Expression of programmed death-1 (CD279) in primary cutaneous B-cell lymphomas with correlation to lymphoma entities and biological behaviour

British Journal of Dermatology

Volumn 169, Issue 6, 2013, Pages 1212-1218

  Mitteldorf, C ^a   Bieri, M ^b   Wey, N ^b   Kerl, K ^c   Kamarachev, J ^c   Pfaltz, M ^b,d   Kutzner, H ^e   Roncador, G ^f   Tomasini, D ^g   Kempf, W ^c,d  

^a Klinikum Hildesheim GmbH   (Germany)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d Research Unit   (Switzerland)

^e Dermatopathologische Gemeinschaftspraxis   (Germany)

^f Centro Nacional de Investigations Oncológicas   (Spain)

^g BUSTO ARSIZIO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PROGRAMMED DEATH 1 RECEPTOR; TRANSCRIPTION FACTOR PAX5; CD3 ANTIGEN;

ADULT; ARTICLE; B CELL LYMPHOMA; CANCER CELL; CD3+ T LYMPHOCYTE; CELL INFILTRATION; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARGE CELL LYMPHOMA; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN LYMPHOMA; T LYMPHOCYTE; FOLLICULAR LYMPHOMA; GERMINAL CENTER; HELPER CELL; METABOLISM; MIDDLE AGED; PATHOLOGY; SKIN TUMOR; TUMOR ASSOCIATED LEUKOCYTE;

ANTIGENS, CD3; FEMALE; GERMINAL CENTER; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOCYTES, TUMOR-INFILTRATING; LYMPHOMA, B-CELL; LYMPHOMA, FOLLICULAR; MALE; MIDDLE AGED; PROGRAMMED CELL DEATH 1 RECEPTOR; SKIN NEOPLASMS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84888997783     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.12579     Document Type: Article

References (32)

1. Willemze R, Jaffe ES, Burg G, et al,. WHO-EORTC classification for cutaneous lymphomas. Blood 2005; 105: 3768-85.
2. Kempf W, Denisjuk N, Kerl K, et al,. Primary cutaneous B-cell lymphomas. J Dtsch Dermatol Ges 2012; 10: 12-22.
3. Crotty S,. Follicular helper CD4 T cells (TFH). Annu Rev Immunol 2011; 29: 621-63.
4. Keir ME, Francisco LM, Sharpe AH,. PD-1 and its ligands in T-cell immunity. Curr Opin Immunol 2007; 19: 309-14.
5. Cetinözman F, Jansen PM, Willemze R,. Expression of programmed death-1 in primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma, cutaneous pseudo-T-cell lymphoma, and other types of cutaneous lymphoma. Am J Surg Pathol 2012; 36: 109-16.
6. Kempf W, Kazakov DV, Cipolat C, et al,. CD4/CD8 double negative mycosis fungoides with PD-1 (CD279) expression-a disease of follicular helper T-cells? Am J Dermatopathol 2012; 34: 757-61.
7. Kantekure K, Yang Y, Raghunath P, et al,. Expression patterns of the immunosuppressive proteins PD-1/CD279 and PD-L1/CD274 at different stages of cutaneous T-cell lymphoma/mycosis fungoides. Am J Dermatopathol 2012; 34: 126-8.
8. Cetinözman F, Jansen PM, Vermeer MH, Willemze R,. Differential expression of programmed peath-1 (PD-1) in Sézary syndrome and mycosis fungoides. Arch Dermatol 2012; 148: 1379-85.
9. Meyerson HJ, Awadallah A, Pavlidakey P, et al,. Follicular center helper T-cell (TFH) marker positive mycosis fungoides/Sézary syndrome. Mod Pathol 2013; 26: 32-43.
10. Xerri L, Chetaille B, Serriari N, et al,. Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. Hum Pathol 2008; 39: 1050-8.
11. Alvaro T, Lejeune M, Salvadõ MT, et al,. Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells. Clin Cancer Res 2005; 11: 1467-73.
12. Carreras J, Lopez-Guillermo A, Rocador G, et al,. High numbers of tumor-infiltrating programmed cell death 1-positive regulatory lymphocytes are associated with improved overall survival in follicular lymphoma. J Clin Oncol 2009; 27: 1470-6.
13. Koch K, Hoster E, Unterhalt M, et al,. The composition of the microenvironment in follicular lymphoma is associated with the stage of the disease. Hum Pathol 2012; 43: 2274-81.
14. Wahlin BE, Aggarwal M, Montes-Moreno S, et al,. A unifying microenvironment model in follicular lymphoma: outcome is predicted by programmed death-1-positive, regulatory, cytotoxic, and helper T cells and macrophages. Clin Cancer Res 2010; 16: 637-50.
15. Thompsen RH, Dong H, Lohse CM, et al,. PD-1 is expressed by tumor infiltrating immune cells and is associated with a poorer outcome for patients with renal cell carcinoma. Clin Cancer Res 2007; 13: 1757-61.
16. Nomi T, Sho M, Akahori T, et al,. Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer. Clin Cancer Res 2007; 13: 2151-7.
17. El-Badry AM, Breitenstein S, Jochum W,. Assessment of hepatic steatosis by expert pathologists: the end of a gold standard. Ann Surg 2009; 250: 691-7.
18. Senff NJ, Noordijk EM, Kim YH, et al,. European Organization for Research and Treatment of Cancer and International Society for Cutaneous Lymphoma consensus recommendations for the management of cutaneous B-cell lymphomas. Blood 2008; 112: 1600-9.
19. Kempf W, Kazakov DV, Mitteldorf C,. Cutaneous lymphomas: an update. Part 2: B-cell lymphomas and related conditions. Am J Dermatopathol 2013; (in press).
20. Zollinger T, Mertz KD, Schmid M, et al,. Borrelia in granuloma annulare, morphea and lichen sclerosus: a PCR-based study and review of the literature. J Cutan Pathol 2010; 37: 571-7.
21. Laurinavicius A, Laurinaviciene A, Ostapenko V, et al,. Immunohistochemistry profiles of breast ductal carcinoma: factor analysis of digital image analysis data. Diagn Pathol 2012; 7: 27.
22. Senff NJ, Hoefnagel JJ, Jansen PM, et al,. Reclassification of 300 primary cutaneous B-cell lymphomas according to the new WHO-EORTC classification for cutaneous lymphomas: comparison with previous classifications and identification of prognostic markers. J Clin Oncol 2007; 25: 1581-7.
23. Dorfman DV, Brown JA, Shahsafaei A, Freeman GJ,. Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma. Am J Surg Pathol 2006; 30: 802-10.
24. Richendollar BG, Pohlman B, Elson P, Hsi ED,. Follicular programmed death 1-positive lymphocytes in the tumor microenvironment are an independent prognostic factor in follicular lymphoma. Hum Pathol 2011; 42: 552-7.
25. Kutzner H, Kerl H, Pfaltz MC, Kempf W,. CD123-positive plasmacytoid dendritic cells in primary cutaneous marginal zone B-cell lymphoma: diagnostic and pathogenetic implications. Am J Surg Pathol 2009; 33: 1307-13.
26. Glas A, Kersten M, Delahaye L, et al,. Gene expression profiling in follicular lymphoma to assess clinical aggressiveness and to guide the choice of treatment. Blood 2005; 105: 301-7.
27. Beswick EJ, Pinchuk IV, Das S, et al,. Expression of the programmed death ligand 1, B7-H1, on gastric epithelial cells after Helicobacter pylori exposure promotes development of CD4+, CD25- FoxP3 regulatory T cells. Infect Immun 2007; 75: 4334-41.
28. Cerroni L, Zöchlinger N, Pütz B, Kerl H,. Infection by Borrelia burgdorferi and cutaneous B-cell lymphoma. J Cutan Pathol 1997; 24: 457-61.
29. Michaelis S, Kazakov DV, Schmid M, et al,. Hepatitis C and G viruses in B-cell lymphomas of the skin. J Cutan Pathol 2003; 30: 369-72.
30. Felcht M, Heck M, Weiss C, et al,. Expression of the T-cell regulatory marker FOXP3 in primary cutaneous large B-cell lymphoma tumour cells. Br J Dermatol 2012; 167: 348-58.
31. Kamarashev J, Schaerer L, Burg G, et al,. Tumor-infiltrating T cells in primary cutaneous B-cell lymphoproliferative disorders. J Cutan Pathol 2001; 28: 448-52.
32. Myklebust JH, Irish JM, Brody J, et al,. High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells. Blood 2013; 121: 1367-76.