Calcitonin measurement in aspiration needle washout fluids has higher sensitivity than cytology in detecting medullary thyroid cancer: A retrospective multicentre study

Clinical Endocrinology

Volumn 80, Issue 1, 2014, Pages 135-140

  Trimboli, Pierpaolo ^a   Cremonini, Nadia ^b   Ceriani, Luca ^c   Saggiorato, Enrico ^d   Guidobaldi, Leo ^a   Romanelli, Francesco ^e   Ventura, Claudio ^a   Laurenti, Oriana ^a   Messuti, Ilaria ^d   Solaroli, Erica ^b   Madaio, Raffaele ^a   Bongiovanni, Massimo ^f   Orlandi, Fabio ^d   Crescenzi, Anna ^a   Valabrega, Stefano ^g   Giovanella, Luca ^c  

^a Ospedale Israelitico di Roma   (Italy)

^b Azienda USL di Bologna   (Italy)

^c ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND   (Switzerland)

^d UNIVERSITY OF TURIN   (Italy)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f INSTITUTE OF PATHOLOGY   (Switzerland)

^g SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN; CHROMOGRANIN A;

ADULT; AGED; ARTICLE; ASPIRATION NEEDLE; ASPIRATION NEEDLE WASHOUT FLUID; BENIGN TUMOR; BODY FLUID; CALCITONIN BLOOD LEVEL; CANCER CYTODIAGNOSIS; CLINICAL ARTICLE; CLINICAL PRACTICE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FALSE NEGATIVE RESULT; FEMALE; FINE NEEDLE ASPIRATION BIOPSY; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; INTERMETHOD COMPARISON; LABORATORY DEVICE; MALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; THYROID MEDULLARY CARCINOMA; THYROIDECTOMY; TUMOR BIOPSY;

ADULT; AGED; BIOPSY, FINE-NEEDLE; CALCITONIN; CYTOLOGICAL TECHNIQUES; FEMALE; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; THYROID GLAND; THYROID NEOPLASMS; THYROID NODULE;

EID: 84889593393     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/cen.12234     Document Type: Article

References (27)

