Structure and Genetics of the Meningococcal Capsule

Handbook of Meningococcal Disease: Infection Biology, Vaccination, Clinical Management

Volumn , Issue , 2006, Pages 145-162

  Frosch, Matthias ^a   Vogel, Ulrich ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Adaptation; Capsule biosynthesis; Genetics; Genetics of capsule expression; Genetics of O acetylation; Meningococcal capsular polysaccharides; Meningococcal capsule; Phase variation; Structure

Indexed keywords

EID: 84889335940     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/3527608508.ch8     Document Type: Chapter

References (87)

1. Kroll, S., Moxon, E.R.1990, The role of bacterial polysaccharide capsules as virulence factors, Curr.Top.Microbiol.Immunol.150, 65-85.
2. Costerton, J.W., Irvin, R.T., Cheng, K.J.1981, The bacterial glycocalyx in nature and disease, Annu.Rev.Microbiol.35, 299-324.
3. Musher, D.M.2003, How contagious are common respiratory tract infections? N.Engl.J.Med.348, 1256-1266.
4. Roberts, I.S.1996, The biochemistry and genetics of capsular polysaccharide production in bacteria, Annu.Rev.Microbiol.50, 285-315.
5. Rosenstein, N.E., Perkins, B.A., Stephens, D.S., Popovic, T., Hughes, J.M.2001, Meningococcal disease, N.Engl.J.Med.344, 1378-1388.
6. Jones, C., Lemercinier, X.2002, Use and validation of NMR assays for the identity and O-acetyl content of capsular polysaccharides from Neisseria meningitidis used in vaccine manufacture, J.Pharm.Biomed.Anal.30, 1233-1247.
7. Jennings, H.J., Bhattacharjee, A.K., Bundle, D.R., Kenny, C.P., Martin, A., Smith, I.C.1977, Structures of the capsular polysaccharides of Neisseria meningitidis as determined by 13C-nuclear magnetic resonance spectroscopy, J.Infect.Dis.136[SUPPL.], S78-S83.
8. Jennings, H.J.1983, Capsular polysaccharides as human vaccines, Adv.Carbohydr.Chem.Biochem.41, 155-208.
9. Bhattacharjee, A.K., Jennings, H.J., Kenny, C.P., Martin, A., Smith, I.C.1976, Structural determination of the polysaccharide antigens of Neisseria meningitidis serogroups Y, W-135, and BO1, Can.J.Biochem.54, 1-8.
10. Bhattacharjee, A.K., Jennings, H.J., Kenny, C.P., Martin, A., Smith, I.C.P.1975, Structural determination of the sialic acid polysaccharide antigens of Neisseria meningitidis serogroups B and C with carbon 13 nuclear magnetic resonance, J.Biol.Chem.250, 1926-1932.
11. Mühlenhoff, M., Eckhardt, M., Gerardy-Schahn, R.1998, Polysialic acid: three-dimensional structure, biosynthesis and function, Curr.Opin.Struct.Biol.8, 558-564.
12. Fairley, C.K., Begg, N., Borrow, R., Fox, A.J., Jones, D.M., Cartwright, K.1996, Conjugate meningococcal serogroup A and C vaccine: reactogenicity and immunogenicity in United Kingdom infants, J.Infect.Dis.174, 1360-1363.
13. Claus, H., Vogel, U., Mühlenhoff, M., Gerardy-Schahn, R., Frosch, M.1997, Molecular divergence of the sia locus in different serogroups of Neisseria meningitidis expressing polysialic acid capsules, Mol.Gen.Genet.257, 28-34.
14. Swartley, J.S., Marfin, A.A., Edupuganti, S., Liu, L.J., Cieslak, P., Perkins, B., Wenger, J.D., and Stephens, D.S.1997, Capsule switching of Neisseria meningitidis, Proc.Natl Acad.Sci.USA 94, 271-276.
