Cold atmospheric argon plasma treatment may accelerate wound healing in chronic wounds: Results of an open retrospective randomized controlled study in vivo

Clinical Plasma Medicine

Volumn 1, Issue 2, 2013, Pages 25-30

  Isbary, G ^a   Stolz, W ^a   Shimizu, T ^b   Monetti, R ^b   Bunk, W ^b   Schmidt, H U ^a   Morfill, G E ^b   Klampfl T G ^b   Steffes, B ^b   Thomas, H M ^b   Heinlin, J ^c   Karrer, S ^c   Landthaler, M ^c   Zimmermann, J L ^b  

^a Klinikum Schwabing   (Germany)

^b MAX PLANCK INSTITUT FÜR EXTRATERRESTRISCHE PHYSIK   (Germany)

^c UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Bacteria; Chronic wound; Cold atmospheric plasma (CAP); Infection; Plasma; Wound healing

Indexed keywords

ADULT; AGED; ARTICLE; BEAM THERAPY; CHRONIC WOUND; CLINICAL EVALUATION; COLD ATMOSPHERIC ARGON PLASMA TREATMENT; CONTROLLED STUDY; FEMALE; HUMAN; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MEDICAL DEVICE; OPEN STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETROSPECTIVE STUDY; TREATMENT DURATION; ULCER; WOUND HEALING;

EID: 84888873223     PISSN: 22128166     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cpme.2013.06.001     Document Type: Article

References (36)

