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Volumn 11, Issue 12, 2013, Pages 2137-2147

Monoclonal antibodies targeting the antifibrinolytic activity of activated thrombin-activatable fibrinolysis inhibitor but not the anti-inflammatory activity on osteopontin and C5a

Author keywords

Fibrinolysis; Inflammation; Plasmin; Thrombin; Thrombin activatable fibrinolysis inhibitor

Indexed keywords

COMPLEMENT COMPONENT C5A; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY TCK11A9; MONOCLONAL ANTIBODY TCK26D6; MYELOPEROXIDASE; OSTEOPONTIN; THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR; THROMBOMODULIN; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG;

EID: 84889690829     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12431     Document Type: Article
Times cited : (17)

References (28)
  • 1
    • 80052437004 scopus 로고    scopus 로고
    • Thrombin activatable fibrinolysis inhibitor
    • Declerck PJ. Thrombin activatable fibrinolysis inhibitor. Hamostaseologie 2011; 31: 165-73.
    • (2011) Hamostaseologie , vol.31 , pp. 165-173
    • Declerck, P.J.1
  • 2
    • 1642398603 scopus 로고    scopus 로고
    • Thrombus lysis by uPA, scuPA and tPA is regulated by plasma TAFI
    • Mutch NJ, Moore NR, Wang E, Booth NA. Thrombus lysis by uPA, scuPA and tPA is regulated by plasma TAFI. J Thromb Haemost 2003; 1: 2000-7.
    • (2003) J Thromb Haemost , vol.1 , pp. 2000-2007
    • Mutch, N.J.1    Moore, N.R.2    Wang, E.3    Booth, N.A.4
  • 3
    • 33748589984 scopus 로고    scopus 로고
    • Fibrinolytic efficacy of Amediplase, Tenecteplase and scu-PA in different external plasma clot lysis models: sensitivity to the inhibitory action of thrombin activatable fibrinolysis inhibitor (TAFI)
    • Guimarães AH, Barrett-Bergshoeff MM, Criscuoli M, Evangelista S, Rijken DC. Fibrinolytic efficacy of Amediplase, Tenecteplase and scu-PA in different external plasma clot lysis models: sensitivity to the inhibitory action of thrombin activatable fibrinolysis inhibitor (TAFI). Thromb Haemost 2006; 96: 325-30.
    • (2006) Thromb Haemost , vol.96 , pp. 325-330
    • Guimarães, A.H.1    Barrett-Bergshoeff, M.M.2    Criscuoli, M.3    Evangelista, S.4    Rijken, D.C.5
  • 4
    • 84871057895 scopus 로고    scopus 로고
    • The hyperfibrinolytic state of mice with combined thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen activator inhibitor-1 gene deficiency is critically dependent on TAFI deficiency
    • Vercauteren E, Peeters M, Hoylaerts MF, Lijnen HR, Meijers JC, Declerck PJ, Gils A. The hyperfibrinolytic state of mice with combined thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen activator inhibitor-1 gene deficiency is critically dependent on TAFI deficiency. J Thromb Haemost 2012; 10: 2555-62.
    • (2012) J Thromb Haemost , vol.10 , pp. 2555-2562
    • Vercauteren, E.1    Peeters, M.2    Hoylaerts, M.F.3    Lijnen, H.R.4    Meijers, J.C.5    Declerck, P.J.6    Gils, A.7
  • 5
    • 0029895009 scopus 로고    scopus 로고
    • TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex
    • Bajzar L, Morser J, Nesheim M. TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex. J Biol Chem 1996; 271: 16603-8.
    • (1996) J Biol Chem , vol.271 , pp. 16603-16608