15. Jennings, H.J., Roy, R., Michon, F.1985, Determinant specificities of the groups B and C polysaccharides of Neisseria meningitidis, J.Immunol.134, 2651-2657.
16. Yamasaki, R., Bacon, B.1991, Three-dimensional structural analysis of the group B polysaccharide of Neisseria meningitidis 6275 by two-dimensional NMR: the polysaccharide is suggested to exist in helical conformations in solution, Biochemistry 30, 851-857.
17. Michon, F., Brisson, J.R., Jennings, H.J.1987, Conformational differences between linear alpha (2→8)-linked homosialooligosaccharides and the epitope of the group B meningococcal polysaccharide, Biochemistry 26, 8399-8405.
18. Brisson, J.R., Jennings, H.J.2001, NMR and molecular modeling of complex carbohydrates and carbohydrate-protein interactions.Applications to anti-bacteria vaccines, Adv.Exp.Med.Biol.491, 543-550.
19. Frosch, M., Gorgen, I., Boulnois, G.J., Timmis, K.N., Bitter-Suermann, D.1985, NZB mouse system for production of monoclonal antibodies to weak bacterial antigens: isolation of an IgG antibody to the polysaccharide capsules of Escherichia coli K1 and group B menin159 gococci, Proc.Natl Acad.Sci.USA 82, 1194-1198.
20. Evans, S.V., Sigurskjold, B.W., Jennings, H.J., Brisson, J.R., To, R., Tse, W.C., Altman, E., Frosch, M., Weisgerber, C., Kratzin, H.D., et al.1995, Evidence for the extended helical nature of polysaccharide epitopes.The 2.8 Å resolution structure and thermodynamics of ligand binding of an antigen binding fragment specific for alpha-(2→8)-polysialic acid, Biochemistry 34, 6737-6744.
21. Orskov, F., Orskov, I., Sutton, A., Schneerson, R., Lin, W., Egan, W., Hoff, G.E., Robbins, J.B.1979, Form variation in Escherichia coli K1: determined by Oacetylation of the capsular polysaccharide, J.Exp.Med.149, 669-685.
22. Michon, F., Huang, C.H., Farley, E.K., Hronowski, L., Di, J., Fusco, P.C.2000, Structure activity studies on group C meningococcal polysaccharide-protein conjugate vaccines: effect of O-acetylation on the nature of the protective epitope, Dev.Biol.103, 151-160.
23. Claus, H., Borrow, R., Achtman, M., Morelli, G., Kantelberg, C., Longworth, E., Frosch, M., Vogel, U.2004, Genetics of capsule O-acetylation in serogroup C, W-135 and Y meningococci,Mol.Microbiol.51, 227-239.
24. Richmond, P., Borrow, R., Goldblatt, D., Findlow, J., Martin, S., Morris, R., Cartwright, K., Miller, E.2001, Ability of 3 different meningococcal C conjugate vaccines to induce immunologic memory after a single dose in UK toddlers, J.Infect.Dis.183, 160-163.
25. Lemercinier, X., Jones, C.1996, Full 1H NMR assignment and detailed O-acetylation patterns of capsular polysaccharides from Neisseria meningitidis used in vaccine production, Carbohydr.Res.296, 83-96.
26. Bundle, D.R., Jennings, H.J., Kenny, C.P.1973, An improved procedure for the isolation of meningococcal polysaccharide antigens and the structural determination of the antigen from serogroup X, Carbohydr.Res.26, 268-270.
27. Bundle, D.R., Jennings, H.J., Kenny, C.P.1974, Studies on the group-specific polysaccharide of Neisseria meningitidis serogroup X and an improved procedure for its isolation, J.Biol.Chem.249, 4797-4801.
28. Bundle, D.R., Smith, I.C., Jennings, H.J.1974, Determination of the structure and conformation of bacterial polysaccharides by carbon 13 nuclear magnetic resonance.Studies on the groupspecific antigens of Neisseria meningitidis serogroups A and X, J.Biol.Chem.249, 2275-2281.