1. Bogle M.A., Arndt K.A., Dover J.S. Evaluation of plasma skin regeneration technology in low-energy full-facial rejuvenation. Arch Dermatol 2007, 143(2):168-174.
2. Farin G., Grund K.E. Technology of argon plasma coagulation with particular regard to endoscopic applications. Endosc Surg Allied Technol 1994, 2(1):71-77.
3. Weltmann K.D., von Woedtke T. Basic requirements for plasma sources in medicine. Eur Phys J Appl Phys 2011, 55(1):13807.
4. Weltmann K.D., Kindel E., von Woedtke T., Haehnel M., Stieber M., Brandenburg R. Atmospheric-pressure plasma sources: prospective tools for plasma medicine. Pure Appl Chem 2010, 82(6):1223-1237.
5. Nosenko T., Shimizu T., Morfill G.E. Designing plasmas for chronic wound disinfection. New J Phys 2009, 11:1-20.
6. Morfill G.E., Kong M.G., Zimmermann J.L. Focus on plasma medicine. New J Phys 2009, 11:1-11.
7. Laroussi M., Hynes W., Akan T., Lu X., Tendero C. The plasma pencil: a source of hypersonic cold plasma bullets for biomedical applications. IEEE Trans Plasma Sci 2008, 36(4):1298-1299.
8. Kong M.G., Kroesen G., Morfill G., Nosenko T., Shimizu T., van Dijk J., et al. Plasma medicine: an introductory review. New J Phys 2009, 11:1-35.
9. Heinlin J., Isbary G., Stolz W., Zeman F., Landthaler M., Morfill G., et al. Randomized two-sided placebo-controlled study on the efficacy and safety of atmospheric non-thermal argon plasma for pruritus. J Eur Acad Dermatol Venereol 2013, 27(3):324-331.
10. Isbary G., Heinlin J., Shimizu T., Zimmermann J.L., Morfill G., Schmidt H.U., et al. Successful and safe use of 2min cold atmospheric argon plasma in chronic wounds: results of a randomized controlled trial. Br J Dermatol 2012, 167(2):404-410.
11. Isbary G, Morfill G, Schmidt HU, Georgi M, Ramrath K, Heinlin J, et al. A first prospective randomized controlled trial to decrease bacterial load using cold atmospheric argon plasma on chronic wounds in patients. Br J Dermatol 2010, 163(1):78-82.
12. Isbary G, Morfill G, Zimmermann J, Shimizu T, Stolz W. Cold atmospheric plasma: a successful treatment of lesions in Hailey-Hailey disease. Arch Dermatol 2011, 147(4):388-390.
13. Maisch T, Shimizu T, Isbary G, Heinlin J, Karrer S, Klampfl TG, et al. Contact-free inactivation of Candida albicans biofilms by cold atmospheric air plasma. Appl Environ Microbiol 2012, 78(12):4242-4247.
14. Maisch T, Shimizu T, Li Y-F, Heinlin J, Karrer S, Morfill G, et al. Decolonisation of MRSA, S. aureus and E. coli by cold-atmospheric plasma using a porcine skin model in vitro. PLoS One 2012, 7(4):e34610.
15. Zimmermann JL, Dumler K, Shimizu T, Morfill GE, Wolf A, Boxhammer V, et al. Effects of cold atmospheric plasmas on adenoviruses in solution. J Phys D: Appl Phys 2011, 44(50):1-9.
16. Klampfl TG, Isbary G, Shimizu T, Li YF, Zimmermann JL, Stolz W, et al. Cold atmospheric air plasma sterilization against spores and other microorganisms of clinical interest. Appl Environ Microbiol 2012, 78(15):5077-5082.
17. Zimmermann JL, Shimizu T, Schmidt HU, Li Y-F, Morfill G, Isbary G. Test for bacterial resistance build-up against plasma treatment. New J Phys 2012, 14:1-14.
18. Shimizu T, Steffes B, Pompl R, Jamitzky F, Bunk W, Ramrath K, et al. Characterization of microwave plasma torch for decontamination. Plasma Process Polym 2008, 5(6):577-582.
19. Shimizu T, Nosenko T, Morfill GE, Sato T, Schmidt H-U, Urayama T. Characterization of low-temperature microwave plasma treatment with and without UV light for disinfection. Plasma Process Polym 2010, 7(3 and 4):288-293.
20. Nosenko T, Shimizu T, Steffes B, Zimmermann J, Stolz W, Schmidt H-U, et al. Low-temperature atmospheric-pressure plasmas as a source of reactive oxygen and nitrogen species for chronic wound disinfection. Free Radical Biol Med 2009, 47:S129.
21. Tipa RS, Kroesen GMW Plasma-stimulated wound healing. IEEE Trans Plasma Sci 2011, 39(11):2978-2979.
22. Wende K, Landsberg K, Lindequist U, Weltmann KD, von Woedtke T. Distinctive activity of a nonthermal atmospheric-pressure plasma jet on eukaryotic and prokaryotic cells in a cocultivation approach of keratinocytes and microorganisms. IEEE Trans Plasma Sci 2010, 38(9):2479-2485.
23. Kalghatgi S, Friedman G, Fridman A, Clyne AM. Endothelial cell proliferation is enhanced by low dose non-thermal plasma through fibroblast growth factor-2 release. Ann Biomed Eng 2010, 38(3):748-757.
24. Rogers LC, Bevilacqua NJ, Armstrong DG, Andros G. Digital planimetry results in more accurate wound measurements: a comparison to standard ruler measurements. J Diabetes Sci Technol 2010, 4(4):799-802.
25. Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, Jeschke MG. Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med 2011, 17(1-2):113-125.
26. Aarabi S, Bhatt KA, Shi Y, Paterno J, Chang EI, Loh SA, et al. Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. FASEB J 2007, 21(12):3250-3261.
27. Broughton G, Janis JE, Attinger CE. The basic science of wound healing. Plast Reconstr Surg 2006, 117(Suppl. 7):12S-34S.
28. Fonder MA, Lazarus GS, Cowan DA, Aronson-Cook B, Kohli AR, Mamelak AJ. Treating the chronic wound: a practical approach to the care of nonhealing wounds and wound care dressings. J Am Acad Dermatol 2008, 58(2):185-206.
29. Margolis D, Berlin JA, Strom BL. Risk factors associated with the failure of a venous leg ulcer to heal. Arch Dermatol 1999, 135:920-926.
30. Margolis DJ, Gelfand JM, Hoffstad O, Berlin JA. Surrogate end points for the treatment of diabetic neuropathic foot ulcers. Diabetes Care 2003, 26(6):1696-1700.
31. Kantor J, Margolis DJ. A multicentre study of percentage change in venous leg ulcer area as a prognostic index of healing at 24 weeks. Br J Dermatol 2000, 142(5):960-964.
32. Margolis DJ, Bilker W, Santanna J, Baumgarten M. Venous leg ulcer: incidence and prevalence in the elderly. J Am Acad Dermatol 2002, 46(3):381-386.
33. Moffatt CJ, Franks PJ. Implementation of a leg ulcer strategy. Br J Dermatol 2004, 151(4):857-867.
34. Kuehn B.M. Chronic wound care guidelines issued. JAMA 2007, 297(9):938-939.
35. Margolis D, Allen-Taylor L, Hoffstad O, Berlin JA. The accuracy of venous leg ulcer prognostic models in a wound care system. Wound Repair Regener 2004, 12:163-168.
36. Kantor J, Margolis D. A multicentre study of percentage change in venous leg ulcer area as a prognostic index of healing at 24 weeks. Br J Dermatol 2000, 142:960-964.