    • Bajzar, L.1    Morser, J.2    Nesheim, M.3
  • 6
    • 0033521034 scopus 로고    scopus 로고
    • Characterization of plasmin-mediated activation of plasma procarboxypeptidase B - modulation by glycosaminoglycans
    • Mao SS, Cooper CM, Wood T, Shafer JA, Gardell SJ. Characterization of plasmin-mediated activation of plasma procarboxypeptidase B - modulation by glycosaminoglycans. J Biol Chem 1999; 274: 35046-52.
    • (1999) J Biol Chem , vol.274 , pp. 35046-35052
    • Mao, S.S.1    Cooper, C.M.2    Wood, T.3    Shafer, J.A.4    Gardell, S.J.5
  • 7
    • 36949028958 scopus 로고    scopus 로고
    • Profibrinolytic activity of the direct thrombin inhibitor melagatran and unfractionated heparin in platelet-poor and platelet-rich clots
    • Semeraro F, Piro D, Rossiello MR, Ammollo T, Colucci M. Profibrinolytic activity of the direct thrombin inhibitor melagatran and unfractionated heparin in platelet-poor and platelet-rich clots. Thromb Haemost 2007; 98: 1208-14.
    • (2007) Thromb Haemost , vol.98 , pp. 1208-1214
    • Semeraro, F.1    Piro, D.2    Rossiello, M.R.3    Ammollo, T.4    Colucci, M.5
  • 8
    • 64849116283 scopus 로고    scopus 로고
    • The contribution of anti-Xa and anti-IIa activities to the profibrinolytic activity of low-molecular-weight heparins
    • Ammollo CT, Semeraro F, Semeraro N, Colucci M. The contribution of anti-Xa and anti-IIa activities to the profibrinolytic activity of low-molecular-weight heparins. Thromb Haemost 2009; 101: 782-5.
    • (2009) Thromb Haemost , vol.101 , pp. 782-785
    • Ammollo, C.T.1    Semeraro, F.2    Semeraro, N.3    Colucci, M.4
  • 9
    • 77952738550 scopus 로고    scopus 로고
    • Dabigatran enhances clot susceptibility to fibrinolysis by mechanisms dependent on and independent of thrombin-activatable fibrinolysis inhibitor
    • Ammollo CT, Semeraro F, Incampo F, Semeraro N, Colucci M. Dabigatran enhances clot susceptibility to fibrinolysis by mechanisms dependent on and independent of thrombin-activatable fibrinolysis inhibitor. J Thromb Haemost 2010; 8: 790-8.
    • (2010) J Thromb Haemost , vol.8 , pp. 790-798
    • Ammollo, C.T.1    Semeraro, F.2    Incampo, F.3    Semeraro, N.4    Colucci, M.5
  • 10
    • 63049108670 scopus 로고    scopus 로고
    • Functional analysis of mutant variants of thrombin activatable fibrinolysis inhibitor resistant to activation by thrombin or plasmin
    • Miah MF, Boffa MB. Functional analysis of mutant variants of thrombin activatable fibrinolysis inhibitor resistant to activation by thrombin or plasmin. J Thromb Haemost 2009; 7: 665-72.
    • (2009) J Thromb Haemost , vol.7 , pp. 665-672
    • Miah, M.F.1    Boffa, M.B.2
  • 11
    • 36148996511 scopus 로고    scopus 로고
    • Thrombin-thrombomodulin connects coagulation and fibrinolysis: more than an in vitro phenomenon
    • Binette TM, Taylor FB Jr, Peer G, Bajzar L. Thrombin-thrombomodulin connects coagulation and fibrinolysis: more than an in vitro phenomenon. Blood 2007; 110: 3168-75.
    • (2007) Blood , vol.110 , pp. 3168-3175
    • Binette, T.M.1    Taylor Jr., F.B.2    Peer, G.3    Bajzar, L.4
  • 12
    • 0037324324 scopus 로고    scopus 로고