29. Swartley, J.S., Liu, L.J., Miller, Y.K., Martin, L.E., Edupuganti, S., Stephens, D.S.1998, Characterization of the gene cassette required for biosynthesis of the (alpha 1→6)-linked N-acetyl-d-mannosamine-1-phosphate capsule of serogroup A Neisseria meningitidis, J.Bacteriol.180, 1533-1539.
30. Tzeng, Y.L., Noble, C., Stephens, D.S.2003, Genetic basis for biosynthesis of the (alpha 1→4)-linked N-acetyl-d-glucosamine-1-phosphate capsule of Neisseria meningitidis serogroup X, Infect.Immun.71, 6712-6720.
31. Berry, D.S., Lynn, F., Lee, C.H., Frasch, C.E., Bash, M.C.2002, Effect of O acetylation of Neisseria meningitidis serogroup A capsular polysaccharide on development of functional immune responses, Infect.Immun.70, 3707-3713.
32. Gudlavalleti, S.K., Datta, A.K., Tzeng, Y.L., Noble, C., Carlson, R.W., Stephens, D.S.2004, The Neisseria meningitidis serogroup A capsular polysaccharide O-3 and O-4 acetyltransferase, J.Biol.Chem.279, 42765-42773.
33. Ashton, F.E., Ryan, A., Diena, B., Jennings, H.J.1983, A new serogroup (L) of Neisseria meningitidis, J.Clin.Microbiol.17, 722-727.
34. Jennings, H.J., Lugowski, C.W., Ashton, F.E., Ryan, J.A.1983, The structure of the capsular polysaccharide obtained from a new serogroup (L) of Neisseria meningitidis, Carbohydr.Res.112, 105-111.
35. Griffiss, J.M., Brandt, B.L.1983, Immunological relationship between the capsular polysaccharides of Neisseria meningitidis serogroups Z and 29E, J.Gen.Microbiol.129, 447-452.
36. Jennings, H.J., Rosell, K.-G., Kenny, C.P.1979, Structural elucidation of the capsular polysaccharide antigen of Neisseria meningitidis serogroup Z using 13C nuclear magnetic resonance, Can.J.Chem.57, 2902-2907.
37. Bhattacharjee, A.K., Jennings, H.J., Kenny, C.P.1978, Structural elucidation of the 3-deoxy-d-manno-octulosonic acid containing meningococcal 29-e capsular polysaccharide antigen using carbon-13 nuclear magnetic resonance, Biochemistry 17, 645-651.
38. Van der Kaaden A., van Doorn-van Wakeren JI, Kamerling, J.P., Vliegenthart, J.F., Tiesjema, R.H.1984, Structure of the capsular antigen of Neisseria meningitidis serogroup H, Eur.J.Biochem.141, 513-519.
39. Adlam, C., Knights, J.M., Mugridge, A., Lindon, J.C., Williams, J.M., Beesley, J.E.1985, Purification, characterization and immunological properties of the capsular polysaccharide of Pasteurella haemolytica serotype T15: its identity with the K62 (K2ab) capsular polysaccharide of Escherichia coli and the capsular polysaccharide of Neisseria meningitidis serogroup H, J.Gen.Microbiol.131, 1963-1972.
40. Beynon, L.M., Richards, J.C., Perry, M.B.1992, Nuclear magnetic resonance analysis of the capsular antigen of Actinobacillus pleuropneumoniae serotype 9.Its identity with the capsular antigen of Escherichia coli K62 (K2ab), Neisseria meningitidis serogroup H and Pasteurella haemolytica serotype T15,Eur.J.Biochem.210, 119-124.
41. Ding, S.Q., Ye, R.B., Zhang, H.C.1981, Three new serogroups of Neisseria meningitidis, J.Biol.Stand.9, 307-315.
42. Van der Kaaden A., Gerwig, G.J., Kamerling, J.P., Vliegenthart, J.F., Tiesjema, R.H.1985, Structure of the capsular antigen of Neisseria meningitidis serogroup K, Eur.J.Biochem.152, 663-668.
