , pp. 153-161
    • Hall, B.K.1
  • 18
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation
    • Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L. and Karsenty, G., Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 1997; 89: 747-754.
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 19
    • 0036225281 scopus 로고    scopus 로고
    • Reaching a genetic and molecular understanding of skeletal development
    • Karsenty, G. and Wagner, E.F., Reaching a genetic and molecular understanding of skeletal development. Dev Cell 2002; 2: 389-406.
    • (2002) Dev Cell , vol.2 , pp. 389-406
    • Karsenty, G.1    Wagner, E.F.2
  • 24
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J.M., Behringer, R. R. and de Crombrugghe, B., The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 2002; 108: 17-29.
    • (2002) Cell , vol.108 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6    De Crombrugghe, B.7
  • 25
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St-Jacques, B., Hammerschmidt, M. and McMahon, A.P., Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev 1999; 13: 2072-2086.
    • (1999) Genes Dev , vol.13 , pp. 2072-2086
    • St-Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 26
    • 0036205735 scopus 로고    scopus 로고
    • FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis
    • Ohbayashi, N., Shibayama, M., Kurotaki, Y., Imanishi, M., Fujimori, T., Itoh, N. and Takada, S., FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev 2002; 16: 870-879.
    • (2002) Genes Dev , vol.16 , pp. 870-879
    • Ohbayashi, N.1    Shibayama, M.2    Kurotaki, Y.3    Imanishi, M.4    Fujimori, T.5    Itoh, N.6    Takada, S.7
  • 27
    • 1842611651 scopus 로고    scopus 로고
    • Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton
    • Long, F., Chung, U.I., Ohba, S., McMahon, J., Kronenberg, H. M. and McMahon, A.P., Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 2004; 131: 1309-1318.
    • (2004) Development , vol.131 , pp. 1309-1318
    • Long, F.1    Chung, U.I.2    Ohba, S.3    McMahon, J.4    Kronenberg, H.M.5    McMahon, A.P.6
  • 28
    • 0031105160 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: an unconventional approach to isolation of first mammalian morphogens
    • Reddi, A.H., Bone morphogenetic proteins: an unconventional approach to isolation of first mammalian morphogens. Cytokine Growth Factor Rev 1997; 8: 11-20.
    • (1997) Cytokine Growth Factor Rev , vol.8 , pp. 11-20
    • Reddi, A.H.1
  • 29
    • 0035179017 scopus 로고    scopus 로고
    • Patterning mechanisms controlling vertebrate limb development
    • Capdevila, J. and Izpisua Belmonte, J.C., Patterning mechanisms controlling vertebrate limb development. Annu Rev Cell Dev Biol 2001; 17: 87-132.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 87-132
    • Capdevila, J.1    Izpisua Belmonte, J.C.2
  • 30
    • 0035374608 scopus 로고    scopus 로고
    • Genetics of craniofacial development and malformation
    • Wilkie, A. O. and Morriss-Kay, G.M., Genetics of craniofacial development and malformation. Nat Rev Genet 2001; 2: 458-468.
    • (2001) Nat Rev Genet , vol.2 , pp. 458-468
    • Wilkie, A.O.1    Morriss-Kay, G.M.2
  • 32
    • 0032521181 scopus 로고    scopus 로고
    • Increased calvaria cell differentiation and bone matrix formation induced by fibroblast growth factor receptor 2 mutations in Apert syndrome
    • Lomri, A., Lemonnier, J., Hott, M., de Parseval, N., Lajeunie, E., Munnich, A., Renier, D. and Marie, P.J., Increased calvaria cell differentiation and bone matrix formation induced by fibroblast growth factor receptor 2 mutations in Apert syndrome. J Clin Invest 1998; 101: 1310-1317.
    • (1998) J Clin Invest , vol.101 , pp. 1310-1317
    • Lomri, A.1    Lemonnier, J.2    Hott, M.3    De Parseval, N.4    Lajeunie, E.5    Munnich, A.6    Renier, D.7    Marie, P.J.8
  • 33
    • 7744225334 scopus 로고    scopus 로고
    • Morphology and chemical composition of connective tissue: cartilage
    • (2nd edn), Royce, P. M. and Steinmann, B. (Eds). Wiley: New York
    • Morris, N.P., Keene, D. R. and Horton, W.A., Morphology and chemical composition of connective tissue: cartilage. In Connective Tissue and its Heritable Disorders (2nd edn), Royce, P. M. and Steinmann, B. (Eds). Wiley: New York, 2002, pp. 41-66.
    • (2002) Connective Tissue and its Heritable Disorders , pp. 41-66
    • Morris, N.P.1    Keene, D.R.2    Horton, W.A.3
  • 34
    • 0011781159 scopus 로고
    • Development of the growth plate during intrauterine life
    • Uhthoff, H. K. and Wiley, J. J. (Eds). Raven Press: New York
    • Uhthoff, H.K., Development of the growth plate during intrauterine life. In Behavior of the Growth Plate, Uhthoff, H. K. and Wiley, J. J. (Eds). Raven Press: New York, 1988, pp. 17-24.
