Design of orthogonal genetic switches based on a crosstalk map of σs, anti-σs, and promoters

Molecular Systems Biology

Volumn 9, Issue , 2013, Pages

  Rhodius, Virgil A ^a   Segall Shapiro, Thomas H ^b   Sharon, Brian D ^c   Ghodasara, Amar ^b   Orlova, Ekaterina ^a   Tabakh, Hannah ^a   Burkhardt, David H ^c   Clancy, Kevin ^d   Peterson, Todd C ^d   Gross, Carol A ^a,c   Voigt, Christopher A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Life Technologies   (United States)

Author keywords

Compiler; genetic circuit; part mining; synthetic biology; systems biology

Indexed keywords

ARTICLE; BACTERIAL GENOME; BINDING KINETICS; CELL FUNCTION; CHIMERA; DNA BINDING; DNA SEQUENCE; DNA SYNTHESIS; ESCHERICHIA COLI; EXTRACYTOPLASMIC FUNCTION; GENE EXPRESSION; GENE MAPPING; GENE SWITCHING; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOME ANALYSIS; MOLECULAR INTERACTION; NONHUMAN; OPERON; POSITION WEIGHT MATRIX; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; SEQUENCE DATABASE; STEADY STATE; WILD TYPE; BIOLOGICAL MODEL; DATA MINING; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PHYLOGENY; PROTEIN BINDING; REGULATOR GENE; GENE CONTROL; GENOME; SIGNAL TRANSDUCTION; SYNTHETIC BIOLOGY; SYSTEMS BIOLOGY;

ESCHERICHIA COLI;

ELBB PROTEIN, E COLI; ESCHERICHIA COLI PROTEIN; SIGMA FACTOR; PROTEIN BINDING;

DATA MINING; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, SWITCH; GENETIC ENGINEERING; MODELS, GENETIC; PHYLOGENY; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SIGMA FACTOR; TRANSCRIPTION, GENETIC;

EID: 84889250030     PISSN: None     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2013.58     Document Type: Article

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