43. Michon, F., Brisson, J.R., Roy, R., Ashton, F.E., Jennings, H.J.1985, Structural determination of the capsular polysaccharide of Neisseria meningitidis group I: a two-dimensional NMR analysis, Biochemistry 24, 5592-5598.
44. Frosch, M., Weisgerber, C., Meyer, T.F.1989, Molecular characterization and expression in Escherichia coli of the gene complex encoding the polysaccharide capsule of Neisseria meningitidis group B, Proc.Natl Acad.Sci.USA 86, 1669-1673.
45. Boulnois, G.J., Roberts, I.S., Hodge, R., Hardy, K.R., Jann, K.B., Timmis, K.N.1987, Analysis of the K1 capsule biosynthesis genes of Escherichia coli: definition of three functional regions for capsule production, Mol.Gen.Genet.208, 242-246.
46. Boulnois, G.J., Roberts, I.S.1990, Genetics of capsular polysaccharide production in bacteria, Curr.Topics Microbiol.Immunol.150, 1-18.
47. Roberts, I.S., Mountford, R., Hodge, R., Jann, K.B., Boulnois, G.J.1988, Common organization of gene clusters for production of different capsular polysaccharides (K antigens) in Escherichia coli, J.Bacteriol.170, 1305-1310.
48. Hammerschmidt, S., Birkholz, C., Zähringer, U., Robertson, B.D., van Putten, J., Ebeling, O., Frosch, M.1994, Contribution of genes from the capsule gene complex (cps) to lipooligosaccharide biosynthesis and serum resistance in Neisseria meningitidis, Mol.Microbiol.11, 885-896.
49. Petering, H., Hammerschmidt, S., Frosch, M., van Putten, J.P., Ison, C.A., Robertson, B.D.1996, Genes associated with meningococcal capsule complex are also found in Neisseria gonorrhoeae, J.Bacteriol.178, 3342-3345.
50. Tettelin, H., Saunders, N.J., Heidelberg, J., et al.2000, Complete genome sequence of Neisseria meningitidis serogroup B strain MC58, Science 287, 1809-1815.
51. Parkhill, J., Achtman, M., James, K.D., et al.2000, TI Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491, Nature 404, 502-506.
52. Claus, H., Maiden, M.C., Wilson, D.J., McCarthy, N.D., Jolley, K.A., Urwin, R., Hessler, F., Frosch, M., Vogel, U.2005, Genetic analysis of meningococci carried by children and young adults, J.Infect.Dis.191, 1263-1271.161
53. Ghosh, S., Roseman, S.1965, The sialic acids.IV.N-acyl-d-glucosamine 6-phosphate 2-epimerase, J.Biol.Chem.240, 1525-1530.
54. Petersen, M., Fessner, W., Frosch, M., Lüneberg, E.2000, The siaA gene involved in capsule polysaccharide biosynthesis of Neisseria meningitidis B codes for N-acylglucosamine-6-phosphate 2-epimerase activity, FEMS Microbiol.Lett.184, 161-164.
55. Edwards, U., Muller, A., Hammerschmidt, S., Gerardy Schahn, R., Frosch, M.1994, Molecular analysis of the biosynthesis pathway of the alpha-2, 8 polysialic acid capsule by Neisseria meningitidis serogroup B, Mol.Microbiol.14, 141-149.
56. Warren, L., Blacklow, R.S.1962, The biosynthesis of cytidine 5x-monophospho-Nacetylneuraminic acid by an enzyme from Neisseria meningitidis, J.Biol.Chem.237, 3527-3534.
57. Ringenberg, M.A., Steenbergen, S.M., Vimr, E.R.2003, The first committed step in the biosynthesis of sialic acid by Escherichia coli K1 does not involve a phosphorylated N-acetylmannosamine intermediate, Mol.Microbiol.50, 961-975.
