Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?

Antioxidants and Redox Signaling

Volumn 19, Issue 16, 2013, Pages 1976-1980

  De Araujo, Aline Dantas ^a   Herzig, Volker ^a   Windley, Monique J ^b   Dziemborowicz, Sławomir ^b   Mobli, Mehdi ^a   Nicholson, Graham M ^b   Alewood, Paul F ^a   King, Glenn F ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DISULFIDE; EPITOPE; CYSTEINE; PROTEIN;

ARTICLE; CYSTINE KNOT MOTIF; DISULFIDE BOND; HYDROGENOLYSIS; INSECTICIDAL ACTIVITY; LD 50; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXIDATION REDUCTION REACTION; OXIDATION REDUCTION STATE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RING CLOSING METATHESIS; SOLID PHASE SYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE;

CYSTEINE; DISULFIDES; MODELS, MOLECULAR; OXIDATION-REDUCTION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEINS;

EID: 84888632197     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2013.5365     Document Type: Article

References (9)

1. Azimi I, Wong JW, and Hogg PJ. Control of mature protein function by allosteric disulfide bonds. Antioxid Redox Signal 14: 113-126, 2011
2. Carugo O, Čema-zar M, Zahariev S, Hudáky I, Gáspá ri Z, Perczel A, and Pongor S. Vicinal disulfide turns. Protein Eng 16: 637-639, 2003
3. Cook KM and Hogg PJ. Post-translational control of protein function by disulfide bond cleavage. Antioxid Redox Signal 18: 1987-2015, 2013
4. Gunning SJ, Maggio F, Windley MJ, Valenzuela SM, King GF, and Nicholson GM. The Janus-faced atracotoxins are specific blockers of invertebrate KCa channels. FEBS J 275: 4045-4059, 2008
5. Maggio F and King GF. Scanning mutagenesis of a Janusfaced atracotoxin reveals a bipartite surface patch that is essential for neurotoxic function. J Biol Chem 277: 22806-22813, 2002
6. Mobli M, de Araujo AD, Lambert LK, Pierens GK, Windley MJ, Nicholson GM, Alewood PF, and King GF. Direct visualization of disulfide bonds through diselenide proxies using 77Se NMR spectroscopy. Angew Chem Int Ed 48: 9312-9314, 2009
7. Muir TW. Semisynthesis of proteins by expressed protein ligation. Annu Rev Biochem 72: 249-289, 2003
8. Wang X-H, Connor M, Smith R, Maciejewski MW, Howden MEH, Nicholson GM, Christie MJ, and King GF. Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge. Nat Struct Biol 7: 505-513, 2000
9. Wouters MA, Fan SW, and Haworth NL. Disulfides as redox switches: From molecular mechanisms to functional significance. Antioxid Redox Signal 12: 53-91, 2010