Intact immunoglobulin heavy/light chain paired assays

Biochimica Clinica

Volumn 37, Issue 5, 2013, Pages 365-369

  Harding, Stephen ^a   Young, Philip ^a   Di Fazio, Marina ^a   Hughes, Richard ^a  

^a Binding Site Group Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M; PARAPROTEIN;

CLONAL EVOLUTION; DISEASE COURSE; ELECTROPHORESIS; FREELITE ASSAY; HEVYLITE IMMUNOASSAY; HUMAN; IMMUNOASSAY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; IMMUNOLOGY TEST KIT; IMMUNOTHERAPY; INTACT IMMUNOGLOBULIN HEAVY LIGHT CHAIN PAIRED ASSAY; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; PATIENT CARE; PRACTICE GUIDELINE; PROGNOSIS; PROGRESSION FREE SURVIVAL; REMISSION; REVIEW; SERUM PROTEIN ELECTROPHORESIS; STEM CELL TRANSPLANTATION;

EID: 84889253286     PISSN: 03930564     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (22)

1. Kyle RA, Therneau TM, Rajkumar SV, Prevalence of monoclonal gammopathy of undetermined significance. N Engl J Med 2006;354:1362-9.
2. Dispenzieri A, Kyle RA. Multiple myeloma: clinical features and indications for therapy. Best Pract Res Clin Haemat 2005;18:553-68.
3. Pinney JH, Smith CJ, Taube JB. Systemic amyloidosis in England: an epidemiological study. Br J Haematol 2013;161:525-32.
4. Tseng CH, Chang CY, Liu KS, et al. Accuracy of serum IgM and IgA monoclonal protein measurements by densitometry. Ann Clin Lab Sci 2003;33:160-6.
5. Ludwig H, Milosavljevic D, Zojer N, et al. Immunoglobulin heavy/light chain ratios improve paraprotein detection and monitoring, identify residual disease and correlate with survival in multiple myeloma patients. Leukemia 2013;27:213-9.
6. Dimopoulos M, Kyle R, Fermand JP, et al. Consensus recommendations for standard investigative workup: report of the International Myeloma Workshop Consensus Panel 3. Blood 2011;117:4701-5.
7. Murray DL, Ryu E, Snyder MR, et al. Quantitation of serum monoclonal proteins: relationship between agarose gel electrophoresis and immunonephelometry. Clin Chem 2009;55:1523-9.
8. Katzmann JA, Snyder MR, Rajkumar SV, et al. Long-term biologic variation of serum protein electrophoresis M-spike, urine M-spike, and monoclonal serum free light chain quantification: implications for monitoring monoclonal gammopathies. Clin Chem 2011;57:1687-92.
9. Waldmann TA, Strober W. Metabolism of immunoglobulins. Prog Allergy 1969;13:1-110.
10. Abraham RS, Charlesworth MC, Owen BA, et al. Trimolecular complexes of lambda light chain dimers in serum of a patient with multiple myeloma. Clin Chem 2002;48:1805-11.
11. Palladini G, Russo P, Bosoni T, et al. Identification of amyloidogenic light chains requires the combination of serum-free light chain assay with immunofixation of serum and urine. Clin Chem 2009;55:499-504.
12. Katzmann JA, Kyle RA, Benson J, et al. Screening panels for detection of monoclonal gammopathies. Clin Chem 2009;55:1517-22.
13. Bradwell AR, Harding SJ, Fourrier NJ, et al. Assessment of monoclonal gammopathies by nephelometric measurement of individual immunoglobulin kappa/lambda ratios. Clin Chem 2009;55:1646-55.
14. Bradwell A, Harding S, Fourrier NJ, et al. Prognostic utility of intact immunoglobulin Ig′κ/Ig′λ ratios in multiple myeloma patients. Leukemia 2013;27:202-7.
15. Katzmann JA, Clark R, Kyle RA, et al. Suppression of uninvolved immunoglobulins defined by heavy/light-chain pair suppression is a risk factor for progression of MGUS. Leukemia 2013;27:208-12.
16. Donato LJ, Zeldenrust SR, Murray DL, et al. A 71-year-old woman with multiple myeloma status after stem cell transplantation. Clin Chem 2011;57:1645-8.
17. Hobbs JR. Growth rates and responses to treatment in human myelomatosis. Br J Haematol 1969;16:607-17.
18. Keats JJ, Chesi M, Egan JB, et al. Clonal competition with alternating dominance in multiple myeloma. Blood 2012;120:1067-76.
19. Zamarin D, Giralt S, Landau H, et al. Patterns of relapse and progression in multiple myeloma patients after auto-SCT: implications for patients' monitoring after transplantation. Bone Marrow Transplant 2013;48:419-24.
20. Magrangeas F, Avet-Loiseau H, Gouraud W, et al. Minor clone provides a reservoir for relapse in multiple myeloma. Leukemia 2013;27:473-81.
21. Kyrtsonis MC, Vassilakopoulos TP, Kafasi N, et al. Prognostic value of serum free light chain ratio at diagnosis in multiple myeloma. Br J Haematol 2007;137:240-3.
22. Snozek CL, Katzmann JA, Kyle RA, et al. Prognostic value of the serum free light chain ratio in newly diagnosed myeloma: proposed incorporation into the international staging system. Leukemia 2008;22:1933-7.