EGCG-rich green tea extract stimulates sRAGE secretion to inhibit S100A12-RAGE axis through ADAM10-mediated ectodomain shedding of extracellular RAGE in type 2 diabetes

Molecular Nutrition and Food Research

Volumn 57, Issue 12, 2013, Pages 2264-2268

  Huang, Shang Ming ^a   Chang, Yin Hsuan ^a   Chao, Ya Chan ^c   Lin, Jer An ^a   Wu, Chi Hao ^b   Lai, Ching Yi ^a   Chan, Kung Chi ^c   Tseng, Shih Ting ^d   Yen, Gow Chin ^a,e  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c PROVIDENCE UNIVERSITY   (Taiwan)

^d KUANG TIEN GENERAL HOSPITAL   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

ADAM10; EGCG; RAGE; S100A12; SRAGE

Indexed keywords

ADAM PROTEIN; ADAM10 PROTEIN, HUMAN; ADVANCED GLYCOSYLATION END PRODUCT RECEPTOR; ADVANCED GLYCOSYLATION END-PRODUCT RECEPTOR; CATECHIN; DRUG DERIVATIVE; EGCG; EPIGALLOCATECHIN GALLATE; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; PLANT EXTRACT; PROTEIN S 100; S100A12 PROTEIN, HUMAN; SECRETASE;

ADAM10; ARTICLE; BLOOD; CAMELLIA SINENSIS; CHEMISTRY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET THERAPY; DRUG EFFECT; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; MONOCYTE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN TERTIARY STRUCTURE; RAGE; S100A12; SRAGE;

ADAM10; EGCG; RAGE; S100A12; SRAGE;

ADAM PROTEINS; AMYLOID PRECURSOR PROTEIN SECRETASES; CAMELLIA SINENSIS; CATECHIN; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MONOCYTES; PLANT EXTRACTS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, IMMUNOLOGIC; S100 PROTEINS;

EID: 84889025220     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201300275     Document Type: Article

References (15)

1. Barlovic, D. P., Soro-Paavonen, A., Jandeleit-Dahm, K. A., RAGE biology, atherosclerosis and diabetes. Clin. Sci. (Lond.) 2011, 121, 43-55.
2. Huang, S. M., Wu, C. H., Yen, G. C., Effects of flavonoids on the expression of the pro-inflammatory response in human monocytes induced by ligation of the receptor for AGEs. Mol. Nutr. Food Res. 2006, 50, 1129-1139.
3. Raucci, A., Cugusi, S., Antonelli, A., Barabino, S. M. et al., A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10). FASEB J. 2008, 22, 3716-3727.
4. Vazzana, N., Santilli, F., Cuccurullo, C., Davi, G., Soluble forms of RAGE in internal medicine. Intern. Emerg. Med. 2009, 4, 389-401.
5. Narotzki, B., Reznick, A. Z., Aizenbud, D., Levy, Y., Green tea: a promising natural product in oral health. Arch. Oral. Biol. 2012, 57, 429-435.
6. Kao, Y. H., Chang, H. H., Lee, M. J., Chen, C. L., Tea, obesity, and diabetes. Mol. Nutr. Food Res. 2006, 50, 188-210.
7. Wolfram, S., Effects of green tea and EGCG on cardiovascular and metabolic health. J. Am. Coll. Nutr. 2007, 26, 373S-388S.
8. Park, S., Yoon, S. J., Tae, H. J., Shim, C. Y., RAGE and cardiovascular disease. Front Biosci. 2011, 16, 486-497.
9. Jiao, L., Chen, L., Alsarraj, A., Ramsey, D. et al., Plasma soluble receptor for advanced glycation end-products and risk of colorectal adenoma. Int. J. Mol. Epidemiol. Genet. 2012, 3, 294-304.
10. Maillard-Lefebvre, H., Boulanger, E., Daroux, M., Gaxatte, C. et al., Soluble receptor for advanced glycation end products: a new biomarker in diagnosis and prognosis of chronic inflammatory diseases. Rheumatology (Oxford) 2009, 48, 1190-1196.
11. Han, S. H., Kim, Y. H., Mook-Jung, I., RAGE: the beneficial and deleterious effects by diverse mechanisms of actions. Mol. Cells 2011, 31, 91-97.
12. Kosaki, A., Hasegawa, T., Kimura, T., Iida, K. et al., Increased plasma S100A12 (EN-RAGE) levels in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 2004, 89, 5423-5428.
13. Yan, S. F., Ramasamy, R., Schmidt, A. M., Soluble RAGE: therapy and biomarker in unraveling the RAGE axis in chronic disease and aging. Biochem. Pharmacol. 2010, 79, 1379-1386.
14. Naka, Y., Bucciarelli, L. G., Wendt, T., Lee, L. K. et al., RAGE axis: Animal models and novel insights into the vascular complications of diabetes. Arterioscler. Thromb. Vasc. Biol. 2004, 24, 1342-1349.
15. Koyama, H., Yamamoto, H., Nishizawa, Y., RAGE and soluble RAGE: potential therapeutic targets for cardiovascular diseases. Mol. Med. 2007, 13, 625-635.