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Volumn 47, Issue 11, 2013, Pages 1478-1487

Pharmacokinetic and Pharmacodynamic Drug Interactions With New Oral Anticoagulants: What Do They Mean for Patients With Atrial Fibrillation?

Author keywords

anticoagulants; atrial fibrillation; drug drug interactions

Indexed keywords

ACETYLSALICYLIC ACID; AMIODARONE; ANTITHROMBOCYTIC AGENT; APIXABAN; BOCEPREVIR; CLARITHROMYCIN; CLOPIDOGREL; CONIVAPTAN; CYTOCHROME P450; CYTOCHROME P450 3A4; DABIGATRAN; DABIGATRAN ETEXILATE; DRONEDARONE; GLYCOPROTEIN; INDINAVIR; ITRACONAZOLE; KETOCONAZOLE; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; MIBEFRADIL; NEFAZODONE; NELFINAVIR; NONSTEROID ANTIINFLAMMATORY AGENT; PERMEABILITY GLYCOPROTEIN; POSACONAZOLE; QUINIDINE; RIFAMPICIN; RIVAROXABAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL;

EID: 84889058769     PISSN: 10600280     EISSN: 15426270     Source Type: Journal    
DOI: 10.1177/1060028013504741     Document Type: Review
Times cited : (98)