1. Cooper, D.S., Doherty, G.M., &, Haugen, B.R., Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer. (2009) Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid, 19, 1167-1214.
2. Gharib, H., Papini, E., Paschke, R., et al,., AACE/AME/ETA Task Force on Thyroid Nodules. (2010) American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: executive summary of recommendations. Journal of Endocrinological Investigation, 33, 287-291.
3. Giovanella, L., &, Suriano, S., (2010) Spurious hypercalcitoninemia and heterophilic antibodies in patients with thyroid nodules. Head and Neck, 33, 95-97.
4. Kim, J.M., Chung, K.W., Kim, S.W., et al,. (2010) Spurious hypercalcitoninemia in patients with nodular thyroid disease induced by heterophilic antibodies. Head and Neck, 32, 68-75.
5. Karanikas, G., Moameni, A., Poetzi, C., et al,. (2004) Frequency and relevance of elevated calcitonin levels in patients with neoplastic and nonneoplastic thyroid disease and in healthy subjects. Journal of Clinical Endocrinology and Metabolism, 85, 919-922.
6. Rodding, A.H., Levine, S.N., &, Fowler, M.R., (2000) Normal preoperative calcitonin levels do not always exclude medullary thyroid carcinoma in patients with large palpable thyroid masses. Thyroid, 10, 919-922.
7. Hamy, A., Pessaux, P., Mirallie, E., et al,. (2005) Central neck dissection in the management of sporadic medullary thyroid microcarcinoma. European Journal of Surgical Oncology, 31, 774-777.
8. Elisei, R., Bottici, V., Luchetti, F., et al,. (2004) Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: experience in 10 864 patients with nodular thyroid disorders. Journal of Clinical Endocrinology and Metabolism, 89, 163-168.
9. Bugalho, M.J.M., Santos, J.R., &, Sobrinho, L., (2005) Preoperative diagnosis of medullary thyroid carcinoma: fine needle aspiration cytology as compared with serum calcitonin measurement. Journal of Surgical Oncology, 91, 56-60.
10. Boi, F., Maurelli, I., Pinna, G., et al,. (2007) Calcitonin measurement in washout fluid from fine needle aspiration of neck masses in patients with primary and metastatic medullary thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism, 92, 2115-2118.
11. Kudo, T., Miyauchi, A., Ito, Y., et al,. (2007) Diagnosis of medullary thyroid carcinoma by calcitonin measurement in fine needle aspiration biopsy specimens. Thyroid, 17, 635-638.
12. Abraham, D., Gault, P.M., Hunt, J., et al,. (2009) Calcitonin estimation in neck lymph node fine-needle aspirate fluid prevents misinterpretation of cytology in patients with metastatic medullary thyroid cancer. Thyroid, 19, 1015-1016.
13. Massaro, F., Dolcino, M., Degrandi, R., et al,. (2009) Calcitonin assay in wash-out fluid after fine-needle aspiration biopsy in patients with a thyroid nodule and border-line value of the hormone. Journal of Endocrinological Investigation, 32, 308-312.
14. Trimboli, P., Rossi, F., Baldelli, R., et al,. (2012) Measuring calcitonin in washout of the needle in patients undergoing fine needle aspiration with suspicious medullary thyroid cancer. Diagnostic Cytopathology, 40, 394-398.
15. t. Experimental and Clinical Endocrinology & Diabetes, 120, 234-237.
16. Giovanella, L., Verburg, F., Imperiali, M., et al,. (2012) Comparison of serum calcitonin and procalcitonin in detecting medullary thyroid carcinoma among patients with thyroid nodules. Clinical Chemistry and Laboratory Medicine, 51, 1477-1488.
17. De Lellis, R., Lloyd, R., Heitz, P., et al,. (2004) Pathology and genetics of tumour of endocrine organs. In:, P. Kleihues, L. Sobin, eds. World Health Organization Classification of Tumours. IARC, Lyon, France, 49-133.
18. Saggiorato, E., Cappia, S., De Giuli, P., et al,. (2001) Galectin-3 as a presurgical immunocytodiagnostic marker of minimally invasive follicular thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism, 86, 5152-5158.
19. Giovanella, L., Ceriani, L., &, Bongiovanni, M., (2013) Calcitonin measurement on fine needle washouts: preanalytical issues and normal reference values. Diagnostic Cytopathology, 41, 226-229.
20. Galen, R.S., &, Gambino, S.L., (1975) How to determine the predictive value and efficiency of a test when reading a scientific paper. In:, R.S. Galen, S.L. Gambino, eds. Beyond Normality: The Predictive Value and Efficiency of Medical Diagnosis. John Wiley, New York, NY, 29-40.
21. Papaparaskeva, K., Nagel, H., &, Droese, M., (2000) Cytologic diagnosis of medullary carcinoma of the thyroid gland. Diagnostic Cytopathology, 22, 351-358.
22. Forrest, C.H., Frost, F.A., de Boer, W.B., et al,. (1998) Medullary carcinoma of the thyroid: accuracy of diagnosis of fine-needle aspiration cytology. Cancer, 84, 295-302.
23. Nikiforov, Y.E., Biddinger, P.W., &, Thompson, L.D., (2009) Diagnostic Pathology and Molecular Genetics of the Thyroid. Lippincott Williams & Wilkins, Philadelphia, PA, USA.
24. Kini, S.R., Miller, J.M., Hamburger, J.I., et al,. (1984) Cytopathology of medullary thyroid carcinoma. Archives of Pathology and Laboratory Medicine, 108, 156-159.
25. Costante, G., Meringolo, D., Durante, C., et al,. (2007) Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules. Journal of Clinical Endocrinology and Metabolism, 92, 450-455.
26. Lee, S., Shin, J.H., Han, B.K., et al,. (2000) Medullary thyroid carcinoma: comparison with papillary thyroid carcinoma and application of current sonographic criteria. American Journal of Roentgenology, 194, 1090-1094.
27. Trimboli, P., Nasrollah, N., Amendola, S., et al,. (2012) Should we use ultrasound features associated with papillary thyroid cancer in diagnosing medullary thyroid cancer? Endocrine Journal, 59, 503-508.