The Influence of Large Clinical Trials in Orthopedic Trauma: Do They Change Practice?

Journal of Orthopaedic Trauma

Volumn 27, Issue 12, 2013, Pages e268-e274

  Khan, Hassan ^a   Hussain, Nasir ^a   Bhandari, Mohit ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Orthopedics; Perceptions; Practice; Randomized trials

Indexed keywords

ARTICLE; CANADA; CLINICAL PRACTICE; CLINICAL TRIAL (TOPIC); CROSS-SECTIONAL STUDY; FEMALE; FRACTURE; HEALTH SURVEY; HUMAN; LIKERT SCALE; MALE; MEDICAL SOCIETY; MULTICENTER STUDY (TOPIC); ORTHOPEDIC SURGEON; ORTHOPEDIC SURGERY; ORTHOPEDICS; OUTCOME ASSESSMENT; PATIENT CARE; PRIORITY JOURNAL; PROBABILITY; PROFESSIONAL KNOWLEDGE; RANDOMIZED CONTROLLED TRIAL (TOPIC); TRAUMA SURGEON;

CANADA; CLINICAL TRIALS AS TOPIC; CROSS-SECTIONAL STUDIES; EVIDENCE-BASED MEDICINE; FRACTURES, BONE; HEALTH CARE SURVEYS; HUMANS; ORTHOPEDIC PROCEDURES; ORTHOPEDICS; PHYSICIAN'S PRACTICE PATTERNS; TREATMENT OUTCOME;

EID: 84889078580     PISSN: 08905339     EISSN: 15312291     Source Type: Journal    
DOI: 10.1097/BOT.0b013e31829642f9     Document Type: Article

References (19)

1. Bhandari M. Evidence-based medicine: why bother? Arthroscopy. 2009;25:296-297.
2. Sackett DL, Rosenberg WM, Gray JA, et al. Evidence based medicine: what it is and what it isn't. 1996. Clin Orthop Relat Res. 2007;455:3-5.
3. Bhandari M. Evidence-Based Orthopedics. United Kingdom: Wiley-Blackwell Publishing Ltd; 2012.
4. Stolberg HO, Norman G, Trop I. Randomized controlled trials. AJR Am J Roentgenol. 2004;183:1539-1544.
5. Benson K, Hartz AJ. A comparison of observational studies and randomized, controlled trials. N Engl J Med. 2000;342:1878-1886.
6. Dijkman BG, Kooistra BW, Pemberton J, et al. Can orthopedic trials change practice? Acta Orthop. 2010;81:122-125.
7. Govender S, Csimma C, Genant HK, et al. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am. 2002;84A:2123-2134.
8. Bosse MJ, MacKenzie EJ, Kellam JF, et al. An analysis of outcomes of reconstruction or amputation of leg-threatening injuries. N Engl J Med. 2002;347:1924-1931.
9. Anglen JO. Comparison of soap and antibiotic solutions for irrigation of lower-limb open fracture wounds. A prospective, randomized study. J Bone Joint Surg Am. 2005;87:1415-1422.
10. McKee MD, Kreder HJ, Mandel S, et al. Nonoperative treatment compared with plate fixation of displaced midshaft clavicular fractures. A multicenter, randomized clinical trial. J Bone Joint Surg Am. 2007;89:1-10.
11. Bhandari M, Guyatt G, Tornetta P, et al. Randomized trial of reamed and unreamed intramedullary nailing of tibial shaft fractures. J Bone Joint Surg Am. 2008;90:2567-2578.
12. Barton TM, Gleeson R, Topliss C, et al. A comparison of the long gamma nail with the sliding hip screw for the treatment of AO/OTA 31-A2 fractures of the proximal part of the femur: a prospective randomized trial. J Bone Joint Surg Am. 2010;92:792-798.
13. Adie S, Harris IA, Naylor JM, et al. Pulsed electromagnetic field stimulation for acute tibial shaft fractures a multicenter, double-blind, randomized trial. J Bone Joint Surg Am. 2011;93:1569-1576.
14. Mahan ST, Osborn E, Bae DS, et al. Changing practice patterns: the impact of randomized clinical trial on surgeons preference for treatment of type 3 supracondylar humerus fractures. J Pediatr Orthop. 2012;32:340-345.
15. Schwenk W, Hasse O, Muller JM. Changing surgical therapy because of clinical studies? [in German]. Zentralbl Chir. 2002;127:258-264.
16. Kizer JR, Cannon CP, McCabe CH, et al. Trends in the use of pharmacotherapies for acute myocardial infarction among physicians who design and/or implement randomized trials versus physicians in routine clinical practice: the MILIS-TIMI experience. Am Heart J. 1999;137:79-92.
17. Weinert CR, Gross CR, Marinelli WA. Impact of randomized trial results on acute lung injury ventilator therapy in teaching hospitals. Am J Respir Crit Care Med. 2003;167:1304-1309.
18. Col NF, McLaughlin TJ, Soumerai SB, et al. The impact of clinical trials on the use of medications for acute myocardial infarction. Results of a community-based study. Arch Intern Med. 1996;156:54-60.
19. Cook RC, Alscher KT, Hsiang YN. A debate on the value and necessity of clinical trials in surgery. Am J Surg. 2003;185:305-310.