    • Different mechanisms contribute to the biphasic pattern of carboxypeptidase U (TAFIa) generation during in vitro clot lysis in human plasma
    • Leurs J, Wissing B-M, Nerme V, Schatteman K, Bijorquist P, Hendriks D. Different mechanisms contribute to the biphasic pattern of carboxypeptidase U (TAFIa) generation during in vitro clot lysis in human plasma. Thromb Haemost 2003; 89: 264-71.
    • (2003) Thromb Haemost , vol.89 , pp. 264-271
    • Leurs, J.1    Wissing, B.-M.2    Nerme, V.3    Schatteman, K.4    Bijorquist, P.5    Hendriks, D.6
  • 13
    • 79960069147 scopus 로고    scopus 로고
    • Identification and characterization of monoclonal antibodies that impair the activation of human thrombin activatable fibrinolysis inhibitor through different mechanisms
    • Mishra N, Vercauteren E, Develter J, Bammens R, Declerck PJ, Gils A. Identification and characterization of monoclonal antibodies that impair the activation of human thrombin activatable fibrinolysis inhibitor through different mechanisms. Thromb Haemost 2011; 106: 90-101.
    • (2011) Thromb Haemost , vol.106 , pp. 90-101
    • Mishra, N.1    Vercauteren, E.2    Develter, J.3    Bammens, R.4    Declerck, P.J.5    Gils, A.6
  • 14
    • 84873034640 scopus 로고    scopus 로고
    • Plasmin and the thrombin-thrombomodulin complex both contribute to TAFI activation in whole blood model thrombi
    • Vercauteren E, Mutch NJ, Declerck PJ, Gils A. Plasmin and the thrombin-thrombomodulin complex both contribute to TAFI activation in whole blood model thrombi. J Thromb Haemost 2013; 11: 190-2.
    • (2013) J Thromb Haemost , vol.11 , pp. 190-192
    • Vercauteren, E.1    Mutch, N.J.2    Declerck, P.J.3    Gils, A.4
  • 15
    • 79955960414 scopus 로고    scopus 로고
    • Evaluation of the profibrinolytic properties of an anti-TAFI monoclonal antibody in a mouse thromboembolism model
    • Vercauteren E, Emmerechts J, Peeters M, Hoylaerts MF, Declerck PJ, Gils A. Evaluation of the profibrinolytic properties of an anti-TAFI monoclonal antibody in a mouse thromboembolism model. Blood 2011; 117: 4615-22.
    • (2011) Blood , vol.117 , pp. 4615-4622
    • Vercauteren, E.1    Emmerechts, J.2    Peeters, M.3    Hoylaerts, M.F.4    Declerck, P.J.5    Gils, A.6
  • 16
    • 0037188376 scopus 로고    scopus 로고
    • Plasmin-mediated activation and inactivation of thrombin-activatable fibrinolysis inhibitor
    • Marx PF, Dawson PE, Bouma BN, Meijers JC. Plasmin-mediated activation and inactivation of thrombin-activatable fibrinolysis inhibitor. Biochemistry 2002; 41: 6688-96.
    • (2002) Biochemistry , vol.41 , pp. 6688-6696
    • Marx, P.F.1    Dawson, P.E.2    Bouma, B.N.3    Meijers, J.C.4
  • 18
    • 34548840834 scopus 로고    scopus 로고
    • Comparative evaluation of stable TAFIa variants: importance of alpha-helix 9 and beta-sheet 11 for TAFIa (in)stability
    • Ceresa E, De Maeyer M, Jonckheer A, Peeters M, Engelborghs Y, Declerck PJ, Gils A. Comparative evaluation of stable TAFIa variants: importance of alpha-helix 9 and beta-sheet 11 for TAFIa (in)stability. J Thromb Haemost 2007; 5: 2105-12.
    • (2007) J Thromb Haemost , vol.5 , pp. 2105-2112
    • Ceresa, E.1    De Maeyer, M.2    Jonckheer, A.3    Peeters, M.4    Engelborghs, Y.5    Declerck, P.J.6    Gils, A.7
  • 19