    • (1988) Behavior of the Growth Plate , pp. 17-24
    • Uhthoff, H.K.1
  • 35
    • 0008405546 scopus 로고
    • Defining the growth plate
    • Uhthoff, H. K. and Wiley, J. J. (Eds). Raven Press: New York
    • Ogden, J. A. and Rosenberg, L.C., Defining the growth plate. In Behavior of the Growth Plate, Uhthoff, H. K. and Wiley, J. J. (Eds). Raven Press: New York, 1988, pp. 1-16.
    • (1988) Behavior of the Growth Plate , pp. 1-16
    • Ogden, J.A.1    Rosenberg, L.C.2
  • 36
    • 0003844593 scopus 로고
    • The Atlas of Mouse Development
    • Academic Press: London
    • Kaufman, M.H., The Atlas of Mouse Development. Academic Press: London, 1992
    • (1992)
    • Kaufman, M.H.1
  • 37
    • 0035574614 scopus 로고    scopus 로고
    • Regulatory mechanisms in the pathways of cartilage and bone formation
    • de Crombrugghe, B., Lefebvre, V. and Nakashima, K., Regulatory mechanisms in the pathways of cartilage and bone formation. Curr Opin Cell Biol 2001; 13: 721-727.
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 721-727
    • De Crombrugghe, B.1    Lefebvre, V.2    Nakashima, K.3
  • 39
    • 0034846904 scopus 로고    scopus 로고
    • L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway
    • Lefebvre, V., Behringer, R. R. and de Crombrugghe, B., L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway. Osteoarthritis Cartilage 2001; 9(Suppl. A): S69-75.
    • Osteoarthritis Cartilage , vol.2001 , Issue.9 SUPPL. A
    • Lefebvre, V.1    Behringer, R.R.2    De Crombrugghe, B.3
  • 40
    • 0028589588 scopus 로고
    • Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9
    • Wagner, T., Wirth, J., Meyer, J., Zabel, B., Held, M., Zimmer, J., Pasantes, J., Bricarelli, F.D., Keutel, J., Hustert, E. and et al., Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9. Cell 1994; 79: 1111-1120.
    • (1994) Cell , vol.79 , pp. 1111-1120
    • Wagner, T.1    Wirth, J.2    Meyer, J.3    Zabel, B.4    Held, M.5    Zimmer, J.6    Pasantes, J.7    Bricarelli, F.D.8    Keutel, J.9    Hustert, E.10
  • 42
    • 0025907108 scopus 로고
    • Spatiotemporal pattern of type X collagen gene expression and collagen deposition in embryonic chick vertebrae undergoing endochondral ossification
    • Iyama, K., Ninomiya, Y., Olsen, B.R., Linsenmayer, T.F., Trelstad, R. L. and Hayashi, M., Spatiotemporal pattern of type X collagen gene expression and collagen deposition in embryonic chick vertebrae undergoing endochondral ossification. Anat Rec 1991; 229: 462-472.
    • (1991) Anat Rec , vol.229 , pp. 462-472
    • Iyama, K.1    Ninomiya, Y.2    Olsen, B.R.3    Linsenmayer, T.F.4    Trelstad, R.L.5    Hayashi, M.6
  • 43
    • 0033027858 scopus 로고    scopus 로고
    • VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
    • Gerber, H.P., Vu, T.H., Ryan, A.M., Kowalski, J.,Werb, Z. and Ferrara, N., VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 1999; 5: 623-628.
    • (1999) Nat Med , vol.5 , pp. 623-628
    • Gerber, H.P.1    Vu, T.H.2    Ryan, A.M.3    Kowalski, J.4    Werb, Z.5    Ferrara, N.6
  • 45
    • 1442358788 scopus 로고    scopus 로고
    • Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate
    • Smits, P., Dy, P., Mitra, S. and Lefebvre, V., Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J Cell Biol 2004; 164: 747-758.
    • (2004) J Cell Biol , vol.164 , pp. 747-758
    • Smits, P.1    Dy, P.2    Mitra, S.3    Lefebvre, V.4
  • 46
    • 0028837742 scopus 로고
    • Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
    • Bitgood, M. J. and McMahon, A.P., Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol 1995; 172: 126-138.
    • (1995) Dev Biol , vol.172 , pp. 126-138
    • Bitgood, M.J.1    McMahon, A.P.2
  • 47
    • 0029750190 scopus 로고    scopus 로고
    • Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    • Vortkamp, A., Lee, K., Lanske, B., Segre, G.V., Kronenberg, H. M. and Tabin, C.J., Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 1996; 273: 613-622.
