Alterations of Hepatic and Splanchnic Microvascular Exchange in Cirrhosis: Local Factors in the Formation of Ascites

Ascites and Renal Dysfunction in Liver Disease: Pathogenesis, Diagnosis, and Treatment: Second Edition

Volumn , Issue , 2007, Pages 174-185

  Henriksen, Jens H ^a,b   Møller, Søren ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b HVIDOVRE HOSPITAL   (Denmark)

Author keywords

Ascites; Cirrhosis; Hydraulic conductivity; Neurohumoral regulation; Oncotic pressure

Indexed keywords

EID: 84889486395     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470987476.ch14     Document Type: Chapter

References (106)

1. Michel CC. Transport of macromolecules through microvascular walls. Cardiovasc Res 1996; 32:644-53.
2. Reed RK, McHale NG, Bert JL, Winlove CP, Laine GA, eds. Interstitium, Connective Tissue and Lymphatics. London: Portland Press, 1995.
3. Aukland K, Nicolaysen G. Interstitial fluid volume: local regulatory mechanisms. Physiol Rev 1981; 61:556-643.
4. Pearl W. Convection and permeation of albumin between plasma and interstitium. Microvasc Res 1975; 10:82-94.
5. Levick JR. Revision of the Starling principle: new views of tissue fluid balance. J Physiol (Loud) 2004; 557: 704.
6. Bennett HS, Luft JH, Hampton JC. Morphological classifications of vertebrae blood capillaries. Am J Physiol 1959; 196:381-90.
7. Crone C, Lassen NA, eds. Alfred Benzon Symposium II: Capillary Permeability. Copenhagen: Munksgaard, 1970.
8. Laine GA, Hall JT, Laine SH, Granger HJ. Transsinusoidal fluid dynamics in canine liver during venous hypertension. Circ Res 1979; 45:317-23.
9. Witte CL, Witte MH, Dumont AE. Lymph imbalance in the genesis and perpetuation of the ascites syndrome in hepatic cirrhosis. Gastroenterology 1980; 78:1059-68.
10. Raybuck HE, Allen L, Harms WS. Absorption of serum from the peritoneal cavity. Am J Physiol 1960; 199:1021-4.
11. Zink J, Greenway CV. Intraperitoneal pressure in formation and reabsorption of ascites in cats. Am J Physiol 1977; 233:185-90.
12. Epstein M, ed. The Kidney in Liver Disease, 4th edn. Philadelphia: Hanley & Belfus, 1996.
13. Losowsky MS, Jones DP, Lieber CS, Davidson CS. Local factors in ascites formation during sodium retention in cirrhosis. N Engl J Med 1963; 268:651-3.
14. Lieberman FL, Denison EK, Reynolds TB. The relationship of plasma volume, portal hypertension, ascites, and renal sodium retention in cirrhosis: the overflow theory of ascites formation. Ann NY Acad Sci 1970; 170:202-12.
15. Schrier RW, Arroyo V, Bernardi M, Epstein M, Henriksen JH, Rodés J. Peripheral arterial vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis. Hepatology 1988; 8:1151-7.
16. Henriksen JH, Winkler K. Peritoneum and ascites formation. In: Bengmark S, ed. Peritoneum and Peritoneal Access. London: Butterworth, 1988; 94-110.
17. Leak LV. Lymphatic endothelial-interstitial interface. Lymphology 1987; 20:196-204.
18. Henriksen JH, Horn T, Christoffersen P. The blood-lymph barrier in the liver. A review based on morphological and functional concepts of normal and cirrhotic liver. Liver 1984; 4:221-32.
19. Taylor AE. Capillary fluid filtration. Starling forces and lymph flow. Circ Res 1981; 49:557-75.
20. Aukland K, Reed RK. Interstitial-lymphatic mechanisms in the control of extracellular fluid volume. Physiol Rev 1993; 73:1-78.
21. Huet P-M, Pomier-Layrargues G, Villeneuve J-P, Varin F, Viallet A. Intrahepatic circulation in liver disease. Semin Liver Dis 1986; 6:277-86.
22. Braet F, Wisse E. Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review. Comp Hepatol 2002; 1:1-20.
