The role of fibroblast growth factor receptor substrate 2 (FRS2) in the regulation of two activity levels of the components of the extracellular signal-regulated kinase (ERK) pathway in the mouse epididymis

Biology of Reproduction

Volumn 89, Issue 2, 2013, Pages

  Xu, Bingfang ^a   Yang, Ling ^a   Hinton, Barry T ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Apoptosis; Epididymal development; ERK pathway; FRS2; Transgenic knockout model

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; FRS2ALPHA PROTEIN, MOUSE; MEMBRANE PROTEIN;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EPIDIDYMIS; EPITHELIUM CELL; MOUSE; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; CYTOLOGY; EPIDIDYMAL DEVELOPMENT; ERK PATHWAY; FRS2; GENETICS; KNOCKOUT MODEL; MALE; METABOLISM; PHYSIOLOGY; TESTIS; TRANSGENIC;

APOPTOSIS; EPIDIDYMAL DEVELOPMENT; ERK PATHWAY; FRS2; KNOCKOUT MODEL; TRANSGENIC;

ANIMALS; EPIDIDYMIS; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MALE; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; TESTIS;

EID: 84889061296     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.112.10718     Document Type: Article

References (29)

1. Hinton BT, Galdamez MM, Sutherland A, Bomgardner D, Xu B, Abdel-Fattah R, Yang L. How do you get six meters of epididymis inside a human scrotum?. J Androl 2011; 32:558-564.
2. Jiang FX, Temple-Smith P, Wreford NG. Postnatal differentiation and development of the rat epididymis: a stereological study. Anat Rec 1994; 238:191-198.
3. Robaire B, Hinton BT, Orgebin-Crist MC. The epididymis In: Neill JD (ed.), Knobil and Neill's Physiology of Reproduction, 3rd ed. New York: Elsevier; 2006: 1071-1148.
4. Welsh M, Saunders PT, Sharpe RM. The critical time window for androgen-dependent development of the Wolffian duct in the rat. Endocrinology 2007; 148:3185-3195.
5. Rodriguez CM, Kirby J, Hinton BT. The development of the epididymis In: Robaire B, Hinton BT (eds.), The Epididymis From Molecules To Clinical Practice. New York: Kluwer Academic/Plenum Publishers; 2002: 251-267.
6. Robaire B, Hermo L. Efferent duct, epididymis, and vas deferens: structure, functions, and their regulation In: Knobil E, Neill JD (eds.), The Physiology of Reproduction, vol. 1. New York: Raven Press; 1988: 999-1080.
7. Xu B, Abdel-Fattah R, Yang L, Crenshaw SA, Black MB, Hinton BT. Testicular lumicrine factors regulate ERK, STAT, and NFKB pathways in the initial segment of the rat epididymis to prevent apoptosis. Biol Reprod 2011; 84:1282-1291.
8. Xu B, Yang L, Lye RJ, Hinton BT. p-MAPK1/3 and DUSP6 regulate epididymal cell proliferation and survival in a region-specific manner in mice.Biol Reprod 2010; 83:807-817.
9. Jegou B, Le Gac F, de Kretser DM. Seminiferous tubule fluid and interstitial fluid production. I. Effects of age and hormonal regulation in immature rats.Biol Reprod 1982; 27:590-595.
10. Gotoh N. Regulation of growth factor signaling by FRS2 family docking/ scaffold adaptor proteins. Cancer Sci 2008; 99:1319-1325.
11. Zhang Y, Zhang J, Lin Y, Lan Y, Lin C, Xuan JW, Shen MM, McKeehan WL, Greenberg NM, Wang F. Role of epithelial cell fibroblast growth factor receptor substrate 2alpha in prostate development, regeneration and tumorigenesis. Development 2008; 135:775-784.
12. Zhang J, Lin Y, Zhang Y, Lan Y, Lin C, Moon AM, Schwartz RJ, Martin JF, Wang F. Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development 2008; 135:3611-3622.
13. Sims-Lucas S, Cullen-McEwen L, Eswarakumar VP, Hains D, Kish K, Becknell B, Zhang J, Bertram JF, Wang F, Bates CM. Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia. Am J Physiol Renal Physiol 2009; 297:F1208-1219.
14. Yu J, Carroll TJ, McMahon AP. Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 2002; 129:5301-5312.
15. Krutskikh A, De Gendt K, Sharp V, Verhoeven G, Poutanen M, Huhtaniemi I. Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia. Endocrinology 2011; 152:689-696.
16. Krutskikh A, Poliandri A, Cabrera-Sharp V, Dacheux JL, Poutanen M. Epididymal protein RNase10 is required for post-testicular sperm maturation and male fertility. FASEB J 2012; 26:4198-209.
17. Zhang Y, McKeehan K, Lin Y, Zhang J, Wang F. Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor. Mol Endocrinol 2008; 22:167-175.
18. Tomsig JL, Turner TT. Growth factors and the epididymis. J Androl 2006; 27:348-357.
19. Turner TT, Johnston DS, Finger JN, Jelinsky SA. Differential gene expression among the proximal segments of the rat epididymis is lost after efferent duct ligation. Biol Reprod 2007; 77:165-171.
20. Kitagaki J, Ueda Y, Chi X, Sharma N, Elder CM, Truffer E, Costantini F, Lewandoski M, Perantoni AO. FGF8 is essential for formation of the ductal system in the male reproductive tract. Development 2011; 138: 5369-5378.
21. Elo T, Sipila P, Valve E, Kujala P, Toppari J, Poutanen M, Harkonen P. Fibroblast growth factor 8b causes progressive stromal and epithelial changes in the epididymis and degeneration of the seminiferous epithelium in the testis of transgenic mice. Biol Reprod 2012; 86:157.
22. Hinton BT, Lan ZJ, Lye RJ, Labus JC. Regulation of epididymal function by testicular factors: The lumicrine hypothesis In: Goldberg E (ed.), The Testis. New York: Springer-Verlag; 2000: 163-173.
23. Lan ZJ, Labus JC, Hinton BT. Regulation of gamma-glutamyl transpeptidase catalytic activity and protein level in the initial segment of the rat epididymis by testicular factors: role of basic fibroblast growth factor. Biol Reprod 1998; 58:197-206.
24. Kirby JL, Yang L, Labus JC, Hinton BT. Characterization of fibroblast growth factor receptors expressed in principal cells in the initial segment of the rat epididymis. Biol Reprod 2003; 68:2314-2321.
25. Gotoh N, Laks S, Nakashima M, Lax I, Schlessinger J. FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. FEBS Lett 2004; 564:14-18.
26. Sims-Lucas S, Cusack B, Eswarakumar VP, Zhang J, Wang F, Bates CM. Independent roles of Fgfr2 and Frs2alpha in ureteric epithelium. Development 2011; 138:1275-1280.
27. Powers CJ, McLeskey SW, Wellstein A. Fibroblast growth factors, their receptors and signaling. Endocr Relat Cancer 2000; 7:165-197.
28. Turner TT, Jones CE, Howards SS, Ewing LL, Zegeye B, Gunsalus GL. On the androgen microenvironment of maturing spermatozoa. Endocrinology 1984; 115:1925-1932.
29. Hamzeh M, Robaire B. Androgens activate mitogen-activated protein kinase via epidermal growth factor receptor/insulin-like growth factor 1 receptor in the mouse PC-1 cell line. J Endocrinol 2011; 209:55-64.