Weight-based enoxaparin dosing for venous thromboembolism prophylaxis in the obese trauma patient

American Journal of Surgery

Volumn 206, Issue 6, 2013, Pages 847-852

  Bickford, Annika ^a   Majercik, Sarah ^a   Bledsoe, Joseph ^a   Smith, Katie ^a   Johnston, Rob ^a   Dickerson, Justin ^a   White, Tom ^a  

^a INTERMOUNTAIN MEDICAL CENTER   (United States)

Author keywords

Anti Xa level; Enoxaparin; Obese; Trauma; Venous thromboembolism prophylaxis; VTE prophylaxis

Indexed keywords

BLOOD CLOTTING FACTOR 10A INHIBITOR; ENOXAPARIN;

ADULT; ARTICLE; BLEEDING; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; INCIDENCE; INJURY; INTRAVASCULAR ULTRASOUND; LOWER EXTREMITY DEEP VEIN THROMBOSIS; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; VENOUS THROMBOEMBOLISM;

ANTI-XA LEVEL; ENOXAPARIN; OBESE; TRAUMA; VENOUS THROMBOEMBOLISM PROPHYLAXIS; VTE PROPHYLAXIS;

ANTICOAGULANTS; BODY MASS INDEX; DOSE-RESPONSE RELATIONSHIP, DRUG; ENOXAPARIN; FEMALE; FOLLOW-UP STUDIES; HUMANS; INJECTIONS, SUBCUTANEOUS; LEG; MALE; MIDDLE AGED; OBESITY; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; ULTRASONOGRAPHY, DOPPLER, DUPLEX; VENOUS THROMBOEMBOLISM; WOUNDS AND INJURIES;

EID: 84889091052     PISSN: 00029610     EISSN: 18791883     Source Type: Journal    
DOI: 10.1016/j.amjsurg.2013.07.020     Document Type: Article

References (26)

1. W.H. Geerts, R.M. Jay, and K.I. Code A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma N Engl J Med 335 1996 701 707
2. W.H. Geerts, K.I. Code, and R.M. Jay A prospective study of venous thromboembolism after major trauma N Engl J Med 331 1994 1601 1606
3. M.M. Knudson, D. Morabito, and G.D. Paiement Use of low molecular weight heparin in preventing thromboembolism in trauma patients J Trauma 41 1996 446 459
4. P.D. Stein, A. Beemath, and R.E. Olson Obesity as a risk factor in venous thromboembolism Am J Med 118 2005 978 980
5. M.M. Knudson, D.G. Ikossi, and L. Khaw Thromboembolism after trauma Ann Surg 240 2004 490 498
6. G.G. Hama, and P.S. Choban Enoxaparin for thromboprophylaxis in morbidly obese patients undergoing bariatric surgery: findings of the prophylaxis against VTE outcomes in bariatric surgery patients receiving enoxaparin (PROBE) study Obes Surg 15 2005 1368 1374
7. M.T. Rondina, M. Wheeler, and G.M. Rodgers Weight-based dosing of enoxaparin for VTE prophylaxis in morbidly obese, medically-ill patients Thromb Res 125 2010 220 223
8. S. Eichinger, G. Hron, and C. Bialonczyk Overweight, obesity, and the risk of recurrent venous thromboembolism Arch Intern Med 168 2008 1678 1683
9. D.A. Garcia, T.P. Baglin, and J.I. Weitz Parenteral anticoagulants: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines Chest 141 2012 e24S e43S
10. E.A. Nutescu, S.A. Spinler, and A. Wittkowsky Low-molecular-weight heparins in renal impairment and obesity: available evidence and clinical practice recommendations across medical and surgical settings Ann Pharmacother 43 2009 1064 1083
11. J. Hirsh, K.A. Bauer, and M.B. Donati Parenteral anticoagulants: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition) Chest 133 2008 141s 159s
12. S.G. Frederiksen, J.L. Hedenbro, and L. Norgren Enoxaparin effect depends on body-weight and current doses may be inadequate in obese patients Br J Surg 90 2003 547 548
13. E.J. Rutherford, W.G. Schooler, and E. Sredzienski Optimal dose of enoxaparin in critically ill trauma and surgical patients J Trauma 58 2005 1167 1170
14. D. Malinoski, F. Jafari, and T. Ewing Standard prophylactic enoxaparin dosing leads to inadequate anti-Xa levels and increased deep venous thrombosis rates in critically ill trauma and surgical patients J Trauma 68 2010 874 880
15. E.P. Simone, A.K. Madan, and D.S. Tichansky Comparison of two low-molecular-weight heparin dosing regimens for patients undergoing laparoscopic bariatric surgery Surg Endosc 22 2008 2392 2395
16. M.J. Borkgren-Okonek, R.W. Hart, and J.A. Pantano Enoxaparin thromboprophylaxis in gastric bypass patients: extended duration, dose stratification, and antifactor Xa activity Surg Obes Relat Dis 4 2008 625 631
17. B.O. Rowan, D.A. Kuhl, and M.D. Lee Anti-Xa levels in bariatric surgery patients receiving prophylactic enoxaparin Obes Surg 18 2008 162 166
18. K.P. Ludwig, H.J. Simons, and M. Mone Implementation of an enoxaparin protocol for venous thromboembolism prophylaxis in obese surgical intensive care unit patients Ann Pharmacother 45 2011 1356 1362
19. ARUP National Reference Laboratory. Heparin anti-Xa, low molecular weight heparin. Available at: http://www.aruplab.com/guides/ug/tests/0030144.jsp. Accessed February 24, 2013.
20. C.A. Pierce, E.R. Haut, and S. Kardooni Surveillance bias and deep vein thrombosis in the national trauma data bank: the more we look, the more we find J Trauma 64 2008 932 937
21. E.R. Haut, E.B. Schneider, and A. Patel Duplex ultrasound screening for deep vein thrombosis in asymptomatic trauma patients: a survey of individual trauma surgeon opinions and current trauma center practices J Trauma 70 2011 27 34
22. C.E. Haas, J.L. Nelsen, and K. Raghavendran Pharmacokinetics and pharmacodynamics of enoxaparin in multiple trauma patients J Trauma 59 2005 1336 1344
23. T.W. Constantini, E. Min, and K. Box Dose adjusting enoxaparin is necessary to achieve adequate venous thromboembolism prophylaxis in trauma patients J Trauma 74 2013 128 135
24. J. Fareed, D. Hoppensteadt, and J. Walenga Pharmacodynamic and pharmacokinetic properties of enoxaparin Clin Pharmacokinet 42 2003 1043 1057
25. G.J. Sanderink, A. Le Liboux, and N. Jariwala The pharmacokinetics and pharmacodynamics of enoxaparin in obese volunteers Clin Pharmacol Ther 72 2002 308 318
26. P.Y. Van, S.D. Cho, and S.J. Underwood Thrombelastography versus antifactor Xa levels in the assessment of prophylactic-dose enoxaparin in critically ill patients J Trauma 66 2009 1509 1517