    • 1542283733 scopus 로고    scopus 로고
    • Hyperprothrombinemia associated with prothrombin G20210A mutation inhibits plasma fibrinolysis through a TAFI-mediated mechanism
    • Colucci M, Binetti BM, Tripodi A, Chantarangkul V, Semeraro N. Hyperprothrombinemia associated with prothrombin G20210A mutation inhibits plasma fibrinolysis through a TAFI-mediated mechanism. Blood 2004; 103: 2157-61.
    • (2004) Blood , vol.103 , pp. 2157-2161
    • Colucci, M.1    Binetti, B.M.2    Tripodi, A.3    Chantarangkul, V.4    Semeraro, N.5
  • 22
    • 0141819138 scopus 로고    scopus 로고
    • The protein C pathway
    • Esmon CT. The protein C pathway. Chest 2003; 124: 26S-32S.
    • (2003) Chest , vol.124
    • Esmon, C.T.1
  • 23
    • 0029793068 scopus 로고    scopus 로고
    • The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent
    • Bajzar L, Nesheim ME, Tracy PB. The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent. Blood 1996; 88: 2093-100.
    • (1996) Blood , vol.88 , pp. 2093-2100
    • Bajzar, L.1    Nesheim, M.E.2    Tracy, P.B.3
  • 24
    • 3142584783 scopus 로고    scopus 로고
    • Carboxypeptidase U (TAFIa) prevents lysis from proceeding into the propagation phase through a threshold-dependent mechanism
    • Leurs J, Nerme V, Sim Y, Hendriks D. Carboxypeptidase U (TAFIa) prevents lysis from proceeding into the propagation phase through a threshold-dependent mechanism. J Thromb Haemost 2004; 2: 416-23.
    • (2004) J Thromb Haemost , vol.2 , pp. 416-423
    • Leurs, J.1    Nerme, V.2    Sim, Y.3    Hendriks, D.4
  • 25
    • 0035071928 scopus 로고    scopus 로고
    • Thrombin activatable fibrinolysis inhibitor (TAFI) does not inhibit in vitro thrombolysis by pharmacological concentrations of t-PA
    • Colucci M, D'Aprile AM, Italia A, Gresele P, Morser J, Semeraro N. Thrombin activatable fibrinolysis inhibitor (TAFI) does not inhibit in vitro thrombolysis by pharmacological concentrations of t-PA. Thromb Haemost 2001; 85: 661-6.
    • (2001) Thromb Haemost , vol.85 , pp. 661-666
    • Colucci, M.1    D'Aprile, A.M.2    Italia, A.3    Gresele, P.4    Morser, J.5    Semeraro, N.6
  • 26
    • 0030920922 scopus 로고    scopus 로고
    • On the mechanism of the antifibrinolytic activity of plasma carboxypeptidase B
    • Sakharov DV, Plow EF, Rijken DC. On the mechanism of the antifibrinolytic activity of plasma carboxypeptidase B. J Biol Chem 1997; 272: 14477-82.
    • (1997) J Biol Chem , vol.272 , pp. 14477-14482
    • Sakharov, D.V.1    Plow, E.F.2    Rijken, D.C.3
  • 27
    • 33644801469 scopus 로고    scopus 로고
    • The interactions between inflammation and coagulation
    • Esmon CT. The interactions between inflammation and coagulation. Br J Haematol 2005; 131: 417-30.
    • (2005) Br J Haematol , vol.131 , pp. 417-430
    • Esmon, C.T.1
  • 28
    • 84857787797 scopus 로고    scopus 로고
    • Thrombin activatable fibrinolysis inhibitor: at the nexus of fibrinolysis and inflammation
    • Colucci M, Semeraro N. Thrombin activatable fibrinolysis inhibitor: at the nexus of fibrinolysis and inflammation. Thromb Res 2012; 129: 314-19.
    • (2012) Thromb Res , vol.129 , pp. 314-319
    • Colucci, M.1    Semeraro, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.