Necrotizing enterocolitis: Prevention, treatment, and outcome

Journal of Pediatric Surgery

Volumn 48, Issue 12, 2013, Pages 2359-2367

  Hall, Nigel J ^a,b   Eaton, Simon ^a   Pierro, Agostino ^b  

^a GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Laparotomy; Necrotizing enterocoltis; Premature infant; Primary anastomosis; Resection

Indexed keywords

ARGININE; CASPASE 3; CELL ADHESION MOLECULE; ENDOTOXIN; GLUTAMINE; IMMUNOGLOBULIN; LACTOFERRIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROBIOTIC AGENT; RECOMBINANT ERYTHROPOIETIN; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST;

ABDOMINAL DISTENSION; ABDOMINAL DRAINAGE; ABDOMINAL MASS; ABDOMINAL TENDERNESS; ANTIBIOTIC PROPHYLAXIS; APNEA; ASPHYXIA; BACTERIAL OVERGROWTH; CESAREAN SECTION; CLOSTRIDIUM; COMPARATIVE STUDY; CONFERENCE PAPER; CONGENITAL HEART DISEASE; CYANOCOBALAMIN DEFICIENCY; DECUBITUS; ECLAMPSIA; ENDOTOXEMIA; ENTERIC FEEDING; ENZYME DEFICIENCY; EXTREMELY LOW BIRTH WEIGHT; FETUS DISTRESS; GANGRENE; GENOTYPE; HUMAN; HYPOTHERMIA; INDUCED HYPOTHERMIA; INFANT MORTALITY; INTESTINAL DYSMOTILITY; INTESTINE ISCHEMIA; INTESTINE OBSTRUCTION; INTESTINE PERFORATION; LAPAROTOMY; LOW BIRTH WEIGHT; MALABSORPTION; META ANALYSIS (TOPIC); MORTALITY; MULTICENTER STUDY (TOPIC); NECROTIZING ENTEROCOLITIS; NONHUMAN; OUTCOME ASSESSMENT; PATENT DUCTUS ARTERIOSUS; PERINATAL ASPHYXIA; PEROPERATIVE COMPLICATION; PERSISTENT PULMONARY HYPERTENSION; PNEUMATOSIS INTESTINALIS; PNEUMOPERITONEUM; PREMATURE FETUS MEMBRANE RUPTURE; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REPERFUSION INJURY; RESPIRATORY DISTRESS SYNDROME; RISK FACTOR; SEPSIS; SHORT BOWEL SYNDROME; NECROTIZING ENTEROCOLTIS; NEWBORN; PRIMARY ANASTOMOSIS; REVIEW; SURGERY; TREATMENT OUTCOME;

LAPAROTOMY; NECROTIZING ENTEROCOLTIS; PREMATURE INFANT; PRIMARY ANASTOMOSIS; RESECTION;

ENTEROCOLITIS, NECROTIZING; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; RISK FACTORS; TREATMENT OUTCOME;

EID: 84889570619     PISSN: 00223468     EISSN: 15315037     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2013.08.006     Document Type: Conference Paper

References (69)

