Hemophagocytic syndrome in children with acute monoblastic leukemia - Another cause of fever of unknown origin

Supportive Care in Cancer

Volumn 21, Issue 12, 2013, Pages 3519-3523

  Lackner, H ^a   Seidel, M G ^a   Strenger, V ^a   Sovinz, P ^a   Schwinger, W ^a   Benesch, M ^a   Sperl, D ^a   Urban, C ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Acute monoblastic leukemia; Hemophagocytosis; Inflammatory syndrome

Indexed keywords

ACID PHOSPHATASE; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; C REACTIVE PROTEIN; CD14 ANTIGEN; CD33 ANTIGEN; CD38 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD56 ANTIGEN; CIDOFOVIR; CLADRIBINE; CYTARABINE; CYTOMEGALOVIRUS ANTIBODY; DAUNORUBICIN; DEXAMETHASONE; ETOPOSIDE; FIBRINOGEN; FOSCARNET SODIUM; GANCICLOVIR; HLA DR ANTIGEN; IDARUBICIN; INTERLEUKIN 2; MITOXANTRONE; NONSPECIFIC ESTERASE; TIOGUANINE; TRIACYLGLYCEROL;

ABDOMINAL PAIN; ACUTE MONOCYTIC LEUKEMIA; ADOLESCENT; ADULT; APLASIA; BONE MARROW BIOPSY; CANCER CHEMOTHERAPY; CHILD; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION 9; CLINICAL ARTICLE; CONFERENCE PAPER; CYTOMEGALOVIRUS INFECTION; CYTOPENIA; DRUG MEGADOSE; FEMALE; FEVER; FOLLOW UP; HEMOPHAGOCYTIC SYNDROME; HUMAN; HYPERFERRITINEMIA; INFLAMMATION; LEUKEMIA REMISSION; LEUKOCYTE COUNT; MALE; MULTIPLE CYCLE TREATMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; PYREXIA IDIOPATHICA; RETROSPECTIVE STUDY; SCHOOL CHILD; SPLEEN INFARCTION;

ADOLESCENT; ADULT; C-REACTIVE PROTEIN; CHILD; CHILD, PRESCHOOL; FEMALE; FEVER OF UNKNOWN ORIGIN; HUMANS; INTERLEUKIN-2; LEUKEMIA, MONOCYTIC, ACUTE; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MALE; RETROSPECTIVE STUDIES; SURVIVAL RATE; YOUNG ADULT;

EID: 84889090189     PISSN: 09414355     EISSN: 14337339     Source Type: Journal    
DOI: 10.1007/s00520-013-1937-x     Document Type: Conference Paper

References (14)

1. Reinhardt D, von Neuhoff C, Sander A, Creutzig U (2012) Genetic prognostic factors in childhood acute myeloid leukemia. Klin Padiatr 224:372-376
2. Chang M, Raimondi SC, Ravindranath Y, Carrol AJ, Camitta B, Gresik MV, Steuber CP, Weinstein H (2000) Prognostic factors in children and adolescents with acute myeloid leukemia (excluding children with Down syndrome and acute promyelocytic leukemia): univariate and recursive partitioning analysis of patients treated on Pediatric Oncology Group (POG) Study 8821. Leukemia 14:1201-1207
3. Creutzig U, Zimmermann M, Dworzak M, Stary J, Lehrnbecher T (2004) Early deaths and treatment-related mortality in children undergoing therapy for acute myeloid leukemia: analysis of the multicenter clinical trials AML-BFM 93 and AML-BFM 98. J Clin Oncol 22:4384-4393
4. Creutzig U, Zimmermann M, Bourquin JP, Dworzak MN, von Neuhoff C, Sander A, Schrauder A, Teigler-Schlegel A, Stary J, Corbacioglu S, Reinhardt D (2011) Second induction with high-dose cytarabine and mitoxandrone: different impact on pediatric AML patients with t(8;21) and with inv(16). Blood 118:5409-5415
5. Wells RJ, Arthur DC, Srivastava A, Heerema NA, Le Beau M, Alonzo TA, Buxton AB, Woods WG, Howells WB, Benjamin DR, Betcher JD, Buckley JD, Feig SA, Kim T, Odom LF, Ruymann FB, Smithson WA, Tannous R, Whitt JK, Wolff L, Tjoa T, Lampkin BC (2002) Prognostic variables in newly diagnosed children and adolescents with acute myeloid leukemia: Children's Cancer Group Study 213. Leukemia 16:601-607
6. Inaba H, Fan Y, Pounds S, Geiger TL, Rubnitz JE, Ribeiro RC, Pui CH, Razzouk BI (2008) Clinical and biologic features and treatment outcome of children with newly diagnosed acute myeloid leukemia and hyperleukocytosis. Cancer 113:522-529
7. Lackner H, Urban C, Sovinz P, Benesch M, Moser A, Schwinger W (2008) Hemophagocytic lymphohistiocytosis as severe adverse event of antineoplastic treatment in children. Haematologica 93:291-294
8. Henter JI, Horne A, Arico M, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, Mc Clain K, Webb D, Winiarsky J, Janka G (2007) HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 48:124-131
9. Janka GE, Schneider EM (2004) Modern management of children with haemophagocytic lymphohistiocytosis. Br J Haematol 124:4-14
10. Ek T, Jarfelt M, Mellander L, Abrahamsson J (2001) Proinflammatory cytokines mediate the systemic inflammatory response associated with high-dose cytarabine treatment in children. Med Pediatr Oncol 37:459-464
11. Hijiya N, Metzger ML, Pounds S, Schmidt JE, Razzouk BI, Rubnitz JE, Howard SC, Nunez CA, Pui CH, Ribeiro RC (2005) Severe cardiopulmonary complications consistent with systemic inflammatory response syndrome caused by leukemia cell lysis in childhood acute myelomonocytic or monocytic leukemia. Pediatr Blood Cancer 44:63-69
12. Russell L, Shaw NJ, Eden OB (1989) Hemophagocytosis and acute monoblastic leukemia. Pediatr Hematol Oncol 6:367-371
13. Doros L, Pandya P, Hinze C, Rossi C, Schore R (2011) Hemophagocytic lymphohistiocytosis as a harbinger of pediatric acute myeloid leukemia. ASPHO 24th Annual Meeting, April 13-16, 2011, Abstract Database (Poster 207)
14. Stark B, Resnitzky P, Jeison M, Luria D, Blau O, Avigad S, Shaft D, Kodman Y, Gobuzov R, Ash S, Stein J, Yaniv I, Barak Y, Zaizov R (1995) A distinct subtype of M4/M5 acute myeloblastic leukemia (AML) associated with t(8:16)(p11:p13), in a patient with the variant t(8:19)(p11:q13) - case report and review of the literature. Leuk Res 19:367-379