Reduction of the dose to the elective neck in head and neck squamous cell carcinoma, a randomized clinical trial using intensity modulated radiotherapy (IMRT). Dosimetrical analysis and effect on acute toxicity

Radiotherapy and Oncology

Volumn 109, Issue 2, 2013, Pages 323-329

  Nuyts, Sandra ^a   Lambrecht, Maarten ^a   Duprez, Fréderic ^b   Daisne, Jean Francois ^c   Van Gestel, Dirk ^e   Van Den Weyngaert, Danielle ^d,e   Platteaux, Nele ^a,f   Geussens, Yasmyne ^a   Voordeckers, Mia ^f   Madani, Indira ^b   De Neve, Wilfried ^b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c Clinique & Maternite Sainte Elisabeth Namer   (Belgium)

^d Ziekenhuis Network Antwerp   (Belgium)

^e UNIVERSITY OF ANTWERP   (Belgium)

^f UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

Author keywords

Dose reduction; Elective nodes; Head and neck cancer; Radiotherapy

Indexed keywords

ACUTE TOXICITY; AGED; ARTICLE; CANCER CONTROL; CANCER PATIENT; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DISEASE SEVERITY; DOSIMETRY; DYSPHAGIA; FEMALE; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; INTENSITY MODULATED RADIATION THERAPY; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION HAZARD; RADIOTHERAPY EQUIPMENT; RANDOMIZED CONTROLLED TRIAL; SPINAL CORD; SWALLOWING; TREATMENT OUTCOME;

DOSE REDUCTION; ELECTIVE NODES; HEAD AND NECK CANCER; RADIOTHERAPY;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RADIOTHERAPY DOSAGE; RADIOTHERAPY, INTENSITY-MODULATED;

EID: 84889602539     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2013.06.044     Document Type: Article

References (28)

1. J. Bourhis, J. Overgaard, and H. Audry Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis Lancet 368 2006 843 854
2. P. Blanchard, B. Baujat, and V. Holostenco Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): a comprehensive analysis by tumour site Radiother Oncol 100 2011 33 40
3. S. Nuyts, P. Dirix, and P.M. Clement Impact of adding concomitant chemotherapy to hyperfractionated accelerated radiotherapy for advanced head-and-neck squamous cell carcinoma Int J Radiat Oncol Biol Phys 73 2009 1088 1095
4. M. Machtay, J. Moughan, and A. Trotti Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis J Clin Oncol 26 2008 3582 3589
5. J.A. Langendijk, P. Doornaert, and I.M. Verdonck-de Leeuw Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy J Clin Oncol 26 2008 3770 3776
6. J.A. Langendijk, P. Doornaert, and D.H. Rietveld A predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer Radiother Oncol 90 2009 189 195
7. P. Dirix, S. Abbeel, and B. Vanstraelen Dysphagia after chemoradiotherapy for head-and-neck squamous cell carcinoma: dose-effect relationships for the swallowing structures Int J Radiat Oncol Biol Phys 75 2009 385 392
8. P.C. Levendag, D.N. Teguh, and P. Voet Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: a dose-effect relationship Radiother Oncol 85 2007 64 73
9. M.E. Christianen, C. Schilstra, and I. Beetz Predictive modelling for swallowing dysfunction after primary (chemo)radiation: results of a prospective observational study Radiother Oncol 105 2012 107 114
10. F.Y. Feng, H.M. Kim, and T.H. Lyden Intensity-modulated chemoradiotherapy aiming to reduce dysphagia in patients with oropharyngeal cancer: clinical and functional results J Clin Oncol 28 2010 2732 2738
11. A. Eisbruch, H.M. Kim, and F.Y. Feng Chemo-IMRT of oropharyngeal cancer aiming to reduce dysphagia: swallowing organs late complication probabilities and dosimetric correlates Int J Radiat Oncol Biol Phys 81 2011 e93 e99
12. W.M. Mendenhall, R.R. Million, and N.J. Cassisi Elective neck irradiation in squamous-cell carcinoma of the head and neck Head Neck Surg 3 1980 15 20
13. J.M. Chow, B.C. Levin, and J.S. Krivit Radiotherapy or surgery for subclinical cervical node metastases Arch Otolaryngol Head Neck Surg 115 1989 981 984
14. G.H. Fletcher Elective irradiation of subclinical disease in cancers of the head and neck Cancer 29 1972 1450 1454
15. F. Duprez, K. Bonte, and N.W. De Regional relapse after intensity-modulated radiotherapy for head-and-neck cancer Int J Radiat Oncol Biol Phys 79 2011 450 458
16. M. Lambrecht, P. Dirix, and W. Van den Bogaert Incidence of isolated regional recurrence after definitive (chemo-)radiotherapy for head and neck squamous cell carcinoma Radiother Oncol 93 2009 498 502
17. L.A. Dawson, Y. Anzai, and L. Marsh Patterns of local-regional recurrence following parotid-sparing conformal and segmental intensity-modulated radiotherapy for head and neck cancer Int J Radiat Oncol Biol Phys 46 2000 1117 1126
18. V. Gregoire, A. Eisbruch, and M. Hamoir Proposal for the delineation of the nodal CTV in the node-positive and the post-operative neck Radiother Oncol 79 2006 15 20
19. V. Gregoire, E. Coche, and G. Cosnard Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy. Proposal for standardizing terminology and procedure based on the surgical experience Radiother Oncol 56 2000 135 150
20. G.W. Sherouse, K. Novins, and E.L. Chaney Computation of digitally reconstructed radiographs for use in radiotherapy treatment design Int J Radiat Oncol Biol Phys 18 1990 651 658
21. C.M. Nutting, J.P. Morden, and K.J. Harrington Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial Lancet Oncol 12 2011 127 136
22. A. Nasman, P. Attner, and L. Hammarstedt Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma? Int J Cancer 125 2009 362 366
23. A. Auluck, G. Hislop, and C. Bajdik Trends in oropharyngeal and oral cavity cancer incidence of human papillomavirus (HPV)-related and HPV-unrelated sites in a multicultural population: the British Columbia experience Cancer 116 2010 2635 2644
24. K.K. Ang, J. Harris, and R. Wheeler Human papillomavirus and survival of patients with oropharyngeal cancer N Engl J Med 363 2010 24 35
25. N. Platteaux, P. Dirix, and E. Dejaeger Dysphagia in head and neck cancer patients treated with chemoradiotherapy Dysphagia 25 2010 139 152
26. M. Bedi, S. Firat, and V.A. Semenenko Elective lymph node irradiation with intensity-modulated radiotherapy: is conventional dose fractionation necessary? Int J Radiat Oncol Biol Phys 83 2012 e87 e92
27. J.K. Salama, K.M. Stenson, and E.O. Kistner Induction chemotherapy and concurrent chemoradiotherapy for locoregionally advanced head and neck cancer: a multi-institutional phase II trial investigating three radiotherapy dose levels Ann Oncol 19 2008 1787 1794
28. H.R. Withers, L.J. Peters, and J.M. Taylor Dose-response relationship for radiation therapy of subclinical disease Int J Radiat Oncol Biol Phys 31 1995 353 359