1. K.O. Schmid, and K. Quaiser Über eine besonders schwer verlaufende Form von Enteritis beim Säugling Österreichische Zeitschrift für Kinderchirurgie 1953 114
2. B. Barlow, T.V. Santulli, and W.C. Heird An experimental study of acute neonatal enterocolitis - the importance of breast milk J Pediatr Surg 9 1974 587 595
3. P.W. Lin, and B.J. Stoll Necrotising enterocolitis Lancet 368 2006 1271 1283
4. C.M. Rees, S. Eaton, and A. Pierro National prospective surveillance study of necrotizing enterocolitis in neonatal intensive care units J Pediatr Surg 45 2010 1391 1397
5. M. Thyoka, P. De Coppi, and S. Eaton Advanced necrotizing enterocolitis. Part 1: mortality Eur J Pediatr Surg 2011 In press
6. S.C. Fitzgibbons, Y. Ching, and D. Yu Mortality of necrotizing enterocolitis expressed by birth weight categories J Pediatr Surg 44 2009 1072 1075
7. G. Malcolm, D. Ellwood, and K. Devonald Absent or reversed end diastolic flow velocity in the umbilical artery and necrotising enterocolitis Arch Dis Child 66 1991 805 807
8. A. Lucas, and T.J. Cole Breast milk and neonatal necrotising enterocolitis Lancet 336 1990 1519 1523
9. J. Meinzen-Derr, B. Poindexter, and L. Wrage Role of human milk in extremely low birth weight infants' risk of necrotizing enterocolitis or death J Perinatol 29 2009 57 62
10. P. Vejchapipat, S. Eaton, and K. Fukumoto Hepatic glutamine metabolism during endotoxemia in neonatal rats Nutrition 18 2002 293 297
11. J. van Acker, F. de Smet, and G. Muyldermans Outbreak of necrotizing enterocolitis associated with Enterobacter sakazakii in powdered milk formula J Clin Microbiol 39 2001 293 297
12. H.A. Rotbart, and M.J. Levin How contagious is necrotizing enterocolitis? Pediatr Infect Dis 2 1983 406 413
13. D.W. Scheifele Role of bacterial toxins in neonatal necrotizing enterocolitis J Pediatr 117 1990 S44 S46
14. D.W. Scheifele, E.M. Olsen, and M.R. Pendray Endotoxinemia and thrombocytopenia during neonatal necrotizing enterocolitis Am J Clin Pathol 83 1985 227 229
15. R.R. Engel Origin of mural gas in necrotizing neterocolitis Pediatr Res 7 1973 292
16. G. Lawrence, J. Bates, and A. Gaul Pathogenesis of neonatal necrotising enterocolitis Lancet 1 1982 137 139
17. M.S. Caplan, and W. Hsueh Necrotizing enterocolitis: role of platelet activating factor, endotoxin, and tumor necrosis factor J Pediatr 117 1990 S47 S51
18. A. Zani, L. Cordischi, and M. Cananzi Assessment of a neonatal rat model of necrotizing enterocolitis Eur J Pediatr Surg 18 2008 423 426
19. M.M. Eibl, H.M. Wolf, and H. Furnkranz Prevention of necrotizing enterocolitis in low-birth-weight infants by IgA-IgG feeding N Engl J Med 319 1988 1 7
20. J. Foster, and M. Cole Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth-weight neonates Cochrane Database Syst Rev 2004 CD001816
21. R.G. Bury, and D. Tudehope Enteral antibiotics for preventing necrotizing enterocolitis in low birthweight or preterm infants Cochrane Database Syst Rev 2001 CD000405
22. P. Manzoni, M. Rinaldi, and S. Cattani Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial JAMA 302 2009 1421 1428
23. D.J. Ledbetter, and S.E. Juul Erythropoietin and the incidence of necrotizing enterocolitis in infants with very low birth weight J Pediatr Surg 35 2000 178 181
24. T.R. Tubman, S.W. Thompson, and W. McGuire Glutamine supplementation to prevent morbidity and mortality in preterm infants Cochrane Database Syst Rev 2008 CD001457
25. H.J. Amin, S.A. Zamora, and D.D. McMillan Arginine supplementation prevents necrotizing enterocolitis in the premature infant J Pediatr 140 2002 425 431