References (37)
  • 1
    • 0035832261 scopus 로고    scopus 로고
    • Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study
    • Go AS,Hylek EM,Phillips KA,et al.Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study.JAMA. 2001;285:2370-2375.
    • (2001) JAMA , vol.285 , pp. 2370-2375
    • Go, A.S.1    Hylek, E.M.2    Phillips, K.A.3
  • 2
    • 33747437950 scopus 로고    scopus 로고
    • ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation)
    • Fuster V,Ryden LE,Cannom DS,et al.ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society.Circulation. 2006;114:e257-e354.
    • (2006) Circulation , vol.114
    • Fuster, V.1    Ryden, L.E.2    Cannom, D.S.3
  • 3
    • 20844437551 scopus 로고    scopus 로고
    • Reviewing the reality: why we need to change
    • Lin P.Reviewing the reality: why we need to change.Eur Heart J. 2005;7:E15-E20.
    • (2005) Eur Heart J , vol.7
    • Lin, P.1
  • 4
    • 79958077792 scopus 로고    scopus 로고
    • Drug and dietary interactions of warfarin and novel oral anticoagulants: an update
    • Nutescu E,Chuatrisorn I,Hellenbart E.Drug and dietary interactions of warfarin and novel oral anticoagulants: an update.J Thromb Thrombolysis. 2011;31:326-343.
    • (2011) J Thromb Thrombolysis , vol.31 , pp. 326-343
    • Nutescu, E.1    Chuatrisorn, I.2    Hellenbart, E.3
  • 5
    • 84889047752 scopus 로고    scopus 로고
    • Princeton, NJ: Bristol Myers Squibb
    • Princeton, NJ: Bristol Myers Squibb; 2010:.
    • (2010)
  • 6
    • 84873105846 scopus 로고    scopus 로고
    • An evidence-based review of apixaban and its potential in the prevention of stroke in patients with atrial fibrillation
    • Deedwania P,Huang GW.An evidence-based review of apixaban and its potential in the prevention of stroke in patients with atrial fibrillation.Core Evid. 2012;7:49-59.
    • (2012) Core Evid , vol.7 , pp. 49-59
    • Deedwania, P.1    Huang, G.W.2
  • 7
    • 25844525489 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor
    • Kubitza D,Becka M,Voith B,Zuehlsdorf M,Wensing G.Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor.Clin Pharmacol Ther. 2005;78:412-421.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 412-421
    • Kubitza, D.1    Becka, M.2    Voith, B.3    Zuehlsdorf, M.4    Wensing, G.5
  • 8
    • 29144518504 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939-an oral, direct factor Xa inhibitor-after multiple dosing in healthy male subjects
    • Kubitza D,Becka M,Wensing G,Voith B,Zuehlsdorf M.Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939-an oral, direct factor Xa inhibitor-after multiple dosing in healthy male subjects.Eur J Clin Pharmacol. 2005;61:873-880.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 873-880
    • Kubitza, D.1    Becka, M.2    Wensing, G.3    Voith, B.4    Zuehlsdorf, M.5
  • 9
    • 58149458160 scopus 로고    scopus 로고
    • Apixaban metabolism and pharmacokinetics after oral administration to humans
    • Raghavan N,Frost CE,Yu Z,et al.Apixaban metabolism and pharmacokinetics after oral administration to humans.Drug Metab Dispos. 2009;37:74-81.
    • (2009) Drug Metab Dispos , vol.37 , pp. 74-81
    • Raghavan, N.1    Frost, C.E.2    Yu, Z.3
  • 10
    • 77952167209 scopus 로고    scopus 로고
    • Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor
    • Stangier J,Clemens A.Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor.Clin Appl Thromb Hemost. 2009;15:9S-16S.
    • (2009) Clin Appl Thromb Hemost , vol.15
    • Stangier, J.1    Clemens, A.2
  • 11
    • 84889000740 scopus 로고    scopus 로고
    • Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals Inc
    • Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals Inc; 2013:.
    • (2013)
  • 12
    • 84889005163 scopus 로고    scopus 로고
    • Titusville, NJ: Janssen Pharmaceuticals Inc
    • Titusville, NJ: Janssen Pharmaceuticals Inc; 2013:.
    • (2013)
  • 13
    • 84889055273 scopus 로고    scopus 로고
    • Princeton, NJ: Bristol Myers Squibb, Pfizer Inc
    • Princeton, NJ: Bristol Myers Squibb, Pfizer Inc; 2012:.
    • (2012)
  • 14
    • 80052825103 scopus 로고    scopus 로고
    • Apixaban versus warfarin in patients with atrial fibrillation
    • Granger CB,Alexander JH,McMurray J,et al.Apixaban versus warfarin in patients with atrial fibrillation.N Engl J Med. 2011;365:981-992.
    • (2011) N Engl J Med , vol.365 , pp. 981-992
    • Granger, C.B.1    Alexander, J.H.2    McMurray, J.3
  • 15
    • 33845493309 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolic drug interactions