58. Edwards, U., Frosch, M.1992, Sequence and functional analysis of the cloned Neisseria meningitidis CMP-NeuNAc synthetase, FEMS Microbiol.Lett.75, 161-166.
59. Troy, F.A.1979, The chemistry and biosynthesis of selected bacterial capsular polymers, Annu.Rev.Microbiol.33, 519-560.
60. Frosch, M., Edwards, U., Bousset, K., Krausse, B., Weisgerber, C.1991, Evidence for a common molecular origin of the capsule gene loci in gram-negative bacteria expressing group II capsular polysaccharides, Mol.Microbiol.5, 1251-1263.
61. Borrow, R., Claus, H., Chaudhry, U., Guiver, M., Kaczmarski, E.B., Frosch, M., Fox, A.J.1998, siaD PCR ELISA for confirmation and identification of serogroup Y and W135 meningococcal infections, FEMS Microbiol.Lett.159, 209-214.
62. Finke, A., Jann, B., Jann, K.1990, CMPKDO-synthetase activity in Escherichia coli expressing capsular polysaccharides, FEMS Microbiol.Lett.57, 129-133.
63. Finke, A., Bronner, D., Nikolaev, A.V., Jann, B., Jann, K.1991, Biosynthesis of the Escherichia coli K5 polysaccharide,a representative of group II capsular polysaccharides: polymerization in vitro and characterization of the product,J.Bacteriol.173, 4088-4094.
64. Gotschlich, E.C., Fraser, B.A., Nishimura, O., Robbins, J.B., Liu, T.Y.1981, Lipid on capsular polysaccharides of gram-negative bacteria, J.Biol.Chem.256, 8915-8921.
65. Tzeng, Y.L., Datta, A., Strole, C., Kolli, V.S., Birck, M.R., Taylor, W.P., Carlson, R.W., Woodard, R.W., Stephens, D.S.2002, KpsF is the arabinose-5-phosphate isomerase required for 3-deoxy-d-mannooctulosonic acid biosynthesis and for both lipooligosaccharide assembly and capsular polysaccharide expression in Neisseria meningitidis, J.Biol.Chem.277, 24103-24113.
66. Davidson, A.L., Chen, J.2004, ATP-binding cassette transporters in bacteria, Annu.Rev.Biochem.73, 241-268.
67. Pavelka, M.S.Jr., Hayes, S.F., Silver, R.P.1994, Characterization of KpsT, the ATP-binding component of the ABCtransporter involved with the export of capsular polysialic acid in Escherichia coli K1, J.Biol.Chem.269, 20149-20158.
68. Frosch, M., Müller, D., Bousset, K., Müller, A.1992, Conserved outer membrane protein of Neisseria meningitidis involved in capsule expression, Infect.Immun.60, 798-803.
69. Paulsen, I.T., Beness, A.M., Saier, M.H.Jr.1997, Computer-based analyses of the protein constituents of transport systems catalysing export of complex carbohydrates in bacteria, Microbiology 143, 2685-2699.
70. Andersen, C.2003, Channel-tunnels: outer membrane components of type I secretion systems and multidrug efflux pumps of Gram-negative bacteria, Rev.Physiol.Biochem.Pharmacol.147, 122-165.
71. Koronakis, V., Sharff, A., Koronakis, E., Luisi, B., Hughes, C.2000, Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export, Nature 405, 914-919.
72. Andersen, C., Koronakis, E., Bokma, E., Eswaran, J., Humphreys, D., Hughes, C., Koronakis, V.2002, Transition to the open state of the TolC periplasmic tunnel entrance, Proc.Natl Acad.Sci.USA 99, 11103-11108.
73. Dinh, T., Paulsen, I.T., Saier, M.H.Jr.1994, A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria, J.Bacteriol.176, 3825-3831.
