Photophysical properties and in vitro and in vivo photoinduced antitumor activity of cationic salts of meso-tetrakis(N-alkyl-3-pyridyl)bacteriochlorins

Journal of Photochemistry and Photobiology B: Biology

Volumn 130, Issue , 2014, Pages 109-114

  Yakubovskaya, Raisa I ^a   Plotnikova, Ekaterina A ^a   Plyutinskaya, Anna D ^a   Morozova, Natalya B ^a   Chissov, Valery I ^a   Makarova, Elena A ^b   Dudkin, Semen V ^b   Lukyanets, Evgeny A ^b   Vorozhtsov, Georgy N ^b  

^a Moscow Hertzen Research Oncological   (Russian Federation)

^b Organic Intermediates and Dyes Institute   (Russian Federation)

Author keywords

Cell; Photocytotoxicity; Photodynamic therapy; Photosensitizer; Synthetic bacteriochlorins; Tissue

Indexed keywords

ANTINEOPLASTIC AGENT; BACTERIOCHLORIN; MESO TETRAKIS(1 METHYL 3 PYRIDYL)TETRAIODIDE BACTERIOCHLORIN; MESO TETRAKIS(1 METHYL 3 PYRIDYL)TETRATOSYLATE BACTERIOCHLORIN; MESO TETRAKIS[1 (4' BROMOBUTYL) 3 PYRIDYL]BACTERIOCHLORIN TETRABROMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER SURVIVAL; CONTROLLED STUDY; DARKNESS; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG SCREENING; DRUG STABILITY; DRUG TUMOR LEVEL; FEMALE; FLUORESCENCE; HEP 2 CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LD 50; LEWIS CARCINOMA; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTODYNAMICS; PHOTOTOXICITY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SURVIVAL TIME;

ANIMALIA;

CELL; PHOTOCYTOTOXICITY; PHOTODYNAMIC THERAPY; PHOTOSENSITIZER; SYNTHETIC BACTERIOCHLORINS; TISSUE;

ANIMALS; CARCINOMA, LEWIS LUNG; FEMALE; MICE; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PORPHYRINS; SALTS; TUMOR BURDEN;

EID: 84889667139     PISSN: 10111344     EISSN: 18732682     Source Type: Journal    
DOI: 10.1016/j.jphotobiol.2013.10.017     Document Type: Article

References (14)

1. S. Gross, A. Scherz, M. Neeman, and Y. Salomon Monitoring photodynamic therapy of solid tumors online by BOLD-contrast MR Nat. Med. 9 2003 1327 1331 (Pubitemid 37279859)
2. R. Allison, G. Downie, R. Cuenca, and X.H. Hu Photosensitizers in clinical PDT Photodiagn. Photodyn. Ther. 1 2004 27 42 (Pubitemid 40311381)
3. N. Ikeda, J. Usuda, and H. Kato New aspects of photodynamic therapy for central type early stage lung cancer Lasers Surg. Med. 43 2011 749 754
4. E.V. Kochneva, E.V. Filonenko, and E.G. Vakulovskaya Photosensitizer radachlorin®: skin cancer PDT phase II clinical trials Photodiagn. Photodyn. Ther. 7 2010 258 267
5. R.K. Pandey, G. Zheng, Porphyrins as photosensitizers in photodynamic therapy, in: Karl M. Kadish, Kevin M. Smith, Roger Guilard (Eds.), The Porphyrin Handbook, 2000, pp. 157-230.
6. J. Da̧browski, M. Krzykawska, and L. Arnaut Tissue uptake study and photodynamic therapy of melanoma-bearing mice with a nontoxic, effective chlorine Chem. Med. Chem. 6 2011 1715 1726
7. Y. Huang, P. Mroz, and T. Zhiyentayev In vitro photodynamic therapy and quantitative structure-activity relationship studies with stable synthetic near-infrared-absorbing bacteriochlorin photosensitizers J. Med. Chem. 53 2010 4018 4027
8. A. Szurko, M. Rams, and A. Sochanik Spectroscopic and biological studies of a novel synthetic chlorin derivative with prospects for use in PDT Bioorg Med. Chem. 17 2009 8197 8205
9. Y. Chen, G. Li, and R. Pandey Synthesis of bacteriochlorins and their potential utility in photodynamic therapy (PDT) Curr. Org. Chem. 8 2004 1105 1134 (Pubitemid 38967686)
10. M. Oertel, S. Schastak, and A. Tannapfel Novel bacteriochlorin for high tissue-penetration: photodynamic properties in human biliary tract cancer cells in vitro and in a mouse tumor model J. Photochem. Photobiol. 71 2003 1 10 (Pubitemid 37258826)
11. S. Schastak, B. Jean, and R. Handzel Improved pharmacokinetics, biodistribution and necrosis in vivo using a new near infra-red photosensitizer: tetrahydroporphyrin tetratosylat J. Photochem. Photobiol. 78 2005 203 213 (Pubitemid 40220988)
12. S. Schastak, A. Shulga, F. Berr, P. Wiedemann, Porphyrins and their use as photosensitizer, US Patent 6,410,568 (2002).
13. S.V. Dudkin, A.A. Ignatova, E.S. Kobzeva, Yu.M. Luzhkov, E.A. Lukyanets, E.A. Makarova, N.B. Morozova, A.A. Pankratov, A.D. Plutinskaya, A.V. Feofanov, V.I Chissov, R.I. Yakubovskaya, Photosensitizer for photodynamic therapy, RU Patent 2,479,585 (2012).
14. T. Mosmann Rapid colorimetric assay for cellular growth and survivals: application to proliferation and cytotoxicity assay J. Immunol. Methods 65 1983 55 63 (Pubitemid 14203433)