    • Leucuta SE,Vlase L.Pharmacokinetics and metabolic drug interactions.Curr Clin Pharmacol. 2006;1:5-20.
    • (2006) Curr Clin Pharmacol , vol.1 , pp. 5-20
    • Leucuta, S.E.1    Vlase, L.2
  • 16
    • 84889058569 scopus 로고    scopus 로고
    • US Food and Drug Administration Advisory Committee Briefing Document: Dabigatran etexilate, Inc. August2010, Accessed September 10, 2013
    • US Food and Drug Administration Advisory Committee Briefing Document: Dabigatran etexilate. Boehringer Ingelheim Pharmaceuticals, Inc. August2010. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterial/Drugs/CardiovascularandRenalDrugsAdvisoryCommittee/UCM226009.pdf. Accessed September 10, 2013.
    • Boehringer Ingelheim Pharmaceuticals
  • 17
    • 84888996189 scopus 로고    scopus 로고
    • US Food and Drug Administration Clinical Review, Inc. August2010, Accessed September 10, 2013
    • US Food and Drug Administration Clinical Review. Dabigatran etexilate. Boehringer Ingelheim Pharmaceuticals, Inc. August2010. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterial/Drugs/CardiovascularandRenalDrugsAdvisoryCommittee/UCM247244.pdf. Accessed September 10, 2013.
    • Dabigatran etexilate. Boehringer Ingelheim Pharmaceuticals
  • 18
    • 28044457103 scopus 로고    scopus 로고
    • Functional interactions between P-glycoprotein and CYP3A in drug metabolism
    • Christians U,Schmitz V,Haschke M.Functional interactions between P-glycoprotein and CYP3A in drug metabolism.Expert Opin Drug Metab Toxicol. 2005;1:641-654.
    • (2005) Expert Opin Drug Metab Toxicol , vol.1 , pp. 641-654
    • Christians, U.1    Schmitz, V.2    Haschke, M.3
  • 19
    • 80052162121 scopus 로고    scopus 로고
    • Apixaban with antiplatelet therapy after acute coronary syndrome
    • Alexander JH,Lopes RD,James S,et al.Apixaban with antiplatelet therapy after acute coronary syndrome.N Eng J Med. 2011;365:699-708.
    • (2011) N Eng J Med , vol.365 , pp. 699-708
    • Alexander, J.H.1    Lopes, R.D.2    James, S.3
  • 20
    • 84883301339 scopus 로고    scopus 로고
    • The effects of the antiplatelet agents, aspirin and naproxen, on pharmacokinetics and pharmacodynamics of the anticoagulant edoxaban, a direct factor Xa inhibitor
    • Mendell J,Lee F,Chen S,Worland V,Shi M,Samama MM.The effects of the antiplatelet agents, aspirin and naproxen, on pharmacokinetics and pharmacodynamics of the anticoagulant edoxaban, a direct factor Xa inhibitor.J Cardiovasc Pharmacol. 2013;62:212-221.
    • (2013) J Cardiovasc Pharmacol , vol.62 , pp. 212-221
    • Mendell, J.1    Lee, F.2    Chen, S.3    Worland, V.4    Shi, M.5    Samama, M.M.6
  • 21
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • Connolly SJ,Ezekowitz MD,Yusuf S,et al.Dabigatran versus warfarin in patients with atrial fibrillation.N Engl J Med. 2009;361:1139-1151.
    • (2009) N Engl J Med , vol.361 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 22
    • 80052592404 scopus 로고    scopus 로고
    • Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    • Patel MR,Mahaffey KW,Garg J,et al.Rivaroxaban versus warfarin in nonvalvular atrial fibrillation.N Engl J Med. 2011;365:883-891.
    • (2011) N Engl J Med , vol.365 , pp. 883-891
    • Patel, M.R.1    Mahaffey, K.W.2    Garg, J.3
  • 23
    • 67649563209 scopus 로고    scopus 로고
    • Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial
    • Goodman SG,Harrington RA,Huber K,et al.Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial.Circulation. 2009;119:2877-2885.
    • (2009) Circulation , vol.119 , pp. 2877-2885
    • Goodman, S.G.1    Harrington, R.A.2    Huber, K.3
  • 24
    • 84878830133 scopus 로고    scopus 로고
    • New oral anticoagulants in addition to single or dual antiplatelet therapy after an acute coronary syndrome: a systematic review and meta-analysis
    • Oldgren J,Wallentin L,Alexander JH,et al.New oral anticoagulants in addition to single or dual antiplatelet therapy after an acute coronary syndrome: a systematic review and meta-analysis.Eur Heart J. 2013;34:1670-1680.
    • (2013) Eur Heart J , vol.34 , pp. 1670-1680
    • Oldgren, J.1    Wallentin, L.2    Alexander, J.H.3
  • 25
    • 67649562905 scopus 로고    scopus 로고
    • Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial
    • Mega JL,Braunwald E,Mohanavelu S,et al.Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial.Lancet. 2009;374:29-38.
    • (2009) Lancet , vol.374 , pp. 29-38
    • Mega, J.L.1    Braunwald, E.2    Mohanavelu, S.3
  • 26
    • 80052232522 scopus 로고    scopus 로고
    • Dabigatran vs. placebo in patients with acute coronary syndromes on dual antiplatelet therapy: a randomized, double-blind, phase II trial