26. S. Eaton, and N.J. Hall The potential of probiotics in the fight against necrotizing enterocolitis Expert Rev Gastroenterol Hepatol 2013 In Press
27. H.C. Lin, C.H. Hsu, and H.L. Chen Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: a multicenter, randomized, controlled trial Pediatrics 122 2008 693 700
28. M. Samanta, M. Sarkar, and P. Ghosh Prophylactic probiotics for prevention of necrotizing enterocolitis in very low birth weight newborns J Trop Pediatr 55 2009 128 131
29. G. Deshpande, S. Rao, and S. Patole Updated meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates Pediatrics 125 2010 921 930
30. R.F. Soll Probiotics: are we ready for routine use? Pediatrics 125 2010 1071 1072
31. S. Sullivan, R.J. Schanler, and J.H. Kim An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products J Pediatr 156 2010 562 567
32. M.A. Quigley, G. Henderson, and M.Y. Anthony Formula milk versus donor breast milk for feeding preterm or low birth weight infants Cochrane Database Syst Rev 2007 CD002971
33. A. Leaf Alimentazione del neonato pretermine IUGR: studio multicentrico ADEPT (Abnormal Doppler Enteral Prescription Trial). (Feeding the IUGR premature newborn infant: the multicenter ADEPT study) Minerva Pediatr 62 2010 31 33
34. P. Karagianni, D.D. Briana, and G. Mitsiakos Early versus delayed minimal enteral feeding and risk for necrotizing enterocolitis in preterm growth-restricted infants with abnormal antenatal Doppler results Am J Perinatol 27 2010 367 373
35. R.M. Moonen, A.D. Paulussen, and N.Y. Souren Carbamoyl phosphate synthetase polymorphisms as a risk factor for necrotizing enterocolitis Pediatr Res 62 2007 188 190
36. A. Treszl, T. Tulassay, and B. Vasarhelyi Genetic basis for necrotizing enterocolitis - risk factors and their relations to genetic polymorphisms Front Biosci 11 2006 570 580
37. V. Sampath, M. Le, and L. Lane The NFKB1 (g.-24519delATTG) variant is associated with necrotizing enterocolitis (NEC) in premature infants J Surg Res 169 2011 E51 E57
38. S. Ragazzi, A. Pierro, and M. Peters Early full blood count and severity of disease in neonates with necrotizing enterocolitis Pediatr Surg Int 19 2003 376 379
39. M. Ververidis, E.M. Kiely, and L. Spitz The clinical significance of thrombocytopenia in neonates with necrotizing enterocolitis J Pediatr Surg 36 2001 799 803
40. N.J. Evennett, N. Alexander, and M. Petrov A systematic review of serologic tests in the diagnosis of necrotizing enterocolitis J Pediatr Surg 44 2009 2192 2201
41. J.P. Derikx, N.J. Evennett, and P.L. Degraeuwe Urine based detection of intestinal mucosal cell damage in neonates with suspected necrotising enterocolitis Gut 56 2007 1473 1475
42. N.J. Evennett, N.J. Hall, and A. Pierro Urinary intestinal fatty acid-binding protein concentration predicts extent of disease in necrotizing enterocolitis J Pediatr Surg 45 2010 735 740
43. R. Faingold, A. Daneman, and G. Tomlinson Necrotizing enterocolitis: assessment of bowel viability with color Doppler US Radiology 235 2005 587 594
44. C.T. Silva, A. Daneman, and O.M. Navarro Correlation of sonographic findings and outcome in necrotizing enterocolitis Pediatr Radiol 37 2007 274 282
45. M.C. Walsh, and R.M. Kliegman Necrotizing enterocolitis: treatment based on staging criteria Pediatr Clin North Am 33 1986 179 201
46. C.A. Coursey, C.L. Hollingsworth, and C. Wriston Radiographic predictors of disease severity in neonates and infants with necrotizing enterocolitis AJR Am J Roentgenol 193 2009 1408 1413