74. Frosch, M., Müller, A.1993, Phospholipid substitution of capsular polysaccharides and mechanisms of capsule formation in Neisseria meningitidis, Mol.Microbiol.8, 483-493.
75. Bronner, D., Sieberth, V., Pazzani, C., Smith, A., Boulnois, G., Roberts, I., Jann, B., Jann, K.1993, Synthesis of the K5 (group II) capsular polysaccharide in transport-deficient recombinant Escherichia coli, FEMS Microbiol.Lett.113, 279-284.
76. Bronner, D., Sieberth, V., Pazzani, C., Roberts, I.S., Boulnois, G.J., Jann, B., Jann, K.1993, Expression of the capsular K5 polysaccharide of Escherichia coli: biochemical and electron microscopic analyses of mutants with defects in region 1 of the K5 gene cluster, J.Bacteriol.175, 5984-5992.
77. Tzeng, Y.L., Datta, A.K., Strole, C.A., Lobritz, M.A., Carlson, R.W., Stephens, D.S.2005, Translocation and surface expression of lipidated serogroup B capsular Polysaccharide in Neisseria meningitidis, Infect.Immun.73, 1491-1505.
78. Hammerschmidt, S., Hilse, R., van Putten, J.P., Gerardy-Schahn, R., Unkmeir, A., Frosch, M.1996, Modulation of cell surface sialic acid expression in Neisseria meningitidis via a transposable genetic element, EMBO J.15, 192-198.
79. Virji, M., Makepeace, K., Ferguson, D.J., Achtman, M., Sarkari, J., Moxon, E.R.1992, Expression of the Opc protein correlates with invasion of epithelial and endothelial cells by Neisseria meningitidis, Mol.Microbiol.6, 2785-2795.
80. Virji, M., Makepeace, K., Ferguson, D.J., Achtman, M., Moxon, E.R.1993, Meningococcal Opa and Opc proteins: their role in colonization and invasion of human epithelial and endothelial cells, Mol.Microbiol., 10, 499-510.
81. Hilse, R., Hammerschmidt, S., Bautsch, W., Frosch, M.1996, Site-specific insertion of IS1301 and distribution in Neisseria meningitidis strains, J.Bacteriol.178, 2527-2532.
82. Hammerschmidt, S., Muller, A., Sillmann, H., Mühlenhoff, M., Borrow, R., Fox, A., van Putten, J., Zollinger, W.D., Gerardy-Schahn, R., Frosch, M.1996, Capsule phase variation in Neisseria meningitidis serogroup B by slipped strand mispairing in the polysialyltransferase gene (siaD): correlation with bacterial invasion and the outbreak of meningococcal disease, Mol.Microbiol.20, 1211-1220.
83. Lavitola, A., Bucci, C., Salvatore, P., Maresca, G., Bruni, C.B., Alifano, P.1999, Intracistronic transcription termination in polysialyltransferase gene (siaD) affects phase variation in Neisseria meningitidis, Mol.Microbiol.33, 119-127.
84. Deghmane, A.E., Petit, S., Topilko, A., Pereira, Y., Giorgini, D., Larribe, M., Taha, M.K.2000, Intimate adhesion of Neisseria meningitidis to human epithelial cells is under the control of the crgA gene, a novel LysR-type transcriptional regulator, EMBO J.19, 1068-1078.
85. Deghmane, A.E., Giorgini, D., Larribe, M., Alonso, J.M., Taha, M.K.2002, Down-regulation of pili and capsule of Neisseria meningitidis upon contact with epithelial cells is mediated by CrgA regulatory protein, Mol.Microbiol.43, 1555-1564.
86. Frosch, M., Meyer, T.F.1992, Transformation-mediated exchange of virulence determinants by co-cultivation of pathogenic Neisseriae, FEMS Microbiol.Lett.79, 345-349.
87. Vogel, U., Claus, H., Frosch, M.2000, Rapid serogroup switching in Neisseria meningitidis [letter], N.Engl.J.Med.342, 219-220.