    • Oldgren J,Budaj A,Granger CB,et al.Dabigatran vs. placebo in patients with acute coronary syndromes on dual antiplatelet therapy: a randomized, double-blind, phase II trial.Eur Heart J. 2011;32:2781-2789.
    • (2011) Eur Heart J , vol.32 , pp. 2781-2789
    • Oldgren, J.1    Budaj, A.2    Granger, C.B.3
  • 27
    • 84862907587 scopus 로고    scopus 로고
    • Rivaroxaban in patients with a recent acute coronary syndrome
    • Mega JL,Braunwald E,Wiviott SD,et al.Rivaroxaban in patients with a recent acute coronary syndrome.N Engl J Med. 2012;366:9-19.
    • (2012) N Engl J Med , vol.366 , pp. 9-19
    • Mega, J.L.1    Braunwald, E.2    Wiviott, S.D.3
  • 28
    • 83055170914 scopus 로고    scopus 로고
    • Dabigatran etexilate in clinical practice: confronting challenges to improve safety and effectiveness
    • Gulseth MP,Wittkowsky AK,Fanikos J,et al.Dabigatran etexilate in clinical practice: confronting challenges to improve safety and effectiveness.Pharmacotherapy. 2011;31:1232-1249.
    • (2011) Pharmacotherapy , vol.31 , pp. 1232-1249
    • Gulseth, M.P.1    Wittkowsky, A.K.2    Fanikos, J.3
  • 30
    • 66449099711 scopus 로고    scopus 로고
    • Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans
    • Weinz C,Schwarz T,Kubitza D,Mueck W,Lang D.Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans.Drug Metab Dispos. 2009;37:1056-1064.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1056-1064
    • Weinz, C.1    Schwarz, T.2    Kubitza, D.3    Mueck, W.4    Lang, D.5
  • 31
    • 84889068101 scopus 로고    scopus 로고
    • US Food and Drug Administration Advisory Committee briefing document, August2011., Accessed September 10, 2013
    • US Food and Drug Administration Advisory Committee briefing document. Rivaroxaban. Johnson & Johnson Pharmaceutical Research & Development. August2011. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/CardiovasclarandRenalDrugsAdvisoryCommittee/UCM270797.pdf. Accessed September 10, 2013.
    • Rivaroxaban. Johnson & Johnson Pharmaceutical Research & Development
  • 32
    • 66449087353 scopus 로고    scopus 로고
    • In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans
    • Lang D,Freudenberger C,Weinz C.In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.Drug Metab Dispos. 2009;37:1046-1055.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1046-1055
    • Lang, D.1    Freudenberger, C.2    Weinz, C.3
  • 33
    • 33645779998 scopus 로고    scopus 로고
    • Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects
    • Kubitza D,Becka M,Zuehlsdorf M,Mueck W.Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects.J Clin Pharmacol. 2006;46:549-558.
    • (2006) J Clin Pharmacol , vol.46 , pp. 549-558
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 34
    • 83155181625 scopus 로고    scopus 로고
    • Effect of multiple doses of omeprazole on the pharmacokinetics, pharmacodynamics, and safety of a single dose of rivaroxaban
    • Moore KT,Plotnikov AN,Thyssen A,et al.Effect of multiple doses of omeprazole on the pharmacokinetics, pharmacodynamics, and safety of a single dose of rivaroxaban.J Cardiovasc Pharmacol. 2011;58:581-588.
    • (2011) J Cardiovasc Pharmacol , vol.58 , pp. 581-588
    • Moore, K.T.1    Plotnikov, A.N.2    Thyssen, A.3
  • 35
    • 33747068794 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban-an oral, direct Factor Xa inhibitor-are not affected by aspirin
    • Kubitza D,Becka M,Mueck W,Zuehlsdorf M.Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban-an oral, direct Factor Xa inhibitor-are not affected by aspirin.J Clin Pharmacol. 2006;46:981-990.
    • (2006) J Clin Pharmacol , vol.46 , pp. 981-990
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 36
    • 58149401862 scopus 로고    scopus 로고
    • Apixaban, an oral direct Factor Xa inhibitor: awaiting the verdict
    • Carreiro J,Ansell J.Apixaban, an oral direct Factor Xa inhibitor: awaiting the verdict.Expert Opin Investig Drugs. 2008;17:1937-1945.
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 1937-1945
    • Carreiro, J.1    Ansell, J.2
  • 37
    • 84876996914 scopus 로고    scopus 로고
    • Effect of famotidine on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor
    • Upreti VV,Song Y,Wang J,et al.Effect of famotidine on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor.Clin Pharmacol. 2013;5:59-66.
    • (2013) Clin Pharmacol , vol.5 , pp. 59-66
    • Upreti, V.V.1    Song, Y.2    Wang, J.3


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