    • (1996) Science , vol.273 , pp. 613-622
    • Vortkamp, A.1    Lee, K.2    Lanske, B.3    Segre, G.V.4    Kronenberg, H.M.5    Tabin, C.J.6
  • 48
    • 0023636820 scopus 로고
    • Morphology and biochemistry of the growth plate
    • Brighton, C.T., Morphology and biochemistry of the growth plate. Rheum Dis Clin North Am 1987; 13: 75-100.
    • (1987) Rheum Dis Clin North Am , vol.13 , pp. 75-100
    • Brighton, C.T.1
  • 50
    • 0031926816 scopus 로고    scopus 로고
    • Bone formation via cartilage models: the »borderline« chondrocyte
    • Bianco, P., Cancedda, F.D., Riminucci, M. and Cancedda, R., Bone formation via cartilage models: the »borderline« chondrocyte. Matrix Biol 1998; 17: 185-192.
    • (1998) Matrix Biol , vol.17 , pp. 185-192
    • Bianco, P.1    Cancedda, F.D.2    Riminucci, M.3    Cancedda, R.4
  • 51
    • 0028067659 scopus 로고
    • Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes
    • Hunziker, E.B., Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes. Microsc Res Tech 1994; 28: 505-519.
    • (1994) Microsc Res Tech , vol.28 , pp. 505-519
    • Hunziker, E.B.1
  • 52
    • 0030481707 scopus 로고    scopus 로고
    • Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family
    • Storm, E. E. and Kingsley, D.M., Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family. Development 1996; 122: 3969-3979.
    • (1996) Development , vol.122 , pp. 3969-3979
    • Storm, E.E.1    Kingsley, D.M.2
  • 53
    • 0029762378 scopus 로고    scopus 로고
    • The role of BMPs and GDFs in development of region-specific skeletal structures
    • King, J.A., Storm, E.E., Marker, P.C., Dileone, R. J. and Kingsley, D.M., The role of BMPs and GDFs in development of region-specific skeletal structures. Ann NY Acad Sci 1996; 785: 70-79.
    • (1996) Ann NY Acad Sci , vol.785 , pp. 70-79
    • King, J.A.1    Storm, E.E.2    Marker, P.C.3    Dileone, R.J.4    Kingsley, D.M.5
  • 54
    • 4244151935 scopus 로고    scopus 로고
    • The skeletal dysplasias: disorders involving cartilage matrix proteins
    • (16th edn), Behrman, R.E., Kliegman, R. M. and Jenson, H. B. (Eds). W.B. Saunders: Philadelphia
    • Horton, W. A. and Hecht, J.T., The skeletal dysplasias: disorders involving cartilage matrix proteins. In Nelson Textbook of Pediatrics (16th edn), Behrman, R.E., Kliegman, R. M. and Jenson, H. B. (Eds). W.B. Saunders: Philadelphia, 2000, pp. 2116-2120.
    • (2000) Nelson Textbook of Pediatrics , pp. 2116-2120
    • Horton, W.A.1    Hecht, J.T.2
  • 55
    • 25044479788 scopus 로고    scopus 로고
    • Chondrodysplasias, part II. Disorders involving cartilage matrix proteins
    • (2nd edn), Royce, P. M. and Steinmann, B. (Eds). Alan R. Liss: New York
    • Horton, W. A. and Hecht, J.A., Chondrodysplasias, part II. Disorders involving cartilage matrix proteins. In Extracellular Matrix and Heritable Disorders of Connective Tissue (2nd edn), Royce, P. M. and Steinmann, B. (Eds). Alan R. Liss: New York, 2002.
    • (2002) Extracellular Matrix and Heritable Disorders of Connective Tissue
    • Horton, W.A.1    Hecht, J.A.2
  • 56
    • 0025871638 scopus 로고
    • Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia
    • Vandenberg, P., Khillan, J.S., Prockop, D.J., Helminen, H., Kontusaari, S. and Ala-Kokko, L., Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia. Proc Natl Acad Sci USA 1991; 88: 7640-7644.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7640-7644
    • Vandenberg, P.1    Khillan, J.S.2    Prockop, D.J.3    Helminen, H.4    Kontusaari, S.5    Ala-Kokko, L.6
  • 57
    • 0025990014 scopus 로고
    • Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-tocysteine mutation in the mouse type II procollagen alpha 1-chain gene
    • Garofalo, S., Vuorio, E., Metsaranta, M., Rosati, R., Toman, D., Vaughan, J., Lozano, G., Mayne, R., Ellard, J., Horton, W. and et al., Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-tocysteine mutation in the mouse type II procollagen alpha 1-chain gene. Proc Natl Acad Sci USA 1991; 88: 9648-9652.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 9648-9652
    • Garofalo, S.1    Vuorio, E.2    Metsaranta, M.3    Rosati, R.4    Toman, D.5    Vaughan, J.6    Lozano, G.7    Mayne, R.8    Ellard, J.9    Horton, W.10
  • 58
    • 0026710239 scopus 로고
    • Chondrodysplasia in transgenic mice harboring a 15-amino acid deletion in the triple helical domain of pro alpha 1(II) collagen chain
    • Metsaranta, M., Garofalo, S., Decker, G., Rintala, M., de Crombrugghe, B. and Vuorio, E., Chondrodysplasia in transgenic mice harboring a 15-amino acid deletion in the triple helical domain of pro alpha 1(II) collagen chain. J Cell Biol 1992; 118: 203-212.