23. Goresky CA, Huet M, Marleau D, Lough JO, Villeneuve JP. Blood tissue exchange in cirrhosis of the liver. In: Tygstrup N, Orlandi F, eds. Cirrhosis of the Liver: Methods and Fields of Research. Amsterdam: Elsevier Science Publishers B.V., 1987; 143-64.
24. Henriksen JH. Permselectivity of the liver blood-lymph (ascitic fluid) barrier to macromolecules in decompensated cirrhosis: relation to calculated pore-size. Clin Physiol 1983; 3:163-71.
25. Horn T, Christoffersen P, Henriksen JH. Alcoholic liver injury: defenestration in non-cirrhotic livers. A scanning electron microscopic study. Hepatology 1987; 7:77-82.
26. Goresky CA. The interstitial space in the liver. Its partitioning effect. In: Crone C, Lassen NA, eds. Alfred Benzon Symposium II: Capillary Permeability. Copenhagen: Munksgaard, 1970; 415-33.
27. Garcia-Diaz M, Alcalde M, de Sande F et al. Low protein concentration in cirrhotic ascites is related to low ascitic concentrations of immunoglobulins G and A. Eur J Gastroenterol Hepatol 1995; 7:963-9.
28. Dubuisson L, Bedin C, Gonzalez P, Garcin H, Bioulac-Sage P, Balabaud C. Sinusoidal capillarization in a model of nodular regenerative hyperplasia induced by selenium intoxication in the rat. In: Wisse E, Knook DL, McCuskey RS, eds. Cells of the Hepatic Sinusoid, Vol 3. Leiden: The Kupffer Cell Foundation, 1991; 222-5.
29. Oikawa H, Masuda T, Kawaguchi J, Sato R. Threedimensional examination of hepatic stellate cells in rat liver and response to endothelin-1 using confocal laser scanning microscopy. J Gastroenterol Hepatol 2002; 17:861-72.
30. Laine GA, Hall JT, Laine SH, Granger HJ. Transsinusoidal fluid dynamics in canine liver. Circ Res 1979; 45:317-23.
31. Granger DN, Miller T, Allen R, Parker RE, Parker JC, Taylor AE. Permselectivity of cat liver blood-lymph barrier to endogenous macromolecules. Gastroenterology 1979; 77:103-9.
32. Yamanaka Y, Araki K, Ogata T. Three-dimensional organization of lymphatics in the dog small intestine: a scanning electron microscopic study on corrosion casts. Arch Histol Cytol 1995; 58:465-74.
33. Johnson PC, Richardson DR. The influence of venous pressure on filtration forces in the intestine. Microvasc Res 1974; 7:296-306.
34. Granger DN, Barrowman JA. Gastrointestinal and liver edema. In: Staub NC, Taylor AE, eds. Edema. New York: Raven, 1984; 615-56.
35. Granger DN, Taylor AE. Permeability of intestinal capillaries to endogenous macromolecules. Am J Physiol 1980; 238: H457-H464.
36. Li B, Silver I, Szalai JP, Johnston MG. Pressure-volume relationships in sheep mesenteric lymphatic vessels in situ: response to hypovolaemia. Microvasc Res 1998; 56:127-38.
37. Flessner MF, Fenstermacher JD, Blasberg RG, Dedrick RL. Peritoneal absorption of macromolecules studied by quantitative autoradiography. Am J Physiol 1985; 248: H26-H32.
38. Rippe B, Rosengren BI, Venturoli D. The peritoneal microcirculation in peritoneal dialysis. Microcirculation 2001; 8:303-20.
39. Rippe B, Simonsen O, Stelin G. Correspondence. Perit Dial Int 1991; 11:181-6.
40. Flessner MF, Dedrick RL, Schultz JS. Exchange of macromolecules between peritoneal cavity and plasma. Am J Physiol 1985; 248: H15-H25.
41. Flesser MR, Parker PJ, Sieber SM. Peritoneal lymphatic uptake of fibrinogen and erythrocytes in the rat. Am J Physiol 1983; 244: H89-H96.
42. Zakaria ER, Simonsen O, Rippe A, Rippe B. Transport of tracer albumin from peritoneum to plasma: role of diaphragmatic, visceral, and parietal lymphatics. Am J Physiol 1996; 270: H1549-H1556.
43. Dichi JB, Dichi I, Maio R et al. Whole-body protein turnover in malnourished patients with Child class B and C cirrhosis on diets low to high in protein energy. Nutrition 2001; 17:239-42.
