Activity and interactions of levofloxacin, linezolid, ethambutol and amikacin in three-drug combinations against Mycobacterium tuberculosis isolates in a human macrophage model

International Journal of Antimicrobial Agents

Volumn 42, Issue 6, 2013, Pages 524-530

  Rey Jurado, Emma ^a   Tudó, Griselda ^a   Soy, Dolors ^a   González Martín, Julian ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Macrophage; Multidrug resistance; Mycobacterium tuberculosis; Second line drugs

Indexed keywords

AMIKACIN; ETHAMBUTOL; LEVOFLOXACIN; LINEZOLID;

ANTIMICROBIAL ACTIVITY; ARTICLE; CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG PENETRATION; DRUG SENSITIVITY; HUMAN; HUMAN CELL; MACROPHAGE CULTURE; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

MACROPHAGE; MULTIDRUG RESISTANCE; MYCOBACTERIUM TUBERCULOSIS; SECOND-LINE DRUGS;

ANTI-BACTERIAL AGENTS; CELL LINE; CHROMATOGRAPHY; COLONY COUNT, MICROBIAL; CULTURE MEDIA; CYTOPLASM; DRUG SYNERGISM; HUMANS; MACROPHAGES; MYCOBACTERIUM TUBERCULOSIS;

EID: 84889079235     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2013.07.014     Document Type: Article

References (26)

1. World Health Organization Multidrug and extensively drug-resistant TB (M/XDR-TB): 2010 global report on surveillance and response 2010 WHO Geneva, Switzerland
2. World Health Organization Guidelines for the programmatic management of drug-resistant tuberculosis 2011 update 2011 WHO Geneva, Switzerland
3. G.F. Schecter, C. Scott, L. True, A. Raftery, J. Flood, and S. Mase Linezolid in the treatment of multidrug-resistant tuberculosis Clin Infect Dis 50 2010 49 55
4. W.J. Koh, Y.R. Kang, K. Jeon, O.J. Kwon, J. Lyu, and W.S. Kim Daily 300 mg dose of linezolid for multidrug-resistant and extensively drug-resistant tuberculosis: updated analysis of 51 patients J Antimicrob Chemother 67 2012 1503 1507
5. H.F. Chambers, J. Turner, G.F. Schecter, M. Kawamura, and P.C. Hopewell Imipenem for treatment of tuberculosis in mice and humans Antimicrob Agents Chemother 49 2005 2816 2821
6. Y. Bhusal, C.M. Shiohira, and N. Yamane Determination of in vitro synergy when three antimicrobial agents are combined against Mycobacterium tuberculosis Int J Antimicrob Agents 26 2005 292 297
7. J.C. Rodriguez Díaz, M. Ruiz, M. López, and G. Royo Synergic activity of fluoroquinolones and linezolid against Mycobacterium tuberculosis Int J Antimicrob Agents 21 2003 354 356
8. E. Rey-Jurado, G. Tudó, J.A. Martínez, and J. González-Martín Synergistic effect of two combinations of antituberculous drugs against Mycobacterium tuberculosis Tuberculosis (Edinb) 92 2012 260 263
9. O.H. Vandal, C.F. Nathan, and S. Ehrt Acid resistance in Mycobacterium tuberculosis J Bacteriol 191 2009 4714 4721
10. M. Barcia-Macay, C. Seral, M.P. Mingeot-Leclercq, P.M. Tulkens, and F. Van Bambeke Pharmacodynamic evaluation of the intracellular activities of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages Antimicrob Agents Chemother 50 2006 841 851
11. S. Carryn, F. Van Bambeke, M.P. Mingeot-Leclercq, and P.M. Tulkens Comparative intracellular (THP-1 macrophage) and extracellular activities of β-lactams, azithromycin, gentamicin, and fluoroquinolones against Listeria monocytogenes at clinically relevant concentrations Antimicrob Agents Chemother 46 2002 2095 2103
12. National Committee for Clinical Laboratory Standards Susceptibility testing of mycobacteria, nocardiae, and other aerobic actinomycetes; approved standard. Document M24-A 2003 NCCLS Wayne, PA
13. S.A. Theus, M.D. Cave, and K.D. Eisenach Activated THP-1 cells: an attractive model for the assessment of intracellular growth rates of Mycobacterium tuberculosis isolates Infect Immun 72 2004 1169 1173
14. Global Alliance for TB drug Development Handbook of anti-tuberculosis agents Tuberculosis (Edinb) 88 2008 85 170
15. V. Lorian Antibiotics in laboratory medicine 2005 Lippincott Williams & Wilkins Philadelphia, PA
16. D. Ordway, M. Viveiros, C. Leandro, M.J. Arroz, and L. Amaral Intracellular activity of clinical concentrations of phenothiazines including thioridiazine against phagocytosed Staphylococcus aureus Int J Antimicrob Agents 20 2002 34 43
17. H. Schwende, E. Fitzke, P. Ambs, and P. Dieter Differences in the state of differentiation of THP-1 cells induced by phorbol ester and 1,25-dihydroxyvitamin D3 J Leukoc Biol 59 1996 555 561
18. G.E. Thwaites, S.M. Bhavnani, T.T. Chau, J.P. Hammel, M.E. Török, and S.A. Van Wart Randomized pharmacokinetic and pharmacodynamic comparison of fluoroquinolones for tuberculous meningitis Antimicrob Agents Chemother 55 2011 3244 3253
19. D.E. Wiskirchen, A. Shepard, J.L. Kuti, and D.P. Nicolau Determination of tissue penetration and pharmacokinetics of linezolid in patients with diabetic foot infections using in vivo microdialysis Antimicrob Agents Chemother 55 2011 4170 4175
20. E. Rey-Jurado, G. Tudó, J.P. de la Bellacasa, M. Espasa, and J. González-Martín In vitro effect of three-drug combinations of antituberculous agents against multidrug-resistant M. tuberculosis isolates Int J Antimicrob Agents 41 2013 278 280
21. C.M. Vallet, B. Marquez, N. Nhiri, A. Anantharajah, M.P. Mingeot-Leclercq, and P.M. Tulkens Modulation of the expression of ABC transporters in murine (J774) macrophages exposed to large concentrations of the fluoroquinolone antibiotic moxifloxacin Toxicology 290 2011 178 186
22. S. Lemaire, P.M. Tulkens, and F. Van Bambeke Contrasting effects of acidic pH on the extracellular and intracellular activities of the anti-Gram-positive fluoroquinolones moxifloxacin and delafloxacin against Staphylococcus aureus Antimicrob Agents Chemother 55 2011 649 658
23. I.H. Hall, U.E. Schwab, E.S. Ward, and T. Ives Disposition and intracellular levels of moxifloxacin in human THP-1 monocytes in unstimulated and stimulated conditions Int J Antimicrob Agents 22 2003 579 587
24. A. Soriano, O. Miró, and J. Mensa Mitochondrial toxicity associated with linezolid N Engl J Med 353 2005 2305 2306
25. S. López, O. Miró, E. Martínez, E. Pedrol, B. Rodríguez-Santiago, and A. Milinkovic Mitochondrial effects of antiretroviral therapies in asymptomatic patients Antivir Ther 9 2004 47 55
26. R. Singla, J.A. Caminero, A. Jaiswal, N. Singla, S. Gupta, and R.K. Bali Linezolid: an effective, safe and cheap drug for patients failing multidrug-resistant tuberculosis treatment in India Eur Respir J 39 2012 956 962