    • (1992) J Cell Biol , vol.118 , pp. 203-212
    • Metsaranta, M.1    Garofalo, S.2    Decker, G.3    Rintala, M.4    De Crombrugghe, B.5    Vuorio, E.6
  • 59
    • 0031016134 scopus 로고    scopus 로고
    • Skeletal development in transgenic mice expressing a mutation at Gly574Ser of type II collagen
    • Maddox, B.K., Garofalo, S., Smith, C., Keene, D. R. and Horton, W.A., Skeletal development in transgenic mice expressing a mutation at Gly574Ser of type II collagen. Dev Dyn 1997; 208: 170-177.
    • (1997) Dev Dyn , vol.208 , pp. 170-177
    • Maddox, B.K.1    Garofalo, S.2    Smith, C.3    Keene, D.R.4    Horton, W.A.5
  • 60
    • 0028856176 scopus 로고
    • Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone
    • Li, S.W., Prockop, D.J., Helminen, H., Fassler, R., Lapvetelainen, T., Kiraly, K., Peltarri, A., Arokoski, J., Lui, H., Arita, M. and et al., Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone. Genes Dev 1995; 9: 2821-2830.
    • (1995) Genes Dev , vol.9 , pp. 2821-2830
    • Li, S.W.1    Prockop, D.J.2    Helminen, H.3    Fassler, R.4    Lapvetelainen, T.5    Kiraly, K.6    Peltarri, A.7    Arokoski, J.8    Lui, H.9    Arita, M.10
  • 61
    • 0032583171 scopus 로고    scopus 로고
    • Collagen II is essential for the removal of the notochord and the formation of intervertebral discs
    • Aszodi, A., Chan, D., Hunziker, E., Bateman, J. F. and Fassler, R., Collagen II is essential for the removal of the notochord and the formation of intervertebral discs. J Cell Biol 1998; 143: 1399-1412.
    • (1998) J Cell Biol , vol.143 , pp. 1399-1412
    • Aszodi, A.1    Chan, D.2    Hunziker, E.3    Bateman, J.F.4    Fassler, R.5
  • 62
    • 0035068434 scopus 로고    scopus 로고
    • Collagens and collagen-related diseases
    • Myllyharju, J. and Kivirikko, K.I., Collagens and collagen-related diseases. Ann Med 2001; 33: 7-21.
    • (2001) Ann Med , vol.33 , pp. 7-21
    • Myllyharju, J.1    Kivirikko, K.I.2
  • 63
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg, H.M., Developmental regulation of the growth plate. Nature 2003; 423: 332-336.
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 64
    • 0023139563 scopus 로고
    • Vascular events associated with the appearance of the secondary center of ossification in the murine distal femoral epiphysis
    • Floyd, W.E., 3rd, Zaleske, D.J., Schiller, A.L., Trahan, C. and Mankin, H.J., Vascular events associated with the appearance of the secondary center of ossification in the murine distal femoral epiphysis. J Bone Joint Surg Am 1987; 69: 185-190.
    • (1987) J Bone Joint Surg Am , vol.69 , pp. 185-190
    • Floyd III, W.E.1    Zaleske, D.J.2    Schiller, A.L.3    Trahan, C.4    Mankin, H.J.5
  • 65
    • 0041656403 scopus 로고    scopus 로고
    • Skeletal development: insights from targeting the mouse genome
    • Horton, W.A., Skeletal development: insights from targeting the mouse genome. Lancet 2003; 362: 560-569.
    • (2003) Lancet , vol.362 , pp. 560-569
    • Horton, W.A.1
  • 66
    • 0035135642 scopus 로고    scopus 로고
    • Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development
    • Chung, U.I., Schipani, E., McMahon, A. P. and Kronenberg, H.M., Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J Clin Invest 2001; 107: 295-304.
    • (2001) J Clin Invest , vol.107 , pp. 295-304
    • Chung, U.I.1    Schipani, E.2    McMahon, A.P.3    Kronenberg, H.M.4
  • 67
    • 0035691559 scopus 로고    scopus 로고
    • Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation
    • Long, F., Zhang, X.M., Karp, S., Yang, Y. and McMahon, A.P., Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 2001; 128: 5099-5108.