44. Krediet RT. Peritoneal physiology-impact on solute and fluid clearance. Adv Ren Replace Ther 2000; 7:271-9.
45. Ricardson PD, Granger DN, Mailman D, Kvietys PR. Permeability characteristics of colonic capillaries. Am J Physiol 1980; 239: G300-G305.
46. Perry MA, Crook WJ, Granger DN. Permeability of gastric capillaries to small and large molecules. Am J Physiol 1981; 241: G478-G486.
47. Ekataksin W, Kaneda K. Liver microvascular architecture: an insight into the pathophysiology of portal hypertension. Semin Liver Dis 1999; 19:359-82.
48. Groszmann RJ. Vasodilatation and hyperdynamic circulatory state in chronic liver disease. In: Bosch, J, Groszmann, RJ, eds. Portal Hypertension. Pathophysiology and Treatment. Oxford: Blackwell, 1994; 17-26.
49. Colombato LA, Albinos A, Groszmann RJ. Role of central blood volume in the development of sodium retention in portal hypertensive rats. Gastroenterology 1996; 110:193-8.
50. Schaffner F, Popper H. Capillarization of hepatic sinusoid in man. Gastroenterology 1963; 44:239-42.
51. Moragas A, Allende H, Sans M. Characteristics of perisinusoidal collagenization in liver cirrhosis: computerassisted quantitative analysis. Anal Quant Cytol Histol 1998; 20:169-77.
52. Salo J, Ginès A, Ginès P et al. Effect of therapeutic paracentesis on plasma volume and transvascular escape rate of albumin in patients with cirrhosis. J Hepatol 1997; 27:645-53.
53. Henriksen JH, Siemssen O, Krintel JJ, Malchow-Møller A, Bendtsen F, Ring-Larsen H. Dynamics of albumin in plasma and ascitic fluid in patients with cirrhosis. J Hepatol 2001; 34:53-60.
54. Henriksen JH, Lassen NA, Parving H-H, Winkler K. Filtration as the main transport mechanism of protein exchange between plasma and the peritoneal cavity in hepatic cirrhosis. Scand J Clin Lab Invest 1980; 40:503-13.
55. Witte MH, Witte CL, Dumont AE. Estimated net transcapillary water and protein flux in the liver and intestine of patients with portal hypertension from hepatic cirrhosis. Gastroenterology 1981; 80:265-72.
56. Rippe B, Stelin G. Simulations of peritoneal solute transport during CAPD. Application of two-pore formalism. Kidney Int 1989; 35:1234-44.
57. Joffe P, Henriksen JH. Bidirectional peritoneal transport of albumin in continuous ambulatory peritoneal dialysis. Nephrol Dial Transplant 1995; 10:1725-32.
58. Shear L, Swartz C, Shinaberger JA, Barry KG. Kinetics of peritoneal fluid absorption in adult man. N Engl J Med 1965; 272:123-9.
59. Rippe B, Perry MA, Granger DN. Permselectivity of the peritoneal membrane. Microvasc Res 1985; 29: 89.
60. Winkler K. Kinetics of elimination from the blood: principles and procedures. In: Henriksen JH, ed. Degradation of Bioactive Substances: Physiology and Pathophysiology. Boca Raton: CRC Press, 1991; 33-45.
61. Runyon BA, Montano AA, Akriviadis EA, Antillon MR, Irving MA, McHutchison JG. The serum-ascites albumin gradient is superior to the exudate-transudate concept in the differential diagnosis of ascites. Ann Intern Med 1992; 117:215-20.
62. Shear L, Santiago C, Gabuzda GJ. Compartmentalization of ascites and edema in patients with hepatic cirrhosis. N Engl J Med 1976; 282:1391-6.
63. Henriksen JH, Brøchner-Mortensen J, Malchow-Møller A, Schlichting P. Over-estimation of glomerular filtration rate by single injection (51Cr)EDTA plasma clearance determination in patients with ascites. Scand J Clin Lab Invest 1980; 40:279-84.
64. Joffe P, Henriksen JH. Aspects of osseous, peritoneal and renal handling of bisphosphonate during peritoneal dialysis: a methodological study. Scand J Clin Lab Invest 1996; 56:327-37.
