Cerebral microbleeds on T2*-weighted images and hemorrhagic transformation after antithrombotic therapies for ischemic stroke

Journal of Stroke and Cerebrovascular Diseases

Volumn 22, Issue 8, 2013, Pages

  Takahashi, Wakoh ^a   Moriya, Yusuke ^a   Mizuma, Atsushi ^a   Uesugi, Tsuyoshi ^a   Ohnuki, Yoichi ^a   Takizawa, Shunya ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

weighted sequences; anticoagulant; antiplatelet agent; gradient echo T2; hemorrhagic transformation; Ischemic stroke; microbleeds

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; FIBRINOLYTIC AGENT;

ADULT; AGED; ALBERTA STROKE PROGRAM EARLY CT SCORE; ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; COMPUTER ASSISTED TOMOGRAPHY; DIFFUSION WEIGHTED IMAGING; DISEASE SEVERITY; FEMALE; HEMORRHAGIC TRANSFORMATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCORING SYSTEM; STROKE PATIENT; SYSTOLIC BLOOD PRESSURE; BRAIN ANGIOGRAPHY; CEREBRAL HEMORRHAGE; CHEMICALLY INDUCED; CHI SQUARE DISTRIBUTION; COMPARATIVE STUDY; DISABILITY; JAPAN; MIDDLE AGED; PREVALENCE; PROCEDURES; RISK; RISK ASSESSMENT; RISK FACTOR; STATISTICAL MODEL; STROKE; TREATMENT OUTCOME; UNIVERSITY HOSPITAL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANTICOAGULANTS; BRAIN ISCHEMIA; CEREBRAL ANGIOGRAPHY; CEREBRAL HEMORRHAGE; CHI-SQUARE DISTRIBUTION; DIFFUSION MAGNETIC RESONANCE IMAGING; DISABILITY EVALUATION; FIBRINOLYTIC AGENTS; HOSPITALS, UNIVERSITY; HUMANS; JAPAN; LOGISTIC MODELS; MIDDLE AGED; ODDS RATIO; PLATELET AGGREGATION INHIBITORS; PREDICTIVE VALUE OF TESTS; PREVALENCE; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; STROKE; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 84889011785     PISSN: 10523057     EISSN: 15328511     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2013.05.037     Document Type: Article

References (23)

1. S.W. Atlas, A.S. Mark, and R.I. Grossman Intracranial hemorrhage: gradient-echo MR imaging at 1.5 T. Comparison with spin-echo imaging and clinical applications Radiology 168 1988 803 807
2. Y. Tsushima, J. Aoki, and K. Endo Brain microhemorrhages detected on T2*-weighted gradient-echo MR images Am J Neuroradiol 24 2003 88 96
3. Y.H. Fan, L. Zhang, and W.W. Lam Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic stroke Stroke 43 2003 2459 2462
4. T. Nishikawa, T. Ueba, and M. Kajiwara Cerebral microbleeds predict first-ever symptomatic cerebrovascular events Clin Neurol Neurosurg 111 2009 825 828
5. H. Bokura, R. Saika, and T. Yamaguchi Microbleeds are associated with subsequent hemorrhagic and ischemic stroke in healthy elderly individuals Stroke 42 2011 1867 1871
6. C.S. Kidwell, J.L. Saver, and J.P. Villablanca Magnetic resonance imaging detection of microbleeds before thrombolysis: an emerging application Stroke 33 2002 95 98
7. N. Nighoghossian, M. Hermier, and P. Adeleine Old microbleeds are a potential risk factor for cerebral bleeding after ischemic stroke. A gradient-echo T2*-weighted brain MRI study Stroke 33 2002 735 742
8. V. Larrue, R. von Kummer, and G. del Zoppo Hemorrhagic transformation in acute ischemic stroke Stroke 28 1997 957 960
9. M. Paciaroni, G. Agnelli, and F. Corea Early hemorrhagic transformation of brain infarction: rate, predictive factors, and influence on clinical outcome. Results of a prospective multicenter study Stroke 39 2008 2249 2256
10. Y. Okada, T. Yamaguchi, and K. Minematsu Hemorrhagic transformation in cerebral embolism Stroke 20 1989 598 603
11. D. Toni, M. Fiorelli, and S. Bastianello Hemorrhagic transformation of brain infarct: predictability in the first 5 hours from stroke onset and influence on clinical outcome Neurology 46 1996 341 345
12. M. Selim, J.N. Fink, and S. Kumar Predictors of hemorrhagic transformation after intravenous recombinant tissue plasminogen activator. Prognostic value of the initial apparent diffusion coefficient and diffusion-weighted lesion volume Stroke 33 2002 2047 2052
13. M.G. Lansberg, V.N. Thijs, R. Bammer on behalf of the DEFUSE investigators Risk factors of symptomatic intracerebral hemorrhage after tPA therapy for acute stroke Stroke 38 2007 2275 2278
14. K. Toyoda, M. Koga, and M. Naganuma Routine use of intravenous low-dose recombinant tissue plasminogen activator in Japanese patients. General outcomes and prognostic factors from the SAMURAI register Stroke 40 2009 3591 3595
15. Y. Hasegawa, Y. Okada, and S. Okuda Early ischemic change on CT versus diffusion-weighted imaging for patients with stroke receiving intravenous recombinant tissue-type plasminogen activator therapy. Stroke acute management with urgent risk-factor assessment and improvement (SAMURAI) rt-PA registry Stroke 42 2011 2196 2200
16. L. Derex, N. Nighoghossian, and M. Hermier Thrombolysis for ischemic stroke in patients with old microbleeds on pretreatment MRI Cerebrovasc Dis 17 2004 238 241
17. W. Kakuda, V.N. Thijs, and M.G. Lansberg Clinical importance of microbleeds in patients receiving IV thrombolysis Neurology 65 2005 1175 1178
18. J. Fiehler, G.W. Albers, and J.M. Boulanger Bleeding risk analysis in stroke imaging before thromboLysis (BRASIL). Pooled analysis of T2*-weighted magnetic resonance imaging data from 570 patients Stroke 38 2007 2738 2744
19. P.A. Barber, M. Hill, M. Eliasziw for the ASPECTS Study Group Imaging of the brain in acute ischaemic stroke: comparison of computed tomography and magnetic resonance diffusion-weighted imaging J Neurol Neurosurg Psychiatry 76 2005 1528 1533
20. P. Trouillas, and R. von Kummer Classification and pathogenesis of cerebral hemorrhages after thrombolysis in ischemic stroke Stroke 2006 556 561 (Review)
21. C.R. Hornig, W. Dorndorf, and A.L. Agnoli Hemorrhagic cerebral infarction. A prospective study Stroke 17 1986 179 185
22. Y. Sakamoto, K. Kimura, and Y. Iguchi Hemorrhagic transformation in acute cerebellar infarction Cerebrovasc Dis 32 2011 327 333
23. S.-H. Lee, B.-S. Kang, and N. Kim Does microbleed predict haemorrhagic transformation after acute atherothrombotic or cardioembolic stroke? J Neurol Neurosurg Psychiatry 79 2008 913 916