    • (2001) Development , vol.128 , pp. 5099-5108
    • Long, F.1    Zhang, X.M.2    Karp, S.3    Yang, Y.4    McMahon, A.P.5
  • 68
    • 0033950445 scopus 로고    scopus 로고
    • Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and-independent pathways
    • Karp, S.J., Schipani, E., St-Jacques, B., Hunzelman, J., Kronenberg, H. and McMahon, A.P., Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and-independent pathways. Development 2000; 127: 543-548.
    • (2000) Development , vol.127 , pp. 543-548
    • Karp, S.J.1    Schipani, E.2    St-Jacques, B.3    Hunzelman, J.4    Kronenberg, H.5    McMahon, A.P.6
  • 69
    • 0028943780 scopus 로고
    • A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia
    • Schipani, E., Kruse, K. and Juppner, H., A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science 1995; 268: 98-100.
    • (1995) Science , vol.268 , pp. 98-100
    • Schipani, E.1    Kruse, K.2    Juppner, H.3
  • 70
    • 0032128253 scopus 로고    scopus 로고
    • Absence of functional receptors for parathyroid hormone and parathyroid hormonerelated peptide in Blomstrand chondrodysplasia
    • Jobert, A.S., Zhang, P., Couvineau, A., Bonaventure, J., Roume, J., Le Merrer, M. and Silve, C., Absence of functional receptors for parathyroid hormone and parathyroid hormonerelated peptide in Blomstrand chondrodysplasia. J Clin Invest 1998; 102: 34-40.
    • (1998) J Clin Invest , vol.102 , pp. 34-40
    • Jobert, A.S.1    Zhang, P.2    Couvineau, A.3    Bonaventure, J.4    Roume, J.5    Le Merrer, M.6    Silve, C.7
  • 71
    • 0033580269 scopus 로고    scopus 로고
    • Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
    • Chuang, P. T. and McMahon, A.P., Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 1999; 397: 617-621.
    • (1999) Nature , vol.397 , pp. 617-621
    • Chuang, P.T.1    McMahon, A.P.2
  • 72
    • 0034747252 scopus 로고    scopus 로고
    • BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation
    • Minina, E.,Wenzel, H.M., Kreschel, C., Karp, S., Gaffield, W., McMahon, A. P. and Vortkamp, A., BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development 2001; 128: 4523-4534.
    • (2001) Development , vol.128 , pp. 4523-4534
    • Minina, E.1    Wenzel, H.M.2    Kreschel, C.3    Karp, S.4    Gaffield, W.5    McMahon, A.P.6    Vortkamp, A.7
  • 73
    • 0036744820 scopus 로고    scopus 로고
    • Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation
    • Minina, E., Kreschel, C., Naski, M.C., Ornitz, D. M. and Vortkamp, A., Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation. Dev Cell 2002; 3: 439-449.
    • (2002) Dev Cell , vol.3 , pp. 439-449
    • Minina, E.1    Kreschel, C.2    Naski, M.C.3    Ornitz, D.M.4    Vortkamp, A.5
  • 74
    • 2442622480 scopus 로고    scopus 로고
    • Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathway
    • Seki, K. and Hata, A., Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathway. J Biol Chem 2004; 279: 18544-18549.
    • (2004) J Biol Chem , vol.279 , pp. 18544-18549
    • Seki, K.1    Hata, A.2
  • 75
    • 0029928791 scopus 로고    scopus 로고
    • Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3
    • Colvin, J.S., Bohne, B.A., Harding, G.W., McEwen, D. G. and Ornitz, D.M., Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat Genet 1996; 12: 390-397.
    • (1996) Nat Genet , vol.12 , pp. 390-397
    • Colvin, J.S.1    Bohne, B.A.2    Harding, G.W.3    McEwen, D.G.4    Ornitz, D.M.5
  • 76
    • 0029917507 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 is a negative regulator of bone growth
    • Deng, C.,Wynshaw-Boris, A., Zhou, F., Kuo, A. and Leder, P., Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 1996; 84: 911-921.
    • (1996) Cell , vol.84 , pp. 911-921
    • Deng, C.1    Wynshaw-Boris, A.2    Zhou, F.3    Kuo, A.4    Leder, P.5
  • 77
    • 0027964261 scopus 로고
    • Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia
    • Shiang, R., Thompson, L.M., Zhu, Y.Z., Church, D.M., Fielder, T.J., Bocian, M., Winokur, S. T. and Wasmuth, J.J., Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell 1994; 78: 335-342.
    • (1994) Cell , vol.78 , pp. 335-342
    • Shiang, R.1    Thompson, L.M.2    Zhu, Y.Z.3    Church, D.M.4    Fielder, T.J.5    Bocian, M.6    Winokur, S.T.7    Wasmuth, J.J.8
  • 80
    • 0032413011 scopus 로고    scopus 로고
    • Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3
    • Naski, M.C., Colvin, J.S., Coffin, J. D. and Ornitz, D.M., Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development 1998; 125: 4977-4988.