65. Zink J, Greenway CV. Control of ascites absorption in anaesthetized cats: effect of intraperitoneal pressure, protein, and furosemide diuresis. Gastroenterology 1977; 73:1119-24.
66. Krediet RT, Struijk DG, Koomen GCM, Hoek FJ, Arisz L. The disappearance of macromolecules from the peritoneal cavity during continuous ambulatory peritoneal dialysis (CAPD) is not dependent on molecular size. Perit Dial Int 1990; 10:147-52.
67. Michel CC. The transport of albumin: a critique of the vesicular system in transendothelial transport. Am Rev Respir Dis 1992; 146:32-6.
68. Rippe BNS. Pores and intercullular junctions. In: Crystal RG, West JB, eds. The Lung. Philadelphia: Lippincott-Raven Publishers, 1997; 663-72.
69. Carlsson O, Nielsen S, Zakaria ER, Rippe B. In vivo inhibition of transcellular water channels (aquaporin-1) during acute peritoneal dialysis in rats. Am J Physiol 1996; 271: H2254-H2262.
70. Schnitzer JE, McIntosh DP, Dvorak AM, Liu J, Oh P. Separation of caveolae from associated microdomains of GPI-anchored proteins. Science 1995; 269:1435-9.
71. Rippe B, Haraldsson B. Transport of macromolecules across microvascular walls: the two-pore theory. Physiol Rev 1994; 74:163-219.
72. Luttwak EM. Quantitative studies of ascitic fluid. Surg Gyn Obs 1973; 136: 269-72.
73. Akriviadis EA, Kapuias D, Hadjigavriel M, Mitsiou A, Goulis J. Serum/ascites albumin gradient: its value as a rational approach to the differential diagnosis of ascites. Scand J Gastroenterol 1996; 31:814-17.
74. Henriksen JH. Colloid osmotic pressure in decompensated cirrhosis. A "mirror image" of portal venous hypertension. Scand J Gastroenterol 1985; 20:170-4.
75. Granger DN, Granger JP, Brace RA, Parker RE, Taylor AE. Analysis of the permeability characteristics of cat intestinal capillaries. Circ Res 1979; 44:335-44.
76. Abu-Hijleh MF, Habbal OA, Moqattash ST. The role of the diaphragm in lymphatic absorption from the peritoneal cavity. J Anat 1995; 186:453-67.
77. Wang T, Waniewski J, Heimburger O, Werynski A, Lindholm B. A quantitative analysis of sodium transport and removal during peritoneal dialysis. Kidney Int 1997; 52:1609-16.
78. Schrier RW, Gurevich AK, Cadnapaphornchai MA. Pathogenesis and management of sodium and water retention in cardiac failure and cirrhosis. Semin Nephrol 2001; 21:157-72.
79. Stanley MM, Shigeru O, Lee KK, Nemchausky BA, Greenlee HB, Allen JI. Peritoneovenous shunting as compared with medical treatment in patients with alcoholic cirrhosis and massive ascites. N Engl J Med 1989; 321:1632-8.
80. Ginès A, Planas R, Angeli P et al. Treatment of patients with cirrhosis and refractory ascites using LeVeen shunt with titanium tip: comparison with therapeutic paracentesis. Hepatology 1995; 22:124-31.
81. Quintero E, Arroyo V, Bory F et al. Paracentesis versus diuretics in the treatment of cirrhotics with tense ascites. Lancet 1985; i:611-12.
82. Henriksen JH, Kiszka-Kanowitz M, Bendtsen F, Møller S. Review article: volume expansion in patients with cirrhosis. Aliment Pharmacol Ther 2002; 16:12-23.
83. Brinch K, Møller S, Bendtsen F, Becker U, Henriksen JH. Plasma volume expansion by albumin in cirrhosis. Relation to blood volume distribution, arterial compliance and severity of disease. J Hepatol 2003; 39:24-31.
84. Ginès P, Guevara M, De Las Heras D, Arroyo V. Review article: albumin for circulatory support in patients with cirrhosis. Aliment Pharmacol Ther 2002; 16:24-31.
85. Tazi KA, Barriere E, Moreau R et al. Role of shear stress in aortic eNOS up-regulation in rats with biliary cirrhosis. Gastroenterology 2002; 122:1869-77.
