Anti-cytokine autoantibodies preceding onset of autoimmune polyendocrine syndrome type i features in early childhood

Journal of Clinical Immunology

Volumn 33, Issue 8, 2013, Pages 1341-1348

  Wolff, A S B ^a   Sarkadi, A K ^b   Marodi L ^b   Karner J ^c   Orlova, E ^d   Oftedal, B E V ^a   Kisand, K ^c   Olah E ^b   Meloni, A ^e   Myhre, A G ^f   Husebye, E S ^a,g   Motaghedi, R ^h   Perheentupa, J ⁱ   Peterson, P ^c   Willcox, N ^j   Meager, A ^k  

^a UNIVERSITY OF BERGEN   (Norway)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c UNIVERSITY OF TARTU   (Estonia)

^d ENDOCRINOLOGY RESEARCH CENTRE   (Russian Federation)

^e UNIVERSITY OF CAGLIARI   (Italy)

^f OSLO UNIVERSITY HOSPITAL   (Norway)

^g HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^h SEATTLE CHILDREN S HOSPITAL   (United States)

ⁱ UNIVERSITY OF HELSINKI   (Finland)

^j UNIVERSITY OF OXFORD   (United Kingdom)

^k NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

more..

Author keywords

AIRE; APECED; autoimmune immuno deficiency; autoimmune polyendocrine syndrome; autoimmunization; candidiasis; cytokine autoantibodies; Interferon omega; Interleukin 17; Interleukin 22

Indexed keywords

ALPHA2 INTERFERON; CYTOKINE ANTIBODY; INTERFERON; INTERLEUKIN 17; INTERLEUKIN 22; OMEGA INTERFERON; UNCLASSIFIED DRUG;

ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; AUTOIMMUNE POLYENDOCRINOPATHY CANDIDIASIS ECTODERMAL DYSTROPHY; AUTOIMMUNITY; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; HUMAN; HYPOPARATHYROIDISM; OUTCOME ASSESSMENT; PATIENT ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION;

ADOLESCENT; ADULT; AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; CYTOKINES; EARLY DIAGNOSIS; FEMALE; HUMANS; INFANT; INTERFERON-ALPHA; INTERLEUKIN-17; INTERLEUKINS; MALE; POLYENDOCRINOPATHIES, AUTOIMMUNE; SYNDROME; YOUNG ADULT;

EID: 84889100576     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-013-9938-6     Document Type: Article

References (27)

1. Anderson MS et al. Projection of an immunological self shadow within the thymus by the aire protein. Science. 2002;298(5597):1395-401.
2. Husebye ES et al. Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I. J Intern Med. 2009;265(5):514-29.
3. Perheentupa J. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Clin Endocrinol Metab. 2006;91(8):2843-50.
4. Meager A et al. Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1. PLoS Med. 2006;3(7):e289.
5. Meloni A et al. Autoantibodies against type I interferons as an additional diagnostic criterion for autoimmune polyendocrine syndrome type I. J Clin Endocrinol Metab. 2008;93(11):4389-97.
6. Kisand K et al. Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. J Exp Med. 2010;207(2):299-308.
7. Puel A et al. Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. J Exp Med. 2010;207:291-7.
8. Oftedal BE et al. Radioimmunoassay for autoantibodies against interferon omega; its use in the diagnosis of autoimmune polyendocrine syndrome type I. Clin Immunol. 2008;129:163-9.
9. Meloni A et al. Autoimmune polyendocrine syndrome type 1: an extensive longitudinal study in Sardinian patients. J Clin Endocrinol Metab. 2012;97(4):1114-24.
10. Orlova EM et al. Autoimmune polyglandular syndrome type 1 in Russian patients: clinical variants and autoimmune regulator mutations. Horm Res Paediatr. 2010;73(6):449-57.
11. Tóth B et al. Novel sequence variation of AIRE and detection of interferon-omega antibodies in early infancy. Clin Endocrinol (Oxf). 2010;72(5):641-7.
12. Wolff AS et al. Autoimmune polyendocrine syndrome type 1 in Norway: phenotypic variation, autoantibodies, and novel mutations in the autoimmune regulator gene. J Clin Endocrinol Metab. 2007;92(2):595-603.
13. Wolff AS et al. Flow cytometry study of blood cell subtypes reflects autoimmune and inflammatory processes in autoimmune polyendocrine syndrome type I. Scand J Immunol. 2010;71(6): 459-67.
14. Ekwall O et al. Identification of tryptophan hydroxylase as an intestinal autoantigen. Lancet. 1998;352(9124):279-83.
15. Oftedal BE et al. Measuring autoantibodies against IL-17F and IL-22 in autoimmune polyendocrine syndrome type I by radioligand binding assay using fusion proteins. Scand J Immunol. 2011;74(3):327-33.
16. Meager A et al. Anti-cytokine autoantibodies in autoimmunity: preponderance of neutralizing autoantibodies against interferon-alpha, interferon-omega and interleukin-12 in patients with thymoma and/or myasthenia gravis. Clin Exp Immunol. 2003;132:128-36.
17. Kärner J et al. Anti-cytokine autoantibodies suggest pathogenetic links with autoimmune regulator deficiency in humans and mice. Clin Exp Immunol. 2013;171(3):263-72.
18. Siegrist CA, Aspinall R. B-cell responses to vaccination at the extremes of age. Nat Rev Immunol. 2009;9(3):185-94.
19. Truck J, Pollard AJ. Challenges in immunisation against bacterial infection in children. Early Hum Dev. 2010;86(11):695-701.
20. Hendrikx LH et al. Different IgG-subclass distributions after whole-cell and acellular pertussis infant primary vaccinations in healthy and pertussis infected children. Vaccine. 2011;29(40):6874-80.
21. Scherbaum WA, Berg PA. Development of adrenocortical failure in non-Addisonian patients with antibodies to adrenal cortex. A clinical follow-up study. Clin Endocrinol (Oxf). 1982;16(4):345-52.
22. Zhang L, Eisenbarth GS. Prediction and prevention of Type 1 diabetes mellitus. J Diabetes. 2011;3(1):48-57.
23. Kisand K et al. Mucocutaneous candidiasis and autoimmunity against cytokines in APECED and thymoma patients: clinical and pathogenetic implications. Eur J Immunol. 2011;41(6):1517-27.
24. Gardner JM et al. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science. 2008;321(5890):843-7.
25. Lee JW et al. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat Immunol. 2007;8(2):181-90.
26. Poliani PL et al. Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells. Am J Pathol. 2010;176(3):1104-12.
27. Meager A, Peterson P, Willcox N. Thymic aberrations and type-I Interferons; attempts to deduce autoimmunizing mechanisms from unexpected clues in monogenic and paraneoplastic syndromes. Clin Exp Immunol. 2008;154:141-51.