    • (1998) Development , vol.125 , pp. 4977-4988
    • Naski, M.C.1    Colvin, J.S.2    Coffin, J.D.3    Ornitz, D.M.4
  • 81
    • 0033456159 scopus 로고    scopus 로고
    • Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis
    • Chen, L., Adar, R., Yang, X., Monsonego, E.O., Li, C., Hauschka, P.V., Yayon, A. and Deng, C.X., Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis. J Clin Invest 1999; 104: 1517-1525.
    • (1999) J Clin Invest , vol.104 , pp. 1517-1525
    • Chen, L.1    Adar, R.2    Yang, X.3    Monsonego, E.O.4    Li, C.5    Hauschka, P.V.6    Yayon, A.7    Deng, C.X.8
  • 82
    • 0032759872 scopus 로고    scopus 로고
    • Skeletal dysplasia and defective chondrocyte differentiation by targeted overexpression of fibroblast growth factor 9 in transgenic mice
    • Garofalo, S., Kliger-Spatz, M., Cooke, J.L., Wolstin, O., Lunstrum, G.P., Moshkovitz, S.M., Horton, W. A. and Yayon, A., Skeletal dysplasia and defective chondrocyte differentiation by targeted overexpression of fibroblast growth factor 9 in transgenic mice. J Bone Miner Res 1999; 14: 1909-1915.
    • (1999) J Bone Miner Res , vol.14 , pp. 1909-1915
    • Garofalo, S.1    Kliger-Spatz, M.2    Cooke, J.L.3    Wolstin, O.4    Lunstrum, G.P.5    Moshkovitz, S.M.6    Horton, W.A.7    Yayon, A.8
  • 83
    • 0034234569 scopus 로고    scopus 로고
    • A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos
    • Iwata, T., Chen, L., Li, C., Ovchinnikov, D.A., Behringer, R.R., Francomano, C. A. and Deng, C.X., A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. Hum Mol Genet 2000; 9: 1603-1613.
    • (2000) Hum Mol Genet , vol.9 , pp. 1603-1613
    • Iwata, T.1    Chen, L.2    Li, C.3    Ovchinnikov, D.A.4    Behringer, R.R.5    Francomano, C.A.6    Deng, C.X.7
  • 84
    • 1842372689 scopus 로고    scopus 로고
    • Signal transduction pathway of human fibroblast growth factor receptor . Identification of a novel 66-kDa phosphoprotein
    • Kanai, M., Goke, M., Tsunekawa, S. and Podolsky, D.K., Signal transduction pathway of human fibroblast growth factor receptor . Identification of a novel 66-kDa phosphoprotein. J Biol Chem 1997; 272: 6621-6628.
    • (1997) J Biol Chem , vol.272 , pp. 6621-6628
    • Kanai, M.1    Goke, M.2    Tsunekawa, S.3    Podolsky, D.K.4
  • 85
    • 0033151612 scopus 로고    scopus 로고
    • FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway
    • Sahni, M., Ambrosetti, D.C., Mansukhani, A., Gertner, R., Levy, D. and Basilico, C., FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. Genes Dev 1999; 13: 1361-1366.
    • (1999) Genes Dev , vol.13 , pp. 1361-1366
    • Sahni, M.1    Ambrosetti, D.C.2    Mansukhani, A.3    Gertner, R.4    Levy, D.5    Basilico, C.6
  • 86
    • 0030896404 scopus 로고    scopus 로고
    • Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism
    • Su, W.C., Kitagawa, M., Xue, N., Xie, B., Garofalo, S., Cho, J., Deng, C., Horton, W. A. and Fu, X.Y., Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism. Nature 1997; 386: 288-292.
    • (1997) Nature , vol.386 , pp. 288-292
    • Su, W.C.1    Kitagawa, M.2    Xue, N.3    Xie, B.4    Garofalo, S.5    Cho, J.6    Deng, C.7    Horton, W.A.8    Fu, X.Y.9
  • 88
    • 1042289662 scopus 로고    scopus 로고
    • Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype
    • Murakami, S., Balmes, G., McKinney, S., Zhang, Z., Givol, D. and de Crombrugghe, B., Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev 2004; 18: 290-305.
    • (2004) Genes Dev , vol.18 , pp. 290-305
    • Murakami, S.1    Balmes, G.2    McKinney, S.3    Zhang, Z.4    Givol, D.5    De Crombrugghe, B.6
  • 89
    • 0036203355 scopus 로고    scopus 로고
    • Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18
    • Liu, Z., Xu, J., Colvin, J. S. and Ornitz, D.M., Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Genes Dev 2002; 16: 859-869.
    • (2002) Genes Dev , vol.16 , pp. 859-869
    • Liu, Z.1    Xu, J.2    Colvin, J.S.3    Ornitz, D.M.4
  • 90
    • 0033974686 scopus 로고    scopus 로고
    • Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway
    • Murakami, S., Kan, M., McKeehan, W. L. and de Crombrugghe, B., Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA 2000; 97: 1113-1118.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1113-1118
    • Murakami, S.1    Kan, M.2    McKeehan, W.L.3    De Crombrugghe, B.4
  • 91
    • 0034067651 scopus 로고    scopus 로고
    • Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer
    • Huang, W., Zhou, X., Lefebvre, V. and de Crombrugghe, B., Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol Cell Biol 2000; 20: 4149-4158.
    • (2000) Mol Cell Biol , vol.20 , pp. 4149-4158
    • Huang, W.1    Zhou, X.2    Lefebvre, V.3    De Crombrugghe, B.4
  • 92
    • 0026472670 scopus 로고
    • Molecular biology and biochemistry of the natriuretic peptide system. II: Natriuretic peptide receptors
    • Nakao, K., Ogawa, Y., Suga, S. and Imura, H., Molecular biology and biochemistry of the natriuretic peptide system. II: Natriuretic peptide receptors. J Hypertens 1992; 10: 1111-1114.
    • (1992) J Hypertens , vol.10 , pp. 1111-1114
    • Nakao, K.1    Ogawa, Y.2    Suga, S.3    Imura, H.4
  • 93
    • 0026656866 scopus 로고
    • Molecular biology and biochemistry of the natriuretic peptide system. I: Natriuretic peptides
    • Nakao, K., Ogawa, Y., Suga, S. and Imura, H., Molecular biology and biochemistry of the natriuretic peptide system. I: Natriuretic peptides. J Hypertens 1992; 10: 907-912.
    • (1992) J Hypertens , vol.10 , pp. 907-912
    • Nakao, K.1    Ogawa, Y.2    Suga, S.3    Imura, H.4
  • 95
    • 0346963598 scopus 로고    scopus 로고
    • MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
    • Vu, T.H., Shipley, J.M., Bergers, G., Berger, J.E., Helms, J.A., Hanahan, D., Shapiro, S.D., Senior, . M. andWerb, Z.,MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 1998; 93: 411-422.
    • (1998) Cell , vol.93 , pp. 411-422
    • Vu, T.H.1    Shipley, J.M.2    Bergers, G.3    Berger, J.E.4    Helms, J.A.5    Hanahan, D.6    Shapiro, S.D.7    Senior, S.M.8    Werb, Z.9
  • 96
    • 0034914814 scopus 로고    scopus 로고
    • Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2
    • Zelzer, E., Glotzer, D.J., Hartmann, C., Thomas, D., Fukai, N., Soker, S. and Olsen, B.R., Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2. Mech Dev 2001; 106: 97-106.
    • (2001) Mech Dev , vol.106 , pp. 97-106
    • Zelzer, E.1    Glotzer, D.J.2    Hartmann, C.3    Thomas, D.4    Fukai, N.5    Soker, S.6    Olsen, B.R.7
  • 97
    • 0035499204 scopus 로고    scopus 로고
    • Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival
    • Schipani, E., Ryan, H.E., Didrickson, S., Kobayashi, T., Knight, M. and Johnson, R.S., Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev 2001; 15: 2865-2876.
    • (2001) Genes Dev , vol.15 , pp. 2865-2876
    • Schipani, E.1    Ryan, H.E.2    Didrickson, S.3    Kobayashi, T.4    Knight, M.5    Johnson, R.S.6
  • 100
    • 0031688245 scopus 로고    scopus 로고
    • Growth plate chondrocytes store latent transforming growth factor (TGF)-beta 1 in their matrix through latent TGF-beta 1 binding protein-1
    • Pedrozo, H.A., Schwartz, Z., Gomez, R., Ornoy, A., Xin-Sheng, W., Dallas, S.L., Bonewald, L.F., Dean, D. D. and Boyan, B.D., Growth plate chondrocytes store latent transforming growth factor (TGF)-beta 1 in their matrix through latent TGF-beta 1 binding protein-1. J Cell Physiol 1998; 177: 343-354.
    • (1998) J Cell Physiol , vol.177 , pp. 343-354
    • Pedrozo, H.A.1    Schwartz, Z.2    Gomez, R.3    Ornoy, A.4    Xin-Sheng, W.5    Dallas, S.L.6    Bonewald, L.F.7    Dean, D.D.8    Boyan, B.D.9
  • 101
    • 0035197240 scopus 로고    scopus 로고
    • Activation of transforming growth factor beta in chondrocytes undergoing endochondral ossification
    • D'Angelo, M., Sarment, D.P., Billings, P. C. and Pacifici, M., Activation of transforming growth factor beta in chondrocytes undergoing endochondral ossification. J Bone Miner Res 2001; 16: 2339-2347.
    • (2001) J Bone Miner Res , vol.16 , pp. 2339-2347
    • D'Angelo, M.1    Sarment, D.P.2    Billings, P.C.3    Pacifici, M.4
  • 102
    • 0346749736 scopus 로고    scopus 로고
    • Skeletal dysplasia, growth hormone treatment and body proportion: comparison with other syndromic and non-syndromic short children
    • Hagenas, L. and Hertel, T., Skeletal dysplasia, growth hormone treatment and body proportion: comparison with other syndromic and non-syndromic short children. Horm Res 2003; 60(Suppl. 3): 65-70.
    • (2003) Horm Res , vol.60 , Issue.SUPPL. 3 , pp. 65-70
    • Hagenas, L.1    Hertel, T.2
  • 103
    • 1542301428 scopus 로고    scopus 로고
    • Evidence supporting dual, IGF-I-independent and IGFI-dependent, roles for GH in promoting longitudinal bone growth
    • Wang, J., Zhou, J., Cheng, C.M., Kopchick, J. J. and Bondy, C.A., Evidence supporting dual, IGF-I-independent and IGFI-dependent, roles for GH in promoting longitudinal bone growth. J Endocrinol 2004; 180: 247-255.
    • (2004) J Endocrinol , vol.180 , pp. 247-255
    • Wang, J.1    Zhou, J.2    Cheng, C.M.3    Kopchick, J.J.4    Bondy, C.A.5
  • 104
    • 0025073322 scopus 로고
    • Clinical application of the tension-stress effect for limb lengthening
    • Ilizarov, G.A., Clinical application of the tension-stress effect for limb lengthening. Clin Orthop 1990; 250: 8-26.
    • (1990) Clin Orthop , vol.250 , pp. 8-26
    • Ilizarov, G.A.1
  • 105
    • 0024222569 scopus 로고
    • (500 cases of lower limb lengthening using a personal technique in achondroplasia)
    • Vilarrubias, J.M., Ginebreda, I. and Fernandez-Fairen, M., (500 cases of lower limb lengthening using a personal technique in achondroplasia). Acta Orthop Belg 1988; 54: 384-390.
    • (1988) Acta Orthop Belg , vol.54 , pp. 384-390
    • Vilarrubias, J.M.1    Ginebreda, I.2    Fernandez-Fairen, M.3
  • 106
    • 0023906431 scopus 로고
    • Current techniques of limb lengthening
    • Paley, D., Current techniques of limb lengthening. J Pediatr Orthop 1988; 8: 73-92.
    • (1988) J Pediatr Orthop , vol.8 , pp. 73-92
    • Paley, D.1
  • 107
    • 0037861955 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor-3 as a therapeutic target for Achondroplasia-genetic short limbed dwarfism
    • Aviezer, D., Golembo, M. and Yayon, A., Fibroblast growth factor receptor-3 as a therapeutic target for Achondroplasia-genetic short limbed dwarfism. Curr Drug Targets 2003; 4: 353-365.
    • (2003) Curr Drug Targets , vol.4 , pp. 353-365
    • Aviezer, D.1    Golembo, M.2    Yayon, A.3
  • 108
    • 0033520472 scopus 로고    scopus 로고
    • Structural basis for FGF receptor dimerization and activation
    • Plotnikov, A.N., Schlessinger, J., Hubbard, S. R. and Mohammadi, M., Structural basis for FGF receptor dimerization and activation. Cell 1999; 98: 641-650.
    • (1999) Cell , vol.98 , pp. 641-650
    • Plotnikov, A.N.1    Schlessinger, J.2    Hubbard, S.R.3    Mohammadi, M.4
  • 109
    • 0035168141 scopus 로고    scopus 로고
    • Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation
    • Hart, K.C., Robertson, S. C. and Donoghue, D.J., Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. Mol Biol Cell 2001; 12: 931-942.
    • (2001) Mol Biol Cell , vol.12 , pp. 931-942
    • Hart, K.C.1    Robertson, S.C.2    Donoghue, D.J.3
  • 110
    • 0037097976 scopus 로고    scopus 로고
    • FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
    • Ornitz, D. M. and Marie, P.J., FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev 2002; 16: 1446-1465.
    • (2002) Genes Dev , vol.16 , pp. 1446-1465
    • Ornitz, D.M.1    Marie, P.J.2
  • 111
    • 0030773251 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 and the human chondrodysplasias
    • Horton, W.A., Fibroblast growth factor receptor 3 and the human chondrodysplasias. Curr Opin Pediatr 1997; 9: 437-442.
    • (1997) Curr Opin Pediatr , vol.9 , pp. 437-442
    • Horton, W.A.1
  • 112
    • 0345743700 scopus 로고    scopus 로고
    • Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia
    • Cho, J.Y., Guo, C., Torello, M., Lunstrum, G.P., Iwata, T., Deng, C. and Horton, W.A., Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia. Proc Natl Acad Sci USA 2004; 101: 609-614.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 609-614
    • Cho, J.Y.1    Guo, C.2    Torello, M.3    Lunstrum, G.P.4    Iwata, T.5    Deng, C.6    Horton, W.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.