86. Møller S, Henriksen JH. Endothelins in chronic liver disease. Scand J Clin Lab Invest 1996; 56:481-90.
87. Wiest R, Groszmann RJ. The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough. Hepatology 2002; 35:478-91.
88. La Villa G, Barletta G, Pantaleo P et al. Hemodynamic, renal, and endocrine effects of acute inhibition of nitric oxide synthase in compensated cirrhosis. Hepatology 2001; 34:19-27.
89. Shah V, Haddad FG, Garcia-Cardena G et al. Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. J Clin Invest 1997; 100:2923-30.
90. Lee FY, Lin HC, Tsai YT et al. Plasma substance P levels in patients with liver cirrhosis: relationship with hemodynamic abnormalities and vasoconstrictor systems. Gastroenterology 1998; 114:336-43.
91. Nguyen LS, Villablanca AC, Rutledge JC. Substance P increases microvascular permeability via nitric oxidemediated convective pathways. Am J Physiol 1995; 268: R1060-R1068.
92. Henriksen JH, Staun-Olsen P, Mogensen NB, Fahrenkrug J. Circulating endogenous vasoactive intestinal polypeptide (VIP) in patients with uraemia and liver cirrhosis. Eur J Clin Invest 1986; 16:211-16.
93. Møller S, Bendtsen F, Schifter S, Henriksen JH. Relation of calcitonin gene-related peptide (CGRP) to systemic vasodilatation and central hypovolaemia in cirrhosis. Scand J Gastroenterol 1996; 31:928-33.
94. Gerbes AL, Møller S, Gülberg V, Henriksen JH. Endothelin-1 and-3 plasma concentrations in patients with cirrhosis: role of splanchnic and renal passage and liver function. Hepatology 1995; 21:735-9.
95. Varin F, Huet PM. Hepatic microcirculation in the perfused cirrhotic rat liver. J Clin Invest 1985; 76:1904-12.
96. Huet PM, Pomier-Layrargues G, Villeneuve JP, Varin F, Viallet A. Intrahepatic circulation in liver disease. Semin Liver Dis 1986; 6:277-86.
97. Henriksen JH, Christensen NJ, Ring-Larsen H. Noradrenalin and adrenaline concentrations in various vascular beds in patients with cirrhosis. Relation to hemodynamics. Clin Physiol 1981; 1:293-304.
98. Hendrickse MR, Thuluvath PJ, Triger DR. Natural history of autonomic neuropathy in chronic liver disease. Lancet 1992; 339:1462-4.
99. Lewis FW, Cohen JA, Rector WG. Autonomic dysfunction in alcoholic cirrhosis: relationship to indicators of sympathetic activation and the occurrence of renal sodium retention. Am J Gastroenterol 1994; 89:1544-7.
100. Moreau R, Lee SS, Hadengue A, Braillon A, Lebrec D. Hemodynamic effects of a clonidine-induced decrease in sympathetic tone in patients with cirrhosis. Hepatology 1987; 7:149-54.
101. Albillos A, Bañares R, Barrios C et al. Oral administration of clonidine in patients with alcoholic cirrhosis. Hemodynamic and liver function effects. Gastroenterology 1992; 102:248-54.
102. Henriksen JH, Bendtsen G, Gerbes AL, Christensen NJ, Ring-Larsen H, Sørensen TIA. Estimated central blood volume in cirrhosis: relationship to sympathetic nervous activity, beta-adrenergic blockade and atrial natriuretic factor. Hepatology 1992; 16:1163-70.
103. Fraser R, Clark SA, Bowler LM et al. The opposite effects of nicotine and pantethine on the porosity of the liver sieve and lipoprotein metabolism. In: Wisse E, Knook DL, Decker K, eds. Cells of the Hepatic Sinusoid, Vol. 2. Rijswijk, The Netherlands: Kupffer Cell Foundation, 1989; 335-8.
104. Pinzani M, Milani S, Defranco R et al. Endothelin-1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells. Gastroenterology 1996; 110:534-48.
105. Rockey DC. Hepatic blood flow regulation by stellate cells in normal and injured liver. Semin Liver Dis 2001; 21:337-49.
106. Rockey DC, Chung JJ. Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension. Gastroenterology 1998; 114:344-51.