47. A. Zani, S. Eaton, and F.F. Leon Captopril reduces the severity of bowel damage in a neonatal rat model of necrotizing enterocolitis J Pediatr Surg 43 2008 308 314
48. J. Lu, M. Pierce, and A. Franklin Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis Pediatr Res 68 2010 225 230
49. G. Stefanutti, A. Pierro, and E.J. Parkinson Moderate hypothermia as a rescue therapy against intestinal ischemia and reperfusion injury in the rat Crit Care Med 36 2008 1564 1572
50. C. Tayman, D. Uckan, and E. Kilic Mesenchymal stem cell therapy in necrotizing enterocolitis: a rat study Pediatr Res 70 2011 489 494
51. A. Zani, M. Cananzi, and F. Fascetti-Leon Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism Gut 2013 10.1136/gutjnl-2012- 303735
52. N.J. Hall, S. Eaton, and M.J. Peters Mild controlled hypothermia in preterm neonates with advanced necrotizing enterocolitis Pediatrics 125 2010 e300 e308
53. C.M. Rees, N.J. Hall, and S. Eaton Surgical strategies for necrotizing enterocolitis: a survey of practice in the United Kingdom Arch Dis Child 90 2005 F152 F155
54. N.J. Hall, J. Curry, and D.P. Drake Resection and primary anastomosis is a valid surgical option for infants with necrotizing enterocolitis who weigh less than 1000 g Arch Surg 140 2005 1149 1151
55. STAT Trial http://www.ucl.ac.uk/ich/research-ich/surgery/stat-trial. Accessed 29-7-2013.
56. O. Ron, M. Davenport, and S. Patel Outcomes of the "clip and drop" technique for multifocal necrotizing enterocolitis J Pediatr Surg 44 2009 749 754
57. M. Thyoka, S. Eaton, and E.M. Kiely Outcomes of diverting jejunostomy for severe necrotizing enterocolitis J Pediatr Surg 46 2011 1041 1044
58. L.S. Book, J.J. Herbst, and S.O. Atherton Necrotizing enterocolitis in low-birth-weight infants fed an elemental formula J Pediatr 87 1975 602 605
59. M.S. Lessin, F.I. Luks, and C.W. Wesselhoeft Jr. Peritoneal drainage as definitive treatment for intestinal perforation in infants with extremely low birth weight (< 750 g) J Pediatr Surg 33 1998 370 372
60. J.D. Rovin, B.M. Rodgers, and R.C. Burns The role of peritoneal drainage for intestinal perforation in infants with and without necrotizing enterocolitis J Pediatr Surg 34 1999 143 147
61. C.M. Rees, S. Eaton, and E.M. Kiely Peritoneal drainage or laparotomy for neonatal bowel perforation? A randomized controlled trial Ann Surg 248 2008 44 51
62. R.L. Moss, R.A. Dimmitt, and D.C. Barnhart Laparotomy versus peritoneal drainage for necrotizing enterocolitis and perforation N Engl J Med 354 2006 2225 2234
63. A. Pierro, S. Eaton, and C.M. Rees Is there a benefit of peritoneal drainage for necrotizing enterocolitis in newborn infants? J Pediatr Surg 45 2010 2117 2118
64. A. Pierro, and N. Hall Surgical treatment of infants with necrotizing enterocolitis Semin Neonatol 8 2003 223 232
65. W.A. Ballance, B.B. Dahms, and N. Shenker Pathology of neonatal necrotizing enterocolitis: a ten-year experience J Pediatr 117 1990 S6 S13
66. M.W. Schaart, A.C. De Bruijn, and D.M. Bouwman Epithelial functions of the residual bowel after surgery for necrotising enterocolitis in human infants J Pediatr Gastroenterol Nutr 49 2009 31 41
67. N.J. Sebire, M. Thyoka, and A. Pierro Histological and immunohistochemical features associated with outcome in neonatal necrotizing enterocolitis Eur J Pediatr Surg 2013 In press
68. C.M. Rees, A. Pierro, and S. Eaton Neurodevelopmental outcomes of neonates with medically and surgically treated necrotizing enterocolitis Arch Dis Child Fetal Neonatal Ed 92 2007 F193 F198
69. S.R. Hintz, D.E. Kendrick, and B.J. Stoll Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis Pediatrics 115 2005 696 703