Developmental and reproductive abnormalities associated with environmental estrogens: Diethylstilbestrol (DES) as an example

Endocrine Disruptors: Effects on Male and Female Reproductive Systems, Second Edition

Volumn , Issue , 2004, Pages 47-65

  Newbold, Retha R ^a   Jefferson, Wendy ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84889779294     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (44)

1. Colborn, T. and Clement, C. Chemically-Induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection. Princeton, NJ: Princeton Scientific, 1992.
2. Colborn, T., vom Saal, F. S., and Soto, A. M. Developmental effects of endocrinedisrupting chemicals in wildlife and humans. Environ. Health Perspect., 101: 378-384, 1993.
3. Colborn, T., Dumanski, D., and Myers, J. P. Our Stolen Future. New York: Penguin Books, Inc., 1996.
4. McLachlan, J. A. Estrogens in the Environment. New York: Elsevier Science Publishing Co., 1985.
5. McLachlan, J. A. Functional toxicology: a new approach to detect biologically active xenobiotics. Environ. Health Perspect., 101: 386-387, 1993.
6. George, F. W. and Wilson, J. D. Sex determination and differentiation. In: E. Knobil, J. D. Neil, L. L. Ewing, G. S. Greenwald, C. L. Markert, and D. W. Pfaff (eds.), The Physiology of Reproduction, pp. 3-26. New York Raven Press, 1988.
7. Bern, H. The Fragile Fetus. In: T. Colborn and C. Clement (eds.), Chemically-Induced Alterations in Sexual and Functioal Development: The Wildlife/Human Connection. Princeton, NJ: Princeton Scientific Publishing Co., 1992.
8. Brawer, J. R., Naftolin, F., Martin, J., and Sonnenschein, C. Effects of a single injection of estradiol valerate on the hypothalamic arcuate nucleus and on reproductive function in the female rat. Endocrinology, 103: 501-512, 1978.
9. Adler, A. J. and Nelson, J. F. Aging and chronic estradiol exposure impair estradiolinduced cornification but not proliferation of vaginal epithelium in C57BL/6J mice. Biol. Reprod., 38: 175-182, 1988.
10. Gluckman, P. D. Intrauterine growth retardation: future research directions. Acta Paediatr. Suppl., 388: 96-99, 1993.
11. Barker, D. J., Eriksson, J. G., Forsen, T., and Osmond, C. Fetal origins of adult disease: strength of effects and biological basis. Int. J. Epidemiol., 31: 1235-1239, 2002.
12. Herbst, A. L. and Bern, H. A. Developmental Effects of Diethylstilbestrol (DES) in Pregnancy. New York: Thieme-Stratton, 1981.
13. Newbold, R. R. and McLachlan, J. A. Transplacental hormonal carcinogenesis: diethylstilbestrol as an example. In: J. Huff, J. Boyd, and J. C. Barrett (eds.), Cellular and Molecular Mechanisms of Hormonal Carcinogenesis: Environmental Influences, pp. 131-147. New York: Wiley-Liss, 1996.
14. Turusov, V. S., Trukhanova, L. S., Parfenov Yu, D., and Tomatis, L. Occurrence of tumours in the descendants of CBA male mice prenatally treated with diethylstilbestrol. Int. J. Cancer, 50: 131-135, 1992.
15. Walker, B. E. and Haven, M. I. Intensity of multigenerational carcinogenesis from diethylstilbestrol in mice. Carcinogenesis, 18: 791-793, 1997.
16. Newbold, R. R., Hanson, R. B., Jefferson, W. N., Bullock, B. C., Haseman, J., and McLachlan, J. A. Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis, 21: 1355-1363, 2000.
17. Newbold, R. R., Hanson, R. B., Jefferson, W. N., Bullock, B. C., Haseman, J., and McLachlan, J. A. Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis, 19: 1655-1663, 1998.
18. Tuchmann-Duplessis, H. and Haegel, P. Illustrated Human Embryology. New York: Springer Verlag, 1982.
19. Newbold, R. R. and McLachlan, J. A. Diethylstilbestrol associated defects in murine genital tract development. In: J. A. McLachlan (ed.), Estrogens in the Environment II: Influences in Development, pp. 288-318. New York: Elsevier, 1985.
20. Newbold, R. Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmental estrogens. Environ. Health Perspect., 103 Suppl 7: 83-87, 1995.
21. McLachlan, J. A., Newbold, R. R., Shah, H. C., Hogan, M. D., and Dixon, R. L. Reduced fertility in female mice exposed transplacentally to diethylstilbestrol (DES). Fertil. Steril., 38: 364-371, 1982.
22. Newbold, R. R., Bullock, B. C., and Mc Lachlan, J. A. Exposure to diethylstilbestrol during pregnancy permanently alters the ovary and oviduct. Biol. Reprod., 28: 735-744, 1983.
23. Haney, A. F., Newbold, R. R., and McLachlan, J. A. Prenatal diethylstilbestrol exposure in the mouse: effects on ovarian histology and steroidogenesis in vitro. Biol Reprod., 30: 471-478, 1984.
24. Davis, B. and Newbold, R. R. Ovarian toxicology. In: P. W. Harvey, K. Rush, and A. Cockburn (eds.), Endocrine and Hormonal Toxicology, pp. 111-124. New York: John Wiley and Sons, 1999.
25. Newbold, R. R., Tyrey, S., Haney, A. F., and McLachlan, J. A. Developmentally arrested oviduct: a structural and functional defect in mice following prenatal exposure to diethylstilbestrol. Teratology, 27: 417-426, 1983.
26. DeCherney, A. H., Cholst, I., and Naftolin, F. Structure and function of the fallopian tubes following exposure to diethylstilbestrol (DES) during gestation. Fertil. Steril., 36: 741-745, 1981.
27. Ma, L., Benson, G. V., Lim, H., Dey, S. K., and Maas, R. L. Abdominal B (AbdB) Hoxa genes: regulation in adult uterus by estrogen and progesterone and repression in mullerian duct by the synthetic estrogen diethylstilbestrol (DES). Dev. Biol., 197: 141-154, 1998.
28. Li, S., Ma, L., Chiang, T., Burow, M., Newbold, R. R., Negishi, M., Barrett, J. C., and McLachlan, J. A. Promoter CpG methylation of Hox-a10 and Hox-a11 in mouse uterus not altered upon neonatal diethylstilbestrol exposure. Mol. Carcinog., 32: 213-219, 2001.
29. Newbold, R. R., Bullock, B. C., and McLachlan, J. A. Diverticulosis and salpingitis isthmica nodosa (SIN) of the fallopian tube. Estrogen-induced diverticulosis and SIN of the mouse oviduct. Am. J. Pathol., 117: 333-335, 1984.
30. Shen, S. C., Bansal, M., Purrazzella, R., Malviya, V., and Strauss, L. Benign glandular inclusions in lymph nodes, endosalpingiosis, and salpingitis isthmica nodosa in a young girl with clear cell adenocarcinoma of the cervix. Am. J. Surg. Pathol., 7: 293-300, 1983.
31. McLachlan, J. A., Newbold, R. R., and Bullock, B. C. Long-term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol. Cancer Research, 40: 3988-3999, 1980.
32. Newbold, R. R., Moore, A. B., and Dixon, D. Characterization of uterine leiomyomas in CD-1 mice following developmental exposure to diethylstilbestrol (DES). Toxicol. Pathol., 30: 611-616, 2002.
33. Baird, D. and Newbold, R. Increased incidence of leiomyomas in DES exposed women. Environ. Health Perspect., submitted.
34. Newbold, R. R. and McLachlan, J. A. Vaginal adenosis and adenocarcinoma in mice exposed prenatally or neonatally to diethylstilbestrol. Cancer Res., 42: 2003-2011, 1982.
35. Sheehan, D. M. and vom Saal, F. S. Low dose effects of endocrine disruptors - a challenge for risk assessment. Risk Policy Report, September 19, 1997.
36. vom Saal, F. S., Timms, B. G., Montano, M. M., Palanza, P., Thayer, K. A., Nagel, S. C., Dhar, M. D., Ganjam, V. K., Parmigiani, S., and Welshons, W. V. Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses. Proc. Natl. Acad. Sci. USA, 94: 2056-2061, 1997.
37. Welshons, W. V., Nagel, S. C., Thayer, K. A., Judy, B. M., and vom Saal, F. S. Lowdose bioactivity of xenoestrogens in animals: fetal exposure to low doses of methoxychlor and other xenoestrogens increases adult prostate size in mice. Toxicol. Ind. Health, 15: 12-25, 1999.
38. Newbold, R., Jefferson, W. N., Padilla-Banks, E., and Haseman, J. Developmental exposure to diethylstilbestrol (DES) alters uterine response to estrogens in prepubescent mice: low verses high dose effects. Reproductive Toxicology, 2004.
39. Padilla-Banks, E., Jefferson, W. N., and Newbold, R. R. The immature mouse is a suitable model for detection of estrogenicity in the uterotropic bioassay. Environ. Health Perspect., 109: 821-826, 2001.
40. Maier, D. B., Newbold, R. R., and McLachlan, J. A. Prenatal diethystilbestrol exposure alters murine uterine responses to prepubertal estrogen stimulation. Endocrinology, 116: 1878-1886, 1985.
41. Jefferson, W. N., Padilla-Banks, E., and Newbold, R. R. Lactoferrin is an estrogen responsive protein in the uterus of mice and rats. Reprod. Toxicol., 14: 103-110, 2000.
42. National Toxicology Program’s Report of the Endocrine Disruptors Low-Dose Peer Review. Research Triangle Park: National Toxicology Program, Department of Health and Human Services, 2001.
43. Melnick, R., Lucier, G., Wolfe, M., Hall, R., Stancel, G., Prins, G., Gallo, M., Reuhl, K., Ho, S., Brown, T., Moore, J., Leaky, J., Haseman, J., and Kohn, M. Summary of the National Toxicology Program’s Report of the Endocrine Disruptors Low Dose Peer Review. Environ. Health Perspect., 110: 427-431, 2002.
44. Couse, J. F., Davis, V. L., Hanson, R. B., Jefferson, W. N., McLachlan, J. A., Bullock, B. C., Newbold, R. R., and Korach, K. S. Accelerated onset of uterine tumors in transgenic mice with aberrant expression of the estrogen receptor after neonatal exposure to diethylstilbestrol. Mol. Carcinog., 19: 236-242, 1997.