Nano-engineered titanium for enhanced bone therapy

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 8812, Issue , 2013, Pages

  Gulati, Karan ^a   Atkins, Gerald J ^b   Findlay, David M ^b   Losic, Dusan ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Bone healing; Bone implants; Bone infection; Bone therapeutics; Local drug delivery; Titania nanotubes

Indexed keywords

BONE HEALING; BONE IMPLANT; BONE INFECTION; LOCAL DRUG DELIVERY; TITANIA NANOTUBES;

CELL ADHESION; DRUG DELIVERY; JOINT PROSTHESES; MEDICAL NANOTECHNOLOGY; NANOTUBES; TITANIUM; TITANIUM DIOXIDE; WIRE;

BONE;

EID: 84888985500     PISSN: 0277786X     EISSN: 1996756X     Source Type: Conference Proceeding    
DOI: 10.1117/12.2027151     Document Type: Conference Paper

References (14)

1. Tran, P.A., Sarin, L., Hurt, R.H. et al., "Opportunities for nanotechnology-enabled bioactive bone implants," J. Mater. Chem. 19(18), 2653-9 (2009)
2. Gulati, K., Aw, M.S., Findlay, D. et al., "Local drug delivery to the bone by drug-releasing implants: perspectives of nano-engineered titania nanotube arrays," Ther. Deliv. 3(7), 857-73 (2012).
3. Losic, D., Simovic, S., "Self-ordered nanopore and nanotube platforms for drug delivery applications," Expert Opin. Drug Deliv. 6(12), 1363-81(2009).
4. Harris, L.G., Mead, L., Muller-Oberlander, E. et al., "Bacteria and cell cytocompatibility studies on coated medical grade titanium surfaces. J. Biomed. Mater. Res. A. 78A(1), 50-8 (2006).
5. Okada, M., Yasuda, S., Kimura, T. et al., "Optimization of amino group density on surfaces of titanium dioxide nanoparticles covalently bonded to a silicone substrate for antibacterial and cell adhesion activities," J. Biomed. Mater. Res. A. 76A(1), 95-101 (2006).
6. Hetrick, E.M., Schoenfisch, M.H., "Reducing implant-related infections: active release strategies," Chem. Soc. Rev. 35(9), 780-9 (2006).
7. Harper, E.J., "Bioactive bone cements," Proc. Inst. Mech. Eng. H. 212(H2), 113-20 (1998).
8. Webster, T.J., Ejiofor, J.U., "Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V, and CoCrMo," Biomaterials. 25(19), 4731-9 (2004).
9. Yao, C., Webster, T.J., "Prolonged Antibiotic Delivery From Anodized Nanotubular Titanium Using a Coprecipitation Drug Loading Method," J. Biomed. Mater. Res. B Appl. Biomater. 91B(2), 587-95 (2009).
10. Zhao, L., Wang, H., Huo, K. et al., "Antibacterial nano-structured titania coating incorporated with silver nanoparticles," Biomaterials. 32(24), 5706-16 (2011).
11. Popat, K.C., Leoni, L., Grimes, C.A., et al., "Influence of engineered titania nanotubular surfaces on bone cells," Biomaterials. 28(21), 3188-97 (2007).
12. Gulati, K., Aw, M.S., Losic, D., "Drug-eluting Ti wires with titania nanotube arrays for bone fixation and reduced bone infection," Nanoscale Res. Lett. 6(1), 571-76 (2011).
13. Gulati, K., Ramakrishnan, S., Aw, M.S. et al., "Biocompatible polymer coating of titania nanotube arrays for improved drug elution and osteoblast adhesion," Acta Biomater. 8(1), 449-56 (2012).
14. Hickok, N.J., Shapiro, I.M., "Immobilized antibiotics to prevent orthopaedic implant infections," Adv. Drug Deliv. Rev. 64